Keywords Parole chiave: Engineered Nanoparticles, Fluorescence Imaging, Magnetic Resonance, Mouse Model, Preclinical Imaging, Theranostic,
Affiliations Affiliazioni: *** IBB - CNR ***
Istituto Italiano di Tecnologia, IIT - Center for Advanced Biomaterials for Health Care, CABHC@CRIB, Napoli, Italia; Centro Interdipartimentale di Ricerca sui Biomateriali, Universita degli Studi di Napoli Federico II, Napoli, Italia; Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Universita degli Studi di Napoli Federico II, Napoli, Italia., IRCCS SDN S.p.A., Napoli, Italia., Istituto Italiano di Tecnologia, IIT - Center for Advanced Biomaterials for Health Care, CABHC@CRIB, Napoli, Italia; Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Universita degli Studi di Napoli Federico II, Napoli, Italia., IRCCS SDN S.p.A., Napoli, Italia; Dipartimento di Scienze Motorie e del Benessere, Universita "Parthenope", Napoli, Italia., Dipartimento di Medicina Sperimentale e Clinica, Universita degli Studi "Magna Graecia" di Catanzaro, Catanzaro, Italia., IBB, CNR, Napoli, Italia., CEINGE Biotecnologie Avanzate, s.c.ar.l., Napoli, Italia; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Napoli, Italia., Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli Federico II, Napoli, Italia; IBB, CNR, Napoli, Italia; CEINGE Biotecnologie Avanzate, s.c.ar.l., Napoli, Italia. Electronic address: adegreco@unina.it.,
References Riferimenti: Not available. Non disponibili.
Multimodal imaging for a theranostic approach in a murine model of B-cell lymphoma with engineered nanoparticles
Nanoparticles (NPs) are a promising tool for in vivo multimodality imaging and theranostic applications. Hyaluronic acid (HA)-based NPs have numerous active groups that make them ideal as tumor-targeted carriers. The B-lymphoma neoplastic cells express on their surfaces a clone-specific immunoglobulin receptor (Ig-BCR). The peptide A20-36 (pA20-36) selectively binds to the Ig-BCR of A20 lymphoma cells. In this work, we demonstrated the ability of core-shell chitosan-HA-NPs decorated with pA20-36 to specifically target A20 cells and reduce the tumor burden in a murine xenograft model. We monitored tumor growth using high-frequency ultrasonography and demonstrated targeting specificity and kinetics of the NPs via in vivo fluorescent reflectance imaging. This result was also confirmed by ex vivo magnetic resonance imaging and confocal microscopy. In conclusion, we demonstrated the ability of NPs loaded with fluorescent and paramagnetic tracers to act as multimodal imaging contrast agents and hence as a non-toxic, highly specific theranostic system.
Multimodal imaging for a theranostic approach in a murine model of B-cell lymphoma with engineered nanoparticles
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(402 visite) Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 DettagliEsporta in BibTeXEsporta in EndNote
Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A * MR Contrast Agents(220 visite) Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555. Impact Factor:1.784 DettagliEsporta in BibTeXEsporta in EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A * Tumor Imaging(280 visite) Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309. Impact Factor:1.148 DettagliEsporta in BibTeXEsporta in EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(535 visite) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 DettagliEsporta in BibTeXEsporta in EndNote
672 Records (639 escludendo Abstract e Conferenze). Impact factor totale: 2283.844 (2211.978 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 2382.024 (2304.278 escludendo Abstract e Conferenze).
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