Home Ricerca Sedi Chi siamo Organigramma Personale Contatti Didattica Login Documenti EN
Progetti in evidenza
(Link esterno)

(1209 visite)

Fondo Europeo Pesca
(622 visite)

(Link esterno)

Fondazione Veronesi
(Link esterno)

(1094 visite)

(1186 visite)

(Link esterno)

(1329 visite)

(1090 visite)

(1028 visite)

MFAG Grant
(1134 visite)

(Link esterno)


Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
[Pulisci modulo]

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (75 visite)

Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F

Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.

Tipo di articolo: Journal Article, Epub,

Impact factor: 3.383, Impact factor a 5 anni: 3.737

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032458223&doi=10.1016%2fj.neuropharm.2017.10.026&partnerID=40&md5=2767897cf0600ed890aecfaa819beac1

Parole chiave: G-Protein βγ Subunits; Long-Term Depression; Metabotropic Glutamate Receptors; Neurodevelopment; Neuronal Death; Polyphosphoinositide Hydrolysis; Receptor-Receptor Cross-Talk; Synaptic Plasticity, G-Protein Betagamma Subunits, Calcium Ion, Metabotropic Receptor 1, 4 Dihydroxyphenylethylene Glycol, 4 Amino 2 Oxabicyclo[3.1.0]hexane 4, 6 Dicarboxylic Acid, 4 Hydroxy 3 Methoxyphenylethylene Glycol, Amino Acid, Amino Acid Receptor Affecting Agent, Fused Heterocyclic Rings, N Methylaspartic Acid, Adult, Animal Cell, Animal Tissue, Astrocyte, Calcium Mobilization, Cell Viability, Central Nervous System, Controlled Study, Embryo, Female, Human, Human Cell, Long Term Depression, Mouse, Nerve Cell Necrosis, Nerve Cell Plasticity, Nonhuman, Perinatal Period, Prefrontal Cortex, Priority Journal, Protein Expression, Protein Hydrolysis, Protein Protein Interaction, Pyramidal Nerve Cell, Signal Transduction, Wild Type, Analogs And Derivatives, C57bl Mouse, Cell Culture, Cytology, Drug Effect, Gene Expression Regulation, Genetics, Long Term Potentiation, Mammalian Embryo, Metabolism, Newborn, Physiology, Bridged Bicyclo Compounds, Excitatory Amino Acid Agents, Long-Term Potentiation, Methoxyhydroxyphenylglycol, Inbred C57bl, N-Methylaspartate, Phosphatidylinositol Phosphates,


*** IBB - CNR ***
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy.
Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232-0697, USA.
Department of Physiology and Pharmacology, University Sapienza of Roma, 00185 Roma, Italy.
PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité, 1141 Paris, France.
Department of Drug Sciences, University of Catania, 95125 Catania, Italy; I.R.C.C.S. Oasi Maria SS, 94018 Troina, Italy.
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy; Department of Physiology and Pharmacology, University Sapienza of Roma, 00185 Roma, Italy.
Centre for the Developing Brain, Department of Perinatal Health and Imaging, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London SE1 7EH, United Kingdom.
Institute of Biostructure and Bioimaging, National Research Council, 95126 Catania, Italy.


Aghajanian, G.K., Marek, G.J., Serotonin model of schizophrenia: emerging role of glutamate mechanisms (2000) Brain Res. Brain Res. Rev., 31, pp. 302-31

Alagarsamy, S., Marino, M.J., Rouse, S.T., Gereau, R.W., 4th, Heinemann, S.F., Conn, P.J., Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems (1999) Nat. Neurosci., 2, pp. 234-240

Alagarsamy, S., Rouse, S.T., Junge, C., Hubert, G.W., Gutman, D., Smith, Y., Conn, P.J., NMDA-induced phosphorylation and regulation of mGluR5 (2002) Pharmacol. Biochem. Behav., 73, pp. 299-306

Alagarsamy, S., Saugstad, J., Warren, L., Mansuy, I.M., Gereau, R.W., 4th, Conn, P.J., NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin (2005) Neuropharmacology, 49, pp. 135-145

Ango, F., Pin, J.P., Tu, J.C., Xiao, B., Worley, P.F., Bockaert, J., Fagni, L., Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation (2000) J. Neurosci., 20, pp. 8710-8716

