A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity (256 visite)
Chemistryselect (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.
Tipo di articolo: Journal Article,
Impact factor: 1.505, Impact factor a 5 anni: 1.505
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041835245&doi=10.1002%2fslct.201701148&partnerID=40&md5=fd4e232077e69de46f05aa0a17525e60
Parole chiave: Amyloid Aggregation, Porphyrin Derivative, Supramolecular Recognition, Toxicity Inhibition,
Affiliazioni:
*** IBB - CNR ***
CNR-IPCF Istituto per i Processi Chimico-Fisici, V.le F. Stagno d'Alcontres 37, Messina, 98158, Italy
CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Program in Translational Biomedicine, Università di Catania, Viale A. Doria 6, Catania, 95125, Italy
Marie Curie action Incipit-Cofund project, PhD Program in Chemical Sciences, CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Riferimenti:
Haass, C., Selkoe, D.J., (2007) Nat. Rev. Mol. Cell Biol., 8, pp. 101-11
Hardy, J., Selkoe, D.J., (2002) Science, 297, pp. 353-356
Bona, P.D., Giuffrida, M.L., Caraci, F., Copani, A., Pignataro, B., Attanasio, F., Cataldo, S., Rizzarelli, E., (2009) J. Pept. Sci., 15, pp. 220-228
Sinopoli, A., Giuffrida, A., Tomasello, M.F., Giuffrida, M.L., Leone, M., Attanasio, F., Caraci, F., Saviano, M., (2016) ChemBioChem, 17, pp. 1541-1549
Tay, W.M., Huang, D., Rosenberry, T.L., Paravastu, A.K., (2013) J. Mol. Biol., 425, pp. 2494-2508
Hubin, E., van Nuland, N.A.J., Broersen, K., Pauwels, K., (2014) Cell. Mol. Life Sci., 71, pp. 3507-3521
Cleary, J.P., Walsh, D.M., Hofmeister, J.J., Shankar, G.M., Kuskowski, M.A., Selkoe, D.J., Ashe, K.H., (2005) Nat. Neurosci., 8, pp. 79-84
Li, S., Hong, S., Shepardson, N.E., Walsh, D.M., Shankar, G.M., Selkoe, D., (2009) Neuron, 62, pp. 788-801
Wilcox, K.C., Lacor, P.N., Pitt, J., Klein, W.L., (2011) Cell. Mol. Neurobiol., 31, pp. 939-948
Jana, M.K., Cappai, R., Pham, C.L.L., Ciccotosto, G.D., (2016) J. Neurochem., 136, pp. 594-608
Lowe, T.L., Strzelec, A., Kiessling, L.L., Murphy, R.M., (2001) Biochemistry, 40, pp. 7882-7889
Bieschke, J., Herbst, M., Wiglenda, T., Friedrich, R.P., Boeddrich, A., Schiele, F., Kleckers, D., Wang, Q., (2012) Nat. Chem. Biol., 8, pp. 93-101
Francioso, A., Punzi, P., Boffi, A., Lori, C., Martire, S., Giordano, C., D'Erme, M., Mosca, L., (2015) Bioorg. Med. Chem., 23, pp. 1671-1683
Goyal, D., Shuaib, S., Mann, S., Goyal, B., (2017) ACS Comb. Sci., 19, pp. 55-80
Tjernberg, L.O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A.R., Thyberg, J., Terenius, L., Nordstedt, C., (1996) J. Biol. Chem., 271, pp. 8545-8548
Soto, C., Sigurdsson, E.M., Morelli, L., Kumar, R.A., Castaño, E.M., Frangione, B., (1998) Nat. Med., 4, pp. 822-826
