Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome (63 visite)
Front Neurol (ISSN: 1664-2295linking, 1664-2295print), 2018 Aug 30; 9(AUG): 728-728.
Tipo di articolo: Journal Article,
Impact factor: 3.508, Impact factor a 5 anni: 4.297
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052805272&doi=10.3389%2ffneur.2018.00728&partnerID=40&md5=cc540862e662a3b94f72f4c8b4e7e944
Parole chiave: Mt-Atp8, Ammonia, Metabolic Encephalopathy, Mitochondria, Valproate, Cytochrome C Oxidase, Lactic Acid, Succinate Dehydrogenase, Valproic Acid, Aged, Article, Brain Cortex Atrophy, Brain Disease, Case Report, Clinical Article, Deterioration, Disease Severity, Dna Sequence, Drowsiness, Drug Dose Titration, Drug Withdrawal, Electroencephalogram, Electron Transport, Enzyme Activity, Epilepsy, Female, Follow Up, Gaze Paralysis, Gene Deletion, Gene Mutation, Genetic Association, Genetic Variability, Human, Human Tissue, Lactate Blood Level, Leukoencephalopathy, Limb Weakness, Mitochondrial Genome, Mt Atp8 Gene, Muscle Biopsy, Muscle Strength, Neurologic Examination, Nuclear Magnetic Resonance Spectroscopy, Single Nucleotide Polymorphism, Treatment Duration, Walking Difficulty,
Affiliazioni:
*** IBB - CNR ***
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Universita degli Studi di Napoli Federico II, Napoli, Italy.
Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa, Italy.
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy.
Riferimenti:
Galimberti, C.A., Diegoli, M., Sartori, I., Uggetti, C., Brega, A., Tartara, A., Brain pseudo-atrophy and mental regression on valproate and a mitochondrial DNA mutation (2006) Neurology, 67, pp. 1715-171
Nesti, C., Meschini, M.C., Meunier, B., Sacchini, M., Doccini, S., Romano, A., Additive effect of nuclear and mitochondrial mutations in a patient with mitochondrial encephalomyopathy (2015) Hum Mol Genet, 24, pp. 3248-3256
Tomson, T., Battino, D., Perucca, E., Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug (2016) Lancet Neurol, 15, pp. 210-218
Verrotti, A., Trotta, D., Morgese, G., Chiarelli, F., Valproate-induced hyperammonemic encephalopathy (2002) Metab Brain Dis, 17, pp. 367-373
Gerstner, T., Buesing, D., Longin, E., Bendl, C., Wenzel, D., Scheid, B., Valproic acid induced encephalopathy-19 new cases in Germany from 1994 to 2003-a side effect associated to VPA-therapy not only in young children (2006) Seizure, 15, pp. 443-448
Lewis, C., Deshpande, A., Tesar, G.E., Dale, R., Valproate-induced hyperammonemic encephalopathy: a brief review (2012) Curr Med Res Opin, 28, pp. 1039-1042
Baganz, I., Dross, P.E., Valproic acid-induced hyperammoncmic encephalopathy: MR appearance (1994) Am J Neuroradiol, 15, pp. 1779-1781
Ziyeh, S., Thiel, T., Spreer, J., Klisch, J., Schumacher, M., Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy (2002) Epilepsia, 43, pp. 1101-1105
Guerrini, R., Belmonte, A., Canapicchi, R., Casalini, C., Perucca, E., Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment (1998) Epilepsia, 39, pp. 27-32
Mock, C.M., Schwetschenau, K.H., Levocarnitine for valproic-acid-induced hyperammonemic encephalopathy (2012) Am J Health Syst Pharm, 69, pp. 35-39
Senior, A.E., Nadanaciva, S., Weber, J., The molecular mechanism of ATP synthesis by F1F0-ATP synthase (2002) Biochim Biophys Acta, 1553, pp. 188-211
Dautant, A., Meier, T., Hahn, A., Tribouillard-Tanvier, D., di Rago, J.P., Kucharczyk, R., ATP Synthase Diseases of Mitochondrial Genetic Origin (2018) Front Physiol, 9, p. 329
Hroudova, J., Fisar, Z., Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers (2010) Neuro Endocrinol Lett, 31, pp. 336-342
Luis, P.B., Ruiter, J.P., Aires, C.C., Soveral, G., de Almeida, I.T., Duran, M., Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation (2007) Biochim Biophys Acta, 1767, pp. 1126-1133
Lam, C.W., Lau, C.H., Williams, J.C., Chan, Y.W., Wong, L.J., Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) triggered by valproate therapy (1997) Eur J Pediatr, 156, pp. 562-564
Chaudhry, N., Patidar, Y., Puri, V., Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate (2013) J Pediatr Neurosci, 8, pp. 135-137
Bianco, A., Martínez-Romero, I., Bisceglia, L., D'Agruma, L., Favia, P., Ruiz-Pesini, E., Mitochondrial DNA copy number differentiates the Leber's hereditary optic neuropathy affected individuals from the unaffected mutation carriers (2016) Brain, 139, pp. 1-3
Front Neurol (ISSN: 1664-2295linking, 1664-2295print), 2018 Aug 30; 9(AUG): 728-728.
