A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity
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A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity (75 visite)

Villari V, Tosto R, Di Natale G, Sinopoli A, Tomasello M, Lazzaro S, Micali N, Pappalardo G

CHEMISTRYSELECT (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.



Tipo di articolo: Journal Article

Impact factor: 1.505, Impact factor a 5 anni: 1.505

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041835245&doi=10.1002%2fslct.201701148&partnerID=40&md5=fd4e232077e69de46f05aa0a17525e60

Parole chiave: Amyloid Aggregation, Porphyrin Derivative, Supramolecular Recognition, Toxicity Inhibition

Affiliazioni:

*** IBB - CNR ***
CNR-IPCF Istituto per i Processi Chimico-Fisici, V.le F. Stagno d'Alcontres 37, Messina, 98158, Italy
CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Program in Translational Biomedicine, Università di Catania, Viale A. Doria 6, Catania, 95125, Italy
Marie Curie action Incipit-Cofund project, PhD Program in Chemical Sciences, CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy


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Molecules that inhibit Aβ misfolding have received considerable attention in view of their potential use in the prevention or treatment of Alzheimer's disease. We designed a peptide-porphyrin conjugate incorporating two recognition sites enabling it to interact strongly with the Aβ42 peptide. The inhibitory effect on Aβ42 fibril formation was determined in aqueous solution by a variety of spectroscopic techniques including UV-vis, fluorescence, Circular Dichroism, Dynamic Light Scattering, Maldi-Time of Flight-Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy. A working mechanism of the antifibrillogenic action of the conjugate was proposed based on the experimental observations. The neuroprotective activity of the conjugate was also inferred by using primary neuronal or neuron-like differentiated SH-SY5Y cell cultures. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Impact factor a 5 anni totale: 96.08 (96.08 escludendo Abstract e Conferenze).







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