Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease(401 views visite) Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
Acs Med Chem Lett (ISSN: 1948-5875), 2016 Sep 26; 7(12): 1145-1150.
Keywords Parole chiave: Alzheimer, S Disease, Amyloid, Mitochondria, Polyamines,
Affiliations Affiliazioni: *** IBB - CNR ***
Department of Pharmacy & Biotechnology, Alma Mater Studiorum-University of Bologna , Via Belmeloro 6, 40126 Bologna, Italy., Faculty of Chemistry, Biological & Chemical Research Centre University of Warsaw , Pasteura 1, 02093 Warsaw, Poland., IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Via Conte Ruggero 73, 94018 Troina, Enna, Italy; Department of Drug Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy., Institute of Biostructure and Bioimaging, National Research Council (CNR) , Via P. Gaifami 18, 95126 Catania, Italy., Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna , Corso D'Augusto 237, 47921 Rimini, Italy.,
References Riferimenti: Not available. Non disponibili.
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease
Spermine conjugates 2-6, carrying variously decorated 3,5-dibenzylidenepiperidin-4-one as bioactive motives, were designed to direct antiaggregating properties into mitochondria, using a polyamine functionality as the vehicle tool. The study confirmed mitochondrial import of the catechol derivative 2, which displayed effective antiaggregating activity and neuroprotective effects against Abeta-induced toxicity. Notably, a key functional role for the polyamine motif in Abeta molecular recognition was also unraveled. This experimental readout, which was supported by in silico studies, gives important new insight into the polyamine's action. Hence, we propose polyamine conjugation as a promising strategy for the development of neuroprotectant leads that may contribute to decipher the complex picture of Abeta toxicity.
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease
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315 Records (279 escludendo Abstract e Conferenze). Impact factor totale: 1190.075 (1088.289 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 1162.33 (1046.453 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Massimiliano Sorbillo on in data Sunday 12 July 2020, 13:14:46 401 views visite. Last view on Ultima visita in data Friday 26 February 2021, 10:21:01