Ouberai, M., Dumy, P., Chierici, S., Garcia, J., (2009) Bioconjug. Chem., 20, pp. 2123-2132
Zhang, Q., Hu, X., Wang, W., Yuan, Z., (2016) Biomacromolecules, 17, pp. 661-668
Bao, Q., Luo, Y., Li, W., Sun, X., Zhu, C., Li, P., Huang, Z.-X., Tan, X., (2011) J. Biol. Inorg. Chem., 16, pp. 809-816
Yuan, C., Gao, Z., (2013) Chem. Res. Toxicol., 26, pp. 262-269
Liu, Y., Carver, J.A., Ho, L.H., Elias, A.K., Musgrave, I.F., Pukala, T.L., (2014) Biochem. Biophys. Res. Commun., 454, pp. 295-300
Zhang, X.-A., Lovejoy, K.S., Jasanoff, A., Lippard, D.P., (2007) Proc. Natl. Acad. Sci., U. S. A., 104, pp. 10780-10785
Hachimine, K., Shibaguchi, H., Kuroki, M., Yamada, H., Kinugasa, T., Nakae, Y., Asano, R., Kuroki, M., (2007) Cancer Sci., 98, pp. 916-920
Wu, C.W., Liao, P.C., Yu, L., Wang, S.T., Chen, S.T., Wu, C.M., Kuo, Y.M., (2004) Neurobiol. Dis., 17, pp. 367-377
Ghosh, C., Mukherjee, S., Seal, M., Ghosh, S., (2016) Dey, Inorg. Chem., 55, pp. 1748-1757
Lee, B.I., Lee, S., Suh, Y.S., Lee, J.S., Kim, A.K., Kwon, O.Y., Yu, K., Park, C.B., (2015) Angew. Chem. - Int. Ed., 54, pp. 11472-11476
Hirabayashi, A., Shindo, Y., Oka, K., Takahashi, D., Toshima, K., (2014) Chem. Commun., 50, pp. 9543-9546
Zhou, Y., Wang, J., Liu, L., Wang, R., Lai, X., Xu, M., (2013) ACS Chem. Neurosci., 4, pp. 535-539
Villari, V., Mazzaglia, A., Darcy, R., O'Driscoll, C.M., Micali, N., (2013) Biomacromolecules, 14, pp. 811-817
Shen, C.L., Scott, G.L., Merchant, F., Murphy, R.M., (1993) Biophys. J., 65, pp. 2383-2395
Bitan, G., Kirkitadze, M.D., Lomakin, A., Vollers, S.S., Benedek, G.B., Teplow, D.B., (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 330-335
Mazzaglia, A., Micali, N., Scolaro, L.M., Attanasio, F., Magrí, A., Pappalardo, G., Villari, V., (2010) J. Phys. Chem. B, 114, pp. 705-713
Villari, V., Mineo, P., Scamporrino, E., Micali, N., (2012) RSC Adv., 2, pp. 12989-12998
Arosio, P., Knowles, T.P.J., Linse, S., (2015) Phys. Chem. Chem. Phys., 17, pp. 7606-7618
Angelini, N., Micali, N., Mineo, P., Scamporrino, E., Villari, V., Vitalini, D., (2005) J. Phys. Chem. B, 109, pp. 18645-18651
Mineo, P., Micali, N., Villari, V., Donato, M.G., Scamporrino, E., (2012) Chem. Eur. J., 18, pp. 12452-12457
Sweeney, P.J., Walker, J.M., (1993) Enzym. Mol. Biol., pp. 277-281. , in, (Ed., M. M. Burrell, Humana Press, Totowa New Jersey
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Stella, A.M.G., Canonico, P.L., Sortino, M.A., (1999) FASEB J., 13, pp. 2225-2234
Giuffrida, M.L., Tomasello, M.F., Pandini, G., Caraci, F., Battaglia, G., Busceti, C., Pietro, P.D., Copani, A., (2015) Front. Cell. Neurosci., 9, p. 297
Chemistryselect (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.
