A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity (236 visite)
Chemistryselect (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.
Tipo di articolo: Journal Article,
Impact factor: 1.505, Impact factor a 5 anni: 1.505
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041835245&doi=10.1002%2fslct.201701148&partnerID=40&md5=fd4e232077e69de46f05aa0a17525e60
Parole chiave: Amyloid Aggregation, Porphyrin Derivative, Supramolecular Recognition, Toxicity Inhibition,
Affiliazioni:
*** IBB - CNR ***
CNR-IPCF Istituto per i Processi Chimico-Fisici, V.le F. Stagno d'Alcontres 37, Messina, 98158, Italy
CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Program in Translational Biomedicine, Università di Catania, Viale A. Doria 6, Catania, 95125, Italy
Marie Curie action Incipit-Cofund project, PhD Program in Chemical Sciences, CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Riferimenti:
Haass, C., Selkoe, D.J., (2007) Nat. Rev. Mol. Cell Biol., 8, pp. 101-11
Hardy, J., Selkoe, D.J., (2002) Science, 297, pp. 353-356
Bona, P.D., Giuffrida, M.L., Caraci, F., Copani, A., Pignataro, B., Attanasio, F., Cataldo, S., Rizzarelli, E., (2009) J. Pept. Sci., 15, pp. 220-228
Sinopoli, A., Giuffrida, A., Tomasello, M.F., Giuffrida, M.L., Leone, M., Attanasio, F., Caraci, F., Saviano, M., (2016) ChemBioChem, 17, pp. 1541-1549
Tay, W.M., Huang, D., Rosenberry, T.L., Paravastu, A.K., (2013) J. Mol. Biol., 425, pp. 2494-2508
Hubin, E., van Nuland, N.A.J., Broersen, K., Pauwels, K., (2014) Cell. Mol. Life Sci., 71, pp. 3507-3521
Cleary, J.P., Walsh, D.M., Hofmeister, J.J., Shankar, G.M., Kuskowski, M.A., Selkoe, D.J., Ashe, K.H., (2005) Nat. Neurosci., 8, pp. 79-84
Li, S., Hong, S., Shepardson, N.E., Walsh, D.M., Shankar, G.M., Selkoe, D., (2009) Neuron, 62, pp. 788-801
Wilcox, K.C., Lacor, P.N., Pitt, J., Klein, W.L., (2011) Cell. Mol. Neurobiol., 31, pp. 939-948
Jana, M.K., Cappai, R., Pham, C.L.L., Ciccotosto, G.D., (2016) J. Neurochem., 136, pp. 594-608
Lowe, T.L., Strzelec, A., Kiessling, L.L., Murphy, R.M., (2001) Biochemistry, 40, pp. 7882-7889
Bieschke, J., Herbst, M., Wiglenda, T., Friedrich, R.P., Boeddrich, A., Schiele, F., Kleckers, D., Wang, Q., (2012) Nat. Chem. Biol., 8, pp. 93-101
Francioso, A., Punzi, P., Boffi, A., Lori, C., Martire, S., Giordano, C., D'Erme, M., Mosca, L., (2015) Bioorg. Med. Chem., 23, pp. 1671-1683
Goyal, D., Shuaib, S., Mann, S., Goyal, B., (2017) ACS Comb. Sci., 19, pp. 55-80
Tjernberg, L.O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A.R., Thyberg, J., Terenius, L., Nordstedt, C., (1996) J. Biol. Chem., 271, pp. 8545-8548
Soto, C., Sigurdsson, E.M., Morelli, L., Kumar, R.A., Castaño, E.M., Frangione, B., (1998) Nat. Med., 4, pp. 822-826
