Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates(148 visite) Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Tipo di articolo: Journal Article,
Impact factor: 5.476, Impact factor a 5 anni: 5.477
*** IBB - CNR *** Institute of Biostructure and Bioimaging, National Research Council", via Mezzocannone 16, 80134, Naples, Italy., Department of Pharmacy, University of Naples "Federico II", via Mezzocannone 16, 80134, Naples, Italy., Department of Physics, University of Naples "Federico II", via Cintia, Naples, Italy., Analytical Chemistry for the Environment and CeSMA (Centro Servizi Metrologici Avanzati), University of Naples "Federico II", via N. Protopisani, 80146, Naples, Italy., Institute of Crystallography, National Research Council, Via Amendola 126/O, Bari, Italy., University of Milan, via Venezian 21, 20133, Milan, Italy.,
Gaglione, M., Malgieri, G., Pacifico, S., Severino, V., D′Abrosca, B., Russo, L., Fiorentino, A., Messere, A., (2013) Molecules, 18, pp. 9147-9162
The study of molecules that self-assemble through noncovalent <br>interactions is one of the most attractive topics in supramolecular <br>chemistry. The use of short peptides or modified nucleotides as building<br> blocks for the aggregates is particularly intriguing because these are <br>very easy to synthesize; moreover, subtle changes in the chemical <br>structure of such building blocks may drastically affect the properties <br>of the aggregates. The ability of peptide nucleic acids (PNA) to <br>aggregate has been very little explored, despite its practical <br>applications. In this work we investigated the self-assembling <br>properties of a PNA dimer, conjugated at the N-terminus to a <br>fluorenylmethoxycarbonyl group. This PNA dimer forms nano-aggregates at <br>low concentration in CHCl<sub>3</sub> /CH<sub>3</sub> OH mixtures. The <br>aggregates retain very interesting fluorescent properties (high quantum <br>yield in the visible region with lifetimes on the nanosecond scale), <br>which make them promising materials for applications in optoelectronics.
260 Records (248 escludendo Abstract e Conferenze). Impact factor totale: 974.479 (939.783 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 994.084 (958.684 escludendo Abstract e Conferenze).