An inorganic overview of natural Aβ fragments: Copper(II) and zinc(II)-mediated pathways (179 views visite)
Coord Chem Rev (ISSN: 0010-8545), 2018; 369: 1-14.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 11.225, 5-year impact factor Impact factor a 5 anni: 12.752
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046631140&doi=10.1016%2fj.ccr.2018.04.004&partnerID=40&md5=76e9f85a682b66f7399d2c6b17e4afa1
Keywords Parole chiave: Alzheimer, S Disease, Aβ-Degrading Enzyme, Metal Ions, Metallostasis, Neurodegenerative Diseases,
Affiliations Affiliazioni:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, CNR Catania, Italy
Inter-university Consortium for The Research on Chemistry of Metals in Biological Systems, Bari, Italy
Department of Chemical Sciences, University of Catania, Catania, Italy
References Riferimenti:
(2016), https://www.alz.co.uk/research/WorldAlzheimerReport2016.pdf, World Alzheimer Report
Selkoe, D.J., Hardy, J., (2016) EMBO Mol. Med., 8, pp. 595-60
Benilova, I., Karran, E., De Strooper, B., (2012) Nat. Neurosci., 15, pp. 349-357
Baranello, R.J., Bharani, K.L., Padmaraju, V., Chopra, N., Lahiri, D.K., Greig, N.H., Pappolla, M.A., Sambamurti, K., (2015) Curr. Alzheimer Res., 12, pp. 32-46
Mullard, A., (2017) Nat. Rev. Drug Discov., 16, pp. 3-5
Sambamurti, K., Vasudevaraju, P., Mintzer, J., Bachman, D., Granholm, C., (2012) J. Alzheimers Dis. Parkinsonism, 2, pp. e115-116
Rosenblum, W.I., (2014) Neurobiol. Aging, 35, pp. 969-974
Acevedo, K.M., Hung, Y.H., Dalziel, A.H., Li, Q.X., Laughton, K., Wikhe, K., Rembach, A., Camakaris, J., (2011) J Biol Chem, 286, pp. 8252-8262
Mayer, M.C., Kaden, D., Schauenburg, L., Hancock, M.A., Voigt, P., Roeser, D., Barucker, C., Multhaup, G., (2014) J. Biol. Chem., 289, pp. 19019-19030
Brewer, G.J., (2015) J. Alzheimers Dis., 46, pp. 593-604
Xu, J., Church, S.J., Patassini, S., Begley, P., Waldvogel, H.J., Curtis, M.A., Faull, R.L.M., Cooper, G.J.S., (2017) Metallomics, 9, pp. 1106-1119
Deibel, M.A., Ehmann, W.D., Markesbery, W.R., (1996) J. Neurol. Sci., 143, pp. 137-142
Crouch, P.J., Hung, L.W., Adlard, P.A., Cortes, M., Lal, V., Filiz, G., Perez, K.A., Barnham, K.J., (2009) Proc. Natl. Acad. Sci. U.S.A., 106, pp. 381-386
Atrian-Blasco, E., Conte-Daban, A., Hureau, C., (2017) Dalton Trans., 46, pp. 12750-12759
Milardi, D., Rizzarelli, E., Neurodegeneration: Metallostasis and Proteostasis (2011), Royal Society of Chemistry Cambridge
White, A.R., Du, T., Laughton, K.M., Volitakis, I., Sharples, R.A., Xilinas, M.E., Hoke, D.E., Masters, C.L., (2006) J. Biol. Chem., 281, pp. 17670-17680
Valentine, J.S., Gralla, E.B., (1997) Science, 278, pp. 817-818
Chang, C.J., (2017) Acc. Chem. Res., 50, pp. 535-538
Bush, A.I., Tanzi, R.E., (2008) Neurotherapeutics, 5, pp. 421-432
Gandhi, S., Refolo, L.M., Sambamurti, K., (2004) J. Mol. Neurosci., 24, pp. 137-143
Willem, M., Tahirovic, S., Busche, M.A., Ovsepian, S.V., Chafai, M., Kootar, S., Hornburg, D., Haass, C., (2015) Nature, 526, pp. 443-447
Wild, K., August, A., Pietrzik, C.U., Kins, S., (2017) Front. Mol. Neurosci., 10
Greenough, M.A., Volitakis, I., Li, Q.X., Laughton, K., Evin, G., Ho, M., Dalziel, A.H., Bush, A.I., (2011) J. Biol. Chem., 286, pp. 9776-9786
Gerber, H., Wu, F., Dimitrov, M., Garcia Osuna, G.M., Fraering, P.C., (2017) J. Biol. Chem., 292, pp. 3751-3767
Thal, D.R., Rub, U., Orantes, M., Braak, H., (2002) Neurology, 58, pp. 1791-1800
Braak, H., Braak, E., (1991) Acta Neuropathol. (Berl), 82, pp. 239-259
Masters, C.L., Simms, G., Weinman, N.A., Multhaup, G., McDonald, B.L., Beyreuther, K., (1985) Proc. Natl. Acad. Sci. U.S.A., 82, pp. 4245-4249
Ricciarelli, R., Fedele, E., (2017) Curr. Neuropharmacol., 15, pp. 926-935
Andreasson, U., Portelius, E., Andersson, M.E., Blennow, K., Zetterberg, H., (2007) Biomark. Med., 1, pp. 59-78
Portelius, E., Tran, A.J., Andreasson, U., Persson, R., Brinkmalm, G., Zetterberg, H., Blennow, K., Westman-Brinkmalm, A., (2007) J. Proteome Res., 6, pp. 4433-4439
Gowing, E., Roher, A.E., Woods, A.S., Cotter, R.J., Chaney, M., Little, S.P., Ball, M.J., (1994) J. Biol. Chem., 269, pp. 10987-10990
Wisniewski, T., Lalowski, M., Bobik, M., Russell, M., Strosznajder, J., Frangione, B., (1996) Biochem. J., 313, pp. 575-580
Cummings, B.J., Su, J.H., Cotman, C.W., White, R., Russell, M.J., (1993) Neurobiol. Aging, 14, pp. 547-560
Wisniewski, H.M., Wegiel, J., Morys, J., Baucher, C., Soltysiak, Z., Kim, K.S., (1990) Alzheimer's Disease. Epidemiology, Neuropathology, Neurochemistry and Clinics, pp. 151-168. , Springer-Verlag Berlin
Lalowski, M., Golabek, A., Lemere, C.A., Selkoe, D.J., Wisniewski, H.M., Beavis, R.C., Frangione, B., Wisniewski, T., (1996) J. Biol. Chem., 271, pp. 33623-33631
Jang, H., Arce, F.T., Ramachandran, S., Capone, R., Azimova, R., Kagan, B.L., Nussinov, R., Lal, R., (2010) Proc. Natl. Acad. Sci. U.S.A., 107, pp. 6538-6543
Selkoe, D.J., Abraham, C.R., Podlisny, M.B., Duffy, L.K., (1986) J. Neurochem., 46, pp. 1820-1834
Mori, H., Takio, K., Ogawara, M., Selkoe, D.J., (1992) J. Biol. Chem., 267, pp. 17082-17086
Miller, D.L., Papayannopoulos, I.A., Styles, J., Bobin, S.A., Lin, Y.Y., Biemann, K., Iqbal, K., (1993) Arch. Biochem. Biophys., 301, pp. 41-52
Roher, A.E., Lowenson, J.D., Clarke, S., Wolkow, C., Wang, R., Cotter, R.J., Reardon, I.M., Ball, M.J., (1993) J. Biol. Chem., 268, pp. 3072-3083
Abeti, R., Abramov, A.Y., Duchen, M.R., (2011) Brain, 134, pp. 1658-1672
Millucci, L., Ghezzi, L., Bernardini, G., Santucci, A., (2010) Curr. Protein Peptide Sci., 11, pp. 54-67
Dal Pra, I., Whitfileld, J.F., Pacchiana, R., Bonafini, C., Talacchi, A., Chakravarthy, B., Armato, U., Chiarini, A., (2011) J. Alzheimer's Dis., 24, pp. 335-347
Blennow, K., Mattsson, N., Scholl, M., Hansson, O., Zetterberg, H., (2015) Trends Pharmacol. Sci., 36, pp. 297-309
Takadera, T., Sakura, N., Mohri, T., Hashimoto, T., (1993) Neurosci. Lett., 161, pp. 41-44
Ohki, E.C., Langan, T.J., Rodgers, K.R., Chou, R.C., (2017) Front. Cