Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents
CNR Ibb | back to homepage
▲NavBar
Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents (41 visite)

Dastru W, Menchise V, Ferrauto G, Fabretto S, Carrera C, Terreno E, Aime S, Delli Castelli D

Chemistryselect (ISSN: 2365-6549), 2018 Jun; 3(22): 6035-6041.



Tipo di articolo: Journal Article

Impact factor: 1.505, Impact factor a 5 anni: 0

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046678126&doi=10.1002%2fslct.201800283&partnerID=40&md5=387919f42ce20c2065a370958ed75251

Parole chiave: Contrast Agents, Lanthanide Complexes, Paracest, Ph Sensitive Agents

Affiliazioni:

*** IBB - CNR ***
Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, via Mezzocannone 16, Napoli, 80134, Italy


Riferimenti:

Zhang, S., Merritt, M., Woessner, D.E., Lenkinski, R.E., Sherry, A.D., (2003) Acc. Chem. Res., 36, pp. 783-79

Zhang, S., Malloy, C.R., Sherry, A.D., (2005) J. Am. Chem. Soc., 127, pp. 17572-17573

Woods, M., Woessner, D.E., Sherry, A.D., (2006) Chem Soc Rev, 35, pp. 500-511

Woods, M., Pasha, A., Zhao, P., Tircso, G., Chowdhury, S., Kiefer, G., Woessner, D.E., Sherry, A.D., (2011) Dalton Trans, 40, pp. 6759-6764

Viswanathan, S., Ratnakar, S.J., Green, K.N., Kovacs, Z., De León-Rodríguez, L.M., Sherry, A.D., (2009) Angew. Chem. Int. Ed., 48, pp. 9330-9333

Viswanathan, S., Kovacs, Z., Green, K.N., Ratnakar, S.J., Sherry, A.D., (2010) Chem. Rev., 110, pp. 2960-3018

van Zijl, P.C.M., Yadav, N.N., (2011) Magn. Reson. Med., 65, pp. 927-948

Terreno, E., Stancanello, J., Longo, D., Castelli, D.D., Milone, L., Sanders, H.M.H.F., Kok, M.B., Aime, S., (2009) Contrast Media Mol. Imaging, 4, pp. 237-247

Swietach, P., Vaughan-Jones, R.D., Harris, A.L., (2007) Cancer Metastasis Rev., 26, pp. 299-310

Sun, P.Z., Longo, D.L., Hu, W., Xiao, G., Wu, R., (2014) Phys. Med. Biol., 59, p. 4493

Sherry, A.D., Woods, M., (2008) Annu Rev Biomed Eng, 10, pp. 391-411

Rofstad, E.K., Mathiesen, B., Kindem, K., Galappathi, K., (2006) Cancer Res., 66, pp. 6699-6707

Ratnakar, S.J., Woods, M., Lubag, A.J.M., Kovács, Z., Sherry, A.D., (2008) J. Am. Chem. Soc., 130, pp. 6-7

Pumphrey, A., Yang, Z., Ye, S., Powell, D.K., Thalman, S., Watt, D.S., Abdel-Latif, A., Vandsburger, M., (2016) NMR Biomed., 29, pp. 74-83

Overly, C.C., Lee, K.D., Berthiaume, E., Hollenbeck, P.J., (1995) Proc. Natl. Acad. Sci., 92, pp. 3156-3160

Olatunde, A.O., Dorazio, S.J., Spernyak, J.A., Morrow, J.R., (2012) J. Am. Chem. Soc., 134, pp. 18503-18505

Gochberg, D.F., (2017) Magn. Reson. Imaging, 38, p. 233

Maxfield, F.R., (2014) Cold Spring Harb. Perspect. Biol., 6, p. 016931. , a, –a

Mani, T., Opina, A.C.L., Zhao, P., Evbuomwan, O.M., Milburn, N., Tircso, G., Kumas, C., Sherry, A.D., (2014) JBIC J. Biol. Inorg. Chem., 19, pp. 161-171

Mani, T., Tircsó, G., Togao, O., Zhao, P., Soesbe, T.C., Takahashi, M., Sherry, A.D., (2009) Contrast Media Mol. Imaging, 4, pp. 183-191

