Home Ricerca Sedi Chi siamo Organigramma Personale Contatti Didattica Login Documenti EN
Progetti in evidenza
INCIPIT
(Link esterno)

ISTAPCA
(1209 visite)

Fondo Europeo Pesca
(622 visite)

Euro-BioImaging
(Link esterno)

Fondazione Veronesi
(Link esterno)

LightDyNAmics
(1094 visite)

 INMiND
(1186 visite)

Instruct-IT
(Link esterno)

 PRIN
(1329 visite)

 eHealthNet
(1090 visite)

Ponrec
(1028 visite)

MFAG Grant
(1134 visite)

MERIT
(Link esterno)


Collegamenti

Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (68 visite)

Caraci F, Nicoletti F, Copani A

Curr Opin Pharmacol (ISSN: 1471-4973electronic, 1471-4892linking), 2017 Dec 23; 38: 1-7.



Tipo di articolo: Journal Article, Review,

Impact factor: 0, Impact factor a 5 anni: 0

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042270659&doi=10.1016%2fj.coph.2017.12.001&partnerID=40&md5=752594f8620931e5cadf5a9f67c668b7

Parole chiave: 4 Amino 2 Oxabicyclo[3.1.0]hexane 4, 6 Dicarboxylic Acid, Alpha Amino 3 Hydroxy 5 Methyl 4 Isoxazolepropionic Acid, Amyloid Beta Protein, Bci 632, Bci 838, Beta Secretase 1, Excitatory Amino Acid Transporter 2, Gamma Secretase, Ionotropic Receptor, Kainic Acid Receptor, Ly566332, Metabotropic Receptor, Metabotropic Receptor Antagonist, Mitogen Activated Protein Kinase, Mitogen Activated Protein Kinase P38, N Methyl Dextro Aspartic Acid, N Methyl Dextro Aspartic Acid Receptor, Presenilin 1, Protein Tyrosine Phosphatase, Tau Protein, Transforming Growth Factor Beta1, Unclassified Drug, 4 Aminobutyric Acid Release, Alzheimer Disease, Amnesia, Animal Cell, Animal Experiment, Complex Formation, Controlled Study, Diffuse Lewy Body Disease, Dimerization, Disease Exacerbation, Down Regulation, Excitotoxicity, Gabaergic Transmission, Genetic Risk, Long Term Potentiation, Mouse, Nerve Cell Plasticity, Nervous System Development, Neuroprotection, Nonhuman, Priority Journal, Protein Aggregation, Protein Expression, Protein Folding, Protein Function, Protein Localization, Pyramidal Nerve Cell, Review, Signal Transduction, Synapse, Working Memory,

Affiliazioni:

*** IBB - CNR ***
Department of Drug Sciences, University of Catania, Catania, Italy; Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy., Department of Physiology and Pharmacology, University of Rome Sapienza, Rome, Italy; Neuromed (IRCCS), Pozzilli, Italy., Department of Drug Sciences, University of Catania, Catania, Italy; Institute of Biostructure and Bioimaging, National Research Council, Catania, Italy. Electronic address: acopani@katamail.com.,



Riferimenti:

Beydoun, M.A., Beydoun, H.A., Gamaldo, A.A., Teel, A., Zonderman, A.B., Wang, Y., Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis (2014) BMC Public Health, 14, p. 64

Selkoe, D.J., Hardy, J., The amyloid hypothesis of Alzheimer's disease at 25 years (2016) EMBO Mol Med, 8, pp. 595-608. , This review is crucial in understanding the role of Aβ in the pathophysiology of AD. It examines all preclinical and clinical evidence in favor of Aβ dyshomeostasis as a validated therapeutic target

McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R., Jr., Kawas, C.H., Klunk, W.E., Mayeux, R., The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease (2011) Alzheimers Dement, 7, pp. 263-269

Jonsson, T., Atwal, J.K., Steinberg, S., Snaedal, J., Jonsson, P.V., Bjornsson, S., Stefansson, H., Maloney, J., A mutation in APP protects against Alzheimer's disease and age-related cognitive decline (2012) Nature, 488, pp. 96-99

Haass, C., Kaether, C., Thinakaran, G., Sisodia, S., Trafficking and proteolytic processing of APP (2012) Cold Spring Harb Perspect Med, 2, p. a006270

Copani, A., The underexplored question of β-amyloid monomers (2017) Eur J Pharmacol

Giuffrida, M.L., Tomasello, M.F., Pandini, G., Caraci, F., Battaglia, G., Busceti, C., Di Pietro, P., Chiechio, S., Monomeric β-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (2015) Front Cell Neurosci, 9, p. 297. , This study identified a precise role for Aβ monomers in maintaining neuronal glucose homeostasis

Mc Donald, J.M., O'Malley, T.T., Liu, W., Mably, A.J., Brinkmalm, G., Portelius, E., Wittbold, W.M., 3rd, Walsh, D.M., The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species (2015) Alzheimers Dement, 11, pp. 1286-1305

Bloom, G.S., Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis (2014) JAMA Neurol, 71, pp. 505-508

De Strooper, B., Karran, E., The cellular phase of Alzheimer's disease (2016) Cell, 164, pp. 603-615

Geddes, J.W., Cotman, C.W., Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease (1986) Neurosci Res, 3, pp. 672-678

Hynd, M.R., Scott, H.L., Dodd, P.R., Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease (2004) Neurochem Int, 45, pp. 583-595

Deng, Y., Xiong, Z., Chen, P., Wei, J., Chen, S., Yan, Z., β-Amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3 (2014) Neurobiol Aging, 35, pp. 449-459

Zhang, D., Jin, B., Ondrejcak, T., Rowan, M.J., Opposite in vivo effects of agents that stimulate or inhibit the glutamate/cysteine exchanger system xc- on the inhibition of hippocampal LTP by Aβ (2016) Hippocampus, 26, pp. 1655-1665

Scimemi, A., Meabon, J.S., Woltjer, R.L., Sullivan, J.M., Diamond, J.S., Cook, D.G., Amyloid-β1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1 (2013) J Neurosci, 33, pp. 5312-5318

Zumkehr, J., Rodriguez-Ortiz, C.J., Cheng, D., Kieu, Z., Wai, T., Hawkins, C., Kilian, J., Kitazawa, M., Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease (2015) Neurobiol Aging, 36, pp. 2260-2271. , This study strongly suggests that a functional loss of the glial glutamate transporter GLT-1 is a major pathological link between Aβ and tau pathology

Schallier, A., Smolders, I., Van Dam, D., Loyens, E., De Deyn, P.P., Michotte, A., Michotte, Y., Massie, A., Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease (2011) J Alzheimers Dis, 24, pp. 287-300

Pin, J.P., Galvez, T., Prézeau, L., Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors (2003) Pharmacol Ther, 98, pp. 325-354

Chuang, S.C., Bianchi, R., Wong, R.K., Group I mGluR activation turns on a voltage-gated inward current in hippocampal pyramidal cells (2000) J Neurophysiol, 83, pp. 2844-2853

Ferraguti, F., Baldani-Guerra, B., Corsi, M., Nakanishi, S., Corti, C., Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors (1999) Eur J Neurosci, 11, pp. 2073-2082

Iacovelli, L., Bruno, V., Salvatore, L., Melchiorri, D., Gradini, R., Caricasole, A., Barletta, E., Nicoletti, F., Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways (2002) J Neurochem, 82, pp. 216-223

Lujan, R., Nusser, Z., Roberts, J.D., Shigemoto, R., Somogyi, P., Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus (1996) Eur J Neurosci, 8, pp. 1488-1500

Schoepp, D.D., Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system (2001) J Pharmacol Exp Ther, 299, pp. 12-20

