X-ray Structure of the Carboplatin-Loaded Apo-Ferritin Nanocage
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X-ray Structure of the Carboplatin-Loaded Apo-Ferritin Nanocage (54 visite)

Pontillo N, Ferraro G, Helliwell JR, Amoresano A, Merlino A

Acs Med Chem Lett (ISSN: 1948-5875), 2017 Feb 28; 8(4): 433-437.



Tipo di articolo: Journal Article,

Impact factor: 3.794, Impact factor a 5 anni: 3.591

Url: Non disponibile.

Parole chiave: Pt-Based Drugs, Carboplatin, Encapsulated Drugs, Ferritin,

Affiliazioni:

*** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, I-80126 Napoli, Italy., School of Chemistry, Faculty of Engineering and Physical Sciences, University of Manchester, Brunswick Street, Manchester M13 9PL, England., CNR Institute of Biostructures and Bioimages, Via Mezzocannone 16, I-80126 Napoli, Italy.,


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The second-generation Pt anticancer agent carboplatin (CBDCA) was encapsulated within the apo horse spleen ferritin (AFt) nanocage, and the X-ray structure of the drug-loaded protein was refined at 1.49 A resolution. Two Pt binding sites, different from the one observed in the cisplatin-encapsulated AFt, were identified in Ft subunits by inspection of anomalous electron density maps at two wavelengths and difference Fourier electron density maps, which provide the necessary sensitivity to discriminate between Pt from CBDCA and Cd ions that are present in the crystallization conditions. Pt centers coordinate to the NE2 atom of His49 and to the NE2 atom of His132, both on the inner surface of the Ft nanocage.
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Impact factor totale: 68.434 (68.434 escludendo Abstract e Conferenze).
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