Li, A.X., Wojciechowski, F., Suchy, M., Jones, C.K., Hudson, R.H.E., Menon, R.S., Bartha, R., (2008) Magn. Reson. Med., 59, pp. 374-381

Lee, Y., Fukushima, S., Bae, Y., Hiki, S., Ishii, T., Kataoka, K., (2007) J. Am. Chem. Soc., 129, pp. 5362-5363

Langereis, S., Keupp, J., van Velthoven, J.L.J., de Roos, I.H.C., Burdinski, D., Pikkemaat, J.A., Grüll, H., (2009) J. Am. Chem. Soc., 131, pp. 1380-1381

Huang, Y., Coman, D., Ali, M.M., Hyder, F., (2015) Contrast Media Mol. Imaging, 10, pp. 51-58

Hingorani, D.V., Montano, L.A., Randtke, E.A., Lee, Y.S., Cárdenas-Rodríguez, J., Pagel, M.D., (2016) Contrast Media Mol. Imaging, 11, pp. 130-138

Du, K., Harris, T.D., (2016) J. Am. Chem. Soc., 138, pp. 7804-7807

Castelli, D.D., Ferrauto, G., Cutrin, J.C., Terreno, E., Aime, S., (2014) Magn. Reson. Med., 71, pp. 326-332

Dixon, W.T., Ren, J., Lubag, A.J.M., Ratnakar, J., Vinogradov, E., Hancu, I., Lenkinski, R.E., Sherry, A.D., (2010) Magn. Reson. Med., 63, pp. 625-632

Delli Castelli, D., Terreno, E., Aime, S., (2011) Angew. Chem. Int. Ed., 50, pp. 1798-1800

Castelli, D.D., Gianolio, E., Crich, S.G., Terreno, E., Aime, S., (2008) Coord. Chem. Rev., 252, pp. 2424-2443

Castelli, D.D., Caligara, M.C., Botta, M., Terreno, E., Aime, S., (2013) Inorg. Chem., 52, pp. 7130-7138

Christensen, K.A., Myers, J.T., Swanson, J.A., (2002) J. Cell Sci., 115, pp. 599-607

Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., (1999) Chem. Rev., 99, pp. 2293-2352

Cakić, N., Savić, T., Stricker-Shaver, J., Truffault, V., Platas-Iglesias, C., Mirkes, C., Pohmann, R., Angelovski, G., (2016) Chem Commun, 52, pp. 9224-9227

Aime, S., Botta, M., Fasano, M., Terreno, E., (1999) Acc. Chem. Res., 32, pp. 941-949

Aime, S., Barge, A., Bruce, J.I., Botta, M., Howard, J.A.K., Moloney, J.M., Parker, D., Woods, M., (1999) J. Am. Chem. Soc., 121, pp. 5762-5771

Muller, R.N., Vander Elst, L., Roch, A., Peters, J.A., Csajbok, E., Gillis, P., (2005) Relaxation by metal-containing nanosystems, 57, pp. 239-292. , Gossuin in Relaxation by metal-containing nanosystems

Ward, K.M., Balaban, R.S., (2000) Magn. Reson. Med., 44, pp. 799-802

Gregorio, E.D., Ferrauto, G., Gianolio, E., Aime, S., (2013) Contrast Media Mol. Imaging, 8, pp. 475-486

Zaiss, M., Angelovski, G., Demetriou, E., McMahon, M.T., Golay, X., Scheffler, K., (2018) Magn. Reson. Med., 79, pp. 1708-1721

Woessner, D.E., Zhang, S., Merritt, M.E., Sherry, A.D., (2005) Magn. Reson. Med., 53, pp. 790-799

Wang, M.-X., Cheng, X.-Y., Jin, M., Cao, Y.-L., Yang, Y.-P., Wang, J.-D., Li, Q., Liu, C.-F., (2015) Exp. Neurol., 271, pp. 112-121

