Monte Carlo GEANT4-based application for in vivo RBE study using small animals at LNS-INFN preclinical hadrontherapy facility (297 views)
Phys Med (ISSN: 1120-1797linking), 2018 Jul 20; 54: 173-178.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.24, 5-year impact factor: 1.712
Url: Not available.
Keywords: Dosimetry , Geant4 , Hadrontherapy , Medical Imaging , Preclinical Studies , Small Animal, Monte Carlo Method , Organs At Risk Radiation Effects , Phantoms, Proton Therapy Adverse Effects Instrumentation Methods , Relative Biological Effectiveness,
Affiliations:
*** IBB - CNR ***
University of Catania, Department of Astronomy and Physics, Catania, Italy
National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, Catania, Italy
Institute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, Cefalu, PA, Italy.
National Physical Laboratory, Hampton Rd, Teddington, Middlesex, UK
Institute of Biostructure and Bioimaging, National Research Council, IBB-CNR, Napoli, Italy
Department of Naples, National Institute for Nuclear Physics, INFN, Naples, Italy.
References:
Paganetti, H., Niemierko, A., Ancukiewicz, M., Gerweck, L.E., Goitein, M., Loeffler, J.S., Relative biological effectiveness (RBE) values for proton beam therapy (2002) Int J Radiat Oncol Biol Phys, 53 (2), pp. 407-42
Paganetti, H., Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer (2014) Phys Med Biol, 59 (22), pp. R419-R472
Cuaron, J.J., Chang, C., Lovelock, M., Higginson, D.S., Mah, D., Cahlon, O., Exponential increase in relative biological effectiveness along distal edge of a proton Bragg peak as measured by deoxyribonucleic acid double-strand breaks (2016) Int J Radiat Oncol Biol Phys, 95 (1), pp. 62-69
Saager, M., Peschke, P., Welzel, T., Huang, L., Brons, S., Grün, R., Late normal tissue response in the rat spinal cord after carbon ion irradiation (2018) Radiat Oncol, 13 (1)
Yeh-Chi, L., Wiliam, H.M., Withers, H.R., The effect of single doses of radiation on mouse spinal cord (1992) Int J Radiat, 27 (June), pp. 309-317
Lo, Y.C., Taylor, J.M., McBride, W.H., Withers, H.R., The effect of fractionated doses of radiation on mouse spinal cord (1993) Int J Radiat Oncol Biol Phys, 27 (2), pp. 309-317
Greubel, C., Assmann, W., Burgdorf, C., Dollinger, G., Du, G., Hable, V., Scanning irradiation device for mice in vivo with pulsed and continuous proton beams (2011) Radiat Environ Biophys, 50 (3), pp. 339-344
Zlobinskaya, O., Siebenwirth, C., Greubel, C., Hable, V., Hertenberger, R., Humble, N., The effects of ultra-high dose rate proton irradiation on growth delay in the treatment of human tumor xenografts in nude mice (2014) Radiat Res, 181 (2), pp. 177-183
Kondo, N., Sakurai, Y., Takata, T., Takai, N., Nakagawa, Y., Tanaka, H., Localized radiation necrosis model in mouse brain using proton ion beams (2015) Appl Radiat Isot, 106, pp. 242-246
Takata, T., Kondo, N., Sakurai, Y., Tanaka, H., Hasegawa, T., Kume, K., Reprint of Localized dose delivering by ion beam irradiation for experimental trial of establishing brain necrosis model (2015) Appl Radiat Isot, 106, pp. 104-106
Habermalz, H.J., Valley, B., Habermalz, E., Radiation myelopathy of the mouse spinal cord-isoeffect correlations after fractionated radiation (1987) Strahlenther Onkol, 163 (9), pp. 626-632. , http://www.ncbi.nlm.nih.gov/pubmed/3660229, URL
Geraci, J.P., Thrower, P.D., Jackson, K.L., Christensen, G.M., Parker, R.G., Fox, M.S., The relative biological effectiveness of fast neutrons for spinal cord injury (1974) Radiat Res, 59 (2), pp. 496-503. , http://www.ncbi.nlm.nih.gov/pubmed/4423730, URL
