Liver diseases in the elderly (335 views visite)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2018 Oct 11; 110(1): 35-51.
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Paper type Tipo di articolo: Journal Article, Review,
Impact factor: 2.863, 5-year impact factor Impact factor a 5 anni: 0.843
Url: Not available. Non disponibile.
Keywords Parole chiave: Age Factors , Carcinoma, Hepatocellular , Cholangitis , Hepatitis , Humans , Liver Diseases Diagnosis Epidemiology Therapy , Liver Neoplasms,
Affiliations Affiliazioni:
*** IBB - CNR ***
Unit of Medicine 3, Department of Medical Sciences, Citta della Salute e della Scienza, Molinette Hospital, University of Turin, Turin, Italy - marilena.durazzo@unito.it.
Unit of Gastroenterology, Molinette-SGAS Hospital, Turin, Italy.
Institute for Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, Turin, Italy.
References Riferimenti:
Not available. Non disponibili.
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2018 Oct 11; 110(1): 35-51.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Review,
Impact factor: 2.863, 5-year impact factor Impact factor a 5 anni: 0.843
Url: Not available. Non disponibile.
Keywords Parole chiave: Age Factors , Carcinoma, Hepatocellular , Cholangitis , Hepatitis , Humans , Liver Diseases Diagnosis Epidemiology Therapy , Liver Neoplasms,
Affiliations Affiliazioni:
*** IBB - CNR ***
Unit of Medicine 3, Department of Medical Sciences, Citta della Salute e della Scienza, Molinette Hospital, University of Turin, Turin, Italy - marilena.durazzo@unito.it.
Unit of Gastroenterology, Molinette-SGAS Hospital, Turin, Italy.
Institute for Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, Turin, Italy.
References Riferimenti:
Not available. Non disponibili.
Liver diseases in the elderly
Due to the progressive increase in life expectancy, the number of elderly people in the world is growing rapidly. Although there are no liver diseases specific of older age, the ageing liver shows some anatomical and physiological changes that can affect the frequency and the clinical behavior of most hepatopathies. In particular, these changes tend to cause an increased vulnerability to acute liver injury and an increased susceptibility to liver fibrosis, accounting for the predisposition to a generally more severe course of liver diseases compared to younger patients. Furthermore, advanced age is also associated with immune system alterations, influencing the manifestation of those hepatopathies that are mediated by host immune response, like viral hepatitis, autoimmune hepatitis but also hepatocellular carcinoma. Despite these changes, total liver function and laboratory values tend to be well maintained in healthy elderly, so that every enzymatic alteration in a geriatric patient should be investigated with the same attention as in a younger one. A proper and early diagnosis is of great importance both considering the age-related more aggressive course of hepatopathies and that age itself does not seem to be a limit for most treatment options, even if specific data are often lacking. This paper focuses on the peculiarities of main liver diseases in geriatrics, with respect to epidemiology, clinical presentation, diagnosis and management, which can be more challenging in advanced age because of the frequent comorbidities and polytherapies.
Due to the progressive increase in life expectancy, the number of elderly people in the world is growing rapidly. Although there are no liver diseases specific of older age, the ageing liver shows some anatomical and physiological changes that can affect the frequency and the clinical behavior of most hepatopathies. In particular, these changes tend to cause an increased vulnerability to acute liver injury and an increased susceptibility to liver fibrosis, accounting for the predisposition to a generally more severe course of liver diseases compared to younger patients. Furthermore, advanced age is also associated with immune system alterations, influencing the manifestation of those hepatopathies that are mediated by host immune response, like viral hepatitis, autoimmune hepatitis but also hepatocellular carcinoma. Despite these changes, total liver function and laboratory values tend to be well maintained in healthy elderly, so that every enzymatic alteration in a geriatric patient should be investigated with the same attention as in a younger one. A proper and early diagnosis is of great importance both considering the age-related more aggressive course of hepatopathies and that age itself does not seem to be a limit for most treatment options, even if specific data are often lacking. This paper focuses on the peculiarities of main liver diseases in geriatrics, with respect to epidemiology, clinical presentation, diagnosis and management, which can be more challenging in advanced age because of the frequent comorbidities and polytherapies.
Liver diseases in the elderly
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Liver diseases in the elderly
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Abenavoli L, Procopio AC, Fagoonee S, Pellicano R, Carbone M, Luzza F, Invernizzi P
* Primary Biliary Cholangitis and Bile Acid Farnesoid X Receptor Agonists (17 visite)
Diseases (ISSN: 2079-9721linking), 2020 Jun 10; 8 (2 ): N/D-N/D.
Impact Factor:
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Di Serafino M, Gioioso M, Severino R, Esposito F, Vezzali N, Ferro F, Pelliccia P, Caprio MG, Iorio R, Vallone G
* Ultrasound findings in paediatric cholestasis: how to image the patient and what to look for (147 visite) (PDF 79 visite)
J Ultrasound (ISSN: 1876-7931linking, 1876-7931electronic), 2020 Mar; 23(1): 1-12.
Impact Factor: 1.547
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Ricco G, Cosma C, Bedogni G, Biasiolo A, Guarino M, Pontisso P, Morisco F, Oliveri F, Cavallone D, Bonino F, Plebani M, Brunetto MR
* Modeling the time-related fluctuations of AFP and PIVKA-II serum levels in patients with cirrhosis undergoing surveillance for hepatocellular carcinoma (23 visite)
Cancer Biomark (ISSN: 1574-0153linking), 2020; 29(2): 189-196.
Impact Factor: 3.436
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Camera L, Pezzullo F, Acampora A, Liuzzi R, Rispo A, Nardone OM, Luglio G, Bucci L, Castiglione F, Brunetti A
* Multi-detector CT enterography in active inflammatory bowel disease: Image quality and diagnostic efficacy of a low-radiation high contrast protocol (75 visite)
Clin Imaging (ISSN: 0899-7071linking), 2019 Nov; 58: 27-33.
Impact Factor: 0.658
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Durazzo M, Bonetto S, Fagoonee S, Morgando A, Pellicano R
* Management of primary biliary cholangitis prior to obeticholic acid availability (122 visite)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 2018 Dec; 109(6): 410-417.
Impact Factor: 0.913
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Testino G, Leone S, Fagoonee S
* Hepatitis C virus, alcohol use disorders and hepatocellular carcinoma (138 visite)
Panminerva Med (ISSN: 1827-1898electronic, 0031-0808linking), 2018 Jul 10; N/D: N/D-N/D.
Impact Factor: 1.957
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Caviglia GP, Fagoonee S
* Role and function of exosomal miR-9-3p in hepatocellular carcinoma (231 visite)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 2018 Feb; 109(1): 4-6.
Impact Factor: 0.913
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Ricco G, Cavallone D, Cosma C, Caviglia GP, Oliveri F, Biasiolo A, Abate ML, Plebani M, Smedile A, Bonino F, Pontisso P, Brunetto MR
* Impact of etiology of chronic liver disease on hepatocellular carcinoma biomarkers (333 visite)
Cancer Biomark (ISSN: 1574-0153), 2017 Dec 15; 21(3): 603-612.
Impact Factor: 2.392
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Durazzo M, Campion D, Fagoonee S, Pellicano R
* Gastrointestinal tract disorders in the elderly (234 visite)
Hepatology (ISSN: 0026-4806, 1827-1669electronic, 0026-4806linking), 2017 Dec; 108(6): 575-591.
Impact Factor: 2.863
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Imbriaco M, De LucaS, Coppola M, Fusari M, Klain M, Puglia M, Mainenti P, Liuzzi R, Maurea S
* Diagnostic Accuracy of Gd-EOB-DTPA for Detection Hepatocellular Carcinoma (HCC): A Comparative Study with Dynamic Contrast Enhanced Magnetic Resonance Imaging (MRI) and Dynamic Contrast Enhanced Computed Tomography (CT) (231 visite)
Pol J Radiol (ISSN: 1733-134xprint, 1733-134xlinking, 1899-0967electronic), 2017 Feb 01; 82: 50-57.
Impact Factor: 0.567
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Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (321 visite)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
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Pelagalli A, Nardelli A, Fontanella R, Zannetti A
* Inhibition of AQP1 Hampers Osteosarcoma and Hepatocellular Carcinoma Progression Mediated by Bone Marrow-Derived Mesenchymal Stem Cells (399 visite) (PDF 305 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2016 Jul 11; 17(7): N/D-N/D.
Impact Factor: 4.556
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Camera L, Romano F, Liccardo I, Liuzzi R, Imbriaco M, Mainenti PP, Pizzuti LM, Segreto S, Maurea S, Brunetti A
* Balancing Radiation and Contrast Media Dose in Single-Pass Abdominal Multidetector CT: Prospective Evaluation of Image Quality (344 visite)
Acad Radiol (ISSN: 1076-6332, 1878-4046electronic, 1076-6332linking), 2015 Nov; 22(11): 1419-1426.
Impact Factor: 1.966
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Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (886 visite) (PDF 273 visite)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 7.36
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Erra P, Puglia M, Ragozzino A, Maurea S, Liuzzi R, Sabino G, Barbuto L, Cuocolo A, Imbriaco M
* Appearance of hepatocellular carcinoma on gadoxetic acid-enhanced hepato-biliary phase MR imaging: a systematic review (241 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 0033-8362linking), 2015 Apr 22; 120(11): 1002-1011.
Impact Factor: 1.523
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (502 visite)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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Moccia M, Erro R, Montella S, Carotenuto A, Pappata S, Orefice G
* Diagnostic challenges of Parkinsonism occurring in multiple sclerosis (230 visite)
Acta Neurol Belg (ISSN: 0300-9009), 2014 Oct 12; 115(3): 513-515.
Impact Factor: 0.894
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Strianese D, Piscopo R, Elefante A, Napoli M, Comune C, Baronissi I, Liuzzi R, Ferrara M, D'Alessandro A, Ruggiero P, Napolitano P, Grassi P, Iuliano A, Russo C, Brunetti A, Bonavolontà G
* Unilateral Proptosis In Thyroid Eye Disease With Subsequent Contralateral Involvement: Retrospective Follow-Up Study (354 visite)
Bmc Ophthalmol (ISSN: 1471-2415), 2013 May 30; 13(1): 21-21.
Impact Factor: 1.075
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Lanzillo R, Mancini M, Liuzzi R, Di Donato O, Salvatore E, Maglio V, Vacca G, Amato L, D'Anna G, Brunetti A, Brescia Morra V
* Chronic cerebrospinal venous insufficiency in multiple sclerosis: a highly prevalent age-dependent phenomenon (400 visite)
Bmc Neurol (ISSN: 1471-2377, 1471-2377linking), 2013 Feb 13; 13: 20-20.
Impact Factor: 2.486
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Franchin A, Corradin ML, Giantin V, Rossi F, Zanatta F, Attanasio F, Toffanello ED, Manzato E
* Diabetes in a geriatric ward: Efficacy and safety of new insulin analogs in very old inpatients (268 visite)
Aging Clin Exp Res (ISSN: 1594-0667, 1720-8319), 2012 Jun; 24(SUPPL.3): 17-19.
Impact Factor: 1.006
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Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G
* Age-related impairment in insulin release: The essential role of β 2-adrenergic receptor (422 visite)
Diabetesdiabetes (ISSN: 0012-1797), 2012; 61(3): 692-701.
Impact Factor: 7.895
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Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Gasperi M, Prinster A, Vacca G, Pivonello C, Orefice G, Colao A, Morra VB
* Insulin-like growth factor (IGF)-I and IGF-binding protein-3 serum levels in relapsing-remitting and secondary progressive multiple sclerosis patients (295 visite)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic), 2011 Dec; 18(12): 1402-1406.
Impact Factor: 3.692
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Durazzo M, Campion D, Fagoonee S, Pellicano R, Sonne JU, Erckenbrecht JF, Grassi M, Petraccia L, Mennuni G, Fontana M, Scarno A, Sabetta S, Fraioli A
* Changes, functional disorders, and diseases in the gastrointestinal tract of elderly (149 visite)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking, 1432-1289electronic), 2011 Jul; 2655108(6): 659-668.
