Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?(31 visite) Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
Frontiers In Molecular Neuroscience (ISSN: 1662-5099, 1662-5099linking), 2018 Nov 13; 11: 414-414.
*** IBB - CNR *** Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy Department of Drug Sciences, University of Catania, Catania, Italy Institute of Biostructure and Bioimaging, National Research Council, Catania, Italy Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy Neuromed, Istituto di Ricovero e Cura a Carattere Scientifico, Pozzilli, Italy Oasi Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico, Troina, Italy
Riferimenti:
Abdul-Ghani, M.A., Valiante, T.A., Carlen, P.L., Pennefather, P.S., Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neurons (1996) J. Neurophysiol., 76, pp. 2691-270
Agrawal, S.K., Theriault, E., Fehlings, M.G., Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury (1998) J. Neurotrauma, 15, pp. 929-941
Agulhon, C., Petravicz, J., McMullen, A.B., Sweger, E.J., Minton, S.K., Taves, S.R., What is the role of astrocyte calcium in neurophysiology? (2008) Neuron, 59, pp. 932-946
Anneser, J.M., Chahli, C., Ince, P.G., Borasio, G.D., Shaw, P.J., Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis (2004) J. Neuropathol. Exp. Neurol., 63, pp. 831-840
Aronica, E., Catania, M.V., Geurts, J., Yankaya, B., Troost, D., Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: Upregulation in reactive astrocytes (2001) Neuroscience, 105, pp. 509-520
Aronica, E., Gorter, J.A., Ijlst-Keizers, H., Rozemuller, A.J., Yankaya, B., Leenstra, S., Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: Opposite regulation of glutamate transporter proteins (2003) Eur. J. Neurosci, 17, pp. 2106-2118
Bakiri, Y., Karadottir, R., Cossell, L., Attwell, D., Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellum (2011) J. Physiol., 589, pp. 559-573
Balazs, R., Miller, S., Romano, C., de Vries, A., Chun, Y., Cotman, C.W., Metabotropic glutamate receptor mGluR5 in astrocytes: Pharmacological properties and agonist regulation (1997) J. Neurochem., 69, pp. 151-163
Barger, S.W., Basile, A.S., Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function (2001) J. Neurochem., 76, pp. 846-854
Battaglia, G., Busceti, C.L., Molinaro, G., Biagioni, F., Traficante, A., Nicoletti, F., Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2006) J. Neurosci., 26, pp. 7222-7229
Battaglia, G., Molinaro, G., Riozzi, B., Storto, M., Busceti, C.L., Spinsanti, P., Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons (2009) Plos One, 4
Battaglia, G., Riozzi, B., Bucci, D., Di Menna, L., Molinaro, G., Pallottino, S., Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis (2015) Neurobiol. Dis., 74, pp. 126-136
Benatti, C., Blom, J.M., Rigillo, G., Alboni, S., Zizzi, F., Torta, R., Disease-induced neuroinflammation and depression (2016) CNS Neurol. Disord. Drug Targets, 15, pp. 414-433
Beneventano, M., Spampinato, S.F., Merlo, S., Chisari, M., Platania, P., Ragusa, M., Shedding of microvesicles from microglia contributes to the effects induced by metabotropic glutamate receptor 5 activation on neuronal death (2017) Front. Pharmacol., 8, p. 812
Berger, J.V., Dumont, A.O., Focant, M.C., Vergouts, M., Sternotte, A., Calas, A.G., Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes (2012) Neuroscience, 205, pp. 29-38
Besong, G., Battaglia, G., D’Onofrio, M., Di Marco, R., Ngomba, R.T., Storto, M., Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures (2002) J. Neurosci., 22, pp. 5403-5411
Betts, M.J., O’Neill, M.J., Duty, S., Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson’s disease (2012) Br. J. Pharmacol., 166, pp. 2317-2330
Block, M.L., Hong, J.S., Chronic microglial activation and progressive dopaminergic neurotoxicity (2007) Biochem. Soc. Trans., 35, pp. 1127-1132
Blumcke, I., Behle, K., Malitschek, B., Kuhn, R., Knopfel, T., Wolf, H.K., Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3, mGluR4a and mGluR5 in human hippocampus (1996) Brain Res, 736, pp. 217-226
Boer, K., Encha-Razavi, F., Sinico, M., Aronica, E., Differential distribution of group I metabotropic glutamate receptors in developing human cortex (2010) Brain Res, 1324, pp. 24-33
Bond, A., Jones, N.M., Hicks, C.A., Whiffin, G.M., Ward, M.A., O’Neill, M.F., Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: Investigations into possible mechanism of action in vivo (2000) J. Pharmacol. Exp. Ther, 294, pp. 800-809
Bond, A., O’Neill, M.J., Hicks, C.A., Monn, J.A., Lodge, D., Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia (1998) Neuroreport, 9, pp. 1191-1193
Bonde, C., Sarup, A., Schousboe, A., Gegelashvili, G., Zimmer, J., Noraberg, J., Neurotoxic and neuroprotective effects of the glutamate transporter inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) during physiological and ischemia-like conditions (2003) Neurochem. Int., 43, pp. 371-380
Bradley, S.J., Challiss, R.A., Defining protein kinase/phosphatase isoenzymic regulation of mGlu(5) receptor-stimulated phospholipase C and Ca2 + responses in astrocytes (2011) Br. J. Pharmacol., 164, pp. 755-771. , doi: 10.1111/j. 1476-5381.2011.01421.x
Bruno, V., Battaglia, G., Casabona, G., Copani, A., Caciagli, F., Nicoletti, F., Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta (1998) J. Neurosci., 18, pp. 9594-9600
Bruno, V., Caraci, F., Copani, A., Matrisciano, F., Nicoletti, F., Battaglia, G., The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (2017) Neuropharmacology, 115, pp. 180-192
Butt, A.M., Vanzulli, I., Papanikolaou, M., de La Rocha, I.C., Hawkins, V.E., Metabotropic glutamate receptors protect oligodendrocytes from acute ischemia in the mouse optic nerve (2017) Neurochem. Res., 42, pp. 2468-2478
Byrnes, K.R., Loane, D.J., Stoica, B.A., Zhang, J., Faden, A.I., Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury (2012) J. Neuroinflammation, 9, p. 43
Byrnes, K.R., Stoica, B., Loane, D.J., Riccio, A., Davis, M.I., Faden, A.I., Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity (2009) Glia, 57, pp. 550-560
Cai, Z., Schools, G.P., Kimelberg, H.K., Metabotropic glutamate receptors in acutely isolated hippocampal astrocytes: Developmental changes of mGluR5 mRNA and functional expression (2000) Glia, 29, pp. 70-80
Caraci, F., Gulisano, W., Guida, C.A., Impellizzeri, A.A., Drago, F., Puzzo, D., A key role for TGF-beta1 in hippocampal synaptic plasticity and memory (2015) Sci. Rep., 5
Caraci, F., Molinaro, G., Battaglia, G., Giuffrida, M.L., Riozzi, B., Traficante, A., Targeting group II metabotropic glutamate (MGlu) receptors for the treatment of psychosis associated with Alzheimer’s disease: Selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (2011) Mol. Pharmacol., 79, pp. 618-626
Caraci, F., Nicoletti, F., Copani, A., Metabotropic glutamate receptors: The potential for therapeutic applications in Alzheimer’s disease (2018) Curr. Opin. Pharmacol., 38, pp. 1-7
Caraci, F., Spampinato, S.F., Morgese, M.G., Tascedda, F., Salluzzo, M.G., Giambirtone, M.C., Neurobiological links between depression and AD: The role of TGF-beta1 signaling as a new pharmacological target (2018) Pharmacol. Res, 130, pp. 374-384. , (b)
Casley, C.S., Lakics, V., Lee, H.G., Broad, L.M., Day, T.A., Cluett, T., Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-beta peptide (2009) Brain Res, 1260, pp. 65-75
Cha, J.H., Farrell, L.A., Ahmed, S.F., Frey, A., Hsiao-Ashe, K.K., Young, A.B., Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein (2001) Neurobiol. Dis., 8, pp. 90-102
Chen, J.H., Ke, K.F., Lu, J.H., Qiu, Y.H., Peng, Y.P., Protection of TGF-beta1 against neuroinflammation and neurodegeneration in Abeta1-42-induced Alzheimer’s disease model rats (2015) Plos One, 10
Chiechio, S., Modulation of chronic pain by metabotropic glutamate receptors (2016) Adv. Pharmacol., 75, pp. 63-89
Ciccarelli, R., D’Alimonte, I., Ballerini, P., D’Auro, M., Nargi, E., Buccella, S., Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes (2007) Mol. Pharmacol., 71, pp. 1369-1380
Ciccarelli, R., Di Iorio, P., Bruno, V., Battaglia, G., D’Alimonte, I., D’Onofrio, M., Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes (1999) Glia, 27, pp. 275-281
Ciccarelli, R., Sureda, F.X., Casabona, G., Di Iorio, P., Caruso, A., Spinella, F., Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and-5 on astrocyte proliferation in culture (1997) Glia, 21, pp. 390-398
Conn, P.J., Pin, J.P., Pharmacology and functions of metabotropic glutamate receptors (1997) Annu. Rev. Pharmacol. Toxicol., 37, pp. 205-237
Corti, C., Battaglia, G., Molinaro, G., Riozzi, B., Pittaluga, A., Corsi, M., The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection (2007) J. Neurosci., 27, pp. 8297-8308
D’Antoni, S., Berretta, A., Seminara, G., Longone, P., Giuffrida-Stella, A.M., Battaglia, G., A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death (2011) Neurobiol. Dis., 42, pp. 252-264
Deng, W., Rosenberg, P.A., Volpe, J.J., Jensen, F.E., Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 6801-6806
Deng, W., Wang, H., Rosenberg, P.A., Volpe, J.J., Jensen, F.E., Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress (2004) Proc. Natl. Acad. Sci. U.S.A, 101, pp. 7751-7756
Dewapriya, P., Li, Y.X., Himaya, S.W., Pangestuti, R., Kim, S.K., Neoechinulin A suppresses amyloid-beta oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity (2013) Neurotoxicology, 35, pp. 30-40
Dewar, D., Chalmers, D.T., Graham, D.I., McCulloch, J., Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer’s disease: An autoradiographic study of the hippocampus (1991) Brain Res, 553, pp. 58-64
Ding, S., Fellin, T., Zhu, Y., Lee, S.Y., Auberson, Y.P., Meaney, D.F., Enhanced astrocytic Ca2 + signals contribute to neuronal excitotoxicity after status epilepticus (2007) J. Neurosci, 27, pp. 10674-10684
Doble, A., The role of excitotoxicity in neurodegenerative disease: Implications for therapy (1999) Pharmacol. Ther., 81, pp. 163-221
Drouin-Ouellet, J., Brownell, A.L., Saint-Pierre, M., Fasano, C., Emond, V., Trudeau, L.E., Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions (2011) Glia, 59, pp. 188-199
Dugan, L.L., Choi, D.W., Excitotoxicity, free radicals, and cell membrane changes (1994) Ann. Neurol, 35, pp. S17-S21
Durand, D., Carniglia, L., Beauquis, J., Caruso, C., Saravia, F., Lasaga, M., Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage (2014) Neuropharmacology, 79, pp. 180-189
Durand, D., Caruso, C., Carniglia, L., Lasaga, M., Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes (2010) J. Neurochem., 112, pp. 420-433
Ettle, B., Schlachetzki, J.C.M., Winkler, J., Oligodendroglia and myelin in neurodegenerative diseases: More than just bystanders? (2016) Mol. Neurobiol., 53, pp. 3046-3062
Farso, M.C., O’Shea, R.D., Beart, P.M., Evidence group I mGluR drugs modulate the activation profile of lipopolysaccharide-exposed microglia in culture (2009) Neurochem. Res., 34, pp. 1721-1728
Fazio, F., Ulivieri, M., Volpi, C., Gargaro, M., Fallarino, F., Targeting metabotropic glutamate receptors for the treatment of neuroinflammation (2018) Curr. Opin. Pharmacol., 38, pp. 16-23
Fazio, F., Zappulla, C., Notartomaso, S., Busceti, C., Bessede, A., Scarselli, P., Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice (2014) Neuropharmacology, 81, pp. 237-243
Fellner, L., Stefanova, N., The role of glia in alpha-synucleinopathies (2013) Mol. Neurobiol., 47, pp. 575-586
Fern, R.F., Matute, C., Stys, P.K., White matter injury: Ischemic and nonischemic (2014) Glia, 62, pp. 1780-1789
Ferrer, I., Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner (2018) Prog. Neurobiol., 169, pp. 24-54
Fiacco, T.A., Agulhon, C., McCarthy, K.D., Sorting out astrocyte physiology from pharmacology (2009) Annu. Rev. Pharmacol. Toxicol., 49, pp. 151-174
Gegelashvili, G., Dehnes, Y., Danbolt, N.C., Schousboe, A., The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms (2000) Neurochem. Int., 37, pp. 163-170
Geurts, J.J., Wolswijk, G., Bo, L., Redeker, S., Ramkema, M., Troost, D., Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions (2005) J. Neuroimmunol., 158, pp. 182-190
Giordano, C., Cristino, L., Luongo, L., Siniscalco, D., Petrosino, S., Piscitelli, F., TRPV1-dependent and-independent alterations in the limbic cortex of neuropathic mice: Impact on glial caspases and pain perception (2012) Cereb. Cortex, 22, pp. 2495-2518
Gomez-Nicola, D., Perry, V.H., Microglial dynamics and role in the healthy and diseased brain: A paradigm of functional plasticity (2015) Neuroscientist, 21, pp. 169-184
Guida, F., Luongo, L., Marmo, F., Romano, R., Iannotta, M., Napolitano, F., Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice (2015) Mol. Brain, 8
Gwak, Y.S., Hulsebosch, C.E., Upregulation of Group I metabotropic glutamate receptors in neurons and astrocytes in the dorsal horn following spinal cord injury (2005) Exp. Neurol., 195, pp. 236-243
Hamilton, N., Vayro, S., Wigley, R., Butt, A.M., Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia (2010) Glia, 58, pp. 66-79
Hardingham, G.E., Bading, H., The Yin and Yang of NMDA receptor signalling (2003) Trends Neurosci, 26, pp. 81-89
Harris, J.J., Attwell, D., The energetics of CNS white matter (2012) J. Neurosci., 32, pp. 356-371
Hathaway, H.A., Pshenichkin, S., Grajkowska, E., Gelb, T., Emery, A.C., Wolfe, B.B., Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism (2015) Neuropharmacology, 93, pp. 199-208
Hellyer, S., Leach, K., Gregory, K.J., Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation (2017) Curr. Opin. Pharmacol., 32, pp. 49-55
Heneka, M.T., Rodriguez, J.J., Verkhratsky, A., Neuroglia in neurodegeneration (2010) Brain Res. Rev., 63, pp. 189-211
Homayoun, H., Moghaddam, B., Group 5 metabotropic glutamate receptors: Role in modulating cortical activity and relevance to cognition (2010) Eur. J. Pharmacol., 639, pp. 33-39
Hossain, M.Z., Unno, S., Ando, H., Masuda, Y., Kitagawa, J., Neuron-glia crosstalk and neuropathic pain: Involvement in the modulation of motor activity in the orofacial region (2017) Int. J. Mol. Sci., 18
Huang, Y.Y., Zhang, Q., Zhang, J.N., Zhang, Y.N., Gu, L., Yang, H.M., Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson’s disease (2018) Brain Behav. Immun., 71, pp. 93-107
Iacovelli, L., Bruno, V., Salvatore, L., Melchiorri, D., Gradini, R., Caricasole, A., Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways (2002) J. Neurochem., 82, pp. 216-223
Iacovelli, L., Felicioni, M., Nistico, R., Nicoletti, F., de Blasi, A., Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins (2014) Neuropharmacology, 77, pp. 303-312
Ibanez, C.F., Andressoo, J.O., Biology of GDNF and its receptors-Relevance for disorders of the central nervous system (2017) Neurobiol. Dis, 97, pp. 80-89
Iyer, A.M., van Scheppingen, J., Milenkovic, I., Anink, J.J., Lim, D., Genazzani, A.A., Metabotropic glutamate receptor 5 in Down’s syndrome hippocampus during development: Increased expression in astrocytes (2014) Curr. Alzheimer Res., 11, pp. 694-705
Jantas, D., Lech, T., Golda, S., Pilc, A., Lason, W., New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection (2018) Neuropharmacology, 141, pp. 223-237
Jantzie, L.L., Talos, D.M., Selip, D.B., An, L., Jackson, M.C., Folkerth, R.D., Developmental regulation of group I metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia (2010) Neuron Glia Biol, 6, pp. 277-288
Ji, R.R., Xu, Z.Z., Gao, Y.J., Emerging targets in neuroinflammation-driven chronic pain (2014) Nat. Rev. Drug Discov., 13, pp. 533-548
Kammermeier, P.J., Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers (2012) Mol. Pharmacol., 82, pp. 438-447
Kaushal, V., Schlichter, L.C., Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra (2008) J. Neurosci., 28, pp. 2221-2230
Kelland, E.E., Toms, N.J., Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death (2001) Eur. J. Pharmacol., 424, pp. R3-R4
Kim, S.U., de Vellis, J., Microglia in health and disease (2005) J. Neurosci. Res., 81, pp. 302-313
Klaver, R., de Vries, H.E., Schenk, G.J., Geurts, J.J., Grey matter damage in multiple sclerosis: A pathology perspective (2013) Prion, 7, pp. 66-75
Knezevic, D., Mizrahi, R., Molecular imaging of neuroinflammation in Alzheimer’s disease and mild cognitive impairment (2018) Prog. Neuropsychopharmacol. Biol. Psychiatry, 80, pp. 123-131
Kobayashi, K., Hayashi, M., Nakano, H., Fukutani, Y., Sasaki, K., Shimazaki, M., Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer’s disease (2002) Neuropathol. Appl. Neurobiol., 28, pp. 238-251
Le Poul, E., Bolea, C., Girard, F., Poli, S., Charvin, D., Campo, B., A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson’s disease (2012) J. Pharmacol. Exp. Ther., 343, pp. 167-177
Lim, D., Iyer, A., Ronco, V., Grolla, A.A., Canonico, P.L., Aronica, E., Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB (2013) Glia, 61, pp. 1134-1145
Liu, F., Zhou, R., Yan, H., Yin, H., Wu, X., Tan, Y., Metabotropic glutamate receptor 5 modulates calcium oscillation and innate immune response induced by lipopolysaccharide in microglial cell (2014) Neuroscience, 281, pp. 24-34
Liu, G.J., Nagarajah, R., Banati, R.B., Bennett, M.R., Glutamate induces directed chemotaxis of microglia (2009) Eur. J. Neurosci., 29, pp. 1108-1118
Lujan, R., Shigemoto, R., Lopez-Bendito, G., Glutamate and GABA receptor signalling in the developing brain (2005) Neuroscience, 130, pp. 567-580
Luyt, K., Varadi, A., Durant, C.F., Molnar, E., Oligodendroglial metabotropic glutamate receptors are developmentally regulated and involved in the prevention of apoptosis (2006) J. Neurochem., 99, pp. 641-656
Macrez, R., Stys, P.K., Vivien, D., Lipton, S.A., Docagne, F., Mechanisms of glutamate toxicity in multiple sclerosis: Biomarker and therapeutic opportunities (2016) Lancet Neurol, 15, pp. 1089-1102
Martin, G.M., Molecular mechanisms of late life dementias (2000) Exp. Gerontol., 35, pp. 439-443
Mastroiacovo, F., Moyanova, S., Cannella, M., Gaglione, A., Verhaeghe, R., Bozza, G., Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia (2017) Mol. Brain, 10