Agostinelli, S., Allison, J., Amako, K., Apostolakis, J., Araujo, H., Arce, P., GEANT4 – A simulation toolkit (2003) Nucl Instrum Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip, 506 (3), pp. 250-303
Dou, Y., Jamieson, D.N., Liu, J., Li, A., Li, L., GEANT4 models for the secondary radiation flux in the collimation system of a 300MeV proton microbeam (2016) Phys Med, 32 (12), pp. 1841-1845. , http://www.ncbi.nlm.nih.gov/pubmed/28341297, URL
McKinnon, S., Guatelli, S., Incerti, S., Ivanchenko, V., Konstantinov, K., Corde, S., Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations (2016) Phys Med, 32 (12), pp. 1584-1593
Resch, A., Landry, G., Kamp, F., Cabal, G., Belka, C., Wilkens, J., Quantification of the uncertainties of a biological model and their impact on variable RBE proton treatment plan optimization (2017) Phys Med, 36, pp. 91-102
Noblet, C., Chiavassa, S., Paris, F., Supiot, S., Lisbona, A., Delpon, G., Underestimation of dose delivery in preclinical irradiation due to scattering conditions (2014) Phys Med, 30 (1), pp. 63-68
Cirrone, G.A.P., Cuttone, G., Guatelli, S., Nigro, S.L., Mascialino, B., Pia, M.G., Implementation of a new Monte Carlo – GEANT4 simulation tool for the development of a proton therapy beam line and verification of the related dose distributions (2005) IEEE Trans Nucl Sci, 52 (1I), pp. 262-265
Chauvie, S., Armando, A., Madsen, J., (2014), http://geant4.web.cern.ch/, DICOM – Readme
(2017), http://geant4-userdoc.web.cern.ch/, Welcome to the Guide for Physics Lists PhysicsListGuide 10.4 documentation
(1968), Report No. 46. International Commission on Radiation Units and Measurements
Pisciotta, P., Russo, G., Marchese, V., Cirrone, G., Romano, F., Lamia, D., Preliminary dosimetric study for preclinical small animal hadrontherapy (2016) Phys Med, 32, p. 53
Russo, G., Pisciotta, P., Cirrone, G.A., Romano, F., Cammarata, F., Marchese, V., Preliminary study for small animal preclinical hadrontherapy facility (2017) Nucl Instrum Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip, 846, pp. 126-134
(2004), http://jhu.technologypublisher.com/technology/18723, 4D Digital Mouse Whole Body (MOBY) Phantom
Segars, W.P., Tsui, B.M.W., Frey, E.C., Johnson, G.A., Berr, S.S., Development of a 4-digital mouse phantom for molecular imaging research (2004) Mol Imaging Biol, 6 (3), pp. 149-159. , http://www.ncbi.nlm.nih.gov/pubmed/15193249, URL
Johnson, A.E.W., Ghassemi, M.M., Nemati, S., Niehaus, K.E., Clifton, D.A., Clifford, G.D., Machine learning and decision support in critical care HHS public access (2016) Proc IEEE Inst Electr Electron Eng, 104 (2), pp. 444-466
Conson, M., Cella, L., Pacelli, R., Comerci, M., Liuzzi, R., Salvatore, M., Automated delineation of brain structures in patients undergoing radiotherapy for primary brain tumors: from atlas to dose-volume histograms (2014) Radiother Oncol, 112 (3), pp. 326-331
Jang, W.H., Shim, S., Wang, T., Yoon, Y., Jang, W.S., Myung, J.K., In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy (2016) Sci Rep, 6 (1), p. 19216. , http://www.nature.com/articles/srep19216, URL
Festing, M.F.W., (2015), http://www.3rs-reduction.co.uk, 3rs-reduction
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050120082&doi=10.1016%2fj.ejmp.2018.07.003&partnerID=40&md5=1542ced88d961a642f5aee08a7d4c45a
Phys Med (ISSN: 1120-1797linking), 2018 Jul 20; 54: 173-178.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.24, 5-year impact factor: 1.712
Url: Not available.
