Severe ulcerative colitis: predictors of response and algorithm proposal for rescue therapy (198 views visite)
Irish J Med Sci (ISSN: 0021-1265), 2017 Jul 29; 187(2): 385-392.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 1.045, 5-year impact factor Impact factor a 5 anni: 1.055
Url: Not available. Non disponibile.
Keywords Parole chiave: Anti-Tnf, Cyclosporine, Infliximab, Rescue Therapy, Ulcerative Colitis, Adult, Algorithms, Drug Therapy, Pathology, Cross-Sectional Studies, Female, Humans, Immunosuppressive Agents, Pharmacology, Therapeutic Use, Retrospective Studies,
Affiliations Affiliazioni:
*** IBB - CNR ***
Gastroenterology-U, General and Specialist Medicine Department, Citta della Salute e della Scienza of Turin, C.so Bramante 88, 10126, Turin, Italy. davrib_1998@yahoo.com., Department of Gastroenterology and Hepatology, Molinette Hospital-S.G.A.S, Via Cavour 31, 10123, Turin, Italy. davrib_1998@yahoo.com., Unit of Gastroenterology and Hepatology, Molinette Hospital, 10126, Turin, Italy., Fourth General Surgery Department, Citta della Salute e della Scienza, Azienda Ospedaliera ed Universitaria, 10126, Turin, Italy., Institute for Biostructures and Bioimages-CNR c/o Molecular Biotechnology Center, University of Torino, 10126, Turin, Italy., Department of Medical Sciences, University of Torino, 10126, Turin, Italy.,
References Riferimenti:
Not available. Non disponibili.
Irish J Med Sci (ISSN: 0021-1265), 2017 Jul 29; 187(2): 385-392.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 1.045, 5-year impact factor Impact factor a 5 anni: 1.055
Url: Not available. Non disponibile.
Keywords Parole chiave: Anti-Tnf, Cyclosporine, Infliximab, Rescue Therapy, Ulcerative Colitis, Adult, Algorithms, Drug Therapy, Pathology, Cross-Sectional Studies, Female, Humans, Immunosuppressive Agents, Pharmacology, Therapeutic Use, Retrospective Studies,
Affiliations Affiliazioni:
*** IBB - CNR ***
Gastroenterology-U, General and Specialist Medicine Department, Citta della Salute e della Scienza of Turin, C.so Bramante 88, 10126, Turin, Italy. davrib_1998@yahoo.com., Department of Gastroenterology and Hepatology, Molinette Hospital-S.G.A.S, Via Cavour 31, 10123, Turin, Italy. davrib_1998@yahoo.com., Unit of Gastroenterology and Hepatology, Molinette Hospital, 10126, Turin, Italy., Fourth General Surgery Department, Citta della Salute e della Scienza, Azienda Ospedaliera ed Universitaria, 10126, Turin, Italy., Institute for Biostructures and Bioimages-CNR c/o Molecular Biotechnology Center, University of Torino, 10126, Turin, Italy., Department of Medical Sciences, University of Torino, 10126, Turin, Italy.,
References Riferimenti:
Not available. Non disponibili.
Severe ulcerative colitis: predictors of response and algorithm proposal for rescue therapy
BACKGROUND: There is no agreeing if rescue therapy can avoid short-term colectomy in patients treated for severe steroid-refractory ulcerative colitis. AIMS: The aim of our study was to identify predictors of response to infliximab and cyclosporine A. METHODS: In this cross-sectional study, 49 patients with severe ulcerative colitis were included. Response to therapy was defined as three or more point reductions in Mayo score after 6 months of treatment and avoidance of colectomy after 1 year. The predictors analysed were gender, age, time from ulcerative colitis diagnosis, months of steroid or/and azathioprine therapy before onset of the severe phase, smoking habits, extension of the disease, laboratory analyses and Mayo score. RESULTS: Patients treated with infliximab showed a statistically significant higher response rate in case of moderate Mayo score (P = 0.04). Ex-smokers had very low chance of response to infliximab (P = 0.03). In the group treated with cyclosporine A, patients with C-reactive protein >3 mg/L had a response rate significantly higher than those with C-reactive protein <3 mg/L (P = 0.03); those with negative C-reactive protein and moderate Mayo score did not responded to therapy, while in the ones with elevated C-reactive protein and/or severe Mayo score, 15 versus 4 responded (P = 0.008). CONCLUSIONS: Our data suggest that cyclosporine A is advisable in ex-smokers. In never smokers or active smokers, infliximab can be prescribed in case of Mayo score 10 and positive CRP.
BACKGROUND: There is no agreeing if rescue therapy can avoid short-term colectomy in patients treated for severe steroid-refractory ulcerative colitis. AIMS: The aim of our study was to identify predictors of response to infliximab and cyclosporine A. METHODS: In this cross-sectional study, 49 patients with severe ulcerative colitis were included. Response to therapy was defined as three or more point reductions in Mayo score after 6 months of treatment and avoidance of colectomy after 1 year. The predictors analysed were gender, age, time from ulcerative colitis diagnosis, months of steroid or/and azathioprine therapy before onset of the severe phase, smoking habits, extension of the disease, laboratory analyses and Mayo score. RESULTS: Patients treated with infliximab showed a statistically significant higher response rate in case of moderate Mayo score (P = 0.04). Ex-smokers had very low chance of response to infliximab (P = 0.03). In the group treated with cyclosporine A, patients with C-reactive protein >3 mg/L had a response rate significantly higher than those with C-reactive protein <3 mg/L (P = 0.03); those with negative C-reactive protein and moderate Mayo score did not responded to therapy, while in the ones with elevated C-reactive protein and/or severe Mayo score, 15 versus 4 responded (P = 0.008). CONCLUSIONS: Our data suggest that cyclosporine A is advisable in ex-smokers. In never smokers or active smokers, infliximab can be prescribed in case of Mayo score 10 and positive CRP.
Severe ulcerative colitis: predictors of response and algorithm proposal for rescue therapy
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Severe ulcerative colitis: predictors of response and algorithm proposal for rescue therapy
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Palma G, Monti S, Cella L
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Phys Med (ISSN: 1120-1797linking), 2020 Jan; 69: 192-204.
Impact Factor: 2.485
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Romeo V, Ricciardi C, Cuocolo R, Stanzione A, Verde F, Sarno L, Improta G, Mainenti PP, D'Armiento M, Brunetti A, Maurea S
* Machine learning analysis of MRI-derived texture features to predict placenta accreta spectrum in patients with placenta previa (70 visite)
Magn Reson Imaging (ISSN: 0730-725xlinking), 2019 Dec; 64: 71-76.
Impact Factor: 2.037
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Actis GC, Pellicano R, Fagoonee S, Ribaldone DG
* History of Inflammatory Bowel Diseases (61 visite)
J Clin Med (ISSN: 2077-0383linking), 2019 Nov 14; 8(11): N/D-N/D.
Impact Factor: 5.688
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Camera L, Pezzullo F, Acampora A, Liuzzi R, Rispo A, Nardone OM, Luglio G, Bucci L, Castiglione F, Brunetti A
* Multi-detector CT enterography in active inflammatory bowel disease: Image quality and diagnostic efficacy of a low-radiation high contrast protocol (76 visite)
Clin Imaging (ISSN: 0899-7071linking), 2019 Nov; 58: 27-33.
Impact Factor: 0.658
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Kujawa A, Kim M, Demetriou E, Anemone A, Livio Longo D, Zaiss M, Golay X
* Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging (23 visite)
J Magn Reson (ISSN: 1090-7807linking), 2019 Mar; 300: 120-134.
Impact Factor:
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Ribaldone DG, Fagoonee S, Astegiano M, Durazzo M, Morgando A, Sprujevnik T, Giordanino C, Baronio M, De Angelis C, Saracco GM, Pellicano R
* Rifabutin-Based Rescue Therapy for Helicobacter pylori Eradication: A Long-Term Prospective Study in a Large Cohort of Difficult-to-Treat Patients (199 visite)
J Clin Med (ISSN: 2077-0383linking), 2019 Feb 6; 8(2): N/D-N/D.
Impact Factor: 5.583
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Romeo V, Maurea S, Cuocolo R, Petretta M, Mainenti PP, Verde F, Coppola M, Dell'Aversana S, Brunetti A
* Characterization of Adrenal Lesions on Unenhanced MRI Using Texture Analysis: A Machine-Learning Approach (172 visite)
J Magn Reson Imaging (ISSN: 1522-2586electronic, 1053-1807linking), 2018 Jul; 48(1): 198-204.
Impact Factor: 1.302
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Monti S, Pacelli R, Cella L, Palma G
* Inter-patient image registration algorithms to disentangle regional dose bioeffects (296 visite) (PDF 154 visite)
Sci Rep (ISSN: 2045-2322linking), 2018 Mar 20; 8(1): 4915-4918.
