Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans(177 views visite)(PDF public pubblico141 views visite) Castello F, Costabile G, Bresciania L, Tassottia M, Naviglio D, Luongo D, Ciciola P, Vitale M, Vetrani C, Galaverna G, Brighenti F, Giacco R, Del Rio D, Mena P
Arch Bioch Bioph (ISSN: 0003-9861linking), 2018 May 15; 646: 1-9.
Keywords Parole chiave: Adult
, Biological Availability
, Chromatography, High Pressure Liquid
, Humans
, Male
, Plant Extracts Analysis Blood Pharmacokinetics Urine
, Polyphenols Analysis Blood Pharmacokinetics Urine
, Spectrometry, Electrospray Ionization
, Tandem Mass Spectrometry
, Vitis Chemistry
, Young Adult
, Bioavailability
, Colonic Catabolite
, Grape Pomace
, Metabolism
, Phenolic Metabolite
, Phenyl-γ-Valerolactone
Affiliations Affiliazioni: *** IBB - CNR ***
Grape pomace, the major byproduct of the wine and juice industry, is a relevant source of bioactive phenolic
compounds. However, polyphenol bioavailability in humans is not well understood, and the inter-individual
variability in the production of phenolic metabolites has not been comprehensively assessed to date. The
pharmacokinetic and excretive profiles of phenolic metabolites after the acute administration of a drink made
from red grape pomace was here investigated in ten volunteers. A total of 35 and 28 phenolic metabolites were
quantified in urine and plasma, respectively. The main circulating metabolites included phenyl-γ-valerolactones,
hydroxybenzoic acids, simple phenols, hydroxyphenylpropionic acids, hydroxycinnamates, and (epi)catechin
phase II conjugates. A high inter-individual variability was shown both in urine and plasma samples, and different
patterns of circulating metabolites were unravelled by applying unsupervised multivariate analysis.
Besides the huge variability in the production of microbial metabolites of colonic origin, an important variability
was observed due to phase II conjugates. These results are of interest to further understand the potential health
benefits of phenolic metabolites on individual basis.
Department of Food & Drugs, University of Parma, Via Volturno 39, 43125 Parma, Italy.
Department of Clinical Medicine and Surgery, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy.
Department of Chemical Sciences, Federico II University of Naples, Via Cintia 21, 80126 Naples, Italy.
CNR-Institute of Biostructures and Bioimaging, Via Tommaso De Amicis, 95, 80131 Naples, Italy.
Institute of Food Science, National Research Council, Via Roma 64, 83100 Avellino, Italy.
Department of Veterinary Science, University of Parma, Via Volturno 39, 43125 Parma, Italy
Microbiome Research Hub, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy. Electronic address: daniele.delrio@un
References Riferimenti: Not available. Non disponibili.
Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans
Grape pomace, the major byproduct of the wine and juice industry, is a relevant source of bioactive phenolic compounds. However, polyphenol bioavailability in humans is not well understood, and the inter-individual variability in the production of phenolic metabolites has not been comprehensively assessed to date. The pharmacokinetic and excretive profiles of phenolic metabolites after the acute administration of a drink made from red grape pomace was here investigated in ten volunteers. A total of 35 and 28 phenolic metabolites were quantified in urine and plasma, respectively. The main circulating metabolites included phenyl-γ-valerolactones, hydroxybenzoic acids, simple phenols, hydroxyphenylpropionic acids, hydroxycinnamates, and (epi)catechin phase II conjugates. A high inter-individual variability was shown both in urine and plasma samples, and different patterns of circulating metabolites were unravelled by applying unsupervised multivariate analysis. Besides the huge variability in the production of microbial metabolites of colonic origin, an important variability was observed due to phase II conjugates. These results are of interest to further understand the potential health benefits of phenolic metabolites on individual basis.
Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans
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609 Records (592 escludendo Abstract e Conferenze). Impact factor totale: 2355.485 (2285.126 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 2343.836 (2262.21 escludendo Abstract e Conferenze).
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