Keywords: Dosimetry , Geant4 , Hadrontherapy , Medical Imaging , Preclinical Studies , Small Animal, Monte Carlo Method , Organs At Risk Radiation Effects , Phantoms, Proton Therapy Adverse Effects Instrumentation Methods , Relative Biological Effectiveness,
Affiliations:
*** IBB - CNR ***
University of Catania, Department of Astronomy and Physics, Catania, Italy
National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, Catania, Italy
Institute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, Cefalu, PA, Italy.
National Physical Laboratory, Hampton Rd, Teddington, Middlesex, UK
Institute of Biostructure and Bioimaging, National Research Council, IBB-CNR, Napoli, Italy
Department of Naples, National Institute for Nuclear Physics, INFN, Naples, Italy.
References:
Paganetti, H., Niemierko, A., Ancukiewicz, M., Gerweck, L.E., Goitein, M., Loeffler, J.S., Relative biological effectiveness (RBE) values for proton beam therapy (2002) Int J Radiat Oncol Biol Phys, 53 (2), pp. 407-42
Paganetti, H., Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer (2014) Phys Med Biol, 59 (22), pp. R419-R472
Cuaron, J.J., Chang, C., Lovelock, M., Higginson, D.S., Mah, D., Cahlon, O., Exponential increase in relative biological effectiveness along distal edge of a proton Bragg peak as measured by deoxyribonucleic acid double-strand breaks (2016) Int J Radiat Oncol Biol Phys, 95 (1), pp. 62-69
Saager, M., Peschke, P., Welzel, T., Huang, L., Brons, S., Grün, R., Late normal tissue response in the rat spinal cord after carbon ion irradiation (2018) Radiat Oncol, 13 (1)
Yeh-Chi, L., Wiliam, H.M., Withers, H.R., The effect of single doses of radiation on mouse spinal cord (1992) Int J Radiat, 27 (June), pp. 309-317
Lo, Y.C., Taylor, J.M., McBride, W.H., Withers, H.R., The effect of fractionated doses of radiation on mouse spinal cord (1993) Int J Radiat Oncol Biol Phys, 27 (2), pp. 309-317
Greubel, C., Assmann, W., Burgdorf, C., Dollinger, G., Du, G., Hable, V., Scanning irradiation device for mice in vivo with pulsed and continuous proton beams (2011) Radiat Environ Biophys, 50 (3), pp. 339-344
Zlobinskaya, O., Siebenwirth, C., Greubel, C., Hable, V., Hertenberger, R., Humble, N., The effects of ultra-high dose rate proton irradiation on growth delay in the treatment of human tumor xenografts in nude mice (2014) Radiat Res, 181 (2), pp. 177-183
Kondo, N., Sakurai, Y., Takata, T., Takai, N., Nakagawa, Y., Tanaka, H., Localized radiation necrosis model in mouse brain using proton ion beams (2015) Appl Radiat Isot, 106, pp. 242-246
Takata, T., Kondo, N., Sakurai, Y., Tanaka, H., Hasegawa, T., Kume, K., Reprint of Localized dose delivering by ion beam irradiation for experimental trial of establishing brain necrosis model (2015) Appl Radiat Isot, 106, pp. 104-106
Habermalz, H.J., Valley, B., Habermalz, E., Radiation myelopathy of the mouse spinal cord-isoeffect correlations after fractionated radiation (1987) Strahlenther Onkol, 163 (9), pp. 626-632. , http://www.ncbi.nlm.nih.gov/pubmed/3660229, URL
Geraci, J.P., Thrower, P.D., Jackson, K.L., Christensen, G.M., Parker, R.G., Fox, M.S., The relative biological effectiveness of fast neutrons for spinal cord injury (1974) Radiat Res, 59 (2), pp. 496-503. , http://www.ncbi.nlm.nih.gov/pubmed/4423730, URL
Agostinelli, S., Allison, J., Amako, K., Apostolakis, J., Araujo, H., Arce, P., GEANT4 – A simulation toolkit (2003) Nucl Instrum Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip, 506 (3), pp. 250-303
Dou, Y., Jamieson, D.N., Liu, J., Li, A., Li, L., GEANT4 models for the secondary radiation flux in the collimation system of a 300MeV proton microbeam (2016) Phys Med, 32 (12), pp. 1841-1845. , http://www.ncbi.nlm.nih.gov/pubmed/28341297, URL
McKinnon, S., Guatelli, S., Incerti, S., Ivanchenko, V., Konstantinov, K., Corde, S., Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations (2016) Phys Med, 32 (12), pp. 1584-1593