Impact Factor: 4.259
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Monti S, Borrelli P, Tedeschi E, Cocozza S, Palma G
* RESUME: Turning an SWI acquisition into a fast qMRI protocol (287 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2017 Dec 20; 12(12): e0189933-e0189933.
Impact Factor: 2.766
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Longo DL, Aime S
* A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol (208 visite)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 2017 Jul 07; 79(3): 1553-1558.
Impact Factor: 4.082
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Granata D, Amato U, Alfano B
* MRI denoising by nonlocal means on multi-GPU (294 visite)
J Real-Time Image Pr (ISSN: 1861-8200), 2016; N/D: 1-11.
Impact Factor: 2.01
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Palma G, Tedeschi E, Borrelli P, Cocozza S, Russo C, Liu S, Ye Y, Comerci M, Alfano B, Salvatore M, Haacke EM, Mancini M
* A Novel Multiparametric Approach to 3D Quantitative MRI of the Brain (596 visite) (PDF 253 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Aug 18; 10(8): e0134963-e0134963.
Impact Factor: 3.057
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Borrelli P, Palma G, Comerci M, Alfano B
* Unbiased noise estimation and denoising in parallel magnetic resonance imaging (408 visite) (PDF 282 visite)
Icassp - Ieee International Conference On Acoustics - Speech And Signal Processing - Proceedings (ISSN: 1520-6149, 1520-61499781479928927), 2014 May; 10.1109/ICASSP.201: 1230-1234.
Impact Factor: 0
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Pedicini P, Fiorentino A, Improta G, Nappi A, Salvatore M, Storto G
* Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma (276 visite)
Clin Transl Oncol (ISSN: 1699-048x), 2013 Nov; 15(11): 919-924.
Impact Factor: 1.6
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Cammisa M, Correra A, Andreotti G, Cubellis MV
* Identification and analysis of conserved pockets on protein surfaces (1116 visite)
Bmc Bioinformatics (ISSN: 1471-2105), 2013 Apr 22; 14: S9-S9.
Impact Factor: 2.672
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Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
* Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography (427 visite)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic, 1078-0998linking), 2013 Apr; 19(4): 991-998.
Impact Factor: 5.475
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Petretta M, Acampa W, Daniele S, Petretta MP, Nappi C, Assante R, Zampella E, Costanzo P, Perrone-Filardi P, Cuocolo A
* Transient ischemic dilation in SPECT myocardial perfusion imaging for prediction of severe coronary artery disease in diabetic patients (463 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2013 Feb; 20(1): 45-52.
Impact Factor: 2.645
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Cesarelli M, Bifulco P, Romano M, Fratini A, D'Addio G, Clemente F
* Spline interpolation to evaluate foveation parameters in Congenital Nystagmus recordings (166 visite)
2013 E Health And Bioengineering Conference, 2013; N/D: N/D-N/D.
Impact Factor: 0
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Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Development of multivariate NTCP models for radiation-induced hypothyroidism: A comparative analysis (421 visite) (PDF 216 visite)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2012 Dec 27; 7(1): 224-224.
Impact Factor: 2.107
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Selvan SE, Amato U, Gallivan KA, Qi C, Carfora MF, Larobina M, Alfano B
* Descent algorithms on oblique manifold for source-adaptive ICA contrast (338 visite) (PDF 206 visite)
Ieee Trans Neural Networks Learn Sys (ISSN: 2162-237x, 2162-2388), 2012 Dec; 23(12): 1930-1947.
Impact Factor: 3.766
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Peluso R, Di Minno MND, Bruner V, Soscia E, Castiglione F, Manguso F, Iervolino S, Scarpa R
* Discovertebral Erosions in Patients with Enteropathic Spondyloarthritis (279 visite)
Journal Of Rheumatology (ISSN: 0315-162x), 2012 Dec; 39(12): 2332-2340.
Impact Factor: 3.258
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Petretta M, Cuocolo A
Prediction models for risk classification in cardiovascular disease (394 visite)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2012 Dec; 39(12): 1959-1969.
Impact Factor: 5.114
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Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T
* Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I (379 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Jul; 53(7): 1065-1073.
Impact Factor: 5.774
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Greco A, Petretta MP, Larobina M, Gargiulo S, Panico M, Nekolla SG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Reproducibility and accuracy of non-invasive measurement of infarct size in mice with high-resolution PET/CT (365 visite)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2012 Jun; 19(3): 492-499.