Ouberai, M., Dumy, P., Chierici, S., Garcia, J., (2009) Bioconjug. Chem., 20, pp. 2123-2132
Zhang, Q., Hu, X., Wang, W., Yuan, Z., (2016) Biomacromolecules, 17, pp. 661-668
Bao, Q., Luo, Y., Li, W., Sun, X., Zhu, C., Li, P., Huang, Z.-X., Tan, X., (2011) J. Biol. Inorg. Chem., 16, pp. 809-816
Yuan, C., Gao, Z., (2013) Chem. Res. Toxicol., 26, pp. 262-269
Liu, Y., Carver, J.A., Ho, L.H., Elias, A.K., Musgrave, I.F., Pukala, T.L., (2014) Biochem. Biophys. Res. Commun., 454, pp. 295-300
Zhang, X.-A., Lovejoy, K.S., Jasanoff, A., Lippard, D.P., (2007) Proc. Natl. Acad. Sci., U. S. A., 104, pp. 10780-10785
Hachimine, K., Shibaguchi, H., Kuroki, M., Yamada, H., Kinugasa, T., Nakae, Y., Asano, R., Kuroki, M., (2007) Cancer Sci., 98, pp. 916-920
Wu, C.W., Liao, P.C., Yu, L., Wang, S.T., Chen, S.T., Wu, C.M., Kuo, Y.M., (2004) Neurobiol. Dis., 17, pp. 367-377
Ghosh, C., Mukherjee, S., Seal, M., Ghosh, S., (2016) Dey, Inorg. Chem., 55, pp. 1748-1757
Lee, B.I., Lee, S., Suh, Y.S., Lee, J.S., Kim, A.K., Kwon, O.Y., Yu, K., Park, C.B., (2015) Angew. Chem. - Int. Ed., 54, pp. 11472-11476
Hirabayashi, A., Shindo, Y., Oka, K., Takahashi, D., Toshima, K., (2014) Chem. Commun., 50, pp. 9543-9546
Zhou, Y., Wang, J., Liu, L., Wang, R., Lai, X., Xu, M., (2013) ACS Chem. Neurosci., 4, pp. 535-539
Villari, V., Mazzaglia, A., Darcy, R., O'Driscoll, C.M., Micali, N., (2013) Biomacromolecules, 14, pp. 811-817
Shen, C.L., Scott, G.L., Merchant, F., Murphy, R.M., (1993) Biophys. J., 65, pp. 2383-2395
Bitan, G., Kirkitadze, M.D., Lomakin, A., Vollers, S.S., Benedek, G.B., Teplow, D.B., (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 330-335
Mazzaglia, A., Micali, N., Scolaro, L.M., Attanasio, F., Magrí, A., Pappalardo, G., Villari, V., (2010) J. Phys. Chem. B, 114, pp. 705-713
Villari, V., Mineo, P., Scamporrino, E., Micali, N., (2012) RSC Adv., 2, pp. 12989-12998
Arosio, P., Knowles, T.P.J., Linse, S., (2015) Phys. Chem. Chem. Phys., 17, pp. 7606-7618
Angelini, N., Micali, N., Mineo, P., Scamporrino, E., Villari, V., Vitalini, D., (2005) J. Phys. Chem. B, 109, pp. 18645-18651
Mineo, P., Micali, N., Villari, V., Donato, M.G., Scamporrino, E., (2012) Chem. Eur. J., 18, pp. 12452-12457
Sweeney, P.J., Walker, J.M., (1993) Enzym. Mol. Biol., pp. 277-281. , in, (Ed., M. M. Burrell, Humana Press, Totowa New Jersey
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Stella, A.M.G., Canonico, P.L., Sortino, M.A., (1999) FASEB J., 13, pp. 2225-2234
Giuffrida, M.L., Tomasello, M.F., Pandini, G., Caraci, F., Battaglia, G., Busceti, C., Pietro, P.D., Copani, A., (2015) Front. Cell. Neurosci., 9, p. 297
Chemistryselect (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.
