Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (53 visite)
Frontiers In Molecular Neuroscience (ISSN: 1662-5099, 1662-5099linking), 2018 Nov 13; 11: 414-414.
Tipo di articolo: Journal Article, Review,
Impact factor: 3.902, Impact factor a 5 anni: 0
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056742399&doi=10.3389%2ffnmol.2018.00414&partnerID=40&md5=ec1863ab0ec0457f84f7a08c11f0b794
Parole chiave: Apoptosis, Metabotropic Glutamate Receptor, Neurodegeneration, Neuroprotection, Transforming Growth Factor-β1, Transforming Growth Factor-Beta1,
Affiliazioni:
*** IBB - CNR ***
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
Department of Drug Sciences, University of Catania, Catania, Italy
Institute of Biostructure and Bioimaging, National Research Council, Catania, Italy
Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
Neuromed, Istituto di Ricovero e Cura a Carattere Scientifico, Pozzilli, Italy
Oasi Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico, Troina, Italy
Riferimenti:
Abdul-Ghani, M.A., Valiante, T.A., Carlen, P.L., Pennefather, P.S., Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neurons (1996) J. Neurophysiol., 76, pp. 2691-270
Agrawal, S.K., Theriault, E., Fehlings, M.G., Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury (1998) J. Neurotrauma, 15, pp. 929-941
Agulhon, C., Petravicz, J., McMullen, A.B., Sweger, E.J., Minton, S.K., Taves, S.R., What is the role of astrocyte calcium in neurophysiology? (2008) Neuron, 59, pp. 932-946
Anneser, J.M., Chahli, C., Ince, P.G., Borasio, G.D., Shaw, P.J., Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis (2004) J. Neuropathol. Exp. Neurol., 63, pp. 831-840
Aronica, E., Catania, M.V., Geurts, J., Yankaya, B., Troost, D., Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: Upregulation in reactive astrocytes (2001) Neuroscience, 105, pp. 509-520
Aronica, E., Gorter, J.A., Ijlst-Keizers, H., Rozemuller, A.J., Yankaya, B., Leenstra, S., Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: Opposite regulation of glutamate transporter proteins (2003) Eur. J. Neurosci, 17, pp. 2106-2118
Bakiri, Y., Karadottir, R., Cossell, L., Attwell, D., Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellum (2011) J. Physiol., 589, pp. 559-573
Balazs, R., Miller, S., Romano, C., de Vries, A., Chun, Y., Cotman, C.W., Metabotropic glutamate receptor mGluR5 in astrocytes: Pharmacological properties and agonist regulation (1997) J. Neurochem., 69, pp. 151-163
Barger, S.W., Basile, A.S., Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function (2001) J. Neurochem., 76, pp. 846-854
Battaglia, G., Busceti, C.L., Molinaro, G., Biagioni, F., Traficante, A., Nicoletti, F., Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2006) J. Neurosci., 26, pp. 7222-7229
Battaglia, G., Molinaro, G., Riozzi, B., Storto, M., Busceti, C.L., Spinsanti, P., Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons (2009) Plos One, 4
Battaglia, G., Riozzi, B., Bucci, D., Di Menna, L., Molinaro, G., Pallottino, S., Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis (2015) Neurobiol. Dis., 74, pp. 126-136
Benatti, C., Blom, J.M., Rigillo, G., Alboni, S., Zizzi, F., Torta, R., Disease-induced neuroinflammation and depression (2016) CNS Neurol. Disord. Drug Targets, 15, pp. 414-433
Beneventano, M., Spampinato, S.F., Merlo, S., Chisari, M., Platania, P., Ragusa, M., Shedding of microvesicles from microglia contributes to the effects induced by metabotropic glutamate receptor 5 activation on neuronal death (2017) Front. Pharmacol., 8, p. 812
Berger, J.V., Dumont, A.O., Focant, M.C., Vergouts, M., Sternotte, A., Calas, A.G., Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes (2012) Neuroscience, 205, pp. 29-38
Besong, G., Battaglia, G., D’Onofrio, M., Di Marco, R., Ngomba, R.T., Storto, M., Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures (2002) J. Neurosci., 22, pp. 5403-5411
Betts, M.J., O’Neill, M.J., Duty, S., Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson’s disease (2012) Br. J. Pharmacol., 166, pp. 2317-2330
Block, M.L., Hong, J.S., Chronic microglial activation and progressive dopaminergic neurotoxicity (2007) Biochem. Soc. Trans., 35, pp. 1127-1132
Blumcke, I., Behle, K., Malitschek, B., Kuhn, R., Knopfel, T., Wolf, H.K., Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3, mGluR4a and mGluR5 in human hippocampus (1996) Brain Res, 736, pp. 217-226
Boer, K., Encha-Razavi, F., Sinico, M., Aronica, E., Differential distribution of group I metabotropic glutamate receptors in developing human cortex (2010) Brain Res, 1324, pp. 24-33
Bond, A., Jones, N.M., Hicks, C.A., Whiffin, G.M., Ward, M.A., O’Neill, M.F., Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: Investigations into possible mechanism of action in vivo (2000) J. Pharmacol. Exp. Ther, 294, pp. 800-809
Bond, A., O’Neill, M.J., Hicks, C.A., Monn, J.A., Lodge, D., Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia (1998) Neuroreport, 9, pp. 1191-1193
Bonde, C., Sarup, A., Schousboe, A., Gegelashvili, G., Zimmer, J., Noraberg, J., Neurotoxic and neuroprotective effects of the glutamate transporter inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) during physiological and ischemia-like conditions (2003) Neurochem. Int., 43, pp. 371-380
Bradley, S.J., Challiss, R.A., Defining protein kinase/phosphatase isoenzymic regulation of mGlu(5) receptor-stimulated phospholipase C and Ca2 + responses in astrocytes (2011) Br. J. Pharmacol., 164, pp. 755-771. , doi: 10.1111/j. 1476-5381.2011.01421.x
Bruno, V., Battaglia, G., Casabona, G., Copani, A., Caciagli, F., Nicoletti, F., Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta (1998) J. Neurosci., 18, pp. 9594-9600
Bruno, V., Caraci, F., Copani, A., Matrisciano, F., Nicoletti, F., Battaglia, G., The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (2017) Neuropharmacology, 115, pp. 180-192
Butt, A.M., Vanzulli, I., Papanikolaou, M., de La Rocha, I.C., Hawkins, V.E., Metabotropic glutamate receptors protect oligodendrocytes from acute ischemia in the mouse optic nerve (2017) Neurochem. Res., 42, pp. 2468-2478
Byrnes, K.R., Loane, D.J., Stoica, B.A., Zhang, J., Faden, A.I., Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury (2012) J. Neuroinflammation, 9, p. 43
Byrnes, K.R., Stoica, B., Loane, D.J., Riccio, A., Davis, M.I., Faden, A.I., Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity (2009) Glia, 57, pp. 550-560
Cai, Z., Schools, G.P., Kimelberg, H.K., Metabotropic glutamate receptors in acutely isolated hippocampal astrocytes: Developmental changes of mGluR5 mRNA and functional expression (2000) Glia, 29, pp. 70-80
Caraci, F., Gulisano, W., Guida, C.A., Impellizzeri, A.A., Drago, F., Puzzo, D., A key role for TGF-beta1 in hippocampal synaptic plasticity and memory (2015) Sci. Rep., 5
Caraci, F., Molinaro, G., Battaglia, G., Giuffrida, M.L., Riozzi, B., Traficante, A., Targeting group II metabotropic glutamate (MGlu) receptors for the treatment of psychosis associated with Alzheimer’s disease: Selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (2011) Mol. Pharmacol., 79, pp. 618-626
Caraci, F., Nicoletti, F., Copani, A., Metabotropic glutamate receptors: The potential for therapeutic applications in Alzheimer’s disease (2018) Curr. Opin. Pharmacol., 38, pp. 1-7
Caraci, F., Spampinato, S.F., Morgese, M.G., Tascedda, F., Salluzzo, M.G., Giambirtone, M.C., Neurobiological links between depression and AD: The role of TGF-beta1 signaling as a new pharmacological target (2018) Pharmacol. Res, 130, pp. 374-384. , (b)
Casley, C.S., Lakics, V., Lee, H.G., Broad, L.M., Day, T.A., Cluett, T., Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-beta peptide (2009) Brain Res, 1260, pp. 65-75
Cha, J.H., Farrell, L.A., Ahmed, S.F., Frey, A., Hsiao-Ashe, K.K., Young, A.B., Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein (2001) Neurobiol. Dis., 8, pp. 90-102
Chen, J.H., Ke, K.F., Lu, J.H., Qiu, Y.H., Peng, Y.P., Protection of TGF-beta1 against neuroinflammation and neurodegeneration in Abeta1-42-induced Alzheimer’s disease model rats (2015) Plos One, 10
Chiechio, S., Modulation of chronic pain by metabotropic glutamate receptors (2016) Adv. Pharmacol., 75, pp. 63-89
Ciccarelli, R., D’Alimonte, I., Ballerini, P., D’Auro, M., Nargi, E., Buccella, S., Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes (2007) Mol. Pharmacol., 71, pp. 1369-1380
Ciccarelli, R., Di Iorio, P., Bruno, V., Battaglia, G., D’Alimonte, I., D’Onofrio, M., Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes (1999) Glia, 27, pp. 275-281
Ciccarelli, R., Sureda, F.X., Casabona, G., Di Iorio, P., Caruso, A., Spinella, F., Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and-5 on astrocyte proliferation in culture (1997) Glia, 21, pp. 390-398
Conn, P.J., Pin, J.P., Pharmacology and functions of metabotropic glutamate receptors (1997) Annu. Rev. Pharmacol. Toxicol., 37, pp. 205-237
Corti, C., Battaglia, G., Molinaro, G., Riozzi, B., Pittaluga, A., Corsi, M., The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection (2007) J. Neurosci., 27, pp. 8297-8308
D’Antoni, S., Berretta, A., Seminara, G., Longone, P., Giuffrida-Stella, A.M., Battaglia, G., A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death (2011) Neurobiol. Dis., 42, pp. 252-264
Deng, W., Rosenberg, P.A., Volpe, J.J., Jensen, F.E., Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 6801-6806
Deng, W., Wang, H., Rosenberg, P.A., Volpe, J.J., Jensen, F.E., Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress (2004) Proc. Natl. Acad. Sci. U.S.A, 101, pp. 7751-7756
Dewapriya, P., Li, Y.X., Himaya, S.W., Pangestuti, R., Kim, S.K., Neoechinulin A suppresses amyloid-beta oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity (2013) Neurotoxicology, 35, pp. 30-40
Dewar, D., Chalmers, D.T., Graham, D.I., McCulloch, J., Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer’s disease: An autoradiographic study of the hippocampus (1991) Brain Res, 553, pp. 58-64
Ding, S., Fellin, T., Zhu, Y., Lee, S.Y., Auberson, Y.P., Meaney, D.F., Enhanced astrocytic Ca2 + signals contribute to neuronal excitotoxicity after status epilepticus (2007) J. Neurosci, 27, pp. 10674-10684
Doble, A., The role of excitotoxicity in neurodegenerative disease: Implications for therapy (1999) Pharmacol. Ther., 81, pp. 163-221
Drouin-Ouellet, J., Brownell, A.L., Saint-Pierre, M., Fasano, C., Emond, V., Trudeau, L.E., Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions (2011) Glia, 59, pp. 188-199
Dugan, L.L., Choi, D.W., Excitotoxicity, free radicals, and cell membrane changes (1994) Ann. Neurol, 35, pp. S17-S21
Durand, D., Carniglia, L., Beauquis, J., Caruso, C., Saravia, F., Lasaga, M., Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage (2014) Neuropharmacology, 79, pp. 180-189
Durand, D., Caruso, C., Carniglia, L., Lasaga, M., Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes (2010) J. Neurochem., 112, pp. 420-433
Ettle, B., Schlachetzki, J.C.M., Winkler, J., Oligodendroglia and myelin in neurodegenerative diseases: More than just bystanders? (2016) Mol. Neurobiol., 53, pp. 3046-3062
Fallarino, F., Volpi, C., Fazio, F., Notartomaso, S., Vacca, C., Busceti, C., Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation (2010) Nat. Med., 16, pp. 897-902
Farso, M.C., O’Shea, R.D., Beart, P.M., Evidence group I mGluR drugs modulate the activation profile of lipopolysaccharide-exposed microglia in culture (2009) Neurochem. Res., 34, pp. 1721-1728
Fazio, F., Ulivieri, M., Volpi, C., Gargaro, M., Fallarino, F., Targeting metabotropic glutamate receptors for the treatment of neuroinflammation (2018) Curr. Opin. Pharmacol., 38, pp. 16-23
Fazio, F., Zappulla, C., Notartomaso, S., Busceti, C., Bessede, A., Scarselli, P., Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice (2014) Neuropharmacology, 81, pp. 237-243
Fellner, L., Stefanova, N., The role of glia in alpha-synucleinopathies (2013) Mol. Neurobiol., 47, pp. 575-586
Fern, R.F., Matute, C., Stys, P.K., White matter injury: Ischemic and nonischemic (2014) Glia, 62, pp. 1780-1789
Ferrer, I., Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner (2018) Prog. Neurobiol., 169, pp. 24-54
Fiacco, T.A., Agulhon, C., McCarthy, K.D., Sorting out astrocyte physiology from pharmacology (2009) Annu. Rev. Pharmacol. Toxicol., 49, pp. 151-174
Gegelashvili, G., Dehnes, Y., Danbolt, N.C., Schousboe, A., The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms (2000) Neurochem. Int., 37, pp. 163-170
Gerber, U., Gee, C.E., Benquet, P., Metabotropic glutamate receptors: Intracellular signaling pathways (2007) Curr. Opin. Pharmacol., 7, pp. 56-61
Geurts, J.J., Wolswijk, G., Bo, L., Redeker, S., Ramkema, M., Troost, D., Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions (2005) J. Neuroimmunol., 158, pp. 182-190
Giordano, C., Cristino, L., Luongo, L., Siniscalco, D., Petrosino, S., Piscitelli, F., TRPV1-dependent and-independent alterations in the limbic cortex of neuropathic mice: Impact on glial caspases and pain perception (2012) Cereb. Cortex, 22, pp. 2495-2518
Gomez-Nicola, D., Perry, V.H., Microglial dynamics and role in the healthy and diseased brain: A paradigm of functional plasticity (2015) Neuroscientist, 21, pp. 169-184
Guida, F., Luongo, L., Marmo, F., Romano, R., Iannotta, M., Napolitano, F., Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice (2015) Mol. Brain, 8
Gwak, Y.S., Hulsebosch, C.E., Upregulation of Group I metabotropic glutamate receptors in neurons and astrocytes in the dorsal horn following spinal cord injury (2005) Exp. Neurol., 195, pp. 236-243
Hamilton, N., Vayro, S., Wigley, R., Butt, A.M., Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia (2010) Glia, 58, pp. 66-79
Hardingham, G.E., Bading, H., The Yin and Yang of NMDA receptor signalling (2003) Trends Neurosci, 26, pp. 81-89
Harris, J.J., Attwell, D., The energetics of CNS white matter (2012) J. Neurosci., 32, pp. 356-371
Hathaway, H.A., Pshenichkin, S., Grajkowska, E., Gelb, T., Emery, A.C., Wolfe, B.B., Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism (2015) Neuropharmacology, 93, pp. 199-208
Hellyer, S., Leach, K., Gregory, K.J., Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation (2017) Curr. Opin. Pharmacol., 32, pp. 49-55
Heneka, M.T., Rodriguez, J.J., Verkhratsky, A., Neuroglia in neurodegeneration (2010) Brain Res. Rev., 63, pp. 189-211
Homayoun, H., Moghaddam, B., Group 5 metabotropic glutamate receptors: Role in modulating cortical activity and relevance to cognition (2010) Eur. J. Pharmacol., 639, pp. 33-39
Hossain, M.Z., Unno, S., Ando, H., Masuda, Y., Kitagawa, J., Neuron-glia crosstalk and neuropathic pain: Involvement in the modulation of motor activity in the orofacial region (2017) Int. J. Mol. Sci., 18
Huang, Y.Y., Zhang, Q., Zhang, J.N., Zhang, Y.N., Gu, L., Yang, H.M., Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson’s disease (2018) Brain Behav. Immun., 71, pp. 93-107
Iacovelli, L., Bruno, V., Salvatore, L., Melchiorri, D., Gradini, R., Caricasole, A., Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways (2002) J. Neurochem., 82, pp. 216-223
Iacovelli, L., Felicioni, M., Nistico, R., Nicoletti, F., de Blasi, A., Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins (2014) Neuropharmacology, 77, pp. 303-312
Ibanez, C.F., Andressoo, J.O., Biology of GDNF and its receptors-Relevance for disorders of the central nervous system (2017) Neurobiol. Dis, 97, pp. 80-89
Iyer, A.M., van Scheppingen, J., Milenkovic, I., Anink, J.J., Lim, D., Genazzani, A.A., Metabotropic glutamate receptor 5 in Down’s syndrome hippocampus during development: Increased expression in astrocytes (2014) Curr. Alzheimer Res., 11, pp. 694-705
Jantas, D., Lech, T., Golda, S., Pilc, A., Lason, W., New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection (2018) Neuropharmacology, 141, pp. 223-237
Jantzie, L.L., Talos, D.M., Selip, D.B., An, L., Jackson, M.C., Folkerth, R.D., Developmental regulation of group I metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia (2010) Neuron Glia Biol, 6, pp. 277-288
Ji, R.R., Xu, Z.Z., Gao, Y.J., Emerging targets in neuroinflammation-driven chronic pain (2014) Nat. Rev. Drug Discov., 13, pp. 533-548
Kammermeier, P.J., Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers (2012) Mol. Pharmacol., 82, pp. 438-447
Kaushal, V., Schlichter, L.C., Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra (2008) J. Neurosci., 28, pp. 2221-2230
Kelland, E.E., Toms, N.J., Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death (2001) Eur. J. Pharmacol., 424, pp. R3-R4
Kim, S.U., de Vellis, J., Microglia in health and disease (2005) J. Neurosci. Res., 81, pp. 302-313
Klaver, R., de Vries, H.E., Schenk, G.J., Geurts, J.J., Grey matter damage in multiple sclerosis: A pathology perspective (2013) Prion, 7, pp. 66-75
Knezevic, D., Mizrahi, R., Molecular imaging of neuroinflammation in Alzheimer’s disease and mild cognitive impairment (2018) Prog. Neuropsychopharmacol. Biol. Psychiatry, 80, pp. 123-131
Kobayashi, K., Hayashi, M., Nakano, H., Fukutani, Y., Sasaki, K., Shimazaki, M., Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer’s disease (2002) Neuropathol. Appl. Neurobiol., 28, pp. 238-251
Le Poul, E., Bolea, C., Girard, F., Poli, S., Charvin, D., Campo, B., A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson’s disease (2012) J. Pharmacol. Exp. Ther., 343, pp. 167-177
Lim, D., Iyer, A., Ronco, V., Grolla, A.A., Canonico, P.L., Aronica, E., Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB (2013) Glia, 61, pp. 1134-1145
Liu, F., Zhou, R., Yan, H., Yin, H., Wu, X., Tan, Y., Metabotropic glutamate receptor 5 modulates calcium oscillation and innate immune response induced by lipopolysaccharide in microglial cell (2014) Neuroscience, 281, pp. 24-34
Liu, G.J., Nagarajah, R., Banati, R.B., Bennett, M.R., Glutamate induces directed chemotaxis of microglia (2009) Eur. J. Neurosci., 29, pp. 1108-1118
Lujan, R., Shigemoto, R., Lopez-Bendito, G., Glutamate and GABA receptor signalling in the developing brain (2005) Neuroscience, 130, pp. 567-580
Luyt, K., Varadi, A., Durant, C.F., Molnar, E., Oligodendroglial metabotropic glutamate receptors are developmentally regulated and involved in the prevention of apoptosis (2006) J. Neurochem., 99, pp. 641-656
Macrez, R., Stys, P.K., Vivien, D., Lipton, S.A., Docagne, F., Mechanisms of glutamate toxicity in multiple sclerosis: Biomarker and therapeutic opportunities (2016) Lancet Neurol, 15, pp. 1089-1102
Martin, G.M., Molecular mechanisms of late life dementias (2000) Exp. Gerontol., 35, pp. 439-443
Mastroiacovo, F., Moyanova, S., Cannella, M., Gaglione, A., Verhaeghe, R., Bozza, G., Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia (2017) Mol. Brain, 10
McMullan, S.M., Phanavanh, B., Li, G.G., Barger, S.W., Metabotropic glutamate receptors inhibit microglial glutamate release (2012) ASN Neuro, 4
Mosher, K.I., Wyss-Coray, T., Microglial dysfunction in brain aging and Alzheimer’s disease (2014) Biochem. Pharmacol., 88, pp. 594-604
Motolese, M., Mastroiacovo, F., Cannella, M., Bucci, D., Gaglione, A., Riozzi, B., Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage (2015) Mol. Brain, 8
Nakamichi, N., Yoshida, K., Ishioka, Y., Makanga, J.O., Fukui, M., Yoneyama, M., Group III metabotropic glutamate receptor activation suppresses self-replication of undifferentiated neocortical progenitor cells (2008) J. Neurochem., 105, pp. 1996-2012
Newcombe, J., Uddin, A., Dove, R., Patel, B., Turski, L., Nishizawa, Y., Glutamate receptor expression in multiple sclerosis lesions (2008) Brain Pathol, 18, pp. 52-61
Nguyen, D., Alavi, M.V., Kim, K.Y., Kang, T., Scott, R.T., Noh, Y.H., A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics (2011) Cell Death Dis, 2, p. e240
Nicoletti, F., Bockaert, J., Collingridge, G.L., Conn, P.J., Ferraguti, F., Schoepp, D.D., Metabotropic glutamate receptors: From the workbench to the bedside (2011) Neuropharmacology, 60, pp. 1017-1041
Niswender, C.M., Conn, P.J., Metabotropic glutamate receptors: Physiology, pharmacology, and disease (2010) Annu. Rev. Pharmacol. Toxicol., 50, pp. 295-322
Oliet, S.H., Piet, R., Poulain, D.A., Control of glutamate clearance and synaptic efficacy by glial coverage of neurons (2001) Science, 292, pp. 923-926
Olmos, G., Llado, J., Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity (2014) Mediators Inflamm, 2014
O’Riordan, K.J., Huang, I.C., Pizzi, M., Spano, P., Boroni, F., Egli, R., Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors (2006) J. Neurosci., 26, pp. 4870-4879
Palazzo, E., Marabese, I., Luongo, L., Guida, F., de Novellis, V., Maione, S., Nociception modulation by supraspinal group III metabotropic glutamate receptors (2017) J. Neurochem., 141, pp. 507-519
Paquet, M., Ribeiro, F.M., Guadagno, J., Esseltine, J.L., Ferguson, S.S., Cregan, S.P., Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis (2013) Mol. Brain, 6, p. 9
Pickering, M., Cumiskey, D., O’Connor, J.J., Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system (2005) Exp. Physiol., 90, pp. 663-670
Piers, T.M., Heales, S.J., Pocock, J.M., Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection (2011) Neurosci. Lett., 505, pp. 140-145
Pin, J.P., Bettler, B., Organization and functions of mGlu and GABAB receptor complexes (2016) Nature, 540, pp. 60-68
Pinteaux-Jones, F., Sevastou, I.G., Fry, V.A., Heales, S., Baker, D., Pocock, J.M., Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors (2008) J. Neurochem., 106, pp. 442-454
Ponnazhagan, R., Harms, A.S., Thome, A.D., Jurkuvenaite, A., Gogliotti, R., Niswender, C.M., The metabotropic glutamate receptor 4 positive allosteric modulator ADX88178 inhibits inflammatory responses in primary microglia (2016) J. Neuroimmune Pharmacol., 11, pp. 231-237
Ribeiro, F.M., Vieira, L.B., Pires, R.G., Olmo, R.P., Ferguson, S.S., Metabotropic glutamate receptors and neurodegenerative diseases (2017) Pharmacol. Res., 115, pp. 179-191
Rodriguez-Kern, A., Gegelashvili, M., Schousboe, A., Zhang, J., Sung, L., Gegelashvili, G., Beta-amyloid and brain-derived neurotrophic factor, BDNF, up-regulate the expression of glutamate transporter GLT-1/EAAT2 via different signaling pathways utilizing transcription factor NF-κB (2003) Neurochem. Int., 43, pp. 363-370
Romano, C., Smout, S., Miller, J.K., O’Malley, K.L., Developmental regulation of metabotropic glutamate receptor 5b protein in rodent brain (2002) Neuroscience, 111, pp. 693-698
Rosenbluth, J., Multiple functions of the paranodal junction of myelinated nerve fibers (2009) J. Neurosci. Res., 87, pp. 3250-3258
Rossi, D.J., Oshima, T., Attwell, D., Glutamate release in severe brain ischaemia is mainly by reversed uptake (2000) Nature, 403, pp. 316-321
Rothstein, J.D., van Kammen, M., Levey, A.I., Martin, L.J., Kuncl, R.W., Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis (1995) Ann. Neurol., 38, pp. 73-84
Schafer, D.P., Lehrman, E.K., Kautzman, A.G., Koyama, R., Mardinly, A.R., Yamasaki, R., Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner (2012) Neuron, 74, pp. 691-705
Shah, A., Silverstein, P.S., Singh, D.P., Kumar, A., Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes (2012) J. Neuroinflammation, 9, p. 52
Shrivastava, A.N., Kowalewski, J.M., Renner, M., Bousset, L., Koulakoff, A., Melki, R., Beta-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors (2013) Glia, 61, pp. 1673-1686
Sorensen, T.L., Tani, M., Jensen, J., Pierce, V., Lucchinetti, C., Folcik, V.A., Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients (1999) J. Clin. Invest., 103, pp. 807-815
Stevens, B., Allen, N.J., Vazquez, L.E., Howell, G.R., Christopherson, K.S., Nouri, N., The classical complement cascade mediates CNS synapse elimination (2007) Cell, 131, pp. 1164-1178
Strachan-Whaley, M., Rivest, S., Yong, V.W., Interactions between microglia and T cells in multiple sclerosis pathobiology (2014) J. Interferon Cytokine Res., 34, pp. 615-622
Streit, W.J., Xue, Q.S., Human CNS immune senescence and neurodegeneration (2014) Curr. Opin. Immunol., 29, pp. 93-96
Sun, W., McConnell, E., Pare, J.F., Xu, Q., Chen, M., Peng, W., Glutamate-dependent neuroglial calcium signaling differs between young and adult brain (2013) Science, 339, pp. 197-200
Tang, F.R., Lee, W.L., Expression of the group II and III metabotropic glutamate receptors in the hippocampus of patients with mesial temporal lobe epilepsy (2001) J. Neurocytol., 30, pp. 137-143
Taylor, D.L., Diemel, L.T., Cuzner, M.L., Pocock, J.M., Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide upregulated in Alzheimer’s disease (2002) J. Neurochem., 82, pp. 1179-1191
Taylor, D.L., Jones, F., Kubota, E.S., Pocock, J.M., Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand (2005) J. Neurosci., 25, pp. 2952-2964
Tichauer, J.E., von Bernhardi, R., Transforming growth factor-beta stimulates beta amyloid uptake by microglia through Smad3-dependent mechanisms (2012) J. Neurosci. Res., 90, pp. 1970-1980
Tilleux, S., Berger, J., Hermans, E., Induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5 (2007) J. Neuroimmunol., 189, pp. 23-30
Tison, F., Keywood, C., Wakefield, M., Durif, F., Corvol, J.C., Eggert, K., A phase 2A trial of the novel mGluR5-negative allosteric modulator dipraglurant for levodopa-induced dyskinesia in parkinson’s disease (2016) Mov. Disord., 31, pp. 1373-1380
Tomimoto, H., Akiguchi, I., Wakita, H., Kimura, J., White matter lesions after occlusion of the bilateral carotid arteries in the rat–temporal profile of cerebral blood flow (CBF), oligodendroglia and myelin (1997) No to Shinkei, 49, pp. 639-644
Ullian, E.M., Sapperstein, S.K., Christopherson, K.S., Barres, B.A., Control of synapse number by glia (2001) Science, 291, pp. 657-661
Vafabakhsh, R., Levitz, J., Isacoff, E.Y., Conformational dynamics of a class C G-protein-coupled receptor (2015) Nature, 524, pp. 497-501
Verderio, C., Extracellular membrane microvesicles and nanotubes in the brain: Understanding their nature, their function in cell-to-cell communication, their role in transcellular spreading of pathological agents and their therapeutic potential (2013) Front. Physiol., 4, p. 163
Verite, J., Janet, T., Chassaing, D., Fauconneau, B., Rabeony, H., Page, G., Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice (2018) J. Neuroinflammation, 15
Vermeiren, C., Hemptinne, I., Vanhoutte, N., Tilleux, S., Maloteaux, J.M., Hermans, E., Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis (2006) J. Neurochem., 96, pp. 719-731
Vermeiren, C., Najimi, M., Vanhoutte, N., Tilleux, S., de Hemptinne, I., Maloteaux, J.M., Acute up-regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes (2005) J. Neurochem., 94, pp. 405-416
Vernon, A.C., Smith, E.J., Stevanato, L., Modo, M., Selective activation of metabotropic glutamate receptor 7 induces inhibition of cellular proliferation and promotes astrocyte differentiation of ventral mesencephalon human neural stem/progenitor cells (2011) Neurochem. Int., 59, pp. 421-431
Wang, J.W., Wang, H.D., Cong, Z.X., Zhang, X.S., Zhou, X.M., Zhang, D.D., Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats (2013) Biochem. Biophys. Res. Commun., 430, pp. 1016-1021
Werner, P., Pitt, D., Raine, C.S., Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage (2001) Ann. Neurol., 50, pp. 169-180
Wilkinson, B.L., Landreth, G.E., The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer’s disease (2006) J. Neuroinflammation, 3, p. 30
Xue, F., Stoica, B.A., Hanscom, M., Kabadi, S.V., Faden, A.I., Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGluR5) attenuate microglial activation (2014) CNS Neurol. Disord. Drug Targets, 13, pp. 558-566
Yang, L., Mao, L., Chen, H., Catavsan, M., Kozinn, J., Arora, A., A signaling mechanism from G alpha q-protein-coupled metabotropic glutamate receptors to gene expression: Role of the c-Jun N-terminal kinase pathway (2006) J. Neurosci., 26, pp. 971-980
Yang, P., Zhang, J., Zhao, L., Jiao, Q., Jin, H., Xiao, X., Developmental distribution pattern of metabotropic glutamate receptor 5 in prenatal human hippocampus (2012) Neurosci. Bull., 28, pp. 704-714
Yao, H.H., Ding, J.H., Zhou, F., Wang, F., Hu, L.F., Sun, T., Enhancement of glutamate uptake mediates the neuroprotection exerted by activating group II or III metabotropic glutamate receptors on astrocytes (2005) J. Neurochem., 92, pp. 948-961
Ye, X., Yu, L., Zuo, D., Zhang, L., Zu, J., Hu, J., Activated mGluR5 protects BV2 cells against OGD/R induced cytotoxicity by modulating BDNF-TrkB pathway (2017) Neurosci. Lett., 654, pp. 70-79
Yin, S., Noetzel, M.J., Johnson, K.A., Zamorano, R., Jalan-Sakrikar, N., Gregory, K.J., Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS (2014) J. Neurosci., 34, pp. 79-94
Zabel, M.K., Kirsch, W.M., From development to dysfunction: Microglia and the complement cascade in CNS homeostasis (2013) Ageing Res. Rev., 12, pp. 749-756
Zhang, Z., Ma, W., Wang, L., Gong, H., Tian, Y., Zhang, J., Activation of type 4 metabotropic glutamate receptor attenuates oxidative stress-induced death of neural stem cells with inhibition of JNK and p38 MAPK signaling (2015) Stem Cells Dev, 24, pp. 2709-2722
Zhao, Z., Nelson, A.R., Betsholtz, C., Zlokovic, B.V., Establishment and dysfunction of the blood-brain barrier (2015) Cell, 163, pp. 1064-1078
Zhou, F., Yao, H.H., Wu, J.Y., Yang, Y.J., Ding, J.H., Zhang, J., Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake (2006) J. Neurosci. Res., 84, pp. 268-277
Zipfel, G.J., Babcock, D.J., Lee, J.M., Choi, D.W., Neuronal apoptosis after CNS injury: The roles of glutamate and calcium (2000) J. Neurotrauma, 17, pp. 857-869
Frontiers In Molecular Neuroscience (ISSN: 1662-5099, 1662-5099linking), 2018 Nov 13; 11: 414-414.
Tipo di articolo: Journal Article, Review,
Impact factor: 3.902, Impact factor a 5 anni: 0
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056742399&doi=10.3389%2ffnmol.2018.00414&partnerID=40&md5=ec1863ab0ec0457f84f7a08c11f0b794
Parole chiave: Apoptosis, Metabotropic Glutamate Receptor, Neurodegeneration, Neuroprotection, Transforming Growth Factor-β1, Transforming Growth Factor-Beta1,
Affiliazioni:
*** IBB - CNR ***
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
Department of Drug Sciences, University of Catania, Catania, Italy
Institute of Biostructure and Bioimaging, National Research Council, Catania, Italy
Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
Neuromed, Istituto di Ricovero e Cura a Carattere Scientifico, Pozzilli, Italy
Oasi Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico, Troina, Italy
Riferimenti:
Abdul-Ghani, M.A., Valiante, T.A., Carlen, P.L., Pennefather, P.S., Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neurons (1996) J. Neurophysiol., 76, pp. 2691-270
Agrawal, S.K., Theriault, E., Fehlings, M.G., Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury (1998) J. Neurotrauma, 15, pp. 929-941
Agulhon, C., Petravicz, J., McMullen, A.B., Sweger, E.J., Minton, S.K., Taves, S.R., What is the role of astrocyte calcium in neurophysiology? (2008) Neuron, 59, pp. 932-946
Anneser, J.M., Chahli, C., Ince, P.G., Borasio, G.D., Shaw, P.J., Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis (2004) J. Neuropathol. Exp. Neurol., 63, pp. 831-840
Aronica, E., Catania, M.V., Geurts, J., Yankaya, B., Troost, D., Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: Upregulation in reactive astrocytes (2001) Neuroscience, 105, pp. 509-520
Aronica, E., Gorter, J.A., Ijlst-Keizers, H., Rozemuller, A.J., Yankaya, B., Leenstra, S., Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: Opposite regulation of glutamate transporter proteins (2003) Eur. J. Neurosci, 17, pp. 2106-2118
Bakiri, Y., Karadottir, R., Cossell, L., Attwell, D., Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellum (2011) J. Physiol., 589, pp. 559-573
Balazs, R., Miller, S., Romano, C., de Vries, A., Chun, Y., Cotman, C.W., Metabotropic glutamate receptor mGluR5 in astrocytes: Pharmacological properties and agonist regulation (1997) J. Neurochem., 69, pp. 151-163
Barger, S.W., Basile, A.S., Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function (2001) J. Neurochem., 76, pp. 846-854
Battaglia, G., Busceti, C.L., Molinaro, G., Biagioni, F., Traficante, A., Nicoletti, F., Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2006) J. Neurosci., 26, pp. 7222-7229
Battaglia, G., Molinaro, G., Riozzi, B., Storto, M., Busceti, C.L., Spinsanti, P., Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons (2009) Plos One, 4
Battaglia, G., Riozzi, B., Bucci, D., Di Menna, L., Molinaro, G., Pallottino, S., Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis (2015) Neurobiol. Dis., 74, pp. 126-136
Benatti, C., Blom, J.M., Rigillo, G., Alboni, S., Zizzi, F., Torta, R., Disease-induced neuroinflammation and depression (2016) CNS Neurol. Disord. Drug Targets, 15, pp. 414-433
Beneventano, M., Spampinato, S.F., Merlo, S., Chisari, M., Platania, P., Ragusa, M., Shedding of microvesicles from microglia contributes to the effects induced by metabotropic glutamate receptor 5 activation on neuronal death (2017) Front. Pharmacol., 8, p. 812
Berger, J.V., Dumont, A.O., Focant, M.C., Vergouts, M., Sternotte, A., Calas, A.G., Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes (2012) Neuroscience, 205, pp. 29-38
Besong, G., Battaglia, G., D’Onofrio, M., Di Marco, R., Ngomba, R.T., Storto, M., Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures (2002) J. Neurosci., 22, pp. 5403-5411
Betts, M.J., O’Neill, M.J., Duty, S., Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson’s disease (2012) Br. J. Pharmacol., 166, pp. 2317-2330
Block, M.L., Hong, J.S., Chronic microglial activation and progressive dopaminergic neurotoxicity (2007) Biochem. Soc. Trans., 35, pp. 1127-1132
Blumcke, I., Behle, K., Malitschek, B., Kuhn, R., Knopfel, T., Wolf, H.K., Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3, mGluR4a and mGluR5 in human hippocampus (1996) Brain Res, 736, pp. 217-226
Boer, K., Encha-Razavi, F., Sinico, M., Aronica, E., Differential distribution of group I metabotropic glutamate receptors in developing human cortex (2010) Brain Res, 1324, pp. 24-33
Bond, A., Jones, N.M., Hicks, C.A., Whiffin, G.M., Ward, M.A., O’Neill, M.F., Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: Investigations into possible mechanism of action in vivo (2000) J. Pharmacol. Exp. Ther, 294, pp. 800-809
Bond, A., O’Neill, M.J., Hicks, C.A., Monn, J.A., Lodge, D., Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia (1998) Neuroreport, 9, pp. 1191-1193
Bonde, C., Sarup, A., Schousboe, A., Gegelashvili, G., Zimmer, J., Noraberg, J., Neurotoxic and neuroprotective effects of the glutamate transporter inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) during physiological and ischemia-like conditions (2003) Neurochem. Int., 43, pp. 371-380
Bradley, S.J., Challiss, R.A., Defining protein kinase/phosphatase isoenzymic regulation of mGlu(5) receptor-stimulated phospholipase C and Ca2 + responses in astrocytes (2011) Br. J. Pharmacol., 164, pp. 755-771. , doi: 10.1111/j. 1476-5381.2011.01421.x
Bruno, V., Battaglia, G., Casabona, G., Copani, A., Caciagli, F., Nicoletti, F., Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta (1998) J. Neurosci., 18, pp. 9594-9600
Bruno, V., Caraci, F., Copani, A., Matrisciano, F., Nicoletti, F., Battaglia, G., The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (2017) Neuropharmacology, 115, pp. 180-192
Butt, A.M., Vanzulli, I., Papanikolaou, M., de La Rocha, I.C., Hawkins, V.E., Metabotropic glutamate receptors protect oligodendrocytes from acute ischemia in the mouse optic nerve (2017) Neurochem. Res., 42, pp. 2468-2478
Byrnes, K.R., Loane, D.J., Stoica, B.A., Zhang, J., Faden, A.I., Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury (2012) J. Neuroinflammation, 9, p. 43
Byrnes, K.R., Stoica, B., Loane, D.J., Riccio, A., Davis, M.I., Faden, A.I., Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity (2009) Glia, 57, pp. 550-560
Cai, Z., Schools, G.P., Kimelberg, H.K., Metabotropic glutamate receptors in acutely isolated hippocampal astrocytes: Developmental changes of mGluR5 mRNA and functional expression (2000) Glia, 29, pp. 70-80
Caraci, F., Gulisano, W., Guida, C.A., Impellizzeri, A.A., Drago, F., Puzzo, D., A key role for TGF-beta1 in hippocampal synaptic plasticity and memory (2015) Sci. Rep., 5
Caraci, F., Molinaro, G., Battaglia, G., Giuffrida, M.L., Riozzi, B., Traficante, A., Targeting group II metabotropic glutamate (MGlu) receptors for the treatment of psychosis associated with Alzheimer’s disease: Selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (2011) Mol. Pharmacol., 79, pp. 618-626
Caraci, F., Nicoletti, F., Copani, A., Metabotropic glutamate receptors: The potential for therapeutic applications in Alzheimer’s disease (2018) Curr. Opin. Pharmacol., 38, pp. 1-7
Caraci, F., Spampinato, S.F., Morgese, M.G., Tascedda, F., Salluzzo, M.G., Giambirtone, M.C., Neurobiological links between depression and AD: The role of TGF-beta1 signaling as a new pharmacological target (2018) Pharmacol. Res, 130, pp. 374-384. , (b)
Casley, C.S., Lakics, V., Lee, H.G., Broad, L.M., Day, T.A., Cluett, T., Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-beta peptide (2009) Brain Res, 1260, pp. 65-75
Cha, J.H., Farrell, L.A., Ahmed, S.F., Frey, A., Hsiao-Ashe, K.K., Young, A.B., Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein (2001) Neurobiol. Dis., 8, pp. 90-102
Chen, J.H., Ke, K.F., Lu, J.H., Qiu, Y.H., Peng, Y.P., Protection of TGF-beta1 against neuroinflammation and neurodegeneration in Abeta1-42-induced Alzheimer’s disease model rats (2015) Plos One, 10
Chiechio, S., Modulation of chronic pain by metabotropic glutamate receptors (2016) Adv. Pharmacol., 75, pp. 63-89
Ciccarelli, R., D’Alimonte, I., Ballerini, P., D’Auro, M., Nargi, E., Buccella, S., Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes (2007) Mol. Pharmacol., 71, pp. 1369-1380
Ciccarelli, R., Di Iorio, P., Bruno, V., Battaglia, G., D’Alimonte, I., D’Onofrio, M., Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes (1999) Glia, 27, pp. 275-281
Ciccarelli, R., Sureda, F.X., Casabona, G., Di Iorio, P., Caruso, A., Spinella, F., Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and-5 on astrocyte proliferation in culture (1997) Glia, 21, pp. 390-398
Conn, P.J., Pin, J.P., Pharmacology and functions of metabotropic glutamate receptors (1997) Annu. Rev. Pharmacol. Toxicol., 37, pp. 205-237
Corti, C., Battaglia, G., Molinaro, G., Riozzi, B., Pittaluga, A., Corsi, M., The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection (2007) J. Neurosci., 27, pp. 8297-8308
D’Antoni, S., Berretta, A., Seminara, G., Longone, P., Giuffrida-Stella, A.M., Battaglia, G., A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death (2011) Neurobiol. Dis., 42, pp. 252-264
Deng, W., Rosenberg, P.A., Volpe, J.J., Jensen, F.E., Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 6801-6806
Deng, W., Wang, H., Rosenberg, P.A., Volpe, J.J., Jensen, F.E., Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress (2004) Proc. Natl. Acad. Sci. U.S.A, 101, pp. 7751-7756
Dewapriya, P., Li, Y.X., Himaya, S.W., Pangestuti, R., Kim, S.K., Neoechinulin A suppresses amyloid-beta oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity (2013) Neurotoxicology, 35, pp. 30-40
Dewar, D., Chalmers, D.T., Graham, D.I., McCulloch, J., Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer’s disease: An autoradiographic study of the hippocampus (1991) Brain Res, 553, pp. 58-64
Ding, S., Fellin, T., Zhu, Y., Lee, S.Y., Auberson, Y.P., Meaney, D.F., Enhanced astrocytic Ca2 + signals contribute to neuronal excitotoxicity after status epilepticus (2007) J. Neurosci, 27, pp. 10674-10684
Doble, A., The role of excitotoxicity in neurodegenerative disease: Implications for therapy (1999) Pharmacol. Ther., 81, pp. 163-221
Drouin-Ouellet, J., Brownell, A.L., Saint-Pierre, M., Fasano, C., Emond, V., Trudeau, L.E., Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions (2011) Glia, 59, pp. 188-199
Dugan, L.L., Choi, D.W., Excitotoxicity, free radicals, and cell membrane changes (1994) Ann. Neurol, 35, pp. S17-S21
Durand, D., Carniglia, L., Beauquis, J., Caruso, C., Saravia, F., Lasaga, M., Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage (2014) Neuropharmacology, 79, pp. 180-189
Durand, D., Caruso, C., Carniglia, L., Lasaga, M., Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes (2010) J. Neurochem., 112, pp. 420-433
Ettle, B., Schlachetzki, J.C.M., Winkler, J., Oligodendroglia and myelin in neurodegenerative diseases: More than just bystanders? (2016) Mol. Neurobiol., 53, pp. 3046-3062
Fallarino, F., Volpi, C., Fazio, F., Notartomaso, S., Vacca, C., Busceti, C., Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation (2010) Nat. Med., 16, pp. 897-902
Farso, M.C., O’Shea, R.D., Beart, P.M., Evidence group I mGluR drugs modulate the activation profile of lipopolysaccharide-exposed microglia in culture (2009) Neurochem. Res., 34, pp. 1721-1728
Fazio, F., Ulivieri, M., Volpi, C., Gargaro, M., Fallarino, F., Targeting metabotropic glutamate receptors for the treatment of neuroinflammation (2018) Curr. Opin. Pharmacol., 38, pp. 16-23
Fazio, F., Zappulla, C., Notartomaso, S., Busceti, C., Bessede, A., Scarselli, P., Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice (2014) Neuropharmacology, 81, pp. 237-243
Fellner, L., Stefanova, N., The role of glia in alpha-synucleinopathies (2013) Mol. Neurobiol., 47, pp. 575-586
Fern, R.F., Matute, C., Stys, P.K., White matter injury: Ischemic and nonischemic (2014) Glia, 62, pp. 1780-1789
Ferrer, I., Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner (2018) Prog. Neurobiol., 169, pp. 24-54
Fiacco, T.A., Agulhon, C., McCarthy, K.D., Sorting out astrocyte physiology from pharmacology (2009) Annu. Rev. Pharmacol. Toxicol., 49, pp. 151-174
Gegelashvili, G., Dehnes, Y., Danbolt, N.C., Schousboe, A., The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms (2000) Neurochem. Int., 37, pp. 163-170
Gerber, U., Gee, C.E., Benquet, P., Metabotropic glutamate receptors: Intracellular signaling pathways (2007) Curr. Opin. Pharmacol., 7, pp. 56-61
Geurts, J.J., Wolswijk, G., Bo, L., Redeker, S., Ramkema, M., Troost, D., Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions (2005) J. Neuroimmunol., 158, pp. 182-190
Giordano, C., Cristino, L., Luongo, L., Siniscalco, D., Petrosino, S., Piscitelli, F., TRPV1-dependent and-independent alterations in the limbic cortex of neuropathic mice: Impact on glial caspases and pain perception (2012) Cereb. Cortex, 22, pp. 2495-2518
Gomez-Nicola, D., Perry, V.H., Microglial dynamics and role in the healthy and diseased brain: A paradigm of functional plasticity (2015) Neuroscientist, 21, pp. 169-184
Guida, F., Luongo, L., Marmo, F., Romano, R., Iannotta, M., Napolitano, F., Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice (2015) Mol. Brain, 8
Gwak, Y.S., Hulsebosch, C.E., Upregulation of Group I metabotropic glutamate receptors in neurons and astrocytes in the dorsal horn following spinal cord injury (2005) Exp. Neurol., 195, pp. 236-243
Hamilton, N., Vayro, S., Wigley, R., Butt, A.M., Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia (2010) Glia, 58, pp. 66-79
Hardingham, G.E., Bading, H., The Yin and Yang of NMDA receptor signalling (2003) Trends Neurosci, 26, pp. 81-89
Harris, J.J., Attwell, D., The energetics of CNS white matter (2012) J. Neurosci., 32, pp. 356-371
Hathaway, H.A., Pshenichkin, S., Grajkowska, E., Gelb, T., Emery, A.C., Wolfe, B.B., Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism (2015) Neuropharmacology, 93, pp. 199-208
Hellyer, S., Leach, K., Gregory, K.J., Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation (2017) Curr. Opin. Pharmacol., 32, pp. 49-55
Heneka, M.T., Rodriguez, J.J., Verkhratsky, A., Neuroglia in neurodegeneration (2010) Brain Res. Rev., 63, pp. 189-211
Homayoun, H., Moghaddam, B., Group 5 metabotropic glutamate receptors: Role in modulating cortical activity and relevance to cognition (2010) Eur. J. Pharmacol., 639, pp. 33-39
Hossain, M.Z., Unno, S., Ando, H., Masuda, Y., Kitagawa, J., Neuron-glia crosstalk and neuropathic pain: Involvement in the modulation of motor activity in the orofacial region (2017) Int. J. Mol. Sci., 18
Huang, Y.Y., Zhang, Q., Zhang, J.N., Zhang, Y.N., Gu, L., Yang, H.M., Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson’s disease (2018) Brain Behav. Immun., 71, pp. 93-107
Iacovelli, L., Bruno, V., Salvatore, L., Melchiorri, D., Gradini, R., Caricasole, A., Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways (2002) J. Neurochem., 82, pp. 216-223
Iacovelli, L., Felicioni, M., Nistico, R., Nicoletti, F., de Blasi, A., Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins (2014) Neuropharmacology, 77, pp. 303-312
Ibanez, C.F., Andressoo, J.O., Biology of GDNF and its receptors-Relevance for disorders of the central nervous system (2017) Neurobiol. Dis, 97, pp. 80-89
Iyer, A.M., van Scheppingen, J., Milenkovic, I., Anink, J.J., Lim, D., Genazzani, A.A., Metabotropic glutamate receptor 5 in Down’s syndrome hippocampus during development: Increased expression in astrocytes (2014) Curr. Alzheimer Res., 11, pp. 694-705
Jantas, D., Lech, T., Golda, S., Pilc, A., Lason, W., New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection (2018) Neuropharmacology, 141, pp. 223-237
Jantzie, L.L., Talos, D.M., Selip, D.B., An, L., Jackson, M.C., Folkerth, R.D., Developmental regulation of group I metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia (2010) Neuron Glia Biol, 6, pp. 277-288
Ji, R.R., Xu, Z.Z., Gao, Y.J., Emerging targets in neuroinflammation-driven chronic pain (2014) Nat. Rev. Drug Discov., 13, pp. 533-548
Kammermeier, P.J., Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers (2012) Mol. Pharmacol., 82, pp. 438-447
Kaushal, V., Schlichter, L.C., Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra (2008) J. Neurosci., 28, pp. 2221-2230
Kelland, E.E., Toms, N.J., Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death (2001) Eur. J. Pharmacol., 424, pp. R3-R4
Kim, S.U., de Vellis, J., Microglia in health and disease (2005) J. Neurosci. Res., 81, pp. 302-313
Klaver, R., de Vries, H.E., Schenk, G.J., Geurts, J.J., Grey matter damage in multiple sclerosis: A pathology perspective (2013) Prion, 7, pp. 66-75
Knezevic, D., Mizrahi, R., Molecular imaging of neuroinflammation in Alzheimer’s disease and mild cognitive impairment (2018) Prog. Neuropsychopharmacol. Biol. Psychiatry, 80, pp. 123-131
Kobayashi, K., Hayashi, M., Nakano, H., Fukutani, Y., Sasaki, K., Shimazaki, M., Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer’s disease (2002) Neuropathol. Appl. Neurobiol., 28, pp. 238-251
Le Poul, E., Bolea, C., Girard, F., Poli, S., Charvin, D., Campo, B., A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson’s disease (2012) J. Pharmacol. Exp. Ther., 343, pp. 167-177
Lim, D., Iyer, A., Ronco, V., Grolla, A.A., Canonico, P.L., Aronica, E., Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB (2013) Glia, 61, pp. 1134-1145
Liu, F., Zhou, R., Yan, H., Yin, H., Wu, X., Tan, Y., Metabotropic glutamate receptor 5 modulates calcium oscillation and innate immune response induced by lipopolysaccharide in microglial cell (2014) Neuroscience, 281, pp. 24-34
Liu, G.J., Nagarajah, R., Banati, R.B., Bennett, M.R., Glutamate induces directed chemotaxis of microglia (2009) Eur. J. Neurosci., 29, pp. 1108-1118
Lujan, R., Shigemoto, R., Lopez-Bendito, G., Glutamate and GABA receptor signalling in the developing brain (2005) Neuroscience, 130, pp. 567-580
Luyt, K., Varadi, A., Durant, C.F., Molnar, E., Oligodendroglial metabotropic glutamate receptors are developmentally regulated and involved in the prevention of apoptosis (2006) J. Neurochem., 99, pp. 641-656
Macrez, R., Stys, P.K., Vivien, D., Lipton, S.A., Docagne, F., Mechanisms of glutamate toxicity in multiple sclerosis: Biomarker and therapeutic opportunities (2016) Lancet Neurol, 15, pp. 1089-1102
Martin, G.M., Molecular mechanisms of late life dementias (2000) Exp. Gerontol., 35, pp. 439-443
Mastroiacovo, F., Moyanova, S., Cannella, M., Gaglione, A., Verhaeghe, R., Bozza, G., Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia (2017) Mol. Brain, 10
McMullan, S.M., Phanavanh, B., Li, G.G., Barger, S.W., Metabotropic glutamate receptors inhibit microglial glutamate release (2012) ASN Neuro, 4
Mosher, K.I., Wyss-Coray, T., Microglial dysfunction in brain aging and Alzheimer’s disease (2014) Biochem. Pharmacol., 88, pp. 594-604
Motolese, M., Mastroiacovo, F., Cannella, M., Bucci, D., Gaglione, A., Riozzi, B., Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage (2015) Mol. Brain, 8
Nakamichi, N., Yoshida, K., Ishioka, Y., Makanga, J.O., Fukui, M., Yoneyama, M., Group III metabotropic glutamate receptor activation suppresses self-replication of undifferentiated neocortical progenitor cells (2008) J. Neurochem., 105, pp. 1996-2012
Newcombe, J., Uddin, A., Dove, R., Patel, B., Turski, L., Nishizawa, Y., Glutamate receptor expression in multiple sclerosis lesions (2008) Brain Pathol, 18, pp. 52-61
Nguyen, D., Alavi, M.V., Kim, K.Y., Kang, T., Scott, R.T., Noh, Y.H., A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics (2011) Cell Death Dis, 2, p. e240
Nicoletti, F., Bockaert, J., Collingridge, G.L., Conn, P.J., Ferraguti, F., Schoepp, D.D., Metabotropic glutamate receptors: From the workbench to the bedside (2011) Neuropharmacology, 60, pp. 1017-1041
Niswender, C.M., Conn, P.J., Metabotropic glutamate receptors: Physiology, pharmacology, and disease (2010) Annu. Rev. Pharmacol. Toxicol., 50, pp. 295-322
Oliet, S.H., Piet, R., Poulain, D.A., Control of glutamate clearance and synaptic efficacy by glial coverage of neurons (2001) Science, 292, pp. 923-926
Olmos, G., Llado, J., Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity (2014) Mediators Inflamm, 2014
O’Riordan, K.J., Huang, I.C., Pizzi, M., Spano, P., Boroni, F., Egli, R., Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors (2006) J. Neurosci., 26, pp. 4870-4879
Palazzo, E., Marabese, I., Luongo, L., Guida, F., de Novellis, V., Maione, S., Nociception modulation by supraspinal group III metabotropic glutamate receptors (2017) J. Neurochem., 141, pp. 507-519
Paquet, M., Ribeiro, F.M., Guadagno, J., Esseltine, J.L., Ferguson, S.S., Cregan, S.P., Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis (2013) Mol. Brain, 6, p. 9
Pickering, M., Cumiskey, D., O’Connor, J.J., Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system (2005) Exp. Physiol., 90, pp. 663-670
Piers, T.M., Heales, S.J., Pocock, J.M., Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection (2011) Neurosci. Lett., 505, pp. 140-145
Pin, J.P., Bettler, B., Organization and functions of mGlu and GABAB receptor complexes (2016) Nature, 540, pp. 60-68
Pinteaux-Jones, F., Sevastou, I.G., Fry, V.A., Heales, S., Baker, D., Pocock, J.M., Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors (2008) J. Neurochem., 106, pp. 442-454
Ponnazhagan, R., Harms, A.S., Thome, A.D., Jurkuvenaite, A., Gogliotti, R., Niswender, C.M., The metabotropic glutamate receptor 4 positive allosteric modulator ADX88178 inhibits inflammatory responses in primary microglia (2016) J. Neuroimmune Pharmacol., 11, pp. 231-237
Ribeiro, F.M., Vieira, L.B., Pires, R.G., Olmo, R.P., Ferguson, S.S., Metabotropic glutamate receptors and neurodegenerative diseases (2017) Pharmacol. Res., 115, pp. 179-191
Rodriguez-Kern, A., Gegelashvili, M., Schousboe, A., Zhang, J., Sung, L., Gegelashvili, G., Beta-amyloid and brain-derived neurotrophic factor, BDNF, up-regulate the expression of glutamate transporter GLT-1/EAAT2 via different signaling pathways utilizing transcription factor NF-κB (2003) Neurochem. Int., 43, pp. 363-370
Romano, C., Smout, S., Miller, J.K., O’Malley, K.L., Developmental regulation of metabotropic glutamate receptor 5b protein in rodent brain (2002) Neuroscience, 111, pp. 693-698
Rosenbluth, J., Multiple functions of the paranodal junction of myelinated nerve fibers (2009) J. Neurosci. Res., 87, pp. 3250-3258
Rossi, D.J., Oshima, T., Attwell, D., Glutamate release in severe brain ischaemia is mainly by reversed uptake (2000) Nature, 403, pp. 316-321
Rothstein, J.D., van Kammen, M., Levey, A.I., Martin, L.J., Kuncl, R.W., Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis (1995) Ann. Neurol., 38, pp. 73-84
Schafer, D.P., Lehrman, E.K., Kautzman, A.G., Koyama, R., Mardinly, A.R., Yamasaki, R., Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner (2012) Neuron, 74, pp. 691-705
Shah, A., Silverstein, P.S., Singh, D.P., Kumar, A., Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes (2012) J. Neuroinflammation, 9, p. 52
Shrivastava, A.N., Kowalewski, J.M., Renner, M., Bousset, L., Koulakoff, A., Melki, R., Beta-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors (2013) Glia, 61, pp. 1673-1686
Sorensen, T.L., Tani, M., Jensen, J., Pierce, V., Lucchinetti, C., Folcik, V.A., Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients (1999) J. Clin. Invest., 103, pp. 807-815
Stevens, B., Allen, N.J., Vazquez, L.E., Howell, G.R., Christopherson, K.S., Nouri, N., The classical complement cascade mediates CNS synapse elimination (2007) Cell, 131, pp. 1164-1178
Strachan-Whaley, M., Rivest, S., Yong, V.W., Interactions between microglia and T cells in multiple sclerosis pathobiology (2014) J. Interferon Cytokine Res., 34, pp. 615-622
Streit, W.J., Xue, Q.S., Human CNS immune senescence and neurodegeneration (2014) Curr. Opin. Immunol., 29, pp. 93-96
Sun, W., McConnell, E., Pare, J.F., Xu, Q., Chen, M., Peng, W., Glutamate-dependent neuroglial calcium signaling differs between young and adult brain (2013) Science, 339, pp. 197-200
Tang, F.R., Lee, W.L., Expression of the group II and III metabotropic glutamate receptors in the hippocampus of patients with mesial temporal lobe epilepsy (2001) J. Neurocytol., 30, pp. 137-143
Taylor, D.L., Diemel, L.T., Cuzner, M.L., Pocock, J.M., Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide upregulated in Alzheimer’s disease (2002) J. Neurochem., 82, pp. 1179-1191
Taylor, D.L., Jones, F., Kubota, E.S., Pocock, J.M., Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand (2005) J. Neurosci., 25, pp. 2952-2964
Tichauer, J.E., von Bernhardi, R., Transforming growth factor-beta stimulates beta amyloid uptake by microglia through Smad3-dependent mechanisms (2012) J. Neurosci. Res., 90, pp. 1970-1980
Tilleux, S., Berger, J., Hermans, E., Induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5 (2007) J. Neuroimmunol., 189, pp. 23-30
Tison, F., Keywood, C., Wakefield, M., Durif, F., Corvol, J.C., Eggert, K., A phase 2A trial of the novel mGluR5-negative allosteric modulator dipraglurant for levodopa-induced dyskinesia in parkinson’s disease (2016) Mov. Disord., 31, pp. 1373-1380
Tomimoto, H., Akiguchi, I., Wakita, H., Kimura, J., White matter lesions after occlusion of the bilateral carotid arteries in the rat–temporal profile of cerebral blood flow (CBF), oligodendroglia and myelin (1997) No to Shinkei, 49, pp. 639-644
Ullian, E.M., Sapperstein, S.K., Christopherson, K.S., Barres, B.A., Control of synapse number by glia (2001) Science, 291, pp. 657-661
Vafabakhsh, R., Levitz, J., Isacoff, E.Y., Conformational dynamics of a class C G-protein-coupled receptor (2015) Nature, 524, pp. 497-501
Verderio, C., Extracellular membrane microvesicles and nanotubes in the brain: Understanding their nature, their function in cell-to-cell communication, their role in transcellular spreading of pathological agents and their therapeutic potential (2013) Front. Physiol., 4, p. 163
Verite, J., Janet, T., Chassaing, D., Fauconneau, B., Rabeony, H., Page, G., Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice (2018) J. Neuroinflammation, 15
Vermeiren, C., Hemptinne, I., Vanhoutte, N., Tilleux, S., Maloteaux, J.M., Hermans, E., Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis (2006) J. Neurochem., 96, pp. 719-731
Vermeiren, C., Najimi, M., Vanhoutte, N., Tilleux, S., de Hemptinne, I., Maloteaux, J.M., Acute up-regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes (2005) J. Neurochem., 94, pp. 405-416
Vernon, A.C., Smith, E.J., Stevanato, L., Modo, M., Selective activation of metabotropic glutamate receptor 7 induces inhibition of cellular proliferation and promotes astrocyte differentiation of ventral mesencephalon human neural stem/progenitor cells (2011) Neurochem. Int., 59, pp. 421-431
Wang, J.W., Wang, H.D., Cong, Z.X., Zhang, X.S., Zhou, X.M., Zhang, D.D., Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats (2013) Biochem. Biophys. Res. Commun., 430, pp. 1016-1021
Werner, P., Pitt, D., Raine, C.S., Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage (2001) Ann. Neurol., 50, pp. 169-180
Wilkinson, B.L., Landreth, G.E., The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer’s disease (2006) J. Neuroinflammation, 3, p. 30
Xue, F., Stoica, B.A., Hanscom, M., Kabadi, S.V., Faden, A.I., Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGluR5) attenuate microglial activation (2014) CNS Neurol. Disord. Drug Targets, 13, pp. 558-566
Yang, L., Mao, L., Chen, H., Catavsan, M., Kozinn, J., Arora, A., A signaling mechanism from G alpha q-protein-coupled metabotropic glutamate receptors to gene expression: Role of the c-Jun N-terminal kinase pathway (2006) J. Neurosci., 26, pp. 971-980
Yang, P., Zhang, J., Zhao, L., Jiao, Q., Jin, H., Xiao, X., Developmental distribution pattern of metabotropic glutamate receptor 5 in prenatal human hippocampus (2012) Neurosci. Bull., 28, pp. 704-714
Yao, H.H., Ding, J.H., Zhou, F., Wang, F., Hu, L.F., Sun, T., Enhancement of glutamate uptake mediates the neuroprotection exerted by activating group II or III metabotropic glutamate receptors on astrocytes (2005) J. Neurochem., 92, pp. 948-961
Ye, X., Yu, L., Zuo, D., Zhang, L., Zu, J., Hu, J., Activated mGluR5 protects BV2 cells against OGD/R induced cytotoxicity by modulating BDNF-TrkB pathway (2017) Neurosci. Lett., 654, pp. 70-79
Yin, S., Noetzel, M.J., Johnson, K.A., Zamorano, R., Jalan-Sakrikar, N., Gregory, K.J., Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS (2014) J. Neurosci., 34, pp. 79-94
Zabel, M.K., Kirsch, W.M., From development to dysfunction: Microglia and the complement cascade in CNS homeostasis (2013) Ageing Res. Rev., 12, pp. 749-756
Zhang, Z., Ma, W., Wang, L., Gong, H., Tian, Y., Zhang, J., Activation of type 4 metabotropic glutamate receptor attenuates oxidative stress-induced death of neural stem cells with inhibition of JNK and p38 MAPK signaling (2015) Stem Cells Dev, 24, pp. 2709-2722
Zhao, Z., Nelson, A.R., Betsholtz, C., Zlokovic, B.V., Establishment and dysfunction of the blood-brain barrier (2015) Cell, 163, pp. 1064-1078
Zhou, F., Yao, H.H., Wu, J.Y., Yang, Y.J., Ding, J.H., Zhang, J., Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake (2006) J. Neurosci. Res., 84, pp. 268-277
Zipfel, G.J., Babcock, D.J., Lee, J.M., Choi, D.W., Neuronal apoptosis after CNS injury: The roles of glutamate and calcium (2000) J. Neurotrauma, 17, pp. 857-869
Neurodegenerative disorders are characterized by excitotoxicity and neuroinflammation that finally lead to slow neuronal degeneration and death. Although neurons are the principal target, glial cells are important players as they contribute by either exacerbating or dampening the events that lead to neuroinflammation and neuronal damage. A dysfunction of the glutamatergic system is a common event in the pathophysiology of these diseases. Metabotropic glutamate (mGlu) receptors belong to a large family of G protein-coupled receptors largely expressed in neurons as well as in glial cells. They often appear overexpressed in areas involved in neurodegeneration, where they can modulate glutamatergic transmission. Of note, mGlu receptor upregulation may involve microglia or, even more frequently, astrocytes, where their activation causes release of factors potentially able to influence neuronal death. The expression of mGlu receptors has been also reported on oligodendrocytes, a glial cell type specifically involved in the development of multiple sclerosis. Here we will provide a general overview on the possible involvement of mGlu receptors expressed on glial cells in the pathogenesis of different neurodegenerative disorders and the potential use of subtype-selective mGlu receptor ligands as candidate drugs for the treatment of neurodegenerative disorders. Negative allosteric modulators (NAM) of mGlu5 receptors might represent a relevant pharmacological tool to develop new neuroprotective strategies in these diseases. Recent evidence suggests that targeting astrocytes and microglia with positive allosteric modulators (PAM) of mGlu3 receptor or oligodendrocytes with mGlu4 PAMS might represent novel pharmacological approaches for the treatment of neurodegenerative disorders. © 2018 Spampinato, Copani, Nicoletti, Sortino and Caraci.