Ballester-Rosado, C.J., Sun, H., Huang, J.Y., Lu, H.C., mGluR5 exerts cell-autonomous influences on the functional and anatomical development of layer IV cortical neurons in the mouse primary somatosensory cortex (2016) J. Neurosci., 36, pp. 8802-8814

Barnes, S.A., Pinto-Duarte, A., Kappe, A., Zembrzycki, A., Metzler, A., Mukamel, E.A., Lucero, J., Behrens, M.M., Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders (2015) Mol. Psychiatry, 20, pp. 1161-1172

Battaglia, G., Fornai, F., Busceti, C.L., Aloisi, G., Cerrito, F., De Blasi, A., Melchiorri, D., Nicoletti, F., Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity (2002) J. Neurosci., 22, pp. 2135-2141

Battaglia, G., Busceti, C.L., Molinaro, G., Biagioni, F., Storto, M., Fornai, F., Nicoletti, F., Bruno, V., Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice (2004) J. Neurosci., 24, pp. 828-835

Battaglia, G., Molinaro, G., Riozzi, B., Storto, M., Busceti, C.L., Spinsanti, P., Bucci, D., Bruno, V., Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons (2009) PLoS One, 4, p. e6591

Battaglia, G., Riozzi, B., Bucci, D., Di Menna, L., Molinaro, G., Pallottino, S., Nicoletti, F., Bruno, V., Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis (2015) Neurobiol. Dis., 74, pp. 126-136

Bishop, J.R., Wang, K., Moline, J., Ellingrod, V.L., Association analysis of the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia (2007) Psychiatr. Genet., 17, p. 358

Bollinger, A.K., Felts, S.A., Brassard, J.C., Engers, L.J., Rodriguez, L.A., Weiner, L.R., Cho, P.H., Lindsley, W.C., Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core (2017), Publication Date (Web): August 3, 2017

Brakeman, P.R., Lanahan, A.A., O'Brien, R., Roche, K., Barnes, C.A., Huganir, R.L., Worley, P.F., Homer: a protein that selectively binds metabotropic glutamate receptors (1997) Nature, 386, pp. 284-288

Bruno, V., Battaglia, G., Casabona, G., Copani, A., Caciagli, F., Nicoletti, F., Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta (1998) J. Neurosci., 18, pp. 9594-9600

Bruno, V., Caraci, F., Copani, A., Matrisciano, F., Nicoletti, F., Battaglia, G., The impact of metabotropic glutamate receptors into active neurodegenerative processes: a “dark side” in the development of new symptomatic treatments for neurologic and psychiatric disorders (2017) Neuropharmacology, 115, pp. 180-192

Caraci, F., Molinaro, G., Battaglia, G., Giuffrida, M.L., Riozzi, B., Traficante, A., Bruno, V., Nicoletti, F., Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (2011) Mol. Pharmacol., 79, pp. 618-626

Caraci, F., Tascedda, F., Merlo, S., Benatti, C., Spampinato, S.F., Munafò, A., Leggio, G.M., Copani, A., Fluoxetine prevents Aβ(1-42)-induced toxicity via a paracrine signaling mediated by transforming-growth-factor-β1 (2016) Front. Pharmacol., 7, p. 389

Carpenter, W.T., Jr., Buchanan, R.W., Schizophrenia (1994) N. Engl. J. Med., 330, pp. 681-690

Casabona, G., Knöpfel, T., Kuhn, R., Gasparini, F., Baumann, P., Sortino, M.A., Copani, A., Nicoletti, F., Expression and coupling to polyphosphoinositide hydrolysis of group I metabotropic glutamate receptors in early postnatal and adult rat brain (1997) Eur. J. Neurosci., 9, pp. 12-17

Catania, M.V., Landwehrmeyer, G.B., Testa, C.M., Standaert, D.G., Penney, J.B., Jr., Young, A.B., Metabotropic glutamate receptors are differentially regulated during development (1994) Neuroscience, 61, pp. 481-495

Chen, Q., He, G., Chen, Q., Wu, S., Xu, Y., Feng, G., Li, Y., He, L., A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population (2005) Schizophr. Res., 73, pp. 21-26

Coccurello, R., Breysse, N., Amalric, M., Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats (2004) Neuropsychopharmacology, 29, pp. 1451-1461

Conti, V., Aghaie, A., Cilli, M., Martin, N., Caridi, G., Musante, L., Candiano, G., Puliti, A., Crv4, a mouse model for human ataxia associated with kyphoscoliosis caused by an mRNA splicing mutation of the metabotropic glutamate receptor 1 (Grm1) (2006) Int. J. Mol. Med., 18, pp. 593-600

Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J., 13, pp. 2225-2234

Corti, C., Crepaldi, L., Mion, S., Roth, A.L., Xuereb, J.H., Ferraguti, F., Altered dimerization of metabotropic glutamate receptor 3 in schizophrenia (2007) Biol. Psychiatry, 62, pp. 747-755

D'Amore, V., von Randow, C., Nicoletti, F., Ngomba, R.T., van Luijtelaar, G., Anti-absence activity of mGlu1 and mGlu5 receptor enhancers and their interaction with a GABA reuptake inhibitor: effect of local infusions in the somatosensory cortex and thalamus (2015) Epilepsia, 56, pp. 1141-1151

D'Antoni, S., Spatuzza, M., Bonaccorso, C.M., Musumeci, S.A., Ciranna, L., Nicoletti, F., Huber, K.M., Catania, M.V., Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with intellectual disability and autism (2014) Neurosci. Biobehav. Rev., 46, pp. 228-241

Díaz-Cabiale, Z., Vivó, M., Del Arco, A., O'Connor, W.T., Harte, M.K., Müller, C.E., Martínez, E., Ferré, S., Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors (2002) Neurosci. Lett., 324, pp. 154-158

Domenici, M.R., Pepponi, R., Martire, A., Tebano, M.T., Potenza, R.L., Popoli, P., Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum (2004) J. Neurochem., 90, pp. 1276-1289

Doumazane, E., Scholler, P., Zwier, J.M., Trinquet, E., Rondard, P., Pin, J.P., A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors (2011) FASEB J., 25, pp. 66-77

DuBois, J.M., Rousset, O.G., Guiot, M.C., Hall, J.A., Reader, A.J., Soucy, J.P., Rosa-Neto, P., Kobayashi, E., Metabotropic glutamate receptor type 5 (mGluR5) cortical abnormalities in focal cortical dysplasia identified in vivo with [11C]ABP688 positron-emission tomography (PET) imaging (2017) Cereb. Cortex, 26, pp. 4170-4179

Egan, M.F., Straub, R.E., Goldberg, T.E., Yakub, I., Callicott, J.H., Hariri, A.R., Mattay, V.S., Weinberger, D.R., Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia (2004) Proc. Natl. Acad. Sci. U. S. A., 101, pp. 12604-12609

El Moustaine, D., Granier, S., Doumazane, E., Scholler, P., Rahmeh, R., Bron, P., Mouillac, B., Pin, J.P., Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling (2012) Proc. Natl. Acad. Sci. U. S. A., 109, pp. 16342-16347

Engers, J.L., Rodriguez, A.L., Konkol, L.C., Morrison, R.D., Thompson, A.D., Byers, F.W., Blobaum, A.L., Emmitte, K.A., Discovery of a selective and CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 with antidepressant and anxiolytic activity in rodents (2015) J. Med. Chem., 58, pp. 7485-7500

Falkai, P., Rossner, M.J., Schulze, T.G., Hasan, A., Brzózka, M.M., Malchow, B., Honer, W.G., Schmitt, A., Kraepelin revisited: schizophrenia from degeneration to failed regeneration (2015) Mol. Psychiatry, 20, pp. 671-676

Ferré, S., Karcz-Kubicha, M., Hope, B.T., Popoli, P., Burgueño, J., Gutiérrez, M.A., Casadó, V., Ciruela, F., Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function (2002) Proc. Natl. Acad. Sci. U. S. A., 99, pp. 11940-11945

Foster, D.J., Gentry, P.R., Lizardi-Ortiz, J.E., Bridges, T.M., Wood, M.R., Niswender, C.M., Sulzer, D., Conn, P.J., M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location (2014) J. Neurosci., 34, pp. 3253-3262

Fujii, Y., Shibata, H., Kikuta, R., Makino, C., Tani, A., Hirata, N., Shibata, A., Fukumaki, Y., Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia (2003) Psychiatr. Genet., 13, pp. 71-76

Genazzani, A.A., L'Episcopo, M.R., Casabona, G., Shinozaki, H., Nicoletti, F., (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl) glycine positively modulates metabotropic glutamate receptors coupled to polyphosphoinositide hydrolysis in rat hippocampal slices (1994) Brain Res., 659, pp. 10-16

Giuffrida, R., Musumeci, S., D'Antoni, S., Bonaccorso, C.M., Giuffrida-Stella, A.M., Oostra, B.A., Catania, M.V., A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive homer proteins in a mouse model of fragile X syndrome (2005) J. Neurosci., 25, pp. 8908-8916

González-Maeso, J., Ang, R.L., Yuen, T., Chan, P., Weisstaub, N.V., López-Giménez, J.F., Zhou, M., Sealfon, S.C., Identification of a serotonin/glutamate receptor complex implicated in psychosis (2008) Nature, 452, pp. 93-97

Goudet, C., Kniazeff, J., Hlavackova, V., Malhaire, F., Maurel, D., Acher, F., Blahos, J., Pin, J.P., Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators (2005) J. Biol. Chem., 280, pp. 24380-24385

Guo, W., Molinaro, G., Collins, K.A., Hays, S.A., Paylor, R., Worley, P.F., Szumlinski, K.K., Huber, K.M., Selective disruption of metabotropic glutamate receptor 5-Homer interactions mimics phenotypes of Fragile X syndrome in mice (2016) J. Neurosci., 36, pp. 2131-2147

Hamilton, A., Esseltine, J.L., DeVries, R.A., Cregan, S.P., Ferguson, S.S., Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease (2014) Mol. Brain, 7, p. 40

Hannan, A.J., Blakemore, C., Katsnelson, A., Vitalis, T., Huber, K.M., Bear, M., Roder, J., Kind, P.C., PLC-beta1, activated via mGluRs, mediatesactivity-dependent differentiation in cerebral cortex (2001) Nat. Neurosci., 4, pp. 282-288

Harrison, P.J., Lyon, L., Sartorius, L.J., Burnet, P.W., Lane, T.A., The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia (2008) J. Psychopharmacol., 22, pp. 308-322

Huang, C.C., Hsu, K.S., The role of NMDA receptors in regulating group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex (2008) Neuropharmacology, 54, pp. 1071-1078

Huang, C.C., Yang, P.C., Lin, H.J., Hsu, K.S., Repeated cocaine administration impairs group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex (2007) J. Neurosci., 27, pp. 2958-2968

Huber, K.M., Gallagher, S.M., Warren, S.T., Bear, M.F., Altered synaptic plasticity in a mouse model of fragile X mental retardation (2002) Proc. Natl. Acad. Sci. U. S. A., 99, pp. 7746-7750

Iacovelli, L., Felicioni, M., Nisticò, R., Nicoletti, F., De Blasi, A., Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins (2014) Neuropharmacology, 77, pp. 303-312

Iacovelli, L., Di Menna, L., Peterlik, D., Stangl, C., Orlando, R., Molinaro, G., De Blasi, A., Nicoletti, F., Type-7 metabotropic glutamate receptors negatively regulate α(1)-adrenergic receptor signalling (2017) Neuropharmacology, 113, pp. 343-353

Iyer, A.M., van Scheppingen, J., Milenkovic, I., Anink, J.J., Lim, D., Genazzani, A.A., Adle-Biassette, H., Aronica, E., Metabotropic glutamate receptor 5 in Down's syndrome hippocampus during development: increased expression in astrocytes (2014) Curr. Alzheimer Res., 11, pp. 694-705

Jin, L.E., Wang, M., Galvin, V.C., Lightbourne, T.C., Conn, P.J., Arnsten, A.F., Paspalas, C.D., mGluR2 versus mGluR3 metabotropic glutamate receptors in primate dorsolateral prefrontal cortex: postsynaptic mGluR3 strengthen working memory networks (2017) Cereb. Cortex, , 2017 Jan 19

Kammermeier, P.J., Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers (2012) Mol. Pharmacol., 82, pp. 438-447

Kammermeier, P.J., Worley, P.F., Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors (2007) Proc. Natl. Acad. Sci. U. S. A., 104, pp. 6055-6060

Kasanetz, F., Lafourcade, M., Deroche-Gamonet, V., Revest, J.M., Berson, N., Balado, E., Fiancette, J.F., Manzoni, O.J., Prefrontal synaptic markers of cocaine addiction-like behavior in rats (2013) Mol. Psychiatry, 18, pp. 729-737

Kinney, G.G., O'Brien, J.A., Lemaire, W., Burno, M., Bickel, D.J., Clements, M.K., Chen, T.B., Williams, D.L., Jr., A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models (2005) J. Pharmacol. Exp. Ther., 313, pp. 199-206

Lin, T.B., Lai, C.Y., Hsieh, M.C., Wang, H.H., Cheng, J.K., Chau, Y.P., Chen, G.D., Peng, H.Y., VPS26A-SNX27 interaction-dependent mGluR5 recycling in dorsal horn neurons mediates neuropathic pain in rats (2015) J. Neurosci., 35, pp. 14943-14955

Linden, A.M., Shannon, H., Baez, M., Yu, J.L., Koester, A., Schoepp, D.D., Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice (2005) Psychopharmacology, 179, pp. 284-291

Loerwald, K.W., Patel, A.B., Huber, K.M., Gibson, J.R., Postsynaptic mGluR5 promotes evoked AMPAR-mediated synaptic transmission onto neocortical layer 2/3 pyramidal neurons during development (2015) J. Neurophysiol., 113, pp. 786-795

López-Bendito, G., Shigemoto, R., Fairén, A., Luján, R., Differential distribution of group I metabotropic glutamate receptors during rat cortical development (2002) Cereb. Cortex, 12, pp. 625-638

Lovell, K.M., Felts, A.S., Rodriguez, A.L., Venable, D.F., Cho, H.P., Morrison, R.D., Byers, F.W., Emmitte, K.A., N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats (2013) Bioorg. Med. Chem. Lett., 23, pp. 3713-3718

Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275

Luoni, A., Gass, P., Brambilla, P., Ruggeri, M., Riva, M.A., Inta, D., Altered expression of schizophrenia-related genes in mice lacking mGlu5 receptors. Eur. Arch (2016) Psychiatry Clin. Neurosci., , 2016 Aug 31, [Epub ahead of print]

Marek, G.J., Wright, R.A., Schoepp, D.D., Monn, J.A., Aghajanian, G.K., Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex (2000) J. Pharmacol. Exp. Ther., 292, pp. 76-87

Masilamoni, G.J., Bogenpohl, J.W., Alagille, D., Delevich, K., Tamagnan, G., Votaw, J.R., Wichmann, T., Smith, Y., Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys (2011) Brain, 134, pp. 2057-2073

Matosin, N., Fernandez-Enright, F., Lum, J.S., Engel, M., Andrews, J.L., Gassen, N.C., Wagner, K.V., Newell, K.A., Molecular evidence of synaptic pathology in the CA1region in schizophrenia (2016) NPJ Schizophr., 2, p. 16022

Miller, S., Romano, C., Cotman, C.W., Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes (1995) J. Neurosci., 15, pp. 6103-6109

Nicoletti, F., Iadarola, M.J., Wroblewski, J.T., Costa, E., Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors (1986) Proc. Natl. Acad. Sci. U. S. A., 83, pp. 1931-1955

Nicoletti, F., Meek, J.L., Iadarola, M.J., Chuang, D.M., Roth, B.L., Costa, E., Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus (1986) J. Neurochem., 46, pp. 40-46

Nicoletti, F., Casabona, G., Genazzani, A.A., L'Episcopo, M.R., Shinozaki, H., (2s,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices (1993) Eur. J. Pharmacol., 245, pp. 297-308

Nicoletti, F., Bockaert, J., Collingridge, G.L., Conn, P.J., Ferraguti, F., Schoepp, D.D., Wroblewski, J.T., Pin, J.P., Metabotropic glutamate receptors: from the workbench to the bedside (2011) Neuropharmacology, 60, pp. 1017-1041

Nishi, A., Liu, F., Matsuyama, S., Hamada, M., Higashi, H., Nairn, A.C., Greengard, P., Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling (2003) Proc. Natl. Acad. Sci. U. S. A., 100, pp. 1322-1327

Norton, N., Williams, H.J., Dwyer, S., Ivanov, D., Preece, A.C., Gerrish, A., Williams, N.M., Owen, M.G., No evidence for association between polymorphisms in GRM3 and schizophrenia (2005) BMC Psychiatry, 5, p. 23

