X-ray Structure of the Carboplatin-Loaded Apo-Ferritin Nanocage
CNR Ibb | back to homepage
▲NavBar
Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


X-ray Structure of the Carboplatin-Loaded Apo-Ferritin Nanocage (89 visite)

Pontillo N, Ferraro G, Helliwell JR, Amoresano A, Merlino A

Acs Med Chem Lett (ISSN: 1948-5875), 2017 Feb 28; 8(4): 433-437.



Tipo di articolo: Journal Article,

Impact factor: 3.794, Impact factor a 5 anni: 3.591

Url: Non disponibile.

Parole chiave: Pt-Based Drugs, Carboplatin, Encapsulated Drugs, Ferritin,

Affiliazioni:

*** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, I-80126 Napoli, Italy., School of Chemistry, Faculty of Engineering and Physical Sciences, University of Manchester, Brunswick Street, Manchester M13 9PL, England., CNR Institute of Biostructures and Bioimages, Via Mezzocannone 16, I-80126 Napoli, Italy.,


Riferimenti:

Non disponibile.

The second-generation Pt anticancer agent carboplatin (CBDCA) was encapsulated within the apo horse spleen ferritin (AFt) nanocage, and the X-ray structure of the drug-loaded protein was refined at 1.49 A resolution. Two Pt binding sites, different from the one observed in the cisplatin-encapsulated AFt, were identified in Ft subunits by inspection of anomalous electron density maps at two wavelengths and difference Fourier electron density maps, which provide the necessary sensitivity to discriminate between Pt from CBDCA and Cd ions that are present in the crystallization conditions. Pt centers coordinate to the NE2 atom of His49 and to the NE2 atom of His132, both on the inner surface of the Ft nanocage.
Nessun risultato.

Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]
Vai a fine pagina   Versione per copia e incolla facile   Esporta tutto in BibTeX   Esporta tutto in EndNote


Cutrin JC, Alberti D, Bernacchioni C, Ciambellotti S, Turano P, Luchinat C, Crich SG, Aime S
* Cancer cell death induced by ferritins and the peculiar role of their labile iron pool (71 visite)
Oncotarget, 2018; N/D: N/D-N/D.
Impact Factor: 5.168
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ferraro G, Ciambellotti S, Messori L, Merlino A
* Cisplatin Binding Sites in Human H-Chain Ferritin (87 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x), 2017 Aug 7; 56(15): 9064-9070.
Impact Factor: 4.7
Dettagli    Esporta in BibTeX    Esporta in EndNote

Picone D, Donnarumma F, Ferraro G, Gotte G, Fagagnini A, Butera G, Donadelli M, Merlino A
* A comparison study on RNase A oligomerization induced by cisplatin, carboplatin and oxaliplatin (107 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2017 Aug; 173: 105-112.
Impact Factor: 3.063
Dettagli    Esporta in BibTeX    Esporta in EndNote

Zanzoni S, Pagano K, D'Onofrio M, Assfalg M, Ciambellotti S, Bernacchioni C, Turano P, Aime S, Ragona L, Molinari H
* Unsaturated Long-Chain Fatty Acids Are Preferred Ferritin Ligands That Enhance Iron Biomineralization (51 visite)
Chemistry, 2017 Jul; N/D: N/D-N/D.
Impact Factor: 5.16
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pontillo N, Pane F, Messori L, Amoresano A, Merlino A
* Cisplatin encapsulation within a ferritin nanocage: A high-resolution crystallographic study (106 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2016; 52(22): 4136-4139.
Impact Factor: 6.319
Dettagli    Esporta in BibTeX    Esporta in EndNote

Crisci V, Mainenti PP, Corvino F, Lauria R, Maurea S
* Bone involvement by adenocarcinoma of the uterine cervix: a rare entity (122 visite)
Pol J Radiol (ISSN: 0137-7183, 1733-134x, 1733-134xlinking), 2015 Feb 14; 80(1): 81-84.
Impact Factor: 0.567
Dettagli    Esporta in BibTeX    Esporta in EndNote

Messori L, Marzo T, Merlino A
* Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts (107 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; N/D: N/D-N/D.
Impact Factor: 3.205
Dettagli    Esporta in BibTeX    Esporta in EndNote

Insabato L, Natella V, Somma A, Persico M, Camera L, Losito NS, Masone S
* Primary Peritoneal Clear Cell Carcinoma Versus Ovarian Carcinoma Versus Malignant Transformation of Endometriosis: A Vexing Issue (123 visite)
Int J Surg Pathol (ISSN: 1066-8969), 2015; 23(3): 211-216.
Impact Factor: 0.782
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cefalo G, Massimino M, Ruggiero A, Barone G, Ridola V, Spreafico F, Potepan P, Abate ME, Mascarin M, Garrè ML, Perilongo G, Madon E, Colosimo C, Riccardi R
* Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: An Italian multi-institutional phase II trial (159 visite)
Neuro-Oncology (ISSN: 1522-8517), 2014 May; 16(5): 748-753.
Impact Factor: 6.776
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (251 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
Dettagli    Esporta in BibTeX    Esporta in EndNote

Risitano AM, Imbriaco M, Marando L, Seneca E, Soscia E, Malcovati L, Iori AP, Pane F, Notaro R, Matarazzo M
* From perpetual haemosiderinuria to possible iron overload: iron redistribution in paroxysmal nocturnal haemoglobinuria patients on eculizumab by magnetic resonance imaging (131 visite)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2012 Sep; 158(3): 415-418.
Impact Factor: 4.942
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (163 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
Dettagli    Esporta in BibTeX    Esporta in EndNote

Limauro D, D'Ambrosio K, Langella E, De Simone G, Galdi I, Pedone C, Pedone E, Bartolucci S
* Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus (125 visite)
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Impact Factor: 3.787
Dettagli    Esporta in BibTeX    Esporta in EndNote

D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (162 visite)
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
Dettagli    Esporta in BibTeX    Esporta in EndNote

Limauro D, Pedone E, Galdi I, Bartolucci S
* Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4 (157 visite)
Febs Journal (ISSN: 1742-464x), 2008 May; 275(9): 2067-2077.
Impact Factor: 3.139
Dettagli    Esporta in BibTeX    Esporta in EndNote

Gridelli C, Manzione L, Perrone F, Veltri E, Cioffi R, Caprio MG, Frontini L, Rossi A, Barletta E, Barzelloni ML, Bilancia D, Gallo C
* Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study (101 visite) (PDF 142 visite)
Br J Cancer (ISSN: 0007-0920print, 0007-0920linking), 2001 Jan 5; 84(1): 38-41.
Impact Factor: 3.942
Dettagli    Esporta in BibTeX    Esporta in EndNote

MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M
IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (138 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Sep; 35(9): 1429-1435.
Impact Factor: 3.491
Dettagli    Esporta in BibTeX    Esporta in EndNote



17 Records (17 escludendo Abstract e Conferenze).
Impact factor totale: 68.434 (68.434 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 66.696 (66.696 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote