Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents (176 views visite)
Chemistryselect (ISSN: 2365-6549), 2018 Jun; 3(22): 6035-6041.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 1.505, 5-year impact factor Impact factor a 5 anni: 1.505
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046678126&doi=10.1002%2fslct.201800283&partnerID=40&md5=387919f42ce20c2065a370958ed75251
Keywords Parole chiave: Contrast Agents, Lanthanide Complexes, Paracest, Ph Sensitive Agents,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, via Mezzocannone 16, Napoli, 80134, Italy
References Riferimenti:
Zhang, S., Merritt, M., Woessner, D.E., Lenkinski, R.E., Sherry, A.D., (2003) Acc. Chem. Res., 36, pp. 783-79
Zhang, S., Malloy, C.R., Sherry, A.D., (2005) J. Am. Chem. Soc., 127, pp. 17572-17573
Woods, M., Woessner, D.E., Sherry, A.D., (2006) Chem Soc Rev, 35, pp. 500-511
Woods, M., Pasha, A., Zhao, P., Tircso, G., Chowdhury, S., Kiefer, G., Woessner, D.E., Sherry, A.D., (2011) Dalton Trans, 40, pp. 6759-6764
Viswanathan, S., Ratnakar, S.J., Green, K.N., Kovacs, Z., De León-Rodríguez, L.M., Sherry, A.D., (2009) Angew. Chem. Int. Ed., 48, pp. 9330-9333
Viswanathan, S., Kovacs, Z., Green, K.N., Ratnakar, S.J., Sherry, A.D., (2010) Chem. Rev., 110, pp. 2960-3018
van Zijl, P.C.M., Yadav, N.N., (2011) Magn. Reson. Med., 65, pp. 927-948
Terreno, E., Stancanello, J., Longo, D., Castelli, D.D., Milone, L., Sanders, H.M.H.F., Kok, M.B., Aime, S., (2009) Contrast Media Mol. Imaging, 4, pp. 237-247
Swietach, P., Vaughan-Jones, R.D., Harris, A.L., (2007) Cancer Metastasis Rev., 26, pp. 299-310
Sun, P.Z., Longo, D.L., Hu, W., Xiao, G., Wu, R., (2014) Phys. Med. Biol., 59, p. 4493
Sherry, A.D., Woods, M., (2008) Annu Rev Biomed Eng, 10, pp. 391-411
Rofstad, E.K., Mathiesen, B., Kindem, K., Galappathi, K., (2006) Cancer Res., 66, pp. 6699-6707
Ratnakar, S.J., Woods, M., Lubag, A.J.M., Kovács, Z., Sherry, A.D., (2008) J. Am. Chem. Soc., 130, pp. 6-7
Pumphrey, A., Yang, Z., Ye, S., Powell, D.K., Thalman, S., Watt, D.S., Abdel-Latif, A., Vandsburger, M., (2016) NMR Biomed., 29, pp. 74-83
Overly, C.C., Lee, K.D., Berthiaume, E., Hollenbeck, P.J., (1995) Proc. Natl. Acad. Sci., 92, pp. 3156-3160
Olatunde, A.O., Dorazio, S.J., Spernyak, J.A., Morrow, J.R., (2012) J. Am. Chem. Soc., 134, pp. 18503-18505
Gochberg, D.F., (2017) Magn. Reson. Imaging, 38, p. 233
Maxfield, F.R., (2014) Cold Spring Harb. Perspect. Biol., 6, p. 016931. , a, –a
Mani, T., Opina, A.C.L., Zhao, P., Evbuomwan, O.M., Milburn, N., Tircso, G., Kumas, C., Sherry, A.D., (2014) JBIC J. Biol. Inorg. Chem., 19, pp. 161-171
Mani, T., Tircsó, G., Togao, O., Zhao, P., Soesbe, T.C., Takahashi, M., Sherry, A.D., (2009) Contrast Media Mol. Imaging, 4, pp. 183-191
Li, A.X., Wojciechowski, F., Suchy, M., Jones, C.K., Hudson, R.H.E., Menon, R.S., Bartha, R., (2008) Magn. Reson. Med., 59, pp. 374-381
Lee, Y., Fukushima, S., Bae, Y., Hiki, S., Ishii, T., Kataoka, K., (2007) J. Am. Chem. Soc., 129, pp. 5362-5363
Langereis, S., Keupp, J., van Velthoven, J.L.J., de Roos, I.H.C., Burdinski, D., Pikkemaat, J.A., Grüll, H., (2009) J. Am. Chem. Soc., 131, pp. 1380-1381
Huang, Y., Coman, D., Ali, M.M., Hyder, F., (2015) Contrast Media Mol. Imaging, 10, pp. 51-58
Hingorani, D.V., Montano, L.A., Randtke, E.A., Lee, Y.S., Cárdenas-Rodríguez, J., Pagel, M.D., (2016) Contrast Media Mol. Imaging, 11, pp. 130-138
Du, K., Harris, T.D., (2016) J. Am. Chem. Soc., 138, pp. 7804-7807
Castelli, D.D., Ferrauto, G., Cutrin, J.C., Terreno, E., Aime, S., (2014) Magn. Reson. Med., 71, pp. 326-332
Dixon, W.T., Ren, J., Lubag, A.J.M., Ratnakar, J., Vinogradov, E., Hancu, I., Lenkinski, R.E., Sherry, A.D., (2010) Magn. Reson. Med., 63, pp. 625-632
Delli Castelli, D., Terreno, E., Aime, S., (2011) Angew. Chem. Int. Ed., 50, pp. 1798-1800
Castelli, D.D., Gianolio, E., Crich, S.G., Terreno, E., Aime, S., (2008) Coord. Chem. Rev., 252, pp. 2424-2443
Castelli, D.D., Caligara, M.C., Botta, M., Terreno, E., Aime, S., (2013) Inorg. Chem., 52, pp. 7130-7138
Christensen, K.A., Myers, J.T., Swanson, J.A., (2002) J. Cell Sci., 115, pp. 599-607
Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., (1999) Chem. Rev., 99, pp. 2293-2352
Cakić, N., Savić, T., Stricker-Shaver, J., Truffault, V., Platas-Iglesias, C., Mirkes, C., Pohmann, R., Angelovski, G., (2016) Chem Commun, 52, pp. 9224-9227
Aime, S., Botta, M., Fasano, M., Terreno, E., (1999) Acc. Chem. Res., 32, pp. 941-949
Aime, S., Barge, A., Bruce, J.I., Botta, M., Howard, J.A.K., Moloney, J.M., Parker, D., Woods, M., (1999) J. Am. Chem. Soc., 121, pp. 5762-5771
Muller, R.N., Vander Elst, L., Roch, A., Peters, J.A., Csajbok, E., Gillis, P., (2005) Relaxation by metal-containing nanosystems, 57, pp. 239-292. , Gossuin in Relaxation by metal-containing nanosystems
Ward, K.M., Balaban, R.S., (2000) Magn. Reson. Med., 44, pp. 799-802
Gregorio, E.D., Ferrauto, G., Gianolio, E., Aime, S., (2013) Contrast Media Mol. Imaging, 8, pp. 475-486
Zaiss, M., Angelovski, G., Demetriou, E., McMahon, M.T., Golay, X., Scheffler, K., (2018) Magn. Reson. Med., 79, pp. 1708-1721
Woessner, D.E., Zhang, S., Merritt, M.E., Sherry, A.D., (2005) Magn. Reson. Med., 53, pp. 790-799
Wang, M.-X., Cheng, X.-Y., Jin, M., Cao, Y.-L., Yang, Y.-P., Wang, J.-D., Li, Q., Liu, C.-F., (2015) Exp. Neurol., 271, pp. 112-121
Huotari, J., Helenius, A., (2011) EMBO J., 30, pp. 3481-3500
Chemistryselect (ISSN: 2365-6549), 2018 Jun; 3(22): 6035-6041.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 1.505, 5-year impact factor Impact factor a 5 anni: 1.505
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046678126&doi=10.1002%2fslct.201800283&partnerID=40&md5=387919f42ce20c2065a370958ed75251
Keywords Parole chiave: Contrast Agents, Lanthanide Complexes, Paracest, Ph Sensitive Agents,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, via Mezzocannone 16, Napoli, 80134, Italy
References Riferimenti:
Zhang, S., Merritt, M., Woessner, D.E., Lenkinski, R.E., Sherry, A.D., (2003) Acc. Chem. Res., 36, pp. 783-79
Zhang, S., Malloy, C.R., Sherry, A.D., (2005) J. Am. Chem. Soc., 127, pp. 17572-17573
Woods, M., Woessner, D.E., Sherry, A.D., (2006) Chem Soc Rev, 35, pp. 500-511
Woods, M., Pasha, A., Zhao, P., Tircso, G., Chowdhury, S., Kiefer, G., Woessner, D.E., Sherry, A.D., (2011) Dalton Trans, 40, pp. 6759-6764
Viswanathan, S., Ratnakar, S.J., Green, K.N., Kovacs, Z., De León-Rodríguez, L.M., Sherry, A.D., (2009) Angew. Chem. Int. Ed., 48, pp. 9330-9333
Viswanathan, S., Kovacs, Z., Green, K.N., Ratnakar, S.J., Sherry, A.D., (2010) Chem. Rev., 110, pp. 2960-3018
van Zijl, P.C.M., Yadav, N.N., (2011) Magn. Reson. Med., 65, pp. 927-948
Terreno, E., Stancanello, J., Longo, D., Castelli, D.D., Milone, L., Sanders, H.M.H.F., Kok, M.B., Aime, S., (2009) Contrast Media Mol. Imaging, 4, pp. 237-247
Swietach, P., Vaughan-Jones, R.D., Harris, A.L., (2007) Cancer Metastasis Rev., 26, pp. 299-310
Sun, P.Z., Longo, D.L., Hu, W., Xiao, G., Wu, R., (2014) Phys. Med. Biol., 59, p. 4493
Sherry, A.D., Woods, M., (2008) Annu Rev Biomed Eng, 10, pp. 391-411
Rofstad, E.K., Mathiesen, B., Kindem, K., Galappathi, K., (2006) Cancer Res., 66, pp. 6699-6707
Ratnakar, S.J., Woods, M., Lubag, A.J.M., Kovács, Z., Sherry, A.D., (2008) J. Am. Chem. Soc., 130, pp. 6-7
Pumphrey, A., Yang, Z., Ye, S., Powell, D.K., Thalman, S., Watt, D.S., Abdel-Latif, A., Vandsburger, M., (2016) NMR Biomed., 29, pp. 74-83
Overly, C.C., Lee, K.D., Berthiaume, E., Hollenbeck, P.J., (1995) Proc. Natl. Acad. Sci., 92, pp. 3156-3160
Olatunde, A.O., Dorazio, S.J., Spernyak, J.A., Morrow, J.R., (2012) J. Am. Chem. Soc., 134, pp. 18503-18505
Gochberg, D.F., (2017) Magn. Reson. Imaging, 38, p. 233
Maxfield, F.R., (2014) Cold Spring Harb. Perspect. Biol., 6, p. 016931. , a, –a
Mani, T., Opina, A.C.L., Zhao, P., Evbuomwan, O.M., Milburn, N., Tircso, G., Kumas, C., Sherry, A.D., (2014) JBIC J. Biol. Inorg. Chem., 19, pp. 161-171
Mani, T., Tircsó, G., Togao, O., Zhao, P., Soesbe, T.C., Takahashi, M., Sherry, A.D., (2009) Contrast Media Mol. Imaging, 4, pp. 183-191
Li, A.X., Wojciechowski, F., Suchy, M., Jones, C.K., Hudson, R.H.E., Menon, R.S., Bartha, R., (2008) Magn. Reson. Med., 59, pp. 374-381
Lee, Y., Fukushima, S., Bae, Y., Hiki, S., Ishii, T., Kataoka, K., (2007) J. Am. Chem. Soc., 129, pp. 5362-5363
Langereis, S., Keupp, J., van Velthoven, J.L.J., de Roos, I.H.C., Burdinski, D., Pikkemaat, J.A., Grüll, H., (2009) J. Am. Chem. Soc., 131, pp. 1380-1381
Huang, Y., Coman, D., Ali, M.M., Hyder, F., (2015) Contrast Media Mol. Imaging, 10, pp. 51-58
Hingorani, D.V., Montano, L.A., Randtke, E.A., Lee, Y.S., Cárdenas-Rodríguez, J., Pagel, M.D., (2016) Contrast Media Mol. Imaging, 11, pp. 130-138
Du, K., Harris, T.D., (2016) J. Am. Chem. Soc., 138, pp. 7804-7807
Castelli, D.D., Ferrauto, G., Cutrin, J.C., Terreno, E., Aime, S., (2014) Magn. Reson. Med., 71, pp. 326-332
Dixon, W.T., Ren, J., Lubag, A.J.M., Ratnakar, J., Vinogradov, E., Hancu, I., Lenkinski, R.E., Sherry, A.D., (2010) Magn. Reson. Med., 63, pp. 625-632
Delli Castelli, D., Terreno, E., Aime, S., (2011) Angew. Chem. Int. Ed., 50, pp. 1798-1800
Castelli, D.D., Gianolio, E., Crich, S.G., Terreno, E., Aime, S., (2008) Coord. Chem. Rev., 252, pp. 2424-2443
Castelli, D.D., Caligara, M.C., Botta, M., Terreno, E., Aime, S., (2013) Inorg. Chem., 52, pp. 7130-7138
Christensen, K.A., Myers, J.T., Swanson, J.A., (2002) J. Cell Sci., 115, pp. 599-607
Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., (1999) Chem. Rev., 99, pp. 2293-2352
Cakić, N., Savić, T., Stricker-Shaver, J., Truffault, V., Platas-Iglesias, C., Mirkes, C., Pohmann, R., Angelovski, G., (2016) Chem Commun, 52, pp. 9224-9227
Aime, S., Botta, M., Fasano, M., Terreno, E., (1999) Acc. Chem. Res., 32, pp. 941-949
Aime, S., Barge, A., Bruce, J.I., Botta, M., Howard, J.A.K., Moloney, J.M., Parker, D., Woods, M., (1999) J. Am. Chem. Soc., 121, pp. 5762-5771
Muller, R.N., Vander Elst, L., Roch, A., Peters, J.A., Csajbok, E., Gillis, P., (2005) Relaxation by metal-containing nanosystems, 57, pp. 239-292. , Gossuin in Relaxation by metal-containing nanosystems
Ward, K.M., Balaban, R.S., (2000) Magn. Reson. Med., 44, pp. 799-802
Gregorio, E.D., Ferrauto, G., Gianolio, E., Aime, S., (2013) Contrast Media Mol. Imaging, 8, pp. 475-486
Zaiss, M., Angelovski, G., Demetriou, E., McMahon, M.T., Golay, X., Scheffler, K., (2018) Magn. Reson. Med., 79, pp. 1708-1721
Woessner, D.E., Zhang, S., Merritt, M.E., Sherry, A.D., (2005) Magn. Reson. Med., 53, pp. 790-799
Wang, M.-X., Cheng, X.-Y., Jin, M., Cao, Y.-L., Yang, Y.-P., Wang, J.-D., Li, Q., Liu, C.-F., (2015) Exp. Neurol., 271, pp. 112-121
Huotari, J., Helenius, A., (2011) EMBO J., 30, pp. 3481-3500
Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents
The aim of this work was to design new pH-sensitive paramagnetic chemical exchange saturation transfer (paraCEST) agents with a more acidic pH readout window with respect to the Yb complex of the 10-(2-hydroxypropyl)-1,4,7,10- tetraazacyclododecane-1,4,7-triacetic acid (HPDO3A). In particular, three HPDO3A derivatives have been synthesized by substituting the methyl group on the 2-hydroxypropyl arm with the electron withdrawing substituents –CF3, –CH2NH2 and –CH2OH. The Yb complexes have been characterized in terms of i) number and relative abundance of isomers present and, ii) pH sensitivity range in CEST applications. The influence of the introduced substituents on the –OH proton acidity and kex has been investigated and the new agents have been compared with the parent Yb-HPDO3A. All complexes showed an increased acidity and an enhanced exchange rate of the –OH proton. As a consequence, the pH-CEST sensitivity has been shifted to more acidic values. Eventually, the –CH2OH bearing derivative has been tested to assess the intra-endosomal pH which is too acidic to be determined with Yb-HPDO3A. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
The aim of this work was to design new pH-sensitive paramagnetic chemical exchange saturation transfer (paraCEST) agents with a more acidic pH readout window with respect to the Yb complex of the 10-(2-hydroxypropyl)-1,4,7,10- tetraazacyclododecane-1,4,7-triacetic acid (HPDO3A). In particular, three HPDO3A derivatives have been synthesized by substituting the methyl group on the 2-hydroxypropyl arm with the electron withdrawing substituents –CF3, –CH2NH2 and –CH2OH. The Yb complexes have been characterized in terms of i) number and relative abundance of isomers present and, ii) pH sensitivity range in CEST applications. The influence of the introduced substituents on the –OH proton acidity and kex has been investigated and the new agents have been compared with the parent Yb-HPDO3A. All complexes showed an increased acidity and an enhanced exchange rate of the –OH proton. As a consequence, the pH-CEST sensitivity has been shifted to more acidic values. Eventually, the –CH2OH bearing derivative has been tested to assess the intra-endosomal pH which is too acidic to be determined with Yb-HPDO3A. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents
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Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (484 visite)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
Dettagli Esporta in BibTeX Esporta in EndNote
Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (351 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
Dettagli Esporta in BibTeX Esporta in EndNote
Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (312 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (471 visite)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
Dettagli Esporta in BibTeX Esporta in EndNote
Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (213 visite)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (488 visite)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (360 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
Dettagli Esporta in BibTeX Esporta in EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (408 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (365 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (350 visite)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
Dettagli Esporta in BibTeX Esporta in EndNote
Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (219 visite)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (401 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
Dettagli Esporta in BibTeX Esporta in EndNote
Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (539 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
Dettagli Esporta in BibTeX Esporta in EndNote
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Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
* A Novel Class of (1) H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by (14) N-Containing Imidazole Moieties (46 visite)
Angew Chem Int Ed Engl (ISSN: 1433-7851linking), 2020 Nov 13; N/D: N/D-N/D.
Impact Factor: 12.959
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Tear LR, Carrera C, Gianolio E, Aime S
* Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues (43 visite)
Chemistry (ISSN: 0947-6539linking), 2020 May 12; 26(27): 6056-6063.
Impact Factor: 4.857
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Granato L, Longo D, Boutry S, Vander Elst L, Henoumont C, Aime S, Muller RN, Laurent S
* Synthesis and Relaxometric Characterization of New Poly[N, N-bis(3-aminopropyl)glycine] (PAPGly) Dendrons Gd-Based Contrast Agents and Their in Vivo Study by Using the Dynamic Contrast-Enhanced MRI Technique at Low Field (1 T) (106 visite)
Chem Biodivers (ISSN: 1612-1872linking), 2019 Nov; 16(11): e1900322-e1900322.
Impact Factor: 1.449
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Cocozza S, Pontillo G, Lanzillo R, Russo C, Petracca M, Di Stasi M, Paolella C, Vola EA, Criscuolo C, Moccia M, Lamberti A, Monti S, Brescia Morra V, Elefante A, Palma G, Tedeschi E, Brunetti A
* MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis (256 visite)
Neuroradiology (ISSN: 0028-3940linking, 1432-1920electronic), 2019 Feb; 61(2): 155-162.
Impact Factor: 1.287
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Baroni S, Ruggiero MR, Aime S, Geninatti Crich S
* Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent (208 visite)
Magn Reson Chem (ISSN: 0749-1581linking), 2019 Jan 24; N/D: N/D-N/D.
Impact Factor: 1.601
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Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (253 visite)
Radiology (ISSN: 0033-8419, 1527-1315), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
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Longo DL, Stefania R, Aime S, Oraevsky A
* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (232 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Aug 7; 18(8): N/D-N/D.
Impact Factor: 3.687
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Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
* EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (255 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Impact Factor: 3.862
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Tedeschi E, Palma G, Canna A, Cocozza S, Russo C, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Morra VB, Salvatore M, Brunetti A, Quarantelli M
* In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents (349 visite)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic), 2016 Feb 23; 26(12): 4577-4584.
Impact Factor: 3.967
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (390 visite)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (258 visite)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
Dettagli Esporta in BibTeX Esporta in EndNote
Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
* Sensitive MRI detection of internalized T contrast agents using magnetization transfer contrast (209 visite)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic), 2015 Oct 16; N/D: N/D-N/D.
Impact Factor: 2.983
Dettagli Esporta in BibTeX Esporta in EndNote
Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (242 visite)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (360 visite)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
Dettagli Esporta in BibTeX Esporta in EndNote
Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* MR Contrast Agents (296 visite)
Mol Pharm (ISSN: 1543-8384), 2011 Sep; 8(5): 1750-1756.
Impact Factor: 4.782
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Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A
* MR Contrast Agents (248 visite)
Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555.
Impact Factor: 1.784
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (435 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
Dettagli Esporta in BibTeX Esporta in EndNote
Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (307 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (484 visite)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
Dettagli Esporta in BibTeX Esporta in EndNote
Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (351 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
Dettagli Esporta in BibTeX Esporta in EndNote
Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (312 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (471 visite)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
Dettagli Esporta in BibTeX Esporta in EndNote
Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (213 visite)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (488 visite)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (360 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
Dettagli Esporta in BibTeX Esporta in EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (408 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (365 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (350 visite)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
Dettagli Esporta in BibTeX Esporta in EndNote
Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (219 visite)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (401 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
Dettagli Esporta in BibTeX Esporta in EndNote
Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (539 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
Dettagli Esporta in BibTeX Esporta in EndNote
31 Records (28 escludendo Abstract e Conferenze).
Impact factor totale: 131.103 (123.617 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 135.791 (127.797 escludendo Abstract e Conferenze).
Impact factor totale: 131.103 (123.617 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 135.791 (127.797 escludendo Abstract e Conferenze).
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