Impact Factor: 0.913
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (378 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Di Lorenzo G, Imbimbo M, Leopardo D, Marciano R, Federico P, Buonerba C, Salvatore B, Marinelli A, Palmieri G. A
* A long-lasting response to sorafenib treatment in an advanced hepatocellular carcinoma patient (253 visite)
Int J Immunopathol Pharmacol (ISSN: 0394-6320), 2010 Jul; 23(3): 951-954.
Impact Factor: 2.685
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Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M
* Bone mineral density in children, adolescents, and young adults with epilepsy (332 visite)
Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146.
Impact Factor: 4.052
Dettagli Esporta in BibTeX Esporta in EndNote
Lanzillo R, Di Somma C, Quarantelli M, Gasperi M, Ventrella G, Prinster A, Vacca G, Orefice G, Colao A, Morra VB
* Serum levels of insulin like growth factor-1 and insulin like growth factor binding protein-3 in relapsing and secondary progressive multiple sclerosis (316 visite)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2009 Sep; 15(9): 1402-1406.
Impact Factor: 3.279
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Gentile I, Viola C, Graf M, Liuzzi R, Quarto M, Cerini R, Piazza M, Borgia G
* A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis (361 visite)
J Clin Gastroenterol (ISSN: 0192-0790), 2009 Jan; 43(1): 81-87.
Impact Factor: 2.207
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De Renzo A, Perna F, Persico M, Mainolfi C, Pace L
* 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of early response in a primary hepatic lymphoma (212 visite)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2006 Jun; 133(6): 580-580.
Impact Factor: 4.498
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Morante A, Romano M, Cuomo A, De Sio I, Cozzolino A, Mucherino C, Salerno R, Blanco C, Romano M
* Massive gastric ulceration after transarterial chemoembolization for hepatocellular carcinoma (170 visite)
Gastrointestinal Endoscopy (ISSN: 0016-5107), 2006 Apr; 63(4): 718-720.
Impact Factor: 4.825
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Sirignano C, Soscia E, Mainenti PP, Camera L, Salvatore M
* Tumor Thrombus In The Right Atrium And In The Inferior Vena Cava As Primary Clinical Manifestations Of Hepatocellular Carcinoma. A Case Report (273 visite)
42 Congresso Nazionale Sirm Milano, 2006; N/D: 1-3.
Impact Factor: 0
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Perrone-Filardi P, Cuocolo A, Brevetti G, Silvestro A, Storto G, Dellegrottaglie S, Corrado L, Cafiero M, Camerino R, Polimeno M, Zarrilli A, Caiazzo G, Maglione A, Petretta A, Chiariello M
* Sodium and diseases in the aged (229 visite)
Clin Ter, 2005 Nov 1; 138(5-6): 199-205.
Impact Factor: 0.329
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Tamburrini S, Brunetti A, Brown MA, Sirlin CB, Casola G
* CT appearance of the normal appendix in adults (277 visite)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic), 2005 Oct; 15(10): 2096-2103.
Impact Factor: 2.437
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
* Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (312 visite)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
Impact Factor: 1.496
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (369 visite)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Romano M, Giojelli A, Tamburrini O, Salvatore M
* Chemoembolization for hepatocellular carcinoma: Effect of intraarterial lidocaine in peri- and post-procedural pain and hospitalization (402 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2003 Apr; 105(4): 350-355.
Impact Factor: 1.368
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Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (392 visite)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
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Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M
Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (481 visite) (PDF 587 visite)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic), 1998 Mar; 39(3): 497-499.
Impact Factor: 2.962
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Ferrara LA, Marotta T, Mainenti G, Borrelli R, Mancini M, Soro S
Resting blood pressure and cardiovascular response to sympathetic stimulation in adolescents (256 visite)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic), 1992 Sep; 36(2): 197-201.
Impact Factor: 0.61
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Romano M, Cerra M, Salvatore M, Onorati A
Effects of ionizing radiations on the activity of valyl tRNA synthetase isolated from rat liver and from Morris hepatoma 7777 (808 visite)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 1974 Jul; 60(4): 301-306.
Impact Factor: 0.408
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45 Records (44 escludendo Abstract e Conferenze).
Impact factor totale: 115.279 (110.781 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 97.578 (92.703 escludendo Abstract e Conferenze).
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