Tipo di articolo: Journal Article,
Impact factor: 1.505, Impact factor a 5 anni: 1.505
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041835245&doi=10.1002%2fslct.201701148&partnerID=40&md5=fd4e232077e69de46f05aa0a17525e60
Parole chiave: Amyloid Aggregation, Porphyrin Derivative, Supramolecular Recognition, Toxicity Inhibition,
Affiliazioni:
*** IBB - CNR ***
CNR-IPCF Istituto per i Processi Chimico-Fisici, V.le F. Stagno d'Alcontres 37, Messina, 98158, Italy
CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Program in Translational Biomedicine, Università di Catania, Viale A. Doria 6, Catania, 95125, Italy
Marie Curie action Incipit-Cofund project, PhD Program in Chemical Sciences, CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Riferimenti:
Haass, C., Selkoe, D.J., (2007) Nat. Rev. Mol. Cell Biol., 8, pp. 101-11
Hardy, J., Selkoe, D.J., (2002) Science, 297, pp. 353-356
Bona, P.D., Giuffrida, M.L., Caraci, F., Copani, A., Pignataro, B., Attanasio, F., Cataldo, S., Rizzarelli, E., (2009) J. Pept. Sci., 15, pp. 220-228
Sinopoli, A., Giuffrida, A., Tomasello, M.F., Giuffrida, M.L., Leone, M., Attanasio, F., Caraci, F., Saviano, M., (2016) ChemBioChem, 17, pp. 1541-1549
Tay, W.M., Huang, D., Rosenberry, T.L., Paravastu, A.K., (2013) J. Mol. Biol., 425, pp. 2494-2508
Hubin, E., van Nuland, N.A.J., Broersen, K., Pauwels, K., (2014) Cell. Mol. Life Sci., 71, pp. 3507-3521
Cleary, J.P., Walsh, D.M., Hofmeister, J.J., Shankar, G.M., Kuskowski, M.A., Selkoe, D.J., Ashe, K.H., (2005) Nat. Neurosci., 8, pp. 79-84
Li, S., Hong, S., Shepardson, N.E., Walsh, D.M., Shankar, G.M., Selkoe, D., (2009) Neuron, 62, pp. 788-801
Wilcox, K.C., Lacor, P.N., Pitt, J., Klein, W.L., (2011) Cell. Mol. Neurobiol., 31, pp. 939-948
Jana, M.K., Cappai, R., Pham, C.L.L., Ciccotosto, G.D., (2016) J. Neurochem., 136, pp. 594-608
Lowe, T.L., Strzelec, A., Kiessling, L.L., Murphy, R.M., (2001) Biochemistry, 40, pp. 7882-7889
Bieschke, J., Herbst, M., Wiglenda, T., Friedrich, R.P., Boeddrich, A., Schiele, F., Kleckers, D., Wang, Q., (2012) Nat. Chem. Biol., 8, pp. 93-101
Francioso, A., Punzi, P., Boffi, A., Lori, C., Martire, S., Giordano, C., D'Erme, M., Mosca, L., (2015) Bioorg. Med. Chem., 23, pp. 1671-1683
Goyal, D., Shuaib, S., Mann, S., Goyal, B., (2017) ACS Comb. Sci., 19, pp. 55-80
Tjernberg, L.O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A.R., Thyberg, J., Terenius, L., Nordstedt, C., (1996) J. Biol. Chem., 271, pp. 8545-8548
Soto, C., Sigurdsson, E.M., Morelli, L., Kumar, R.A., Castaño, E.M., Frangione, B., (1998) Nat. Med., 4, pp. 822-826
Ouberai, M., Dumy, P., Chierici, S., Garcia, J., (2009) Bioconjug. Chem., 20, pp. 2123-2132
Zhang, Q., Hu, X., Wang, W., Yuan, Z., (2016) Biomacromolecules, 17, pp. 661-668
Bao, Q., Luo, Y., Li, W., Sun, X., Zhu, C., Li, P., Huang, Z.-X., Tan, X., (2011) J. Biol. Inorg. Chem., 16, pp. 809-816
Yuan, C., Gao, Z., (2013) Chem. Res. Toxicol., 26, pp. 262-269
Liu, Y., Carver, J.A., Ho, L.H., Elias, A.K., Musgrave, I.F., Pukala, T.L., (2014) Biochem. Biophys. Res. Commun., 454, pp. 295-300
Zhang, X.-A., Lovejoy, K.S., Jasanoff, A., Lippard, D.P., (2007) Proc. Natl. Acad. Sci., U. S. A., 104, pp. 10780-10785
Hachimine, K., Shibaguchi, H., Kuroki, M., Yamada, H., Kinugasa, T., Nakae, Y., Asano, R., Kuroki, M., (2007) Cancer Sci., 98, pp. 916-920
Wu, C.W., Liao, P.C., Yu, L., Wang, S.T., Chen, S.T., Wu, C.M., Kuo, Y.M., (2004) Neurobiol. Dis., 17, pp. 367-377
Ghosh, C., Mukherjee, S., Seal, M., Ghosh, S., (2016) Dey, Inorg. Chem., 55, pp. 1748-1757
Lee, B.I., Lee, S., Suh, Y.S., Lee, J.S., Kim, A.K., Kwon, O.Y., Yu, K., Park, C.B., (2015) Angew. Chem. - Int. Ed., 54, pp. 11472-11476