Tamaru, Y., Nomura, S., Mizuno, N., Shigemoto, R., Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites (2001) Neuroscience, 106, pp. 481-503

Kinoshita, A., Shigemoto, R., Ohishi, H., van der Putten, H., Mizuno, N., Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: a light and electron microscopic study (1998) J Comp Neurol, 393, pp. 332-352

Ohishi, H., Shigemoto, R., Nakanishi, S., Mizuno, N., Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat (1993) Neuroscience, 53, pp. 1009-1018

Corti, C., Aldegheri, L., Somogyi, P., Ferraguti, F., Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS (2002) Neuroscience, 110, pp. 403-420

Saugstad, J.A., Kinzie, J.M., Shinohara, M.M., Segerson, T.P., Westbrook, G.L., Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile (1997) Mol Pharmacol, 51, pp. 119-125

Nakajima, Y., Iwakabe, H., Akazawa, C., Nawa, H., Shigemoto, R., Mizuno, N., Nakanishi, S., Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate (1993) J Biol Chem, 268, pp. 11868-11873

Zhang, Y., Chen, K., Sloan, S.A., Bennett, M.L., Scholze, A.R., O'Keeffe, S., Phatnani, H.P., Ruderisch, N., An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex (2014) J Neurosci, 34, pp. 11929-11947

Tallaksen-Greene, S.J., Kaatz, K.W., Romano, C., Albin, R.L., Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons (1998) Brain Res, 780, pp. 210-217

Ferraguti, F., Klausberger, T., Cobden, P., Baude, A., Roberts, J.D., Szucs, P., Kinoshita, A., Dalezios, Y., Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus (2005) J Neurosci, 25, pp. 10520-10536

El Moustaine, D., Granier, S., Doumazane, E., Scholler, P., Rahmeh, R., Bron, P., Mouillac, B., Pin, J.P., Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling (2012) Proc Natl Acad Sci U S A, 109, pp. 16342-16347

Romano, C., Yang, W.L., O'Malley, K.L., Metabotropic glutamate receptor 5 is a disulfide-linked dimer (1996) J Biol Chem, 271, pp. 28612-28616

Moreno Delgado, D., Møller, T.C., Ster, J., Giraldo, J., Maurel, D., Rovira, X., Scholler, P., Durroux, T., Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells (2017) Elife, , This study is the first to demonstrate the existence of intergroup mGlu heterodimers in native neurons by using a heterodimer-specific conformational LRET-based biosensor

Pin, J.P., Bettler, B., Organization and functions of mGlu and GABA(B) receptor complexes (2016) Nature, 540, pp. 60-68

Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., DeTeresa, R., Hill, R., Hansen, L.A., Katzman, R., Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment (1991) Ann Neurol, 30, pp. 572-580

Mucke, L., Masliah, E., Yu, G.Q., Mallory, M., Rockenstein, E.M., Tatsuno, G., Hu, K., McConlogue, L., High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation (2000) J Neurosci, 20, pp. 4050-4058

Bhattacharyya, S., Inside story of group I metabotropic glutamate receptors (mGluRs) (2016) Int J Biochem Cell Biol, 77, pp. 205-212

Wang, Q., Wu, J., Rowan, M.J., Anwyl, R., Beta-amyloid inhibition of long-term potentiation is mediated via tumor necrosis factor (2005) Eur J Neurosci, 22, pp. 2827-2832

Chen, X., Lin, R., Chang, L., Xu, S., Wei, X., Zhang, J., Wang, C., Wang, Q., Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3 (2013) Neuroscience, 253, pp. 435-443. , This study demonstrates that Aβ-enhanced LTD depends on mGlu1/5 receptors but not on NMDA receptors

Lee, H.K., Min, S.S., Gallagher, M., Kirkwood, A., NMDA receptor-independent long-term depression correlates with successful aging in rats (2005) Nat Neurosci, 8, pp. 1657-1659

Ménard, C., Quirion, R., Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain (2012) Front Pharmacol, 3, p. 182

D'Amelio, M., Cavallucci, V., Middei, S., Marchetti, C., Pacioni, S., Ferri, A., Diamantini, A., Battistini, L., Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease (2011) Nat Neurosci, 14, pp. 69-76

Um, J.W., Kaufman, A.C., Kostylev, M., Heiss, J.K., Stagi, M., Takahashi, H., Kerrisk, M.E., Koleske, A.J., Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein (2013) Neuron, 79, pp. 887-902. , The authors of this study demonstrate that mGlu5 receptor is required for the synaptotoxic signaling of Aβ oligomers bound to cellular prion protein

Dohler, F., Sepulveda-Falla, D., Krasemann, S., Altmeppen, H., Schlüter, H., Hildebrand, D., Zerr, I., Glatzel, M., High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease (2014) Brain, 137, pp. 873-886

Salazar, S.V., Strittmatter, S.M., Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease (2017) Biochem Biophys Res Commun, 483, pp. 1143-1147

Haas, L.T., Kostylev, M.A., Strittmatter, S.M., Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5) (2014) J Biol Chem, 289, pp. 28460-28477

Hamilton, A., Esseltine, J.L., DeVries, R.A., Cregan, S.P., Ferguson, S.S., Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease (2014) Mol Brain, 7, p. 40

Hamilton, A., Vasefi, M., Vander Tuin, C., McQuaid, R.J., Anisman, H., Ferguson, S.S., Chronic pharmacological mGluR5 inhibition prevents cognitive impairment and reduces pathogenesis in an Alzheimer disease mouse model (2016) Cell Rep, 15, pp. 1859-1865. , The authors show that chronic administration of the orally bioavailable mGlu5 receptor NAM, CTEP, reverses cognitive decline in APPswe/PS1ΔE9 mice and reduces Aβ concentration and deposition

Malter, J.S., Ray, B.C., Westmark, P.R., Westmark, C.J., Fragile X syndrome and Alzheimer's disease: another story about APP and beta-amyloid (2010) Curr Alzheimer Res, 7, pp. 200-206

Homayoun, H., Moghaddam, B., Group 5 metabotropic glutamate receptors: role in modulating cortical activity and relevance to cognition (2010) Eur J Pharmacol, 639, pp. 33-39

Haas, L.T., Salazar, S.V., Smith, L.M., Zhao, H.R., Cox, T.O., Herber, C.S., Degnan, A.P., Albright, C.F., Silent allosteric modulation of mGluR5 maintains glutamate signaling while rescuing Alzheimer's mouse phenotypes (2017) Cell Rep, 20, pp. 76-88. , This study is highly relevant in validating the role of mGlu5 receptor as a new target for AD. The authors demonstrate that a 4 week treatment with a potent mGlu5 receptor NAL (BMS-984923) spares normal mGlu5 receptor signaling, while rescuing memory deficits in the APPswe/PS1ΔE9 transgenic mouse brain

Foster, D.J., Conn, P.J., Allosteric modulation of GPCRs: new insights and potential utility for treatment of schizophrenia and other CNS disorders (2017) Neuron, 94, pp. 431-446

Blanchard, B.J., Thomas, V.L., Ingram, V.M., Mechanism of membrane depolarization caused by the Alzheimer Abeta1-42 peptide (2002) Biochem Biophys Res Commun, 293, pp. 1197-1203

Ovsepian, S.V., Blazquez-Llorca, L., Freitag, S.V., Rodrigues, E.F., Herms, J., Ambient glutamate promotes paroxysmal hyperactivity in cortical pyramidal neurons at amyloid plaques via presynaptic mGluR1 receptors (2017) Cereb Cortex, 27, pp. 4733-4749

Albasanz, J.L., Dalfó, E., Ferrer, I., Martín, M., Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes (2005) Neurobiol Dis, 20, pp. 685-693

Nitsch, R.M., Deng, A., Wurtman, R.J., Growdon, J.H., Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain (1997) J Neurochem, 69, pp. 704-712

Bruno, V., Battaglia, G., Copani, A., Giffard, R.G., Raciti, G., Raffaele, R., Shinozaki, H., Nicoletti, F., Activation of class II or III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration (1995) Eur J Neurosci, 7, pp. 1906-1913

Miyamoto, M., Ishida, M., Shinozaki, H., Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat (1997) Neuroscience, 77, pp. 131-140

Bond, A., Jones, N.M., Hicks, C.A., Whiffin, G.M., Ward, M.A., O'Neill, M.F., Kingston, A.E., Schoepp, D.D., Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo (2000) J Pharmacol Exp Ther, 294, pp. 800-809

Copani, A., Bruno, V., Battaglia, G., Leanza, G., Pellitteri, R., Russo, A., Stanzani, S., Nicoletti, F., Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide (1995) Mol Pharmacol, 47, pp. 890-897

Kim, S.H., Fraser, P.E., Westaway, D., St George-Hyslop, P.H., Ehrlich, M.E., Gandy, S., Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals (2010) J Neurosci, 30, pp. 3870-3875

Higgins, G.A., Ballard, T.M., Kew, J.N., Richards, J.G., Kemp, J.A., Adam, G., Woltering, T., Mutel, V., Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent (2004) Neuropharmacology, 46, pp. 907-917

Yoshimizu, T., Shimazaki, T., Ito, A., Chaki, S., An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats (2006) Psychopharmacology (Berl), 186, pp. 587-593

Taylor, D.L., Diemel, L.T., Cuzner, M.L., Pocock, J.M., Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up-regulated in Alzheimer's disease (2002) J Neurochem, 82, pp. 1179-1191

Kim, S.H., Steele, J.W., Lee, S.W., Clemenson, G.D., Carter, T.A., Treuner, K., Gadient, R., Barlow, C., Proneurogenic group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse (2014) Mol Psychiatry, 19, pp. 1235-1242. , Chronic treatment of APP (E693Q) mice with BCI-838 was associated with reversal of amnestic behavior, reduction in anxiety, reduction in Aβ levels, and stimulation of hippocampal neurogenesis

Elder, G.A., Gama Sosa, M.A., De Gasperi, R., Transgenic mouse models of Alzheimer's disease (2010) Mt Sinai J Med, 77, pp. 69-81

Chen, Y.R., Glabe, C.G., Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42 (2006) J Biol Chem, 281, pp. 24414-24422

Caraci, F., Molinaro, G., Battaglia, G., Giuffrida, M.L., Riozzi, B., Traficante, A., Bruno, V., Wang, X., Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (2011) Mol Pharmacol, 79, pp. 618-626

Caraci, F., Spampinato, S., Sortino, M.A., Bosco, P., Battaglia, G., Bruno, V., Drago, F., Copani, A., Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection (2012) Cell Tissue Res, 347, pp. 291-301

Lee, H.G., Zhu, X., O'Neill, M.J., Webber, K., Casadesus, G., Marlatt, M., Raina, A.K., Smith, M.A., The role of metabotropic glutamate receptors in Alzheimer's disease (2004) Acta Neurobiol Exp (Wars), 64, pp. 89-98

Bruno, V., Copani, A., Bonanno, L., Knoepfel, T., Kuhn, R., Roberts, P.J., Nicoletti, F., Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures (1996) Eur J Pharmacol, 310, pp. 61-66

Maj, M., Bruno, V., Dragic, Z., Yamamoto, R., Battaglia, G., Inderbitzin, W., Stoehr, N., Flor, P.J., (−)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection (2003) Neuropharmacology, 45, pp. 895-906