Ohnuma, T., Augood, S.J., Arai, H., McKenna, P.J., Emson, P.C., Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the PFC from normal individuals and patients with schizophrenia (1998) Brain Res. Mol. Brain Res., 56, pp. 207-217

Otani, S., Auclair, N., Desce, J.M., Roisin, M.P., Crépel, F., Dopamine receptors and groups I and II mGluRs cooperate for long-term depression induction in rat prefrontal cortex through converging postsynaptic activation of MAP kinases (1999) J. Neurosci., 19, pp. 9788-9802

Otani, S., Daniel, H., Takita, M., Crépel, F., Long-term depression induced by postsynaptic group II metabotropic glutamate receptors linked to phospholipase C and intracellular calcium rises in rat prefrontal cortex (2002) J. Neurosci., 22, pp. 3434-3444

Pignatelli, M., Piccinin, S., Molinaro, G., Di Menna, L., Riozzi, B., Cannella, M., Motolese, M., Bruno, V., Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling Angelman syndrome (2014) J. Neurosci., 34, pp. 4558-4566

Premont, R.T., Inglese, J., Lefkowitz, R.J., Protein kinases that phosphorylate activated G protein-coupled receptors (1995) FASEB J., 9, pp. 175-182

Reid, S.N., Romano, C., Hughes, T., Daw, N.W., Developmental and sensory-dependentchanges of phosphoinositide-linked metabotropic glutamate receptors (1998) J. Comp. Neurol., 389, pp. 577-583

Rives, M.L., Vol, C., Fukazawa, Y., Tinel, N., Trinquet, E., Ayoub, M.A., Shigemoto, R., Prézeau, L., Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration (2009) EMBO J., 28, pp. 2195-2208

Rodriguez, A.L., Grier, M.D., Jones, C.K., Herman, E.J., Kane, A.S., Smith, R.L., Williams, R., Conn, P.J., Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity (2010) Mol. Pharmacol., 78, pp. 1105-1123

Romano, C., Miller, J.K., Hyrc, K., Dikranian, S., Mennerick, S., Takeuchi, Y., Goldberg, M.P., O'Malley, K.L., Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu5 dimerization (2001) Mol. Pharmacol., 59, pp. 46-53

Ronesi, J.A., Collins, K.A., Hays, S.A., Tsai, N.P., Guo, W., Birnbaum, S.G., Hu, J.H., Huber, K.M., Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome (2012) Nat. Neurosci., 15, pp. 431-440

Rong, R., Ahn, J.Y., Huang, H., Nagata, E., Kalman, D., Kapp, J.A., Tu, J., Ye, K., PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis (2003) Nat. Neurosci., 6, pp. 1153-1161

Schoepp, D.D., Salhoff, C.R., Wright, R.A., Johnson, B.G., Burnett, J.P., Mayne, N.G., Belagaje, R., Monn, J.A., The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors (1996) Neuropharmacology, 35, pp. 1661-1672

Schwab, S.G., Plummer, C., Albus, M., Borrmann-Hassenbach, M., Lerer, B., Trixler, M., Maier, W., Wildenauer, D.B., DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study (2008) Psychiatr. Genet., 18, pp. 25-30

Sevastyanova, T.N., Kammermeier, P.J., Cooperative signaling between homodimers of metabotropic glutamate receptors 1 and 5 (2014) Mol. Pharmacol., 86, pp. 492-504

Tabata, T., Araishi, K., Hashimoto, K., Hashimotodani, Y., van der Putten, H., Bettler, B., Kano, M., Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA (2004) Proc. Natl. Acad. Sci. U. S. A., 101, pp. 16952-16957

Tamminga, C.A., Holcomb, H.H., Phenotype of schizophrenia: a review and formulation (2005) Mol. Psychiatry, 10, pp. 27-39

Vinson, P.N., Conn, P.J., Metabotropic glutamate receptors as therapeutic targets for schizophrenia (2012) Neuropharmacology, 62, pp. 1461-1472

Walker, A.G., Wenthur, C.J., Xiang, Z., Rook, J.M., Emmitte, K.A., Niswender, C.M., Lindsley, C.W., Conn, P.J., Metabotropic glutamate receptor 3 activation is required for long-term depression in medial PFC and fear extinction (2015) Proc. Natl. Acad. Sci. U. S. A., 112, pp. 1196-1201