Tipo di articolo: Journal Article,
Impact factor: 3.508, Impact factor a 5 anni: 4.297
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052805272&doi=10.3389%2ffneur.2018.00728&partnerID=40&md5=cc540862e662a3b94f72f4c8b4e7e944
Parole chiave: Mt-Atp8, Ammonia, Metabolic Encephalopathy, Mitochondria, Valproate, Cytochrome C Oxidase, Lactic Acid, Succinate Dehydrogenase, Valproic Acid, Aged, Article, Brain Cortex Atrophy, Brain Disease, Case Report, Clinical Article, Deterioration, Disease Severity, Dna Sequence, Drowsiness, Drug Dose Titration, Drug Withdrawal, Electroencephalogram, Electron Transport, Enzyme Activity, Epilepsy, Female, Follow Up, Gaze Paralysis, Gene Deletion, Gene Mutation, Genetic Association, Genetic Variability, Human, Human Tissue, Lactate Blood Level, Leukoencephalopathy, Limb Weakness, Mitochondrial Genome, Mt Atp8 Gene, Muscle Biopsy, Muscle Strength, Neurologic Examination, Nuclear Magnetic Resonance Spectroscopy, Single Nucleotide Polymorphism, Treatment Duration, Walking Difficulty,
Affiliazioni:
*** IBB - CNR ***
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Universita degli Studi di Napoli Federico II, Napoli, Italy.
Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa, Italy.
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy.
Riferimenti:
Galimberti, C.A., Diegoli, M., Sartori, I., Uggetti, C., Brega, A., Tartara, A., Brain pseudo-atrophy and mental regression on valproate and a mitochondrial DNA mutation (2006) Neurology, 67, pp. 1715-171
Nesti, C., Meschini, M.C., Meunier, B., Sacchini, M., Doccini, S., Romano, A., Additive effect of nuclear and mitochondrial mutations in a patient with mitochondrial encephalomyopathy (2015) Hum Mol Genet, 24, pp. 3248-3256
Tomson, T., Battino, D., Perucca, E., Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug (2016) Lancet Neurol, 15, pp. 210-218
Verrotti, A., Trotta, D., Morgese, G., Chiarelli, F., Valproate-induced hyperammonemic encephalopathy (2002) Metab Brain Dis, 17, pp. 367-373
Gerstner, T., Buesing, D., Longin, E., Bendl, C., Wenzel, D., Scheid, B., Valproic acid induced encephalopathy-19 new cases in Germany from 1994 to 2003-a side effect associated to VPA-therapy not only in young children (2006) Seizure, 15, pp. 443-448
Lewis, C., Deshpande, A., Tesar, G.E., Dale, R., Valproate-induced hyperammonemic encephalopathy: a brief review (2012) Curr Med Res Opin, 28, pp. 1039-1042
Baganz, I., Dross, P.E., Valproic acid-induced hyperammoncmic encephalopathy: MR appearance (1994) Am J Neuroradiol, 15, pp. 1779-1781
Ziyeh, S., Thiel, T., Spreer, J., Klisch, J., Schumacher, M., Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy (2002) Epilepsia, 43, pp. 1101-1105
Guerrini, R., Belmonte, A., Canapicchi, R., Casalini, C., Perucca, E., Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment (1998) Epilepsia, 39, pp. 27-32
Mock, C.M., Schwetschenau, K.H., Levocarnitine for valproic-acid-induced hyperammonemic encephalopathy (2012) Am J Health Syst Pharm, 69, pp. 35-39
Senior, A.E., Nadanaciva, S., Weber, J., The molecular mechanism of ATP synthesis by F1F0-ATP synthase (2002) Biochim Biophys Acta, 1553, pp. 188-211
Dautant, A., Meier, T., Hahn, A., Tribouillard-Tanvier, D., di Rago, J.P., Kucharczyk, R., ATP Synthase Diseases of Mitochondrial Genetic Origin (2018) Front Physiol, 9, p. 329
Hroudova, J., Fisar, Z., Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers (2010) Neuro Endocrinol Lett, 31, pp. 336-342
Luis, P.B., Ruiter, J.P., Aires, C.C., Soveral, G., de Almeida, I.T., Duran, M., Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation (2007) Biochim Biophys Acta, 1767, pp. 1126-1133
Lam, C.W., Lau, C.H., Williams, J.C., Chan, Y.W., Wong, L.J., Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) triggered by valproate therapy (1997) Eur J Pediatr, 156, pp. 562-564
Chaudhry, N., Patidar, Y., Puri, V., Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate (2013) J Pediatr Neurosci, 8, pp. 135-137
Bianco, A., Martínez-Romero, I., Bisceglia, L., D'Agruma, L., Favia, P., Ruiz-Pesini, E., Mitochondrial DNA copy number differentiates the Leber's hereditary optic neuropathy affected individuals from the unaffected mutation carriers (2016) Brain, 139, pp. 1-3
Introduction: There are several reported cases of patients developing motor and cognitive neurological impairment under treatment with valproic acid (VPA). We describe a woman who developed a subacute encephalopathy after VPA intake, harboring a mitochondrial DNA variant, previously described as causing VPA sensitivity in one pediatric patient. Material and Methods: A 65-year old woman developed a progressive, severe neurological deterioration after a 3 month treatment with valproate sodium, 800 mg daily. Magnetic resonance spectroscopy (MRS), muscle histochemical analysis and assay of mitochondrial enzymatic activities, and mitochondrial DNA sequencing were performed. Results: Neurological examination showed drowsiness, vertical gaze palsy, inability to either stand or walk, diffuse weakness, increased tendon reflexes. Blood lactate was increased, EEG showed diffuse theta and delta activity, MRI subcortical atrophy and leukoencephalopathy, MRS marked reduction of the NAA spectrum, with a small signal compatible with presence of lactate. Muscle biopsy evidenced presence of ragged red fibers (20%) and reduced COX reactivity. Assay of the muscle enzymatic activities showed multiple deficiencies of the electron transport chain and reduced ATP production. The mt.8393C > T variant in the MT-ATP8 gene was found in homoplasmy. The patient considerably improved after valproate withdrawal. Conclusion: The variant we found has been reported both as a polymorphism and, in a single patient, as related to the valproate-induced encephalopathy. The present case is the first bearing this mutation in homoplasmy. In case of neurological symptoms after starting VPA therapy, once hyperammonemia and liver failure have been ruled out, mtDNA abnormalities should be considered. © 2018 De Michele, Sorrentino, Nesti, Rubegni, Ruggiero, Peluso, Antenora, Quarantelli, Filla, De Michele and Santorelli.
Nessun risultato. |
Nessun risultato. |
Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Skiba J, Bernas T, Trzybinski D, Wozniak K, Ferraro G, Marasco D, Merlino A, Shafikov MZ, Czerwieniec R, Kowalski K
* Mitochondria Targeting with Luminescent Rhenium(I) Complexes (127 visite)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2017 May 15; 22(5): N/D-N/D.
Impact Factor: 3.098
Dettagli Esporta in BibTeX Esporta in EndNote
Cavallari E, Carrera C, Aime S, Reineri F
* (13) C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro (53 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 Jan 23; 23(5): 1200-1204.
Impact Factor: 5.16
Dettagli Esporta in BibTeX Esporta in EndNote
Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
* Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease (153 visite)
Acs Med Chem Lett (ISSN: 1948-5875), 2016 Sep 26; 7(12): 1145-1150.
Impact Factor: 3.746
Dettagli Esporta in BibTeX Esporta in EndNote
Magri A, Di Rosa MC, Tomasello MF, Guarino F, Reina S, Messina A, De Pinto V
* Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes (174 visite)
Bba-Bioenergetics (ISSN: 0005-2728, 0006-3002print), 2016 Mar 4; 1857(6): 789-798.
Impact Factor: 4.932
Dettagli Esporta in BibTeX Esporta in EndNote
Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G
* Adrenergic Receptors (26 visite)
Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (367 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
Dettagli Esporta in BibTeX Esporta in EndNote
Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (236 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995), 2015 Sep 15; 54(36): 5646-5656.
Impact Factor: 2.876
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M, Gomez-Monterrey I, Campiglia P, Novellino E, Illario M, Trimarco B, De Luca N, Iaccarino G
* New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (148 visite)
Br J Cancer (ISSN: 0007-0920, 0007-0920print), 2015 Jan 6; 112(1): 77-85.