Impact Factor: 2.847
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Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
* Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (466 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
Impact Factor: 3.463
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Alfano B, Comerci M, Larobina M, Prinster A, Hornak JP, Selvan SE, Amato U, Quarantelli M, Tedeschi G, Brunetti A, Salvatore M
* An MRI digital brain phantom for validation of segmentation methods (459 visite) (PDF 652 visite)
Med Image Anal (ISSN: 1361-8415, 1361-8423, 1361-8415linking), 2011 Jun; 15(3): 329-339.
Impact Factor: 4.424
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Ceccarelli M, Speranza A, Grimaldi D, Lamonaca F
* A Computer Vision Approach to Micro-Nucleus automatic detection and surface measurements (377 visite)
Vols 1 3i2mtc (ISSN: 0018-9456), 2010 Sep 10; 59(9): 2383-2390.
Impact Factor: 1.79
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (454 visite)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
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Slomka PJ, Le Meunier L, Hayes SW, Acampa W, Oba M, Haemer GG, Berman DS, Germano G
* Comparison of Myocardial Perfusion (82)Rb PET Performed with CT- and Transmission CT-Based Attenuation Correction (237 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2008 Dec; 49(12): 1992-1998.
Impact Factor: 6.662
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Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (338 visite)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
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Selvaggi F, Cuocolo A, Giuliani A, Sciaudone G, Riegler G, Mainolfi C, Caprio MG, Panico M, Fiume I
* The role of scintigraphic defecography in the assessment of bowel function after restorative proctocolectomy for ulcerative colitis (258 visite)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 2006 Jul; 21(5): 448-452.
Impact Factor: 2.006
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Del Guerra A, Bartoli A, Belcari N, Herbert D, Motta A, Vaiano A, Di Domenico G, Sabba N, Moretti E, Zavattini G, Lazzarotti M, Sensi L, Larobina M
* Performance evaluation of the fully engineered YAP-(S)PET scanner for small animal imaging (255 visite)
Ieee Transactions On Nuclear Science (ISSN: 0018-9499), 2006 Jun; 53(3): 1078-1083.
Impact Factor: 1.497
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Barone V, De Rienzo F, Langella E, Menziani MC, Rega N, Sola M
* A computational protocol to probe the role of solvation effects on the reduction potential of azurin mutants (237 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jan 1; 62(1): 262-269.
Impact Factor: 3.73
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Selavaggi F, Cuocolo A, Giuliani A, Sciaudone G, Riegler G, Mainolfi C, Caprio MG, Panico M, Fiume I
* The Role Of Scientigraphic Defecography In The Assessment Of Bowel Function After Restorative Proctocolectomy For Ulcerative Colitis (207 visite)
Int J Colorectal Dis, 2006; 5: 448-452.
Impact Factor: 2.017
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Storto G, Cirillo P, Eufrasia Vicario ML, Pellegrino T, Sorrentino AR, Petretta M, Galasso G, De Sanctis V, Piscione F, Cuocolo A
* Estimation of coronary flow reserve by Tc-99m sestamibi imaging in patients with coronary artery disease: Comparison with the results of intracoronary Doppler technique (356 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2004 Nov; 11(6): 682-688.
Impact Factor: 1.849
Dettagli Esporta in BibTeX Esporta in EndNote
Del Guerra A, Bartoli A, Belcari N, Herbert D, Motta A, Vaiano A, Di Domenico G, Sabba N, Moretti E, Zavattini G, Lazzarotti M, Sensi L, Larobina M
* Performance evaluation of the fully engineered YAP-(S)PET scanner for small animal imaging (385 visite)
2004 Ieee Nuclear Science Symposium Conference Record Vols 1 7, 2004; 5: 2990-2994.
Impact Factor: 0
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Vitagliano L, Berisio R, Mastrangelo A, Mazzarella L, Zagari A
* Preferred proline puckerings in cis and trans peptide groups: Implications for collagen stability (482 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2001 Dec; 10(12): 2627-2632.
Impact Factor: 3.472
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Fonti R, Latella G, Caprilli R, Frieri G, Marcheggiano A, Sambuy Y
Carbonic anhydrase I reduction in colonic mucosa of patients with active ulcerative colitis (308 visite)
Digestive Diseases And Sciences (ISSN: 0163-2116), 1998; 43(9): 2086-2092.
Impact Factor: 1.972
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44 Records (41 escludendo Abstract e Conferenze).
Impact factor totale: 128.646 (125.974 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 112.419 (108.928 escludendo Abstract e Conferenze).
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