Wang, T., Pentyala, S., Rebecchi, M.J., Scarlata, S., Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins (1999) Biochemistry, 38, pp. 1517-1524

Wijetunge, L.S., Till, S.M., Gillingwater, T.H., Ingham, C.A., Kind, P.C., mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex (2008) J. Neurosci., 28, pp. 13028-13037

Xiao, B., Tu, J.C., Petralia, R.S., Yuan, J.P., Doan, A., Breder, C.D., Ruggiero, A., Worley, P.F., Homer regulates the association of group 1metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins (1998) Neuron, 21, pp. 707-716

Yin, S., Niswender, C.M., Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indications (2014) Cell. Signal, 10, pp. 2284-2297

mGlu5 receptors are involved in mechanisms of activity-dependent
synaptic plasticity, and are targeted by drugs developed for the
treatment of CNS disorders. We report that mGlu3 receptors, which are
traditionally linked to the control of neurotransmitter release, support
mGlu5 receptor signaling in neurons and largely contribute to the
robust mGlu5 receptor-mediated polyphosphoinositide hydrolysis in the
early postnatal life. In cortical pyramidal neurons, mGlu3 receptor
activation potentiated mGlu5 receptor-mediated somatic Ca2+
mobilization, and mGlu3 receptor-mediated long-term depression in the
prefrontal cortex required the endogenous activation of mGlu5 receptors.
The interaction between mGlu3 and mGlu5 receptors was also relevant to
mechanisms of neuronal toxicity, with mGlu3 receptors shaping the
influence of mGlu5 receptors on excitotoxic neuronal death. These
findings shed new light into the complex role played by mGlu receptors
in physiology and pathology, and suggest reconsideration of some of the
current dogmas in the mGlu receptor field
Nessun risultato.
Nessun risultato.

Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
[Pulisci modulo]

Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (13 visite)
Frontiers In Molecular Neuroscience (ISSN: 1662-5099, 1662-5099linking), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pontillo G, Cocozza S, Brunetti A, Brescia Morra V, Riccio E, Russo C, Sacca F, Tedeschi E, Pisani A, Quarantelli M
* Reduced Intracranial Volume in Fabry Disease: Evidence of Abnormal Neurodevelopment? (28 visite)
Front Neurol (ISSN: 1664-2295linking, 1664-2295print), 2018 Aug 17; 9(AUG): 672-672.
Impact Factor: 3.508
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sciacca MFM, Monaco I, La Rosa C, Milardi D
* The active role of Ca(2+) ions in Abeta-mediated membrane damage (8 visite)
Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Apr 5; 54(29): 3629-3631.
Impact Factor: 6.169
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (68 visite)
Curr Opin Pharmacol (ISSN: 1471-4973electronic, 1471-4892linking), 2017 Dec 23; 38: 1-7.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (76 visite)
Neuropharm (ISSN: 1873-7064electronic, 0028-3908linking), 2016 Apr 30; N/D: N/D-N/D.
Impact Factor: 5.012
Dettagli    Esporta in BibTeX    Esporta in EndNote

Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (146 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
Dettagli    Esporta in BibTeX    Esporta in EndNote

Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (134 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
Dettagli    Esporta in BibTeX    Esporta in EndNote

Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (142 visite)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
Dettagli    Esporta in BibTeX    Esporta in EndNote

Russo Krauss I, Merlino A, Randazzo A, Novellino E, Mazzarella L, Sica F
* High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity (122 visite)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2012 Sep; 40(16): 8119-8128.
Impact Factor: 8.278
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (153 visite)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (234 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (267 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
Dettagli    Esporta in BibTeX    Esporta in EndNote

Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (109 visite)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (91 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
Dettagli    Esporta in BibTeX    Esporta in EndNote

Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (97 visite)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (110 visite)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
Dettagli    Esporta in BibTeX    Esporta in EndNote

16 Records (15 escludendo Abstract e Conferenze).
Impact factor totale: 69.425 (64.411 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 61.07 (55.779 escludendo Abstract e Conferenze).

    Esporta in BibTeX    Esporta in EndNote

Ultima modifica di Marco Comerci in data Friday 16 March 2018, 13:58:19
75 visite. Ultima visita in data Friday 28 December 2018, 5:32:20

Webmaster and developer: Marco Comerci
Per problemi e suggerimenti: adminibb.cnr.it
Ultimo aggiornamento: Friday 15 February 2019, 13:06:47