Impact Factor: 5.569
Dettagli Esporta in BibTeX Esporta in EndNote
Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (177 visite)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
Dettagli Esporta in BibTeX Esporta in EndNote
Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (174 visite)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
Dettagli Esporta in BibTeX Esporta in EndNote
Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (248 visite)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone R, Ranieri A, Montella S, Cappabianca P, Quarantelli M, Esposito F, Cardillo G, Bonavita V
* Intracranial pressure in unresponsive chronic migraine (165 visite)
J Neurol (ISSN: 0340-5354, 1432-1459, 0340-5354print), 2014 Jul; 261(7): 1365-1373.
Impact Factor: 3.377
Dettagli Esporta in BibTeX Esporta in EndNote
Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (396 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G
* Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization (108 visite)
Transl Med Unisa (ISSN: 2239-9747electronic, 2239-9747linking), 2014 Apr 8; 10: 3-7.
Impact Factor: 2.256
Dettagli Esporta in BibTeX Esporta in EndNote
Bilo L, Peluso S, Antenora A, De Rosa A, Auletta G, Pappata S, De Michele G
* Parkinsonism may be part of the symptom complex of DOOR syndrome (112 visite)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1353-8020print), 2014 Apr; 20(4): 463-465.
Impact Factor: 3.972
Dettagli Esporta in BibTeX Esporta in EndNote
Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (200 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Rizzarelli E, Tomaselli GA, Satriano C, Trusso Sfrazzetto G
* A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging (147 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2014; 50(69): 9835-9838.
Impact Factor: 6.834
Dettagli Esporta in BibTeX Esporta in EndNote
Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
* Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (177 visite)
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504.
Impact Factor: 2.332
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (249 visite)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Impact Factor: 1.219
Dettagli Esporta in BibTeX Esporta in EndNote
Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
* Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy (187 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2013 Sep; 125: 16-25.
Impact Factor: 3.274
Dettagli Esporta in BibTeX Esporta in EndNote
Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (177 visite)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
Dettagli Esporta in BibTeX Esporta in EndNote
Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (215 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
Dettagli Esporta in BibTeX Esporta in EndNote
Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (147 visite)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (152 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
Dettagli Esporta in BibTeX Esporta in EndNote
Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (183 visite)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (196 visite)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
Dettagli Esporta in BibTeX Esporta in EndNote
Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (168 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800.
Impact Factor: 2.464
Dettagli Esporta in BibTeX Esporta in EndNote
Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (139 visite)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
Dettagli Esporta in BibTeX Esporta in EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (226 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
Dettagli Esporta in BibTeX Esporta in EndNote
Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (194 visite)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
Dettagli Esporta in BibTeX Esporta in EndNote
Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M
* Bone mineral density in children, adolescents, and young adults with epilepsy (169 visite)
Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146.
Impact Factor: 4.052
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (227 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (323 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (272 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
Dettagli Esporta in BibTeX Esporta in EndNote
Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (157 visite)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
Dettagli Esporta in BibTeX Esporta in EndNote
Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (186 visite)
Bba-Bioenergetics (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
Dettagli Esporta in BibTeX Esporta in EndNote
De Leva MF, Varrone A, Filla A, Quarantelli M, Bilo L, Piscitelli V, Salvatore E, Ammendola S, Striano S, De Michele G, Bonavita V, Pappata S
* Neuroimaging follow-up in a case of Rasmussen's encephalitis with dyskinesias (138 visite)
Mov Disord (ISSN: 0885-3185, 1531-8257), 2007 Oct 31; 22(14): 2117-2121.
Impact Factor: 3.207
Dettagli Esporta in BibTeX Esporta in EndNote
Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (147 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (129 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (162 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (140 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
Dettagli Esporta in BibTeX Esporta in EndNote
De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (199 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
Dettagli Esporta in BibTeX Esporta in EndNote
Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (193 visite)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (243 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
Dettagli Esporta in BibTeX Esporta in EndNote
Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (147 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
Dettagli Esporta in BibTeX Esporta in EndNote
Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (118 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
Dettagli Esporta in BibTeX Esporta in EndNote
Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (181 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
Dettagli Esporta in BibTeX Esporta in EndNote
47 Records (42 escludendo Abstract e Conferenze).
Impact factor totale: 180.771 (162.246 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 185.63 (165.512 escludendo Abstract e Conferenze).
Impact factor totale: 180.771 (162.246 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 185.63 (165.512 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Monday 17 September 2018, 12:27:14
63 visite. Ultima visita in data Friday 08 November 2019, 23:25:46
ibb.cnr.it