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Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (75 visite)

Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F

Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.



Tipo di articolo: Journal Article, Epub,

Impact factor: 3.383, Impact factor a 5 anni: 3.737

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032458223&doi=10.1016%2fj.neuropharm.2017.10.026&partnerID=40&md5=2767897cf0600ed890aecfaa819beac1

Parole chiave: G-Protein βγ Subunits; Long-Term Depression; Metabotropic Glutamate Receptors; Neurodevelopment; Neuronal Death; Polyphosphoinositide Hydrolysis; Receptor-Receptor Cross-Talk; Synaptic Plasticity, G-Protein Betagamma Subunits, Calcium Ion, Metabotropic Receptor 1, 4 Dihydroxyphenylethylene Glycol, 4 Amino 2 Oxabicyclo[3.1.0]hexane 4, 6 Dicarboxylic Acid, 4 Hydroxy 3 Methoxyphenylethylene Glycol, Amino Acid, Amino Acid Receptor Affecting Agent, Fused Heterocyclic Rings, N Methylaspartic Acid, Adult, Animal Cell, Animal Tissue, Astrocyte, Calcium Mobilization, Cell Viability, Central Nervous System, Controlled Study, Embryo, Female, Human, Human Cell, Long Term Depression, Mouse, Nerve Cell Necrosis, Nerve Cell Plasticity, Nonhuman, Perinatal Period, Prefrontal Cortex, Priority Journal, Protein Expression, Protein Hydrolysis, Protein Protein Interaction, Pyramidal Nerve Cell, Signal Transduction, Wild Type, Analogs And Derivatives, C57bl Mouse, Cell Culture, Cytology, Drug Effect, Gene Expression Regulation, Genetics, Long Term Potentiation, Mammalian Embryo, Metabolism, Newborn, Physiology, Bridged Bicyclo Compounds, Excitatory Amino Acid Agents, Long-Term Potentiation, Methoxyhydroxyphenylglycol, Inbred C57bl, N-Methylaspartate, Phosphatidylinositol Phosphates,

Affiliazioni:

*** IBB - CNR ***
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy.
Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232-0697, USA.
Department of Physiology and Pharmacology, University Sapienza of Roma, 00185 Roma, Italy.
PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité, 1141 Paris, France.
Department of Drug Sciences, University of Catania, 95125 Catania, Italy; I.R.C.C.S. Oasi Maria SS, 94018 Troina, Italy.
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy; Department of Physiology and Pharmacology, University Sapienza of Roma, 00185 Roma, Italy.
Centre for the Developing Brain, Department of Perinatal Health and Imaging, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London SE1 7EH, United Kingdom.
Institute of Biostructure and Bioimaging, National Research Council, 95126 Catania, Italy.



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mGlu5 receptors are involved in mechanisms of activity-dependent
synaptic plasticity, and are targeted by drugs developed for the
treatment of CNS disorders. We report that mGlu3 receptors, which are
traditionally linked to the control of neurotransmitter release, support
mGlu5 receptor signaling in neurons and largely contribute to the
robust mGlu5 receptor-mediated polyphosphoinositide hydrolysis in the
early postnatal life. In cortical pyramidal neurons, mGlu3 receptor
activation potentiated mGlu5 receptor-mediated somatic Ca2+
mobilization, and mGlu3 receptor-mediated long-term depression in the
prefrontal cortex required the endogenous activation of mGlu5 receptors.
The interaction between mGlu3 and mGlu5 receptors was also relevant to
mechanisms of neuronal toxicity, with mGlu3 receptors shaping the
influence of mGlu5 receptors on excitotoxic neuronal death. These
findings shed new light into the complex role played by mGlu receptors
in physiology and pathology, and suggest reconsideration of some of the
current dogmas in the mGlu receptor field
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Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (13 visite)
Frontiers In Molecular Neuroscience (ISSN: 1662-5099, 1662-5099linking), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
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Pontillo G, Cocozza S, Brunetti A, Brescia Morra V, Riccio E, Russo C, Sacca F, Tedeschi E, Pisani A, Quarantelli M
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Impact Factor: 3.508
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Sciacca MFM, Monaco I, La Rosa C, Milardi D
* The active role of Ca(2+) ions in Abeta-mediated membrane damage (8 visite)
Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Apr 5; 54(29): 3629-3631.
Impact Factor: 6.169
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (68 visite)
Curr Opin Pharmacol (ISSN: 1471-4973electronic, 1471-4892linking), 2017 Dec 23; 38: 1-7.
Impact Factor: 0
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (76 visite)
Neuropharm (ISSN: 1873-7064electronic, 0028-3908linking), 2016 Apr 30; N/D: N/D-N/D.
Impact Factor: 5.012
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (146 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (134 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (142 visite)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Russo Krauss I, Merlino A, Randazzo A, Novellino E, Mazzarella L, Sica F
* High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity (122 visite)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2012 Sep; 40(16): 8119-8128.
Impact Factor: 8.278
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (153 visite)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (234 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (267 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (109 visite)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (91 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (97 visite)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (110 visite)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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16 Records (15 escludendo Abstract e Conferenze).
Impact factor totale: 69.425 (64.411 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 61.07 (55.779 escludendo Abstract e Conferenze).







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