Hirabayashi, A., Shindo, Y., Oka, K., Takahashi, D., Toshima, K., (2014) Chem. Commun., 50, pp. 9543-9546
Zhou, Y., Wang, J., Liu, L., Wang, R., Lai, X., Xu, M., (2013) ACS Chem. Neurosci., 4, pp. 535-539
Villari, V., Mazzaglia, A., Darcy, R., O'Driscoll, C.M., Micali, N., (2013) Biomacromolecules, 14, pp. 811-817
Shen, C.L., Scott, G.L., Merchant, F., Murphy, R.M., (1993) Biophys. J., 65, pp. 2383-2395
Bitan, G., Kirkitadze, M.D., Lomakin, A., Vollers, S.S., Benedek, G.B., Teplow, D.B., (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 330-335
Mazzaglia, A., Micali, N., Scolaro, L.M., Attanasio, F., Magrí, A., Pappalardo, G., Villari, V., (2010) J. Phys. Chem. B, 114, pp. 705-713
Villari, V., Mineo, P., Scamporrino, E., Micali, N., (2012) RSC Adv., 2, pp. 12989-12998
Arosio, P., Knowles, T.P.J., Linse, S., (2015) Phys. Chem. Chem. Phys., 17, pp. 7606-7618
Angelini, N., Micali, N., Mineo, P., Scamporrino, E., Villari, V., Vitalini, D., (2005) J. Phys. Chem. B, 109, pp. 18645-18651
Mineo, P., Micali, N., Villari, V., Donato, M.G., Scamporrino, E., (2012) Chem. Eur. J., 18, pp. 12452-12457
Sweeney, P.J., Walker, J.M., (1993) Enzym. Mol. Biol., pp. 277-281. , in, (Ed., M. M. Burrell, Humana Press, Totowa New Jersey
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Stella, A.M.G., Canonico, P.L., Sortino, M.A., (1999) FASEB J., 13, pp. 2225-2234
Giuffrida, M.L., Tomasello, M.F., Pandini, G., Caraci, F., Battaglia, G., Busceti, C., Pietro, P.D., Copani, A., (2015) Front. Cell. Neurosci., 9, p. 297
Molecules that inhibit Aβ misfolding have received considerable attention in view of their potential use in the prevention or treatment of Alzheimer's disease. We designed a peptide-porphyrin conjugate incorporating two recognition sites enabling it to interact strongly with the Aβ42 peptide. The inhibitory effect on Aβ42 fibril formation was determined in aqueous solution by a variety of spectroscopic techniques including UV-vis, fluorescence, Circular Dichroism, Dynamic Light Scattering, Maldi-Time of Flight-Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy. A working mechanism of the antifibrillogenic action of the conjugate was proposed based on the experimental observations. The neuroprotective activity of the conjugate was also inferred by using primary neuronal or neuron-like differentiated SH-SY5Y cell cultures. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Nessun risultato. |
Nessun risultato. |
Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (186 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
Dettagli Esporta in BibTeX Esporta in EndNote
D'Urso A, Randazzo R, Rizzo V, Gangemi CMA, Romanucci V, Zarrelli A, Tomaselli G, Milardi D, Borbone N, Purrello R, Piccialli G, Di Fabio G, Oliviero G
* Stabilization vs. destabilization of G-quadruplex superstructures: the role of the porphyrin derivative having spermine arms (200 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2017 Jul 14; 19(26): 17404-17410.
Impact Factor: 3.906
Dettagli Esporta in BibTeX Esporta in EndNote
Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
* Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease (304 visite)
Acs Med Chem Lett (ISSN: 1948-5875), 2016 Sep 26; 7(12): 1145-1150.
Impact Factor: 3.746
Dettagli Esporta in BibTeX Esporta in EndNote
Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (377 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Bellia F, Vecchio G
* Cyclodextrin 3-functionalized with 8-hydroxyquinoline as an antioxidant inhibitor of metal-induced amyloid aggregation (280 visite)
Chempluschem (ISSN: 2192-6506), 2015; 80(4): 762-770.