Huotari, J., Helenius, A., (2011) EMBO J., 30, pp. 3481-3500



The aim of this work was to design new pH-sensitive paramagnetic chemical exchange saturation transfer (paraCEST) agents with a more acidic pH readout window with respect to the Yb complex of the 10-(2-hydroxypropyl)-1,4,7,10- tetraazacyclododecane-1,4,7-triacetic acid (HPDO3A). In particular, three HPDO3A derivatives have been synthesized by substituting the methyl group on the 2-hydroxypropyl arm with the electron withdrawing substituents –CF3, –CH2NH2 and –CH2OH. The Yb complexes have been characterized in terms of i) number and relative abundance of isomers present and, ii) pH sensitivity range in CEST applications. The influence of the introduced substituents on the –OH proton acidity and kex has been investigated and the new agents have been compared with the parent Yb-HPDO3A. All complexes showed an increased acidity and an enhanced exchange rate of the –OH proton. As a consequence, the pH-CEST sensitivity has been shifted to more acidic values. Eventually, the –CH2OH bearing derivative has been tested to assess the intra-endosomal pH which is too acidic to be determined with Yb-HPDO3A. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
▼    MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles
Nessun risultato.

Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]
Vai a fine pagina   Versione per copia e incolla facile   Esporta tutto in BibTeX   Esporta tutto in EndNote


Cocozza S, Pontillo G, Lanzillo R, Russo C, Petracca M, Di Stasi M, Paolella C, Vola EA, Criscuolo C, Moccia M, Lamberti A, Monti S, Brescia Morra V, Elefante A, Palma G, Tedeschi E, Brunetti A
* MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis (3 visite)
Neuroradiology (ISSN: 0028-3940linking, 1432-1920electronic), 2019 Feb; 61(2): 155-162.
Impact Factor: 1.287
Dettagli    Esporta in BibTeX    Esporta in EndNote

Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (55 visite)
RADIOLOGY (ISSN: 0033-8419), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
Dettagli    Esporta in BibTeX    Esporta in EndNote

Longo DL, Stefania R, Aime S, Oraevsky A
* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (51 visite)
INT J MOL SCI (ISSN: 1422-0067), 2017 Aug 7; 18(8): N/D-N/D.
Impact Factor: 3.687
Dettagli    Esporta in BibTeX    Esporta in EndNote

Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
* EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (43 visite)
INT J PHARMACEUT (ISSN: 0378-5173), 2017; 525(1): 275-281.
Impact Factor: 3.862
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tedeschi E, Palma G, Canna A, Cocozza S, Russo C, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Morra VB, Salvatore M, Brunetti A, Quarantelli M
* In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents (112 visite)
EUR RADIOL (ISSN: 0938-7994), 2016 Feb 23; 26(12): 4577-4584.
Impact Factor: 3.967
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (147 visite)
J BIOMED NANOTECHNOL (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
Dettagli    Esporta in BibTeX    Esporta in EndNote

Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (89 visite)
INT J CANCER (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
Dettagli    Esporta in BibTeX    Esporta in EndNote

Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
* Sensitive MRI detection of internalized T contrast agents using magnetization transfer contrast (116 visite)
NMR BIOMED (ISSN: 0952-3480), 2015 Oct 16; N/D: N/D-N/D.
Impact Factor: 2.983
Dettagli    Esporta in BibTeX    Esporta in EndNote

Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (101 visite)
INVEST RADIOL (ISSN: 0020-9996), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (152 visite)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
Dettagli    Esporta in BibTeX    Esporta in EndNote

Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* MR Contrast Agents (108 visite)
Mol Pharm (ISSN: 1543-8384), 2011 Sep; 8(5): 1750-1756.
Impact Factor: 4.782
Dettagli    Esporta in BibTeX    Esporta in EndNote

Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A
* MR Contrast Agents (119 visite)
Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555.
Impact Factor: 1.784
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (187 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (143 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (115 visite)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (152 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
Dettagli    Esporta in BibTeX    Esporta in EndNote

Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (113 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (208 visite)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (99 visite)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (130 visite)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (129 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (145 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (140 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (140 visite)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
Dettagli    Esporta in BibTeX    Esporta in EndNote

Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (101 visite)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (138 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (153 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
Dettagli    Esporta in BibTeX    Esporta in EndNote



27 Records (24 escludendo Abstract e Conferenze).
Impact factor totale: 110.237 (102.751 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 119.289 (111.295 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote