Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology (388 views visite)
Beilstein J Nanotech (ISSN: 2190-4286), 2017 Nov 20; 8(1): 2446-2453.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 2.968, 5-year impact factor Impact factor a 5 anni: 3.191
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037535994&doi=10.3762%2fbjnano.8.243&partnerID=40&md5=2644aed5b25fd9e5ef545f91aada13f0
Keywords Parole chiave: Alzheimer, S Disease, Tem, Florescence, High Sensitivity, Peptide, Silicon Oxide, Bins, Bioassay, Efficiency, Glycoproteins, High Resolution Transmission Electron Microscopy, Microarrays, Neurodegenerative Diseases, Amyloid-Beta Peptides, Experimental Investigations, Fibrillar Aggregates, Intermediate Structures, Microarray Technologies,
Affiliations Affiliazioni:
*** IBB - CNR ***
STMicroelectronics, Stradale Primosole, 95121, Catania, Italy., CNR-Istituto di Biostrutture e Bioimmagini, Catania, Italy., IMM-CNR, Catania, Italy.,
References Riferimenti:
Hardy, J., (2002) Neurobiol. Aging, 23, pp. 1073-107
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J.M., Masters, C.L., Grzeschik, K.-H., Multhaup, G., Müller-Hill, B., (1987) Nature, 325, pp. 733-736
Haass, C., Selkoe, D., (2007) J. Nat. Rev. Mol. Cell Biol., 8, pp. 101-112
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., (2009) J. Neurosci., 29, pp. 10582-10587
Wennmalm, S., Chmyrov, V., Widengren, J., Tjernberg, L., (2015) Anal. Chem., 87, pp. 11700-11705
Frid, P., Anisimov, S.V., Popovic, N., (2007) Brain Res. Rev., 53, pp. 135-160
Solomon, B., (2007) Curr. Opin. Invest. Drugs (BioMed Cent.), 8, pp. 519-524
Yang, D.-S., Yip, C.M., Huang, T.H.J., Chakrabartty, A., Fraser, P.E., (1999) J. Biol. Chem., 274, pp. 32970-32974
Begum, A.N., Jones, M.R., Lim, G.P., Morihara, T., Kim, P., Heath, D.D., Rock, C.L., Frautschy, S.A., (2008) J. Pharmacol. Exp. Ther., 326, pp. 196-208
Attanasio, F., Convertino, M., Magno, A., Caflisch, A., Corazza, A., Haridas, H., Esposito, G., Rizzarelli, E., (2013) ChemBioChem, 14, pp. 583-592
De Bona, P., Giuffrida, M.L., Caraci, F., Copani, A., Pignataro, B., Attanasio, F., Cataldo, S., Rizzarelli, E., (2009) J. Pept. Sci., 15, pp. 220-228
Soto, C., Sigurdsson, E.M., Morelli, L., Kumar, R.A., Castaño, E.M., Frangione, B., (1998) Nat. Med., 4, pp. 822-826
Soto, P., Griffin, M.A., Shea, J.-E., (2007) Biophys. J., 93, pp. 3015-3025
Bieschke, J., Russ, J., Friedrich, R.P., Ehrnhoefer, D.E., Wobst, H., Neugebauer, K., Wanker, E.E., (2010) Proc. Natl. Acad. Sci. U. S. A., 107, pp. 7710-7715
Brener, O., Dunkelmann, T., Gremer, L., van Groen, T., Mirecka, E.A., Kadish, I., Willuweit, A., Willbold, D., (2015) Sci. Rep., 5, p. 13222
Rzepecki, P., Nagel-Steger, L., Feuerstein, S., Linne, U., Molt, O., Zadmard, R., Aschermann, K., Riesner, D., (2004) J. Biol. Chem., 279, pp. 47497-47505
Sciacca, M.F.M., Romanucci, V., Zarrelli, A., Monaco, I., Lolicato, F., Spinella, N., Galati, C., Milardi, D., (2017) ACS Chem. Neurosci., 8, pp. 1767-1778
Grasso, G., Santoro, A.M., Lanza, V., Sbardella, D., Tundo, G.R., Ciaccio, C., Marini, S., Milardi, D., (2017) Coord. Chem. Rev., 347, pp. 1-22
Pannuzzo, M., Milardi, D., Raudino, A., Karttunen, M., La Rosa, C., (2013) Phys. Chem. Chem. Phys., 15, pp. 8940-8951
Pannuzzo, M., Raudino, A., Milardi, D., La Rosa, C., Karttunen, M., (2013) Sci. Rep., 3, p. 2781
Chen, J., Armstrong, A.H., Koehler, A.N., Hecht, M.H.J., (2010) Am. Chem. Soc., 132, pp. 17015-17022
Harper, J.D., Lansbury, P.T., (1997) Annu. Rev. Biochem., 66, pp. 385-407
O'Nuallain, B., Shivaprasad, S., Kheterpal, I., Wetzel, R., (2005) Biochemistry, 44, pp. 12709-12718
Volle, J.-N., Chambon, G., Sayah, A., Reymond, C., Fasel, N., Gijs, M.A.M., (2003) Biosens. Bioelectron., 19, pp. 457-464
Bras, M., Dugas, V., Bessueille, F., Cloarec, J.P., Martin, J.R., Cabrera, M., Chauvet, J.P., Garrigues, M., (2004) Biosens. Bioelectron., 20, pp. 797-806
Arrabito, G., Galati, C., Castellano, S., Pignataro, B., (2013) Lab Chip, 13, pp. 68-72
Cretich, M., di Carlo, G., Longhi, R., Gotti, C., Spinella, N., Coffa, S., Galati, C., Chiari, M., (2009) Anal. Chem., 81, pp. 5197-5203
Cretich, M., Galati, C., Renna, L., Condorelli, G.G., Gagni, P., Chiari, M., (2014) Sens. Actuators, B, 192, pp. 15-22
Chalifour, R.J., McLaughlin, R.W., Lavoie, L., Morissette, C., Tremblay, N., Boulé, M., Sarazin, P., Gervais, F., (2003) J. Biol. Chem., 278, pp. 34874-34881
Tjernberg, L.O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A.R., Thyberg, J., Terenius, L., Nordstedt, C., (1996) J. Biol. Chem., 271, pp. 8545-8548
Rzepecki, P., Steger, L.N., Feuerstein, S., Linne, U., Molt, O., Zadmard, R., Aschermann, K., Riesner, D., (2006) J. Neurochem., 97, pp. 82-86
Ashmarin, I.P., Nezavibatko, V.N., Myasoedov, N.F., Kamenskii, A.A., Grivennikov, I.A., Ponomareva-Stepnaya, M.A., Andreeva, L.A., Ryasina, T.V., (1997) Zh. Vyssh. Nervn. Deyat. im. I. P. Pavlova, 47, pp. 420-430
Bashkatova, V.G., Koshelev, V.B., Fadyukova, O.E., Alexeev, A.A., Vanin, A.F., Rayevsky, K.S., Ashmarin, I.P., Armstrong, D.M., (2001) Brain Res., 894, pp. 145-149
Potaman, V.N., Antonova, L.V., Dubynin, V.A., Zaitzev, D.A., Kamensky, A.A., Myasoedov, N.F., Nezavibatko, V.N., (1991) Neurosci. Lett., 127, pp. 133-136
Storozhevykh, T.P., Tukhbatova, G.R., Senilova, Y.E., Pinelis, V.G., Andreeva, L.A., Myasoyedov, N.F., (2007) Bull. Exp. Biol. Med., 143, pp. 601-604
Tabbì, G., Magrì, A., Giuffrida, A., Lanza, V., Pappalardo, G., Naletova, I., Nicoletti, V.G., Rizzarelli, E.J., (2015) Inorg. Biochem., 142, pp. 39-46
Seilheimer, B., Bohrmann, B., Bondolfi, L., Müller, F., Stüber, D., Döbeli, H., (1997) J. Struct. Biol., 119, pp. 59-71
Hansson, O., Zetterberg, H., Peder, B.P., Andreasson, U., Londos, E., Minthon, L., Blennow, K., (2007) Dementia Geriatr. Cognit. Disord., 23, pp. 316-320
Goldsbury, C.S., Wirtz, S., Müller, S.A., Sunderji, S., Wicki, P., Aebi, U., Frey, P., (2000) J. Struct. Biol., 130, pp. 217-231
Morales-Narváez, E., Montón, H., Fomicheva, A., Merkoçi, A., (2012) Anal. Chem., 84, pp. 6821-6827
Renna, L., Galati, C., Spinella, N.M.R., Coffa, S., Optically Accessible Microfluidic Diagnostic Device., , U.S. Patent Dec 1, 2011
Sinopoli, A., Magrì, A., Milardi, D., Pappalardo, M., Pucci, P., Flagiello, A., Titman, J.J., Grasso, G., (2014) Metallomics, 6, pp. 1841-1852
Beilstein J Nanotech (ISSN: 2190-4286), 2017 Nov 20; 8(1): 2446-2453.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.968, 5-year impact factor Impact factor a 5 anni: 3.191
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037535994&doi=10.3762%2fbjnano.8.243&partnerID=40&md5=2644aed5b25fd9e5ef545f91aada13f0
Keywords Parole chiave: Alzheimer, S Disease, Tem, Florescence, High Sensitivity, Peptide, Silicon Oxide, Bins, Bioassay, Efficiency, Glycoproteins, High Resolution Transmission Electron Microscopy, Microarrays, Neurodegenerative Diseases, Amyloid-Beta Peptides, Experimental Investigations, Fibrillar Aggregates, Intermediate Structures, Microarray Technologies,