Impact Factor: 2.836
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Grasso GI, Bellia F, Attanasio F, Viale M, Vecchio G
* Soluble sugar-based quinoline derivatives as new antioxidant modulators of metal-induced amyloid aggregation (407 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2015; 54(6): 2591-2602.
Impact Factor: 4.82
Dettagli Esporta in BibTeX Esporta in EndNote
Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (297 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
Dettagli Esporta in BibTeX Esporta in EndNote
Improta R, Ferrante C, Bozio R, Barone V
* The polarizability in solution of tetra-phenyl-porphyrin derivatives in their excited electronic states: A PCM/TD-DFT study (223 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2009; 11(22): 4664-4673.
Impact Factor: 4.116
Dettagli Esporta in BibTeX Esporta in EndNote
Castiglioni E, Abbate S, Longhi G, Gangemi R, Lauceri R, Purrello R
* Absorption flattening as one cause of distortion of circular dichroism spectra of Δ-RuPhen3·H2TPPS complex (201 visite)
Chirality (ISSN: 0899-0042), 2007 Sep; 19(8): 642-646.
Impact Factor: 2.436
Dettagli Esporta in BibTeX Esporta in EndNote
Mammana A, D'Urso A, Lauceri R, Purrello R
* Switching off and on the supramolecular chiral memory in porphyrin assemblies (170 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2007 Jul 4; 129(26): 8062-8063.
Impact Factor: 7.885
Dettagli Esporta in BibTeX Esporta in EndNote
Puglisi A, Purrello R, Rizzarelli E, Sortino S, Vecchio G
* Spectroscopic and self-association behavior of a porphyrin-β- cyclodextrin conjugate (295 visite)
New J Chem (ISSN: 1144-0546), 2007; 31(8): 1499-1506.
Impact Factor: 2.651
Dettagli Esporta in BibTeX Esporta in EndNote
Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (292 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
Impact Factor: 2.286
Dettagli Esporta in BibTeX Esporta in EndNote
Lauceria R, Purrellob R
* Transfer, memory and amplification of chirality in porphyrin aggregates (209 visite)
Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
Impact Factor: 1.715
Dettagli Esporta in BibTeX Esporta in EndNote
Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V
* Design of a new mimochrome with unique topology (333 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2003 Nov 21; 9(22): 5643-5654.
Impact Factor: 4.353
Dettagli Esporta in BibTeX Esporta in EndNote
Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
* Non-covalent synthesis in aqueous solution of discrete multi-porphyrin aggregates with programmable stoichiometry and sequence (262 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Dec 11; 124(49): 14536-14537.
Impact Factor: 6.201
Dettagli Esporta in BibTeX Esporta in EndNote
Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (354 visite)
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
Impact Factor: 9.023
Dettagli Esporta in BibTeX Esporta in EndNote
Lauceri R, Purrello R, Shetty SJ, Vicente MGH
* Interactions of anionic carboranylated porphyrins with DNA [3] (216 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2001 Jun 20; 123(24): 5835-5836.
Impact Factor: 6.079
Dettagli Esporta in BibTeX Esporta in EndNote
De Luca S, Bruno G, Fattorusso R, Isernia C, Pedone C, Morelli G
New synthetic tools for peptide-tetraphenylporphyrin derivatives (203 visite)
Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1998 Jul; 5(4): 269-276.
Impact Factor: 0.557
Dettagli Esporta in BibTeX Esporta in EndNote
Bustamante C, Gurrieri S, Pasternack RF, Purrello R, Rizzarelli E
Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides (302 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Sep; 34(8): 1099-1104.
Impact Factor: 2.425
Dettagli Esporta in BibTeX Esporta in EndNote
19 Records (19 escludendo Abstract e Conferenze).
Impact factor totale: 84.393 (84.393 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 96.08 (96.08 escludendo Abstract e Conferenze).
Impact factor totale: 84.393 (84.393 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 96.08 (96.08 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Gennaro Angrisano in data Sunday 12 July 2020, 13:14:43
256 visite. Ultima visita in data Wednesday 29 July 2020, 0:55:48
ibb.cnr.it