The essential player in adipogenesis GRP78 is a novel KCTD15 interactor(11 visite) Smaldone G, Pirone L, Capolupo A, Vitagliano L, Monti MC, Di Gaetano S, Pedone E
Impact factor: 1.427, Impact factor a 5 anni: 3.227
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Parole chiave: 3t3-L1 Cells, Adipocytes, Cytology, Metabolism, Adipogenesis, Animals, Heat-Shock Proteins, Mice, Potassium Channels, Protein Binding, Interactors, Kctd Family,
Affiliazioni:
*** IBB - CNR *** IRCCS SDN, Naples, Italy., Institute of Biostructures and Bioimaging, CNR, Naples 80134, Italy., Department of Pharmacy, University of Salerno, Fisciano, Salerno 84084, Italy; PhD Program in Drug Discovery and Development, University of Salerno, Fisciano, SA 84084, Italy., Department of Pharmacy, University of Salerno, Fisciano, Salerno 84084, Italy. Electronic address: mcmonti@unisa.it., Institute of Biostructures and Bioimaging, CNR, Naples 80134, Italy. Electronic address: digaetan@unina.it., Institute of Biostructures and Bioimaging, CNR, Naples 80134, Italy. Electronic address: empedone@unina.it.,
Riferimenti:
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KCTD15 is a member of the K+ Channel Tetramerization Domain family, implicated in crucial physio-pathological processes. Recent evidences suggest that KCTD15 is an obesity-linked protein in humans and its Drosophila homologue is involved in food uptake. KCTD15 molecular mechanism in these processes is still unknown. To fill this gap, KCTD15 was biophysically characterized showing a folded, pentameric region endowed with a remarkable thermal stability. Notably, the C-terminal domain significantly contributes to the stabilization of the BTB N-terminal domain. The availability of large amount of stable recombinant protein also made possible a functional proteomic approach in 3T3-L1 cells to search for novel KCTD15 interactors. These investigations led to the discovery that GRP78 is a KCTD15 partner in all the adipogenesis phases. Our data clearly prove the physical interaction of the two proteins and also indicate that GRP78 plays an active role in the stabilization of KCTD15. Furthermore, the presence in Drosophila of a GRP78 homologue corroborates the physiological role played by the complex KCTD15-GRP78 in the adipogenesis process and indicates that it is evolutionarily conserved. Present results also suggest that KCTD15 may be a new target for obesity control.
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(20 visite) NEW ENGL J MED (ISSN: 0028-4793), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 DettagliEsporta in BibTeXEsporta in EndNote
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489 Records (452 escludendo Abstract e Conferenze). Impact factor totale: 2146.543 (1993.764 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 2234.004 (2068.633 escludendo Abstract e Conferenze).
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