Affiliations Affiliazioni:
*** IBB - CNR ***
STMicroelectronics, Stradale Primosole, 95121, Catania, Italy., CNR-Istituto di Biostrutture e Bioimmagini, Catania, Italy., IMM-CNR, Catania, Italy.,
References Riferimenti:
Hardy, J., (2002) Neurobiol. Aging, 23, pp. 1073-107
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J.M., Masters, C.L., Grzeschik, K.-H., Multhaup, G., Müller-Hill, B., (1987) Nature, 325, pp. 733-736
Haass, C., Selkoe, D., (2007) J. Nat. Rev. Mol. Cell Biol., 8, pp. 101-112
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., (2009) J. Neurosci., 29, pp. 10582-10587
Wennmalm, S., Chmyrov, V., Widengren, J., Tjernberg, L., (2015) Anal. Chem., 87, pp. 11700-11705
Frid, P., Anisimov, S.V., Popovic, N., (2007) Brain Res. Rev., 53, pp. 135-160
Solomon, B., (2007) Curr. Opin. Invest. Drugs (BioMed Cent.), 8, pp. 519-524
Yang, D.-S., Yip, C.M., Huang, T.H.J., Chakrabartty, A., Fraser, P.E., (1999) J. Biol. Chem., 274, pp. 32970-32974
Begum, A.N., Jones, M.R., Lim, G.P., Morihara, T., Kim, P., Heath, D.D., Rock, C.L., Frautschy, S.A., (2008) J. Pharmacol. Exp. Ther., 326, pp. 196-208
Attanasio, F., Convertino, M., Magno, A., Caflisch, A., Corazza, A., Haridas, H., Esposito, G., Rizzarelli, E., (2013) ChemBioChem, 14, pp. 583-592
De Bona, P., Giuffrida, M.L., Caraci, F., Copani, A., Pignataro, B., Attanasio, F., Cataldo, S., Rizzarelli, E., (2009) J. Pept. Sci., 15, pp. 220-228
Soto, C., Sigurdsson, E.M., Morelli, L., Kumar, R.A., Castaño, E.M., Frangione, B., (1998) Nat. Med., 4, pp. 822-826
Soto, P., Griffin, M.A., Shea, J.-E., (2007) Biophys. J., 93, pp. 3015-3025
Bieschke, J., Russ, J., Friedrich, R.P., Ehrnhoefer, D.E., Wobst, H., Neugebauer, K., Wanker, E.E., (2010) Proc. Natl. Acad. Sci. U. S. A., 107, pp. 7710-7715
Brener, O., Dunkelmann, T., Gremer, L., van Groen, T., Mirecka, E.A., Kadish, I., Willuweit, A., Willbold, D., (2015) Sci. Rep., 5, p. 13222
Rzepecki, P., Nagel-Steger, L., Feuerstein, S., Linne, U., Molt, O., Zadmard, R., Aschermann, K., Riesner, D., (2004) J. Biol. Chem., 279, pp. 47497-47505
Sciacca, M.F.M., Romanucci, V., Zarrelli, A., Monaco, I., Lolicato, F., Spinella, N., Galati, C., Milardi, D., (2017) ACS Chem. Neurosci., 8, pp. 1767-1778
Grasso, G., Santoro, A.M., Lanza, V., Sbardella, D., Tundo, G.R., Ciaccio, C., Marini, S., Milardi, D., (2017) Coord. Chem. Rev., 347, pp. 1-22
Pannuzzo, M., Milardi, D., Raudino, A., Karttunen, M., La Rosa, C., (2013) Phys. Chem. Chem. Phys., 15, pp. 8940-8951
Pannuzzo, M., Raudino, A., Milardi, D., La Rosa, C., Karttunen, M., (2013) Sci. Rep., 3, p. 2781
Chen, J., Armstrong, A.H., Koehler, A.N., Hecht, M.H.J., (2010) Am. Chem. Soc., 132, pp. 17015-17022
Harper, J.D., Lansbury, P.T., (1997) Annu. Rev. Biochem., 66, pp. 385-407
O'Nuallain, B., Shivaprasad, S., Kheterpal, I., Wetzel, R., (2005) Biochemistry, 44, pp. 12709-12718
Volle, J.-N., Chambon, G., Sayah, A., Reymond, C., Fasel, N., Gijs, M.A.M., (2003) Biosens. Bioelectron., 19, pp. 457-464
Bras, M., Dugas, V., Bessueille, F., Cloarec, J.P., Martin, J.R., Cabrera, M., Chauvet, J.P., Garrigues, M., (2004) Biosens. Bioelectron., 20, pp. 797-806
Arrabito, G., Galati, C., Castellano, S., Pignataro, B., (2013) Lab Chip, 13, pp. 68-72