Mosher, K.I., Wyss-Coray, T., Microglial dysfunction in brain aging and Alzheimer’s disease (2014) Biochem. Pharmacol., 88, pp. 594-604
Motolese, M., Mastroiacovo, F., Cannella, M., Bucci, D., Gaglione, A., Riozzi, B., Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage (2015) Mol. Brain, 8
Nakamichi, N., Yoshida, K., Ishioka, Y., Makanga, J.O., Fukui, M., Yoneyama, M., Group III metabotropic glutamate receptor activation suppresses self-replication of undifferentiated neocortical progenitor cells (2008) J. Neurochem., 105, pp. 1996-2012
Newcombe, J., Uddin, A., Dove, R., Patel, B., Turski, L., Nishizawa, Y., Glutamate receptor expression in multiple sclerosis lesions (2008) Brain Pathol, 18, pp. 52-61
Nguyen, D., Alavi, M.V., Kim, K.Y., Kang, T., Scott, R.T., Noh, Y.H., A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics (2011) Cell Death Dis, 2, p. e240
Nicoletti, F., Bockaert, J., Collingridge, G.L., Conn, P.J., Ferraguti, F., Schoepp, D.D., Metabotropic glutamate receptors: From the workbench to the bedside (2011) Neuropharmacology, 60, pp. 1017-1041
Niswender, C.M., Conn, P.J., Metabotropic glutamate receptors: Physiology, pharmacology, and disease (2010) Annu. Rev. Pharmacol. Toxicol., 50, pp. 295-322
Oliet, S.H., Piet, R., Poulain, D.A., Control of glutamate clearance and synaptic efficacy by glial coverage of neurons (2001) Science, 292, pp. 923-926
Olmos, G., Llado, J., Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity (2014) Mediators Inflamm, 2014
O’Riordan, K.J., Huang, I.C., Pizzi, M., Spano, P., Boroni, F., Egli, R., Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors (2006) J. Neurosci., 26, pp. 4870-4879
Palazzo, E., Marabese, I., Luongo, L., Guida, F., de Novellis, V., Maione, S., Nociception modulation by supraspinal group III metabotropic glutamate receptors (2017) J. Neurochem., 141, pp. 507-519
Paquet, M., Ribeiro, F.M., Guadagno, J., Esseltine, J.L., Ferguson, S.S., Cregan, S.P., Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis (2013) Mol. Brain, 6, p. 9
Pickering, M., Cumiskey, D., O’Connor, J.J., Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system (2005) Exp. Physiol., 90, pp. 663-670
Pin, J.P., Bettler, B., Organization and functions of mGlu and GABAB receptor complexes (2016) Nature, 540, pp. 60-68
Pinteaux-Jones, F., Sevastou, I.G., Fry, V.A., Heales, S., Baker, D., Pocock, J.M., Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors (2008) J. Neurochem., 106, pp. 442-454
Ponnazhagan, R., Harms, A.S., Thome, A.D., Jurkuvenaite, A., Gogliotti, R., Niswender, C.M., The metabotropic glutamate receptor 4 positive allosteric modulator ADX88178 inhibits inflammatory responses in primary microglia (2016) J. Neuroimmune Pharmacol., 11, pp. 231-237
Rodriguez-Kern, A., Gegelashvili, M., Schousboe, A., Zhang, J., Sung, L., Gegelashvili, G., Beta-amyloid and brain-derived neurotrophic factor, BDNF, up-regulate the expression of glutamate transporter GLT-1/EAAT2 via different signaling pathways utilizing transcription factor NF-κB (2003) Neurochem. Int., 43, pp. 363-370
Romano, C., Smout, S., Miller, J.K., O’Malley, K.L., Developmental regulation of metabotropic glutamate receptor 5b protein in rodent brain (2002) Neuroscience, 111, pp. 693-698
Rosenbluth, J., Multiple functions of the paranodal junction of myelinated nerve fibers (2009) J. Neurosci. Res., 87, pp. 3250-3258
Rossi, D.J., Oshima, T., Attwell, D., Glutamate release in severe brain ischaemia is mainly by reversed uptake (2000) Nature, 403, pp. 316-321
Rothstein, J.D., van Kammen, M., Levey, A.I., Martin, L.J., Kuncl, R.W., Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis (1995) Ann. Neurol., 38, pp. 73-84
Schafer, D.P., Lehrman, E.K., Kautzman, A.G., Koyama, R., Mardinly, A.R., Yamasaki, R., Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner (2012) Neuron, 74, pp. 691-705
Shah, A., Silverstein, P.S., Singh, D.P., Kumar, A., Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes (2012) J. Neuroinflammation, 9, p. 52
Shrivastava, A.N., Kowalewski, J.M., Renner, M., Bousset, L., Koulakoff, A., Melki, R., Beta-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors (2013) Glia, 61, pp. 1673-1686
Sorensen, T.L., Tani, M., Jensen, J., Pierce, V., Lucchinetti, C., Folcik, V.A., Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients (1999) J. Clin. Invest., 103, pp. 807-815
Strachan-Whaley, M., Rivest, S., Yong, V.W., Interactions between microglia and T cells in multiple sclerosis pathobiology (2014) J. Interferon Cytokine Res., 34, pp. 615-622
Streit, W.J., Xue, Q.S., Human CNS immune senescence and neurodegeneration (2014) Curr. Opin. Immunol., 29, pp. 93-96
Sun, W., McConnell, E., Pare, J.F., Xu, Q., Chen, M., Peng, W., Glutamate-dependent neuroglial calcium signaling differs between young and adult brain (2013) Science, 339, pp. 197-200
Tang, F.R., Lee, W.L., Expression of the group II and III metabotropic glutamate receptors in the hippocampus of patients with mesial temporal lobe epilepsy (2001) J. Neurocytol., 30, pp. 137-143
Taylor, D.L., Diemel, L.T., Cuzner, M.L., Pocock, J.M., Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide upregulated in Alzheimer’s disease (2002) J. Neurochem., 82, pp. 1179-1191
Taylor, D.L., Jones, F., Kubota, E.S., Pocock, J.M., Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand (2005) J. Neurosci., 25, pp. 2952-2964
Tichauer, J.E., von Bernhardi, R., Transforming growth factor-beta stimulates beta amyloid uptake by microglia through Smad3-dependent mechanisms (2012) J. Neurosci. Res., 90, pp. 1970-1980
Tilleux, S., Berger, J., Hermans, E., Induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5 (2007) J. Neuroimmunol., 189, pp. 23-30
Tison, F., Keywood, C., Wakefield, M., Durif, F., Corvol, J.C., Eggert, K., A phase 2A trial of the novel mGluR5-negative allosteric modulator dipraglurant for levodopa-induced dyskinesia in parkinson’s disease (2016) Mov. Disord., 31, pp. 1373-1380
Tomimoto, H., Akiguchi, I., Wakita, H., Kimura, J., White matter lesions after occlusion of the bilateral carotid arteries in the rat–temporal profile of cerebral blood flow (CBF), oligodendroglia and myelin (1997) No to Shinkei, 49, pp. 639-644
Ullian, E.M., Sapperstein, S.K., Christopherson, K.S., Barres, B.A., Control of synapse number by glia (2001) Science, 291, pp. 657-661
Vafabakhsh, R., Levitz, J., Isacoff, E.Y., Conformational dynamics of a class C G-protein-coupled receptor (2015) Nature, 524, pp. 497-501
Verderio, C., Extracellular membrane microvesicles and nanotubes in the brain: Understanding their nature, their function in cell-to-cell communication, their role in transcellular spreading of pathological agents and their therapeutic potential (2013) Front. Physiol., 4, p. 163
Verite, J., Janet, T., Chassaing, D., Fauconneau, B., Rabeony, H., Page, G., Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice (2018) J. Neuroinflammation, 15
Vermeiren, C., Hemptinne, I., Vanhoutte, N., Tilleux, S., Maloteaux, J.M., Hermans, E., Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis (2006) J. Neurochem., 96, pp. 719-731
Vermeiren, C., Najimi, M., Vanhoutte, N., Tilleux, S., de Hemptinne, I., Maloteaux, J.M., Acute up-regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes (2005) J. Neurochem., 94, pp. 405-416
Vernon, A.C., Smith, E.J., Stevanato, L., Modo, M., Selective activation of metabotropic glutamate receptor 7 induces inhibition of cellular proliferation and promotes astrocyte differentiation of ventral mesencephalon human neural stem/progenitor cells (2011) Neurochem. Int., 59, pp. 421-431
Wang, J.W., Wang, H.D., Cong, Z.X., Zhang, X.S., Zhou, X.M., Zhang, D.D., Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats (2013) Biochem. Biophys. Res. Commun., 430, pp. 1016-1021
Werner, P., Pitt, D., Raine, C.S., Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage (2001) Ann. Neurol., 50, pp. 169-180
Wilkinson, B.L., Landreth, G.E., The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer’s disease (2006) J. Neuroinflammation, 3, p. 30
Xue, F., Stoica, B.A., Hanscom, M., Kabadi, S.V., Faden, A.I., Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGluR5) attenuate microglial activation (2014) CNS Neurol. Disord. Drug Targets, 13, pp. 558-566
Yang, L., Mao, L., Chen, H., Catavsan, M., Kozinn, J., Arora, A., A signaling mechanism from G alpha q-protein-coupled metabotropic glutamate receptors to gene expression: Role of the c-Jun N-terminal kinase pathway (2006) J. Neurosci., 26, pp. 971-980
Yang, P., Zhang, J., Zhao, L., Jiao, Q., Jin, H., Xiao, X., Developmental distribution pattern of metabotropic glutamate receptor 5 in prenatal human hippocampus (2012) Neurosci. Bull., 28, pp. 704-714
Yao, H.H., Ding, J.H., Zhou, F., Wang, F., Hu, L.F., Sun, T., Enhancement of glutamate uptake mediates the neuroprotection exerted by activating group II or III metabotropic glutamate receptors on astrocytes (2005) J. Neurochem., 92, pp. 948-961
Ye, X., Yu, L., Zuo, D., Zhang, L., Zu, J., Hu, J., Activated mGluR5 protects BV2 cells against OGD/R induced cytotoxicity by modulating BDNF-TrkB pathway (2017) Neurosci. Lett., 654, pp. 70-79
Yin, S., Noetzel, M.J., Johnson, K.A., Zamorano, R., Jalan-Sakrikar, N., Gregory, K.J., Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS (2014) J. Neurosci., 34, pp. 79-94
Zabel, M.K., Kirsch, W.M., From development to dysfunction: Microglia and the complement cascade in CNS homeostasis (2013) Ageing Res. Rev., 12, pp. 749-756
Zhang, Z., Ma, W., Wang, L., Gong, H., Tian, Y., Zhang, J., Activation of type 4 metabotropic glutamate receptor attenuates oxidative stress-induced death of neural stem cells with inhibition of JNK and p38 MAPK signaling (2015) Stem Cells Dev, 24, pp. 2709-2722
Zhao, Z., Nelson, A.R., Betsholtz, C., Zlokovic, B.V., Establishment and dysfunction of the blood-brain barrier (2015) Cell, 163, pp. 1064-1078
Zhou, F., Yao, H.H., Wu, J.Y., Yang, Y.J., Ding, J.H., Zhang, J., Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake (2006) J. Neurosci. Res., 84, pp. 268-277
Zipfel, G.J., Babcock, D.J., Lee, J.M., Choi, D.W., Neuronal apoptosis after CNS injury: The roles of glutamate and calcium (2000) J. Neurotrauma, 17, pp. 857-869
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(64 visite) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 DettagliEsporta in BibTeXEsporta in EndNote
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(42 visite) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 DettagliEsporta in BibTeXEsporta in EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A * Tumor Imaging(146 visite) Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309. Impact Factor:1.148 DettagliEsporta in BibTeXEsporta in EndNote
142 Records (125 escludendo Abstract e Conferenze). Impact factor totale: 706.452 (636.794 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 714.883 (638.269 escludendo Abstract e Conferenze).
ibb.cnr.it