Coyle, J.T., Price, D.L., DeLong, M.R., Alzheimer's disease: a disorder of cortical cholinergic innervation (1983) Science, 219, pp. 1184-1190

Gu, Z., Cheng, J., Zhong, P., Qin, L., Liu, W., Yan, Z., Aβ selectively impairs mGluR7 modulation of NMDA signaling in basal forebrain cholinergic neurons: implication in Alzheimer's disease (2014) J Neurosci, 34, pp. 13614-13628. , This study demonstrates that Aβ impairs the mGlu7-mediated regulation of NMDA receptor currents in rodent basal forebrain cholinergic neurons, suggesting the potential role of mGlu7 as a new target to prevent the degeneration of cholinergic neurons in AD

Gerlai, R., Roder, J.C., Hampson, D.R., Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor (1998) Behav Neurosci, 112, pp. 525-532

Hölscher, C., Schmid, S., Pilz, P.K., Sansig, G., van der Putten, H., Plappert, C.F., Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory (2004) Behav Brain Res, 154, pp. 473-481

Goddyn, H., Callaerts-Vegh, Z., Stroobants, S., Dirikx, T., Vansteenwegen, D., Hermans, D., van der Putten, H., D'Hooge, R., Deficits in acquisition and extinction of conditioned responses in mGluR7 knockout mice (2008) Neurobiol Learn Mem, 90, pp. 103-111

Caraci, F., Gulisano, W., Guida, C.A., Impellizzeri, A.A., Drago, F., Puzzo, D., Palmeri, A., A key role for TGF-β1 in hippocampal synaptic plasticity and memory (2015) Sci Rep, 5, p. 11252. , This is the first study that demonstrates the primary role of TGF-β1 in hippocampal long-term potentiation and object recognition memory formation in mice

Di Menna, L., Joffe, M.E., Iacovelli, L., Orlando, R., Lindsley, C.W., Mairesse, J., Gressèns, P., Nicoletti, F., Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (2017) Neuropharmacology



A dysfunction of glutamate signaling is implicated at several levels in the pathogenesis of Alzheimer's disease. Currently, metabotropic glutamate receptors, which have a wide distribution in the central nervous system and activate a multitude of cell signaling pathways, are pursued as targets for therapeutic intervention in Alzheimer's disease. Research is still limited, but results underscore the relevance of ongoing studies. Here we discuss the latest updates regarding metabotropic glutamate receptors and their role in Alzheimer's disease, as well as promising metabotropic glutamate receptor ligands that have been investigated in preclinical models of Alzheimer's disease. © 2017 Elsevier Ltd
Nessun risultato.
Nessun risultato.

Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


Sciacca MFM, Monaco I, La Rosa C, Milardi D
* The active role of Ca(2+) ions in Abeta-mediated membrane damage (8 visite)
Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Apr 5; 54(29): 3629-3631.
Impact Factor: 6.169
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pelagalli A, Nardelli A, Lucarelli E, Zannetti A, Brunetti A
* Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (49 visite)
J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Impact Factor: 4.08
Dettagli    Esporta in BibTeX    Esporta in EndNote

Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (75 visite)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
Dettagli    Esporta in BibTeX    Esporta in EndNote

Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (3 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
Dettagli    Esporta in BibTeX    Esporta in EndNote

Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (102 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.317
Dettagli    Esporta in BibTeX    Esporta in EndNote

Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PLS, Carrotta R
* Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains (3 visite)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2016; 208: 9-16.
Impact Factor: 2.362
Dettagli    Esporta in BibTeX    Esporta in EndNote

Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (576 visite) (PDF 171 visite)
Cancer Lett (ISSN: 1872-7980electronic, 0304-3835linking), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 5.992
Dettagli    Esporta in BibTeX    Esporta in EndNote

Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (176 visite)
Front Cell Neurosci (ISSN: 1662-5102electronic, 1662-5102linking), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (176 visite)
Eur J Pharmacol (ISSN: 1879-0712electronic, 0014-2999linking), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
Dettagli    Esporta in BibTeX    Esporta in EndNote

Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (125 visite)
Int J Biochem Cell Biol International Journal Of Biochemistry And Cell Biology (ISSN: 1878-5875, 1357-7272, 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
Dettagli    Esporta in BibTeX    Esporta in EndNote

Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (3 visite)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor:
Dettagli    Esporta in BibTeX    Esporta in EndNote

Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (182 visite)
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (225 visite)
Cancer Cell (ISSN: 1878-3686, 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
Dettagli    Esporta in BibTeX    Esporta in EndNote

Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (110 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
Dettagli    Esporta in BibTeX    Esporta in EndNote

Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (128 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
Dettagli    Esporta in BibTeX    Esporta in EndNote

Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (120 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
Dettagli    Esporta in BibTeX    Esporta in EndNote

Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (174 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
Dettagli    Esporta in BibTeX    Esporta in EndNote

Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (121 visite)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
Dettagli    Esporta in BibTeX    Esporta in EndNote

Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (107 visite)
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
Dettagli    Esporta in BibTeX    Esporta in EndNote

Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (193 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (164 visite)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (178 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
Dettagli    Esporta in BibTeX    Esporta in EndNote

Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (159 visite)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
Dettagli    Esporta in BibTeX    Esporta in EndNote

Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (172 visite)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
Dettagli    Esporta in BibTeX    Esporta in EndNote

Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (151 visite)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
Dettagli    Esporta in BibTeX    Esporta in EndNote

Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (120 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (153 visite)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
Dettagli    Esporta in BibTeX    Esporta in EndNote

Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (177 visite)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
Dettagli    Esporta in BibTeX    Esporta in EndNote

Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (154 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (234 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
Dettagli    Esporta in BibTeX    Esporta in EndNote

Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (128 visite)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
Dettagli    Esporta in BibTeX    Esporta in EndNote

Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (131 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
* Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (163 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
Impact Factor: 3.463
Dettagli    Esporta in BibTeX    Esporta in EndNote

Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (116 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
Dettagli    Esporta in BibTeX    Esporta in EndNote

Zaccaro L, Garcia-lopez Mt Gonzalez-muniz RG
* TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach (102 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2011 Jun 15; 21(12): 3541-3545.
Impact Factor: 2.554
Dettagli    Esporta in BibTeX    Esporta in EndNote

Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (126 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (267 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
Dettagli    Esporta in BibTeX    Esporta in EndNote

Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (168 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
Dettagli    Esporta in BibTeX    Esporta in EndNote

Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (148 visite)
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
Dettagli    Esporta in BibTeX    Esporta in EndNote

Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (119 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
Dettagli    Esporta in BibTeX    Esporta in EndNote

Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (137 visite)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
Dettagli    Esporta in BibTeX    Esporta in EndNote

Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (174 visite)
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
Dettagli    Esporta in BibTeX    Esporta in EndNote

Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (143 visite)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Viral fusion peptides induce several signal transduction pathway activations that are essential for interleukin-10 and beta-interferon production (128 visite)
Intervirology (ISSN: 1423-0100, 0300-5526), 2010; 53(6): 381-389.
Impact Factor: 1.756
Dettagli    Esporta in BibTeX    Esporta in EndNote

Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (139 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
Dettagli    Esporta in BibTeX    Esporta in EndNote

Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (169 visite)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
Dettagli    Esporta in BibTeX    Esporta in EndNote

Illario M, Monaco S, Cavallo AL, Esposito I, Formisano P, D'Andrea LD, Cipolletta E, Trimarco B, Fenzi G, Rossi G, Vitale M
* Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (84 visite)
Cell Signal Cellular Signalling (ISSN: 0898-6568), 2009 May; 21(5): 786-792.
Impact Factor: 4.094
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (108 visite)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (183 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
Dettagli    Esporta in BibTeX    Esporta in EndNote

D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (153 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (135 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
Dettagli    Esporta in BibTeX    Esporta in EndNote

Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (109 visite)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tornatore L, Montil SM, Marasco D, Dathan N, Vitale RM, Benedetti E, Pedone C, Papa S, Franzoso G, Ruvo M
* Gadd45beta dimerization does not affect MKK7 binding (111 visite)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 367-368.
Impact Factor: 2.02
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (91 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
Dettagli    Esporta in BibTeX    Esporta in EndNote

Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (130 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
Dettagli    Esporta in BibTeX    Esporta in EndNote

Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (97 visite)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (110 visite)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (124 visite)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
Dettagli    Esporta in BibTeX    Esporta in EndNote

Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (128 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
Dettagli    Esporta in BibTeX    Esporta in EndNote

Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (116 visite)
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
Dettagli    Esporta in BibTeX    Esporta in EndNote

Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (124 visite)
Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
Dettagli    Esporta in BibTeX    Esporta in EndNote

Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (156 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
Dettagli    Esporta in BibTeX    Esporta in EndNote

Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (111 visite)
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
Dettagli    Esporta in BibTeX    Esporta in EndNote

Chiechio S, Copani A, Gereau R, Nicoletti F
* Acetyl-l-carnitine in neuropathic pain (80 visite)
Cns Drugs (ISSN: 1172-7047), 2007; 21: 38-38.
Impact Factor: 4.514
Dettagli    Esporta in BibTeX    Esporta in EndNote

Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (117 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
Dettagli    Esporta in BibTeX    Esporta in EndNote

Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (140 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
Dettagli    Esporta in BibTeX    Esporta in EndNote

Iaccarino G, Izzo R, Trimarco V, Cipolletta E, Lanni F, Sorriento D, Iovino GL, Rozza F, De Luca N, Priante O, Di Renzo G, Trimarco B
* β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (100 visite)
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Impact Factor: 8.066
Dettagli    Esporta in BibTeX    Esporta in EndNote

Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (93 visite)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic), 2006; 27(4): 606-613.
Impact Factor: 5.599
Dettagli    Esporta in BibTeX    Esporta in EndNote

Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (100 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
Dettagli    Esporta in BibTeX    Esporta in EndNote

Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (107 visite)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
Dettagli    Esporta in BibTeX    Esporta in EndNote

Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (115 visite)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
Dettagli    Esporta in BibTeX    Esporta in EndNote

Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (249 visite)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (125 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
Dettagli    Esporta in BibTeX    Esporta in EndNote

Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (152 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
Impact Factor: 2.863
Dettagli    Esporta in BibTeX    Esporta in EndNote

Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (117 visite)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
Dettagli    Esporta in BibTeX    Esporta in EndNote

Galdiero S, Capasso D, Vitiello M, D'Isanto M, Pedone C, Galdiero M
* Protein P2 from Haemophilus influenzae: The role of its surface exposed loops on the mitogen-activated protein kinase cascade (84 visite)
Infection And Immunity (ISSN: 0019-9567), 2003 May; 71(5): 2798-2809.
Impact Factor: 3.875
Dettagli    Esporta in BibTeX    Esporta in EndNote

Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (164 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Fusion in Coq (107 visite)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596.
Impact Factor: 0.415
Dettagli    Esporta in BibTeX    Esporta in EndNote

Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (122 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
Dettagli    Esporta in BibTeX    Esporta in EndNote



79 Records (74 escludendo Abstract e Conferenze).
Impact factor totale: 320.336 (296.479 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 326.86 (303.221 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote

Ultima modifica di Marco Comerci in data Thursday 06 December 2018, 13:10:06
68 visite. Ultima visita in data Friday 28 December 2018, 5:17:15

Webmaster and developer: Marco Comerci
Per problemi e suggerimenti: adminibb.cnr.it
Ultimo aggiornamento: Wednesday 20 February 2019, 11:48:26