Cretich, M., di Carlo, G., Longhi, R., Gotti, C., Spinella, N., Coffa, S., Galati, C., Chiari, M., (2009) Anal. Chem., 81, pp. 5197-5203
Cretich, M., Galati, C., Renna, L., Condorelli, G.G., Gagni, P., Chiari, M., (2014) Sens. Actuators, B, 192, pp. 15-22
Chalifour, R.J., McLaughlin, R.W., Lavoie, L., Morissette, C., Tremblay, N., Boulé, M., Sarazin, P., Gervais, F., (2003) J. Biol. Chem., 278, pp. 34874-34881
Tjernberg, L.O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A.R., Thyberg, J., Terenius, L., Nordstedt, C., (1996) J. Biol. Chem., 271, pp. 8545-8548
Rzepecki, P., Steger, L.N., Feuerstein, S., Linne, U., Molt, O., Zadmard, R., Aschermann, K., Riesner, D., (2006) J. Neurochem., 97, pp. 82-86
Ashmarin, I.P., Nezavibatko, V.N., Myasoedov, N.F., Kamenskii, A.A., Grivennikov, I.A., Ponomareva-Stepnaya, M.A., Andreeva, L.A., Ryasina, T.V., (1997) Zh. Vyssh. Nervn. Deyat. im. I. P. Pavlova, 47, pp. 420-430
Bashkatova, V.G., Koshelev, V.B., Fadyukova, O.E., Alexeev, A.A., Vanin, A.F., Rayevsky, K.S., Ashmarin, I.P., Armstrong, D.M., (2001) Brain Res., 894, pp. 145-149
Potaman, V.N., Antonova, L.V., Dubynin, V.A., Zaitzev, D.A., Kamensky, A.A., Myasoedov, N.F., Nezavibatko, V.N., (1991) Neurosci. Lett., 127, pp. 133-136
Storozhevykh, T.P., Tukhbatova, G.R., Senilova, Y.E., Pinelis, V.G., Andreeva, L.A., Myasoyedov, N.F., (2007) Bull. Exp. Biol. Med., 143, pp. 601-604
Tabbì, G., Magrì, A., Giuffrida, A., Lanza, V., Pappalardo, G., Naletova, I., Nicoletti, V.G., Rizzarelli, E.J., (2015) Inorg. Biochem., 142, pp. 39-46
Seilheimer, B., Bohrmann, B., Bondolfi, L., Müller, F., Stüber, D., Döbeli, H., (1997) J. Struct. Biol., 119, pp. 59-71
Hansson, O., Zetterberg, H., Peder, B.P., Andreasson, U., Londos, E., Minthon, L., Blennow, K., (2007) Dementia Geriatr. Cognit. Disord., 23, pp. 316-320
Goldsbury, C.S., Wirtz, S., Müller, S.A., Sunderji, S., Wicki, P., Aebi, U., Frey, P., (2000) J. Struct. Biol., 130, pp. 217-231
Morales-Narváez, E., Montón, H., Fomicheva, A., Merkoçi, A., (2012) Anal. Chem., 84, pp. 6821-6827
Renna, L., Galati, C., Spinella, N.M.R., Coffa, S., Optically Accessible Microfluidic Diagnostic Device., , U.S. Patent Dec 1, 2011
Sinopoli, A., Magrì, A., Milardi, D., Pappalardo, M., Pucci, P., Flagiello, A., Titman, J.J., Grasso, G., (2014) Metallomics, 6, pp. 1841-1852
Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology
Although the formation of β-amyloid (Aβ) fibrils in neuronal tissues is a hallmark of Alzheimer disease (AD), small-sized Aβ oligomers rather than mature fibrils have been identified as the most neurotoxic species. Therefore, the design of new inhibitors, able to prevent the aggregation of Aβ, is believed to be a promising therapeutic approach to AD. Unfortunately, the short-lived intermediate structures that occur in a solution along the Aβ aggregation pathway escape conventional experimental investigations and there is urgent need of new tools aimed at the discovery of agents targeting monomeric Aβ and blocking the early steps of amyloid aggregation. Here, we show the combination of high-efficiency slides (HESs) with peptide microarrays as a promising tool for identifying small peptides that bind Aβ monomers. To this aim, HESs with two immobilized reference peptides, (i.e., KLVFF and Semax) with opposite behavior, were investigated for binding to fluorescently labeled Aβ peptide. Transmission electron microscopy was used to demonstrate Aβ fibrillar aggregates missing. The use of HESs was critical to ensure convenient output of the fluorescent microarrays. The resulting sensitivity, as well as the low sample consumption and the high potential for miniaturization, suggests that the proposed combination of peptide microarrays and highly efficient slides would be a very effective technology for molecule profiling in AD drug discovery. © 2017 Galati et al.
Although the formation of β-amyloid (Aβ) fibrils in neuronal tissues is a hallmark of Alzheimer disease (AD), small-sized Aβ oligomers rather than mature fibrils have been identified as the most neurotoxic species. Therefore, the design of new inhibitors, able to prevent the aggregation of Aβ, is believed to be a promising therapeutic approach to AD. Unfortunately, the short-lived intermediate structures that occur in a solution along the Aβ aggregation pathway escape conventional experimental investigations and there is urgent need of new tools aimed at the discovery of agents targeting monomeric Aβ and blocking the early steps of amyloid aggregation. Here, we show the combination of high-efficiency slides (HESs) with peptide microarrays as a promising tool for identifying small peptides that bind Aβ monomers. To this aim, HESs with two immobilized reference peptides, (i.e., KLVFF and Semax) with opposite behavior, were investigated for binding to fluorescently labeled Aβ peptide. Transmission electron microscopy was used to demonstrate Aβ fibrillar aggregates missing. The use of HESs was critical to ensure convenient output of the fluorescent microarrays. The resulting sensitivity, as well as the low sample consumption and the high potential for miniaturization, suggests that the proposed combination of peptide microarrays and highly efficient slides would be a very effective technology for molecule profiling in AD drug discovery. © 2017 Galati et al.
Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology
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Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology
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* Structure and Orientation of the gH625-644 Membrane Interacting Region of Herpes Simplex Virus Type 1 in a Membrane Mimetic System (323 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Apr 10; 51(14): 3121-3128.
Impact Factor: 3.377
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Merlino A, Vitiello G, Grimaldi M, Sica F, Busi E, Basosi R, D’Ursi A, Fragneto G, Paduano L, D’Errico G
* Destabilization of Lipid Membranes by a Peptide Derived from Glycoprotein gp36 of Feline Immunodeficiency Virus: A Combined Molecular Dynamics/Experimental Study (408 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2012 Jan 12; 116(1): 401-412.
Impact Factor: 3.607
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Magliulo M, Cella L, Pacelli R
* Novel technique radio frequency identification (RFID) based to manage patient flow in a radiotherapy department (272 visite)
Proc Ieee Embs Int Conf Biomed Health Informatics (ISSN: 9781-4577, 9781-457721779), 2012; N/D: 972-975.
Impact Factor: 0.41
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (446 visite)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Vitiello G, Falanga A, Galdiero M, Marsh D, Galdiero S, D'Errico G
* Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (488 visite)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Oct; 1808(10): 2517-2526.
Impact Factor: 3.99
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Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (434 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (622 visite)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (454 visite)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (533 visite)
Bba-Gen Subjects (ISSN: 0006-3002, 0005-2736, 0925-4439), 2010 Mar; 1798(3): 579-591.
Impact Factor: 4.647
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Pilla P, Malachovská V, Sandomenico A, Ruvo M, Giordano M, Cutolo A, Cusano A
* High Sensitivity Transition-Tuned Long Period Grating For Label-Free Immunosensing (186 visite)
Proc Spie Int Soc Opt Eng Spie, 2010; 7653: 76531X-76531X.
Impact Factor: 0.958
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Vitagliano L, Stanzione F, De Simone A, Esposito L
* Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (377 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1161-1171.
Impact Factor: 2.605
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Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (310 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
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Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (413 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
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Chambery A, Vissers JPC, Langridge JI, Lonardo E, Minchiotti G, Ruvo M, Parente A
* Qualitative and quantitative proteomic profiling of cripto-1- embryonic stem cells by means of accurate mass LC-MS analysis (753 visite)
J Proteome Res (ISSN: 1535-3893), 2009; 8(2): 1047-1058.
Impact Factor: 5.132
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
* Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (515 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
Impact Factor: 5.52
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Milardi D, Pappalardo M, Pannuzzo M, Grasso DM, Rosa CL
* The role of the Cys2-Cys7 disulfide bridge in the early steps of Islet amyloid polypeptide aggregation: A molecular dynamics study (423 visite)
Chem Phys Lett (ISSN: 0009-2614), 2008 Oct 1; 463(4-6): 396-399.
Impact Factor: 2.169
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Pietropaolo A, Raiola L, Muccioli L, Tiberio G, Zannoni C, Fattorusso R, Isernia C, La Mendola D, Pappalardo G, Rizzarelli E
* An NMR and molecular dynamics investigation of the avian prion hexarepeat conformational features in solution (271 visite)
Chem Phys Lett (ISSN: 0009-2614), 2007 Jul 6; 442(1-3): 110-118.
Impact Factor: 2.207
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (501 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
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Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M
* Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (341 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
Impact Factor: 5.115
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Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (343 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
* Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (581 visite)
Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
Impact Factor: 3.11
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (369 visite)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappata S, Barone P
* Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease (3902 visite)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2004 Dec 14; 63(11): 2097-2103.
Impact Factor: 5.973
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Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
* Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease (329 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
Impact Factor: 1.368
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Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
* Synthetic peptides mimicking the interleukin-6/gp130 interaction: A two-helix bundle system. Design and confirmational studies (427 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003; 9(2): 90-105.
Impact Factor: 1.377
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Monti SM, Borrelli RC, Ritieni A, Fogliano V
A comparison of color formation and Maillard reaction products of a lactose-lysine and lactose-N(α)-acetyllysine model system (400 visite)
J Agric Food Chem (ISSN: 0021-8561), 2000; 48(4): 1041-1046.
Impact Factor: 1.56
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Del Vecchio S, Ciarmiello A, Salvatore M
Clinical imaging of multidrug resistance in cancer (345 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1999 Jun; 43(2): 125-131.
Impact Factor: 2.125
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Monti SM, Ritieni A, Graziani G, Randazzo G, Mannina L, Segre AL, Fogliano V
LC/MS analysis and antioxidative efficiency of Maillard reaction products from a lactose-lysine model system (415 visite)
J Agric Food Chem (ISSN: 0021-8561), 1999 Apr; 47(4): 1506-1513.
Impact Factor: 1.453
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (523 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (431 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (373 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Lauro GM, Fonti R, Margotta V
Phylogenetic evolution of intermediate filament associated proteins in ependymal cells of several adult poikilotherm vertebrates (380 visite)
Journal Fur Hirnforschung (ISSN: 0021-8359), 1991; 32(2): 257-261.
Impact Factor: 0
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46 Records (44 escludendo Abstract e Conferenze).
Impact factor totale: 194.603 (193.235 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 203.094 (201.782 escludendo Abstract e Conferenze).
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Gaia S, Ciruolo M, Ribaldone DG, Rolle E, Migliore E, Mosso E, Vola S, Risso A, Fagoonee S, Saracco GM, Carucci P
* Higher Efficiency of Percutaneous Microwave (MWA) Than Radiofrequency Ablation (RFA) in Achieving Complete Response in Cirrhotic Patients with Early Hepatocellular Carcinoma (8 visite)
Curr Oncol (ISSN: 1718-7729electronic, 1198-0052linking), 2021 Feb 25; 28(2): 1034-1044.
Impact Factor: 2.048
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Di Dato F, Spadarella S, Puoti MG, Caprio MG, Pagliardini S, Zuppaldi C, Vallone G, Fecarotta S, Esposito G, Iorio R, Parenti G, Spagnuolo MI
* Daily Fructose Traces Intake and Liver Injury in Children with Hereditary Fructose Intolerance (161 visite) (PDF 84 visite)
Nutrients (ISSN: 2072-6643linking, 2072-6643electronic), 2019 Oct 07; 11(10): N/D-N/D.
Impact Factor: 4.171
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Buonanno M, Di Fiore A, Langella E, D’ambrosio K, Supuran CT, Monti SM, De Simone G
* The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior (236 visite)
Int J Mol Sc (ISSN: 1661-6596, 1422-0067, 1422-0067electronic), 2018 May; 19(6): 19-24.
Impact Factor: 3.687
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (305 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-baruffi M, Carvalho I, Campo VL
* Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion (608 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2017 Nov 1; 25(21): 6049-6059.
Impact Factor: 2.881
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Quero G, Consales M, Severino R, Vaiano P, Boniello A, Sandomenico A, Ruvo M, Borriello A, Diodato L, Zuppolini S, Giordano M, Nettore IC, Mazzarella C, Colao A, Macchia PE, Santorelli F, Cutolo A, Cusano A
* Long period fiber grating nano-optrode for cancer biomarker detection (280 visite) (PDF 194 visite)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2016 Feb 13; 80: 590-600.
Impact Factor: 7.78
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Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (488 visite)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
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Vitiello G, Falanga A, Petruk AA, Merlino A, Fragneto G, Paduano L, Galdiero S, D'Errico G
* Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism (349 visite)
Soft Matter (ISSN: 1744-683x), 2015; 11(15): 3003-3016.
Impact Factor: 3.798
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (530 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Accardo A, Vitiello M, Tesauro D, Galdiero M, Finamore E, Martora F, Mansi R, Ringhieri P, Morelli G
* Self-assembled or mixed peptide amphiphile micelles from herpes simplex virus glycoproteins as potential immunomodulatory treatment (448 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 May 7; 9(1): 2137-2148.
Impact Factor: 4.383
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (433 visite)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
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Vitiello G, Fragneto G, Petruk AA, Falanga A, Galdiero S, D'Ursi A, Merlino A, D'Errico G
* Cholesterol modulates the fusogenic activity of a membranotropic domain of the FIV glycoprotein gp36 (364 visite)
Soft Matter (ISSN: 1744-683x), 2013; 9(28): 6442-6456.
Impact Factor: 4.151
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (840 visite)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Riccio A, Cubellis MV
* Gain of function in CDKN1C (479 visite)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
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Galdiero S, Russo L, Falanga A, Cantisani M, Vitiello M, Fattorusso R, Malgieri G, Galdiero M, Isernia C
* Structure and Orientation of the gH625-644 Membrane Interacting Region of Herpes Simplex Virus Type 1 in a Membrane Mimetic System (323 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Apr 10; 51(14): 3121-3128.
Impact Factor: 3.377
Dettagli Esporta in BibTeX Esporta in EndNote
Merlino A, Vitiello G, Grimaldi M, Sica F, Busi E, Basosi R, D’Ursi A, Fragneto G, Paduano L, D’Errico G
* Destabilization of Lipid Membranes by a Peptide Derived from Glycoprotein gp36 of Feline Immunodeficiency Virus: A Combined Molecular Dynamics/Experimental Study (408 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2012 Jan 12; 116(1): 401-412.
Impact Factor: 3.607
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Magliulo M, Cella L, Pacelli R
* Novel technique radio frequency identification (RFID) based to manage patient flow in a radiotherapy department (272 visite)
Proc Ieee Embs Int Conf Biomed Health Informatics (ISSN: 9781-4577, 9781-457721779), 2012; N/D: 972-975.
Impact Factor: 0.41
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (446 visite)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
Dettagli Esporta in BibTeX Esporta in EndNote
Vitiello G, Falanga A, Galdiero M, Marsh D, Galdiero S, D'Errico G
* Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (488 visite)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Oct; 1808(10): 2517-2526.
Impact Factor: 3.99
Dettagli Esporta in BibTeX Esporta in EndNote
Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (434 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
Dettagli Esporta in BibTeX Esporta in EndNote
Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (622 visite)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (454 visite)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (533 visite)
Bba-Gen Subjects (ISSN: 0006-3002, 0005-2736, 0925-4439), 2010 Mar; 1798(3): 579-591.
Impact Factor: 4.647
Dettagli Esporta in BibTeX Esporta in EndNote
Pilla P, Malachovská V, Sandomenico A, Ruvo M, Giordano M, Cutolo A, Cusano A
* High Sensitivity Transition-Tuned Long Period Grating For Label-Free Immunosensing (186 visite)
Proc Spie Int Soc Opt Eng Spie, 2010; 7653: 76531X-76531X.
Impact Factor: 0.958
Dettagli Esporta in BibTeX Esporta in EndNote
Vitagliano L, Stanzione F, De Simone A, Esposito L
* Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (377 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1161-1171.
Impact Factor: 2.605
Dettagli Esporta in BibTeX Esporta in EndNote
Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (310 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
Dettagli Esporta in BibTeX Esporta in EndNote
Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (413 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
Dettagli Esporta in BibTeX Esporta in EndNote
Chambery A, Vissers JPC, Langridge JI, Lonardo E, Minchiotti G, Ruvo M, Parente A
* Qualitative and quantitative proteomic profiling of cripto-1- embryonic stem cells by means of accurate mass LC-MS analysis (753 visite)
J Proteome Res (ISSN: 1535-3893), 2009; 8(2): 1047-1058.
Impact Factor: 5.132
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
* Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (515 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
Impact Factor: 5.52
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Milardi D, Pappalardo M, Pannuzzo M, Grasso DM, Rosa CL
* The role of the Cys2-Cys7 disulfide bridge in the early steps of Islet amyloid polypeptide aggregation: A molecular dynamics study (423 visite)
Chem Phys Lett (ISSN: 0009-2614), 2008 Oct 1; 463(4-6): 396-399.
Impact Factor: 2.169
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Pietropaolo A, Raiola L, Muccioli L, Tiberio G, Zannoni C, Fattorusso R, Isernia C, La Mendola D, Pappalardo G, Rizzarelli E
* An NMR and molecular dynamics investigation of the avian prion hexarepeat conformational features in solution (271 visite)
Chem Phys Lett (ISSN: 0009-2614), 2007 Jul 6; 442(1-3): 110-118.
Impact Factor: 2.207
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (501 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
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Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M
* Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (341 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
Impact Factor: 5.115
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Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (343 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
* Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (581 visite)
Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
Impact Factor: 3.11
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (369 visite)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappata S, Barone P
* Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease (3902 visite)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2004 Dec 14; 63(11): 2097-2103.
Impact Factor: 5.973
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Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
* Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease (329 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
Impact Factor: 1.368
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Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
* Synthetic peptides mimicking the interleukin-6/gp130 interaction: A two-helix bundle system. Design and confirmational studies (427 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003; 9(2): 90-105.
Impact Factor: 1.377
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Monti SM, Borrelli RC, Ritieni A, Fogliano V
A comparison of color formation and Maillard reaction products of a lactose-lysine and lactose-N(α)-acetyllysine model system (400 visite)
J Agric Food Chem (ISSN: 0021-8561), 2000; 48(4): 1041-1046.
Impact Factor: 1.56
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Del Vecchio S, Ciarmiello A, Salvatore M
Clinical imaging of multidrug resistance in cancer (345 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1999 Jun; 43(2): 125-131.
Impact Factor: 2.125
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Monti SM, Ritieni A, Graziani G, Randazzo G, Mannina L, Segre AL, Fogliano V
LC/MS analysis and antioxidative efficiency of Maillard reaction products from a lactose-lysine model system (415 visite)
J Agric Food Chem (ISSN: 0021-8561), 1999 Apr; 47(4): 1506-1513.
Impact Factor: 1.453
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (523 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (431 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (373 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Lauro GM, Fonti R, Margotta V
Phylogenetic evolution of intermediate filament associated proteins in ependymal cells of several adult poikilotherm vertebrates (380 visite)
Journal Fur Hirnforschung (ISSN: 0021-8359), 1991; 32(2): 257-261.
Impact Factor: 0
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46 Records (44 escludendo Abstract e Conferenze).
Impact factor totale: 194.603 (193.235 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 203.094 (201.782 escludendo Abstract e Conferenze).
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