Tipo di articolo: Journal Article,
Impact factor: 1.505, Impact factor a 5 anni: 1.505
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041835245&doi=10.1002%2fslct.201701148&partnerID=40&md5=fd4e232077e69de46f05aa0a17525e60
Parole chiave: Amyloid Aggregation, Porphyrin Derivative, Supramolecular Recognition, Toxicity Inhibition,
Affiliazioni:
*** IBB - CNR ***
CNR-IPCF Istituto per i Processi Chimico-Fisici, V.le F. Stagno d'Alcontres 37, Messina, 98158, Italy
CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Program in Translational Biomedicine, Università di Catania, Viale A. Doria 6, Catania, 95125, Italy
Marie Curie action Incipit-Cofund project, PhD Program in Chemical Sciences, CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Riferimenti:
Haass, C., Selkoe, D.J., (2007) Nat. Rev. Mol. Cell Biol., 8, pp. 101-11
Hardy, J., Selkoe, D.J., (2002) Science, 297, pp. 353-356
Bona, P.D., Giuffrida, M.L., Caraci, F., Copani, A., Pignataro, B., Attanasio, F., Cataldo, S., Rizzarelli, E., (2009) J. Pept. Sci., 15, pp. 220-228
Sinopoli, A., Giuffrida, A., Tomasello, M.F., Giuffrida, M.L., Leone, M., Attanasio, F., Caraci, F., Saviano, M., (2016) ChemBioChem, 17, pp. 1541-1549
Tay, W.M., Huang, D., Rosenberry, T.L., Paravastu, A.K., (2013) J. Mol. Biol., 425, pp. 2494-2508
Hubin, E., van Nuland, N.A.J., Broersen, K., Pauwels, K., (2014) Cell. Mol. Life Sci., 71, pp. 3507-3521
Cleary, J.P., Walsh, D.M., Hofmeister, J.J., Shankar, G.M., Kuskowski, M.A., Selkoe, D.J., Ashe, K.H., (2005) Nat. Neurosci., 8, pp. 79-84
Li, S., Hong, S., Shepardson, N.E., Walsh, D.M., Shankar, G.M., Selkoe, D., (2009) Neuron, 62, pp. 788-801
Wilcox, K.C., Lacor, P.N., Pitt, J., Klein, W.L., (2011) Cell. Mol. Neurobiol., 31, pp. 939-948
Jana, M.K., Cappai, R., Pham, C.L.L., Ciccotosto, G.D., (2016) J. Neurochem., 136, pp. 594-608
Lowe, T.L., Strzelec, A., Kiessling, L.L., Murphy, R.M., (2001) Biochemistry, 40, pp. 7882-7889
Bieschke, J., Herbst, M., Wiglenda, T., Friedrich, R.P., Boeddrich, A., Schiele, F., Kleckers, D., Wang, Q., (2012) Nat. Chem. Biol., 8, pp. 93-101
Francioso, A., Punzi, P., Boffi, A., Lori, C., Martire, S., Giordano, C., D'Erme, M., Mosca, L., (2015) Bioorg. Med. Chem., 23, pp. 1671-1683
Goyal, D., Shuaib, S., Mann, S., Goyal, B., (2017) ACS Comb. Sci., 19, pp. 55-80
Tjernberg, L.O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A.R., Thyberg, J., Terenius, L., Nordstedt, C., (1996) J. Biol. Chem., 271, pp. 8545-8548
Soto, C., Sigurdsson, E.M., Morelli, L., Kumar, R.A., Castaño, E.M., Frangione, B., (1998) Nat. Med., 4, pp. 822-826
Ouberai, M., Dumy, P., Chierici, S., Garcia, J., (2009) Bioconjug. Chem., 20, pp. 2123-2132
Zhang, Q., Hu, X., Wang, W., Yuan, Z., (2016) Biomacromolecules, 17, pp. 661-668
Bao, Q., Luo, Y., Li, W., Sun, X., Zhu, C., Li, P., Huang, Z.-X., Tan, X., (2011) J. Biol. Inorg. Chem., 16, pp. 809-816
Yuan, C., Gao, Z., (2013) Chem. Res. Toxicol., 26, pp. 262-269
Liu, Y., Carver, J.A., Ho, L.H., Elias, A.K., Musgrave, I.F., Pukala, T.L., (2014) Biochem. Biophys. Res. Commun., 454, pp. 295-300
Zhang, X.-A., Lovejoy, K.S., Jasanoff, A., Lippard, D.P., (2007) Proc. Natl. Acad. Sci., U. S. A., 104, pp. 10780-10785
Hachimine, K., Shibaguchi, H., Kuroki, M., Yamada, H., Kinugasa, T., Nakae, Y., Asano, R., Kuroki, M., (2007) Cancer Sci., 98, pp. 916-920
Wu, C.W., Liao, P.C., Yu, L., Wang, S.T., Chen, S.T., Wu, C.M., Kuo, Y.M., (2004) Neurobiol. Dis., 17, pp. 367-377
Ghosh, C., Mukherjee, S., Seal, M., Ghosh, S., (2016) Dey, Inorg. Chem., 55, pp. 1748-1757
Lee, B.I., Lee, S., Suh, Y.S., Lee, J.S., Kim, A.K., Kwon, O.Y., Yu, K., Park, C.B., (2015) Angew. Chem. - Int. Ed., 54, pp. 11472-11476
Hirabayashi, A., Shindo, Y., Oka, K., Takahashi, D., Toshima, K., (2014) Chem. Commun., 50, pp. 9543-9546
Zhou, Y., Wang, J., Liu, L., Wang, R., Lai, X., Xu, M., (2013) ACS Chem. Neurosci., 4, pp. 535-539
Villari, V., Mazzaglia, A., Darcy, R., O'Driscoll, C.M., Micali, N., (2013) Biomacromolecules, 14, pp. 811-817
Shen, C.L., Scott, G.L., Merchant, F., Murphy, R.M., (1993) Biophys. J., 65, pp. 2383-2395
Bitan, G., Kirkitadze, M.D., Lomakin, A., Vollers, S.S., Benedek, G.B., Teplow, D.B., (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 330-335
Mazzaglia, A., Micali, N., Scolaro, L.M., Attanasio, F., Magrí, A., Pappalardo, G., Villari, V., (2010) J. Phys. Chem. B, 114, pp. 705-713
Villari, V., Mineo, P., Scamporrino, E., Micali, N., (2012) RSC Adv., 2, pp. 12989-12998
Arosio, P., Knowles, T.P.J., Linse, S., (2015) Phys. Chem. Chem. Phys., 17, pp. 7606-7618
Angelini, N., Micali, N., Mineo, P., Scamporrino, E., Villari, V., Vitalini, D., (2005) J. Phys. Chem. B, 109, pp. 18645-18651
Mineo, P., Micali, N., Villari, V., Donato, M.G., Scamporrino, E., (2012) Chem. Eur. J., 18, pp. 12452-12457
Sweeney, P.J., Walker, J.M., (1993) Enzym. Mol. Biol., pp. 277-281. , in, (Ed., M. M. Burrell, Humana Press, Totowa New Jersey
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Stella, A.M.G., Canonico, P.L., Sortino, M.A., (1999) FASEB J., 13, pp. 2225-2234
Giuffrida, M.L., Tomasello, M.F., Pandini, G., Caraci, F., Battaglia, G., Busceti, C., Pietro, P.D., Copani, A., (2015) Front. Cell. Neurosci., 9, p. 297
Molecules that inhibit Aβ misfolding have received considerable attention in view of their potential use in the prevention or treatment of Alzheimer's disease. We designed a peptide-porphyrin conjugate incorporating two recognition sites enabling it to interact strongly with the Aβ42 peptide. The inhibitory effect on Aβ42 fibril formation was determined in aqueous solution by a variety of spectroscopic techniques including UV-vis, fluorescence, Circular Dichroism, Dynamic Light Scattering, Maldi-Time of Flight-Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy. A working mechanism of the antifibrillogenic action of the conjugate was proposed based on the experimental observations. The neuroprotective activity of the conjugate was also inferred by using primary neuronal or neuron-like differentiated SH-SY5Y cell cultures. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Impact factor totale: 84.393 (84.393 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 96.08 (96.08 escludendo Abstract e Conferenze).
Impact factor totale: 84.393 (84.393 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 96.08 (96.08 escludendo Abstract e Conferenze).
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