Resch, A., Landry, G., Kamp, F., Cabal, G., Belka, C., Wilkens, J., Quantification of the uncertainties of a biological model and their impact on variable RBE proton treatment plan optimization (2017) Phys Med, 36, pp. 91-102
Noblet, C., Chiavassa, S., Paris, F., Supiot, S., Lisbona, A., Delpon, G., Underestimation of dose delivery in preclinical irradiation due to scattering conditions (2014) Phys Med, 30 (1), pp. 63-68
Cirrone, G.A.P., Cuttone, G., Guatelli, S., Nigro, S.L., Mascialino, B., Pia, M.G., Implementation of a new Monte Carlo – GEANT4 simulation tool for the development of a proton therapy beam line and verification of the related dose distributions (2005) IEEE Trans Nucl Sci, 52 (1I), pp. 262-265
Chauvie, S., Armando, A., Madsen, J., (2014), http://geant4.web.cern.ch/, DICOM – Readme
(2017), http://geant4-userdoc.web.cern.ch/, Welcome to the Guide for Physics Lists PhysicsListGuide 10.4 documentation
(1968), Report No. 46. International Commission on Radiation Units and Measurements
Pisciotta, P., Russo, G., Marchese, V., Cirrone, G., Romano, F., Lamia, D., Preliminary dosimetric study for preclinical small animal hadrontherapy (2016) Phys Med, 32, p. 53
Russo, G., Pisciotta, P., Cirrone, G.A., Romano, F., Cammarata, F., Marchese, V., Preliminary study for small animal preclinical hadrontherapy facility (2017) Nucl Instrum Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip, 846, pp. 126-134
(2004), http://jhu.technologypublisher.com/technology/18723, 4D Digital Mouse Whole Body (MOBY) Phantom
Segars, W.P., Tsui, B.M.W., Frey, E.C., Johnson, G.A., Berr, S.S., Development of a 4-digital mouse phantom for molecular imaging research (2004) Mol Imaging Biol, 6 (3), pp. 149-159. , http://www.ncbi.nlm.nih.gov/pubmed/15193249, URL
Johnson, A.E.W., Ghassemi, M.M., Nemati, S., Niehaus, K.E., Clifton, D.A., Clifford, G.D., Machine learning and decision support in critical care HHS public access (2016) Proc IEEE Inst Electr Electron Eng, 104 (2), pp. 444-466
Conson, M., Cella, L., Pacelli, R., Comerci, M., Liuzzi, R., Salvatore, M., Automated delineation of brain structures in patients undergoing radiotherapy for primary brain tumors: from atlas to dose-volume histograms (2014) Radiother Oncol, 112 (3), pp. 326-331
Jang, W.H., Shim, S., Wang, T., Yoon, Y., Jang, W.S., Myung, J.K., In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy (2016) Sci Rep, 6 (1), p. 19216. , http://www.nature.com/articles/srep19216, URL
Festing, M.F.W., (2015), http://www.3rs-reduction.co.uk, 3rs-reduction
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050120082&doi=10.1016%2fj.ejmp.2018.07.003&partnerID=40&md5=1542ced88d961a642f5aee08a7d4c45a
Monte Carlo GEANT4-based application for in vivo RBE study using small animals at LNS-INFN preclinical hadrontherapy facility
Preclinical studies represent an important step towards a deep understanding of the biological response to ionizing radiations. The effectiveness of proton therapy is higher than photons and, for clinical purposes, a fixed value of 1.1 is used for the relative biological effectiveness (RBE) of protons considered 1.1. Recent in vitro studies have reported that the RBE along the spread-out Bragg peak (SOBP) is not constant and, in particular, the RBE value increases on the distal part of SOBP. The present work has been carried-out in the perspective of a preclinical hadrontherapy facility at LNS-INFN and was focused on the experimental preparation of an in vivo study concerning the RBE variation along the SOBP. The main purpose of this work was to determine, using GEANT4-based Monte Carlo simulations, the best configuration for small animal treatments. The developed GEANT4 application simulates the proton-therapy beam line of LNS-INFN (CATANA facility) and allows to import the DICOM-CT images as targets. The RBE will be evaluated using a deterministic radiation damage like myelopathy as end-point. In fact, the dose at which the 50% of animals will show the myelopathy is supposed to be LET-dependent. In this work, we studied different treatment configurations in order to choose the best two that maximize the LET difference reducing as much as possible the dose released to healthy tissue. The results will be useful to plan hadrontherapy treatments for preclinical in vivo studies and, in particular, for the future in vivo RBE studies. © 2018 Associazione Italiana di Fisica Medica
Preclinical studies represent an important step towards a deep understanding of the biological response to ionizing radiations. The effectiveness of proton therapy is higher than photons and, for clinical purposes, a fixed value of 1.1 is used for the relative biological effectiveness (RBE) of protons considered 1.1. Recent in vitro studies have reported that the RBE along the spread-out Bragg peak (SOBP) is not constant and, in particular, the RBE value increases on the distal part of SOBP. The present work has been carried-out in the perspective of a preclinical hadrontherapy facility at LNS-INFN and was focused on the experimental preparation of an in vivo study concerning the RBE variation along the SOBP. The main purpose of this work was to determine, using GEANT4-based Monte Carlo simulations, the best configuration for small animal treatments. The developed GEANT4 application simulates the proton-therapy beam line of LNS-INFN (CATANA facility) and allows to import the DICOM-CT images as targets. The RBE will be evaluated using a deterministic radiation damage like myelopathy as end-point. In fact, the dose at which the 50% of animals will show the myelopathy is supposed to be LET-dependent. In this work, we studied different treatment configurations in order to choose the best two that maximize the LET difference reducing as much as possible the dose released to healthy tissue. The results will be useful to plan hadrontherapy treatments for preclinical in vivo studies and, in particular, for the future in vivo RBE studies. © 2018 Associazione Italiana di Fisica Medica
Monte Carlo GEANT4-based application for in vivo RBE study using small animals at LNS-INFN preclinical hadrontherapy facility
| ▼ High-resolution positron emission tomography of the ischaemic mouse heart |
| ▼ Animal Care, interventional procedures, anesthesia and analgesia of murine models in preclinical imaging |
Monte Carlo GEANT4-based application for in vivo RBE study using small animals at LNS-INFN preclinical hadrontherapy facility
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Celentano L, Laccetti P, Liuzzi R, Mettivier G, Montesi MC, Autiero M, Riccio P, Roberti G, Russo P, Salvatore M
* Preliminary tests of a prototype system for optical and radionuclide imaging in small animals (309 views)
Ieee Nuclear Science Symposium And Medical Imaging Conference, 2002; 3: 1746-1750.
Impact Factor: 0
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (476 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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Cella L, Lomax A, Miralbell R
* New techniques in hadrontherapy: Intensity modulated proton beams (245 views)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2001; 17(SUPPL.1): 100-102.
Impact Factor: 0.556
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Alfano B, Bandettini A, Bencivelli W, Bertolucci E, Bottigli U, Conti M, Del Guerra A, Fantacci ME, Gambaccini M, Larobina M, Marziani M, Randaccio P, Rosso V, Russo P, Stefanini A
Digital imaging in radiology: preliminary results obtained with a high spatial resolution 2D silicon detector (285 views)
Ieee Transactions On Nuclear Science (ISSN: 0018-9499), 1993 Sep; 40(4pt1): 987-991.
Impact Factor: 1.048
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* Measurement of [123I]FP-CIT binding to the dopamine transporter (DAT) in healthy mouse striatum using dedicated small animal SPECT imaging: feasibility, optimization and validation (438 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785linking, 1824-4785print, 1827-1936electronic), 2018 Mar; 62(1): 112-117.