Nessun risultato. |
Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Dubbioso R, Ruggiero L, Esposito M, Tarantino P, De Angelis M, Aruta F, Pappata S, Ugga L, Piperno A, Iorio R, Santoro L, Iodice R, Manganelli F
* Different cortical excitability profiles in hereditary brain iron and copper accumulation (0 visite)
Neurol Sci (ISSN: 1590-1874linking), 2019 Nov 26; N/D: N/D-N/D.
Impact Factor:
Dettagli Esporta in BibTeX Esporta in EndNote
Maievskyi O, Samborska I, Kovalchuk O, Fagoonee S, Falalyeyeva T
* The Role of Hyperhomocysteinemia on the Development of Changes in the Lungs (0 visite)
Rev Recent Clin Trials (ISSN: 1574-8871linking), 2019 Nov 14; N/D: N/D-N/D.
Impact Factor:
Dettagli Esporta in BibTeX Esporta in EndNote
Nicoletti F, Orlando R, Di Menna L, Cannella M, Notartomaso S, Mascio G, Iacovelli L, Matrisciano F, Fazio F, Caraci F, Copani A, Battaglia G, Bruno V
* Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia (49 visite)
Front Psychiatry (ISSN: 1664-0640linking), 2019 Feb 14; 10: 49-49.
Impact Factor: 2.857
Dettagli Esporta in BibTeX Esporta in EndNote
Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G
* Clinical proof of concept for a safe and effective NF-kappaB-targeting strategy in multiple myeloma (77 visite)
Br J Haematol (ISSN: 1365-2141electronic, 0007-1048linking), 2018 Sep 26; N/D: N/D-N/D.
Impact Factor: 4.498
Dettagli Esporta in BibTeX Esporta in EndNote
Carafa V, Nebbioso A, Cuomo F, Rotili D, Cobellis G, Bontempo P, Baldi A, Spugnini EP, Citro G, Chambery A, Russo R, Ruvo M, Ciana P, Maravigna L, Shaik J, Radaelli E, De Antonellis P, Tarantino D, Pirolli A, Ragno R, Zollo M, Stunnenberg HG, Mai A, Altucci L
* RIP1-HAT1-SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer (74 visite)
Clin Cancer Res (ISSN: 1078-0432print, 1078-0432linking), 2018 Jun 15; 24(12): 2886-2900.
Impact Factor: 6.488
Dettagli Esporta in BibTeX Esporta in EndNote
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (92 visite)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
Dettagli Esporta in BibTeX Esporta in EndNote
Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (158 visite)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
Dettagli Esporta in BibTeX Esporta in EndNote
Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (185 visite)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
Dettagli Esporta in BibTeX Esporta in EndNote
Farina B, Sturlese M, Mascanzoni F, Caporale A, Monti A, Sorbo GD, Fattorusso R, Ruvo M, Doti N
* Binding mode of AIF(370–394) peptide to CypA: insights from NMR, label-free and molecular docking studies (90 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2018; 475(14): 2377-2393.
Impact Factor: 4.897
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (97 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (196 visite)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (105 visite)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
Dettagli Esporta in BibTeX Esporta in EndNote
Doti N, Ruvo M
* Relevance and therapeutic potential of CypA targeting to block apoptosis inducing factor-mediated neuronal cell death (219 visite)
Neural Regen Res (ISSN: 1673-5374), 2017 Sep; 12(9): 1428-1429.
Impact Factor: 2.234
Dettagli Esporta in BibTeX Esporta in EndNote
Sciacca MFM, Romanucci V, Zarrelli A, Monaco I, Lolicato F, Spinella N, Galati C, Grasso G, D'Urso L, Romeo M, Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C, Milardi D
* Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (148 visite) (PDF 121 visite)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2017 Jun 09; N/D: N/D-N/D.
Impact Factor: 4.211
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, Santoro AM, Lanza V, Sbardella D, Tundo GR, Ciaccio C, Marini S, Coletta M, Milardi D
* The double faced role of copper in Ab homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration (126 visite)
Coordination Chemistry Reviews, 2017 Jun; N/D: 1-22.
Impact Factor: 13.324
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A
* The underexplored question of beta-amyloid monomers (97 visite)
Eur J Pharmacol (ISSN: 0014-2999), 2017 May 31; N/D: N/D-N/D.
Impact Factor: 3.04
Dettagli Esporta in BibTeX Esporta in EndNote
Farina B, Di Sorbo G, Chambery A, Caporale A, Leoni G, Russo R, Mascanzoni F, Raimondo D, Fattorusso R, Ruvo M, Doti N
* Structural and biochemical insights of CypA and AIF interaction (146 visite)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Apr 25; 7(1): 1138-1138.
Impact Factor: 4.122
Dettagli Esporta in BibTeX Esporta in EndNote
Florenzano F, Veronica C, Ciasca G, Ciotti MT, Pittaluga A, Olivero G, Feligioni M, Iannuzzi F, Latina V, Sciacca MFM, Sinopoli A, Milardi D, Pappalardo G, De Spirito M, Papi M, Atlante A, Bobba A, Borreca A, Calissano P, Amadoro G
* Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies (108 visite)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Apr 22; N/D: N/D-N/D.
Impact Factor: 5.168
Dettagli Esporta in BibTeX Esporta in EndNote
D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (118 visite)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (115 visite) (PDF 138 visite)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (111 visite)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2016 Apr 30; N/D: N/D-N/D.
Impact Factor: 5.012
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (231 visite)
Rsc Adv (ISSN: 2046-2069), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
Dettagli Esporta in BibTeX Esporta in EndNote
De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (396 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
Dettagli Esporta in BibTeX Esporta in EndNote
Pignataro G, Ziaco B, Tortiglione A, Gala R, Cuomo O, Vinciguerra A, Lapi D, Mastantuono T, Anzilotti S, D'Andrea LD, Pedone C, Di Renzo G, Annunziato L, Cataldi M
* Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion (150 visite)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2015 Sep 16; 6(9): 1517-1525.
Impact Factor: 4.348
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (329 visite)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
Dettagli Esporta in BibTeX Esporta in EndNote
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (64 visite)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M, Gomez-Monterrey I, Campiglia P, Novellino E, Illario M, Trimarco B, De Luca N, Iaccarino G
* New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (179 visite)
Br J Cancer (ISSN: 0007-0920, 0007-0920print), 2015 Jan 6; 112(1): 77-85.
Impact Factor: 5.569
Dettagli Esporta in BibTeX Esporta in EndNote
Travaglia A, Pietropaolo A, Di Martino R, Nicoletti VG, La Mendola D, Calissano P, Rizzarelli E
* A Small Linear Peptide Encompassing the NGF N-Terminus Partly Mimics the Biological Activities of the Entire Neurotrophin in PC12 Cells (170 visite)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic, 1948-7193linking), 2015; 6(8): 1379-1392.
Impact Factor: 4.348
Dettagli Esporta in BibTeX Esporta in EndNote
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (65 visite)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
Dettagli Esporta in BibTeX Esporta in EndNote
Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (195 visite)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
Dettagli Esporta in BibTeX Esporta in EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (205 visite)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
Dettagli Esporta in BibTeX Esporta in EndNote
Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (191 visite)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
Dettagli Esporta in BibTeX Esporta in EndNote
Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (268 visite)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
Dettagli Esporta in BibTeX Esporta in EndNote
Salvatore E, Tedeschi E, Mollica C, Vicidomini C, Varrone A, Coda ARD, Brunetti A, Salvatore M, De Michele G, Filla A, Pappata S
* Supratentorial and infratentorial damage in spinocerebellar ataxia 2: a diffusion-weighted MRI study (186 visite)
Mov Disord (ISSN: 0885-3185, 1531-8257), 2014 May; 29(6): 780-786.
Impact Factor: 5.68
Dettagli Esporta in BibTeX Esporta in EndNote
De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F
* Renal cells from spermatogonial germline stem cells protect against kidney injury (161 visite)
J Am Soc Nephrol (ISSN: 1046-6673), 2014 Feb; 25(2): 316-328.
Impact Factor: 9.343
Dettagli Esporta in BibTeX Esporta in EndNote
Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (227 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
Dettagli Esporta in BibTeX Esporta in EndNote
Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (257 visite)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Rizzarelli E
* Carnosine and Cognitive Deficits (41 visite)
Diet And Nutr In Dement And Cogn Decline (ISSN: 9780-1240793979780124078246), 2014; N/D: 973-982.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (280 visite)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Impact Factor: 1.219
Dettagli Esporta in BibTeX Esporta in EndNote
Russo E, Guerra A, Marotta V, Faggiano A, Colao A, Del Vecchio S, Tonacchera M, Vitale M
* Radioiodide induces apoptosis in human thyroid tissue in culture (196 visite)
Endocrine (ISSN: 1355-008x, 1355-008xlinking), 2013 Dec; 44(3): 729-734.
Impact Factor: 3.527
Dettagli Esporta in BibTeX Esporta in EndNote
Bergamo P, Cocca E, Palumbo R, Gogliettino M, Rossi M, Palmieri G
* RedOx status, proteasome and APEH: Insights into anticancer mechanisms of t10, c12-conjugated linoleic acid isomer on A375 melanoma cells (228 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013 Nov 19; 8(11): N/D-N/D.
Impact Factor: 3.534
Dettagli Esporta in BibTeX Esporta in EndNote
Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (212 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Nov 7; 4(11): e911-e911.
Impact Factor: 5.177
Dettagli Esporta in BibTeX Esporta in EndNote
Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
* Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy (213 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2013 Sep; 125: 16-25.
Impact Factor: 3.274
Dettagli Esporta in BibTeX Esporta in EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (252 visite)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
Dettagli Esporta in BibTeX Esporta in EndNote
Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (168 visite)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
Dettagli Esporta in BibTeX Esporta in EndNote
Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (197 visite)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
Dettagli Esporta in BibTeX Esporta in EndNote
Greco A, Fiumara G, Gargiulo S, Gramanzini M, Brunetti A, Cuocolo A
* High-resolution positron emission tomography/computed tomography imaging of the mouse heart (216 visite)
Exp Physiol Experimental Physiology (ISSN: 1469-445x, 0958-0670), 2013 Mar; 98(3): 645-651.
Impact Factor: 2.871
Dettagli Esporta in BibTeX Esporta in EndNote
Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (249 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
Dettagli Esporta in BibTeX Esporta in EndNote
Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (204 visite)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
Dettagli Esporta in BibTeX Esporta in EndNote
Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM
* Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (160 visite)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348.
Impact Factor: 2.689
Dettagli Esporta in BibTeX Esporta in EndNote
Costa B, Bendinelli S, Gabelloni P, Da Pozzo E, Daniele S, Scatena F, Vanacore R, Campiglia P, Bertamino A, Gomez-Monterrey I, Sorriento D, Del Giudice C, Iaccarino G, Novellino E, Martini C
* Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor (145 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013; 8(8): e72281-e72281.
Impact Factor: 3.534
Dettagli Esporta in BibTeX Esporta in EndNote
Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (262 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (202 visite)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (202 visite)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
Dettagli Esporta in BibTeX Esporta in EndNote
Sandomenico A, Russo A, Palmieri G, Bergamo P, Gogliettino M, Falcigno L, Ruvo M
* Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation (232 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012 Mar 8; 55(5): 2102-2111.
Impact Factor: 5.614
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (380 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (297 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
Dettagli Esporta in BibTeX Esporta in EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (189 visite)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (319 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
Dettagli Esporta in BibTeX Esporta in EndNote
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (210 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
Dettagli Esporta in BibTeX Esporta in EndNote
Gargiulo S, Greco A, Gramanzini M, Petretta MP, Ferro A, Larobina M, Panico M, Brunetti A, Cuocolo A
* PET/CT imaging in mouse models of myocardial ischemia (353 visite)
J Biomed Biotechnol (ISSN: 1110-7251, 1110-7243), 2012; 2012: 541872-541872.
Impact Factor: 2.88
Dettagli Esporta in BibTeX Esporta in EndNote
Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (279 visite)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
Dettagli Esporta in BibTeX Esporta in EndNote
Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (210 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
Dettagli Esporta in BibTeX Esporta in EndNote
Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (234 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
Dettagli Esporta in BibTeX Esporta in EndNote
Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (277 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (275 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (173 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
Dettagli Esporta in BibTeX Esporta in EndNote
Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (176 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
Dettagli Esporta in BibTeX Esporta in EndNote
Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (297 visite)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
Dettagli Esporta in BibTeX Esporta in EndNote
Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (202 visite)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (396 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
Dettagli Esporta in BibTeX Esporta in EndNote
Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (237 visite)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
Dettagli Esporta in BibTeX Esporta in EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (204 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
Dettagli Esporta in BibTeX Esporta in EndNote
Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (202 visite)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
Dettagli Esporta in BibTeX Esporta in EndNote
Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (236 visite)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (356 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
Dettagli Esporta in BibTeX Esporta in EndNote
Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP
* Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (202 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2010 Apr 8; 5(4): N/D-N/D.
Impact Factor: 4.411
Dettagli Esporta in BibTeX Esporta in EndNote
Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (187 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
Dettagli Esporta in BibTeX Esporta in EndNote
Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano MF
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (145 visite)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (186 visite)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (234 visite)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (173 visite)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR
* The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (139 visite)
Oncogene (ISSN: 1476-5594, 0950-9232), 2009 Nov 19; 28(46): 4075-4094.
Impact Factor: 7.135
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (164 visite)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
Dettagli Esporta in BibTeX Esporta in EndNote
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion Proteins Leading to Neurodegeneration (vol 5, pg 579, 2008) (124 visite)
Current Alzheimer Research (ISSN: 1567-2050), 2009 Jun; 6(3): N/D-N/D.
Impact Factor: 4.971
Dettagli Esporta in BibTeX Esporta in EndNote
Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (145 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (243 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (211 visite)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (152 visite)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
Dettagli Esporta in BibTeX Esporta in EndNote
Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (182 visite)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (332 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
Dettagli Esporta in BibTeX Esporta in EndNote
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (178 visite)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (188 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
Dettagli Esporta in BibTeX Esporta in EndNote
Palumbo R, Brescia F, Capasso D, Sannino A, Sarti M, Capri M, Grassilli E, Scarfì MR
* Exposure to 900 MHz radiofrequency radiation induces caspase 3 activation in proliferating human lymphocytes (146 visite)
Radiat Res (ISSN: 0033-7587), 2008 Sep; 170(3): 327-334.
Impact Factor: 3.043
Dettagli Esporta in BibTeX Esporta in EndNote
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (204 visite)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (283 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
Dettagli Esporta in BibTeX Esporta in EndNote
Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (154 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
Dettagli Esporta in BibTeX Esporta in EndNote
Gustavsson T, Banyasz A, Sarkar N, Markovitsi D, Improta R
* Statin: New life for an old drug (168 visite)
Pharmacol Res Academic Press, 2008 Jun 23; 350(1-3): 1-2.
Impact Factor: 3.976
Dettagli Esporta in BibTeX Esporta in EndNote
Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (144 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (155 visite)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (212 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (186 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (191 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (277 visite)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (246 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
Dettagli Esporta in BibTeX Esporta in EndNote
Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (164 visite)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
Dettagli Esporta in BibTeX Esporta in EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (343 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
Dettagli Esporta in BibTeX Esporta in EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (182 visite)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
Dettagli Esporta in BibTeX Esporta in EndNote
Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (187 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
Dettagli Esporta in BibTeX Esporta in EndNote
De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (200 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
Dettagli Esporta in BibTeX Esporta in EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (200 visite)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (183 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
Dettagli Esporta in BibTeX Esporta in EndNote
Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (189 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (116 visite)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
Dettagli Esporta in BibTeX Esporta in EndNote
Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (199 visite)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (191 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Salvatore B, Paone G, Fonti R, Salvatore M
* Functional imaging of multidrug resistance in breast cancer (231 visite)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2006; 21(SUPPL.1): 24-27.
Impact Factor: 0.313
Dettagli Esporta in BibTeX Esporta in EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (152 visite)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic), 2006; 27(4): 606-613.
Impact Factor: 5.599
Dettagli Esporta in BibTeX Esporta in EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (225 visite)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (178 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
Dettagli Esporta in BibTeX Esporta in EndNote
Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (227 visite)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
Dettagli Esporta in BibTeX Esporta in EndNote
Pace L, Del Vecchio S, Salvatore M
* Technetium 99m sestamibi in multiple myeloma (129 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 2005 Jan; 234(1): 312-313.
Impact Factor: 5.377
Dettagli Esporta in BibTeX Esporta in EndNote
Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (203 visite)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
Dettagli Esporta in BibTeX Esporta in EndNote
Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (153 visite)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
Dettagli Esporta in BibTeX Esporta in EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (183 visite)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
Dettagli Esporta in BibTeX Esporta in EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (418 visite)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
Dettagli Esporta in BibTeX Esporta in EndNote
Pace L, Del Vecchio S, Salvatore M, Walker RC, Angtuaco E, Sethi R, Fassas A, Barlogie B
* Technetium 99m sestamibi in multiple myeloma [3] (multiple letters) (191 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 2005; 234(1): 312-313.
Impact Factor: 5.377
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (190 visite)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Salvatore B, Paone G, Fonti R, Iommelli F, De Renzo A, Rotoli B, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing non-Hodgkin's lymphoma patients during drug-induced apoptosis (197 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
Impact Factor: 3.935
Dettagli Esporta in BibTeX Esporta in EndNote
Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (168 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
Dettagli Esporta in BibTeX Esporta in EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (249 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (265 visite) (PDF 113 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(SUPPL.1): S88-S88.
Impact Factor: 3.935
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Zannetti A, Caracó C, Del Vecchio S, Salvatore M
* Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (264 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004; 31(4): 521-527.
Impact Factor: 3.935
Dettagli Esporta in BibTeX Esporta in EndNote
Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (203 visite)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
Dettagli Esporta in BibTeX Esporta in EndNote
Spalletti-cernia D, Sorrentino R, Di Gaetano S, Arciello A, Garbi C, Piccoli R, D'Alessio G, Vecchio G, Laccetti P, Santoro M
* Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis (174 visite)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
Impact Factor: 5.873
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (253 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (239 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
Dettagli Esporta in BibTeX Esporta in EndNote
Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (188 visite)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (227 visite)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
Dettagli Esporta in BibTeX Esporta in EndNote
Salvatore M, Fonti R
* New frontiers of nuclear medicine (252 visite)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (201 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Ciarmiello A, Zannetti A, Fonti R, Botti G, D'Aiuto G, Salvatore M
Efflux rate of Tc-99m-MIBI and apoptosis in untreated breast cancer patients (205 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2000 May; 41(5): N/D-N/D.
Impact Factor: 3.617
Dettagli Esporta in BibTeX Esporta in EndNote
Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (134 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
Dettagli Esporta in BibTeX Esporta in EndNote
Russo GL, Della Pietra V, Mercurio C, Palumbo R, Iacomino G, Russo M, Tosto M, Zappia V
Protective effects of butyric acid in colon cancer (99 visite)
Adv Exp Med Biol (ISSN: 0065-2598print, 0065-2598linking), 1999; 472: 131-147.
Impact Factor: 0.446
Dettagli Esporta in BibTeX Esporta in EndNote
144 Records (128 escludendo Abstract e Conferenze).
Impact factor totale: 706.452 (640.886 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 714.883 (642.806 escludendo Abstract e Conferenze).
Impact factor totale: 706.452 (640.886 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 714.883 (642.806 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Thursday 07 February 2019, 8:04:01
53 visite. Ultima visita in data Friday 24 January 2020, 18:00:54
ibb.cnr.it