Impact Factor: 2.413
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Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-crich S, Giovenzana GB, Aime S
* Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners (391 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2015 Oct 16; 75: 47-57.
Impact Factor: 8.387
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Russo P, Larobina M, Di Lillo F, Del Vecchio S, Mettivier G
* Combined SPECT/CT and PET/CT for breast imaging (417 views)
Nucl Instrum Meth A (ISSN: 0168-9002), 2015; 809: 58-66.
Impact Factor: 1.2
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Orlandini S, Pasquini B, Gotti R, Giuffrida A, Paternostro F, Furlanetto S
* Analytical quality by design in the development of a cyclodextrin-modified capillary electrophoresis method for the assay of metformin and its related substances (192 views)
Electrophoresis (ISSN: 0173-0835), 2014; 35(17): 2538-2545.
Impact Factor: 3.028
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Zannetti A, Iommelli F, De Rosa V, Salvatore M, Del Vecchio S
* Small animal SPECT with 99m-Tc-Hynic-annexin V for detection of non-small cell lung cancer resistance to EGFR antagonists and its reversal by Bcl-xL inhibitors (384 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
Impact Factor: 5.114
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Greco A, Mancini M, Gargiulo S, Gramanzini M, Claudio PP, Brunetti A, Salvatore M
* Ultrasound biomicroscopy in small animal research: Applications in molecular and preclinical imaging (459 views)
J Biomed Biotechnol (ISSN: 1110-7243, 1110-7251), 2012; 2012: 519238-519238.
Impact Factor: 2.88
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Brunetti A, Cuocolo A
* European Science Foundation calls for more and better medical imaging research (213 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Sep; 35(9): 1749-1757.
Impact Factor: 4.532
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Brunetti A, Cuocolo A
* Medical Imaging for Improved Patient Care (194 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Sep; 35(9): 1750-1757.
Impact Factor: 4.532
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Cusanno F, Cisbani E, Colilli S, Fratoni R, Garibaldi F, Giuliani F, Gricia M, Lucentini M, Magliozzi ML, Santarivenere F, Torrioli S, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, De Vincentis G, Scopinaro F
* Results of clinical trials with SPEM (252 views)
Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50.
Impact Factor: 3.221
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Garibaldi F, Cisbani E, Colilli S, Cusanno F, Fratoni R, Giuliani F, Gricia M, Lucentini M, Fratoni R, Lo Meo S, Magliozzi ML, Santanvenere F, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, Lanza RC, De Vincentis G, Scopinaro F
* Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer (322 views)
Nucl Instrum Meth A (ISSN: 0168-9002), 2006 Dec 20; 569(2SPEC.ISS.): 286-290.
Impact Factor: 1.185
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Del Guerra A, Bartoli A, Belcari N, Herbert D, Motta A, Vaiano A, Di Domenico G, Sabba N, Moretti E, Zavattini G, Lazzarotti M, Sensi L, Larobina M
* Performance evaluation of the fully engineered YAP-(S)PET scanner for small animal imaging (274 views)
Ieee Transactions On Nuclear Science (ISSN: 0018-9499), 2006 Jun; 53(3): 1078-1083.
Impact Factor: 1.497
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Larobina M, Brunetti A, Salvatore M
* Small animal PET: A review of commercially available imaging systems (325 views) (PDF 228 views)
Curr Med Imaging Rev (ISSN: 1573-4056, 1573-4056linking), 2006 May; 2(2): 187-192.
Impact Factor: 1.059
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (502 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
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Del Guerra A, Bartoli A, Belcari N, Herbert A, Motta A, Vaiano A, Di Domenico G, Sabbia N, Moretti E, Zavattini G, Lazzarotti M, Sensi L, Larobina M, Uccelli L
* Performance Evalutation Of The Fully Engineered Yap-(s) Pet Scanner For Small Animal Imaging (191 views)
Ieee Transactions On Nuclear Science, 2006; 53: 1078-1083.
Impact Factor: 1.455
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Autiero M, Liuzzi R, Riccio P, Roberti G
* Determination of the concentration scaling law of the scattering coefficient of water solutions of intralipid at 832 nm by comparison between collimated detection measurements and Monte Carlo simulations (293 views)
Lasers Surg Med (ISSN: 0196-8092, 0196-8092print, 0196-8092linking), 2005 Jun; 36(5): 414-422.
Impact Factor: 2.249
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Romano M, Mainenti PP, Imbriaco M, Amato B, Markabaoui K, Tamburrini O, Salvatore M
* Multidetector row CT angiography of the abdominal aorta and lower extremities in patients with peripheral arterial occlusive disease: diagnostic accuracy and interobserver agreement (277 views)
European Journal Of Radiology (ISSN: 0720-048x), 2004 Jun; 50(3): 303-308.
Impact Factor: 1.745
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Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (563 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
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Del Guerra A, Bartoli A, Belcari N, Herbert D, Motta A, Vaiano A, Di Domenico G, Sabba N, Moretti E, Zavattini G, Lazzarotti M, Sensi L, Larobina M
* Performance evaluation of the fully engineered YAP-(S)PET scanner for small animal imaging (386 views)
2004 Ieee Nuclear Science Symposium Conference Record Vols 1 7, 2004; 5: 2990-2994.
Impact Factor: 0
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Celentano L, Laccetti P, Liuzzi R, Mettivier G, Montesi MC, Autiero M, Riccio P, Roberti G, Russo P, Salvatore M
* Preliminary Tests of a Prototype System for Optical and Radionuclide Imaging in Small Animals (332 views)
Ieee Transactions On Nuclear Science (ISSN: 0018-9499), 2003 Oct; 50(5II): 1693-1701.
Impact Factor: 1.119
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Accardo A, Candido G, Jellù V, Toffanin R, Vittur F
* Ex vivo assessment of trabecular bone structure from three-dimensional projection reconstruction MR micro-images (380 views)
Ieee Trans Biomed Eng (ISSN: 0018-9294), 2003; 50(8): 967-977.
Impact Factor: 1.398
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Imbriaco M, Ignarra R, De Rosa N, Lambiase G, Romano M, Ragozzino A
* Parosteal lipoma of the rib: CT findings and pathologic correlation (265 views)
Clin Imaging (ISSN: 0899-7071, 1873-4499, 0899-7071linking), 2003; 27(6): 435-437.
Impact Factor: 0.658
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Celentano L, Laccetti P, Liuzzi R, Mettivier G, Montesi MC, Autiero M, Riccio P, Roberti G, Russo P, Salvatore M
* Preliminary tests of a prototype system for optical and radionuclide imaging in small animals (309 views)
Ieee Nuclear Science Symposium And Medical Imaging Conference, 2002; 3: 1746-1750.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (476 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
View Export to BibTeX Export to EndNote
Cella L, Lomax A, Miralbell R
* New techniques in hadrontherapy: Intensity modulated proton beams (245 views)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2001; 17(SUPPL.1): 100-102.
Impact Factor: 0.556
View Export to BibTeX Export to EndNote
Alfano B, Bandettini A, Bencivelli W, Bertolucci E, Bottigli U, Conti M, Del Guerra A, Fantacci ME, Gambaccini M, Larobina M, Marziani M, Randaccio P, Rosso V, Russo P, Stefanini A
Digital imaging in radiology: preliminary results obtained with a high spatial resolution 2D silicon detector (285 views)
Ieee Transactions On Nuclear Science (ISSN: 0018-9499), 1993 Sep; 40(4pt1): 987-991.
Impact Factor: 1.048
View Export to BibTeX Export to EndNote
25 Records (22 excluding Abstracts).
Total impact factor: 60.431 (52.437 excluding Abstracts).
Total 5 year impact factor: 66.295 (58.787 excluding Abstracts).
Total impact factor: 60.431 (52.437 excluding Abstracts).
Total 5 year impact factor: 66.295 (58.787 excluding Abstracts).
297 views. Last view on Tuesday 12 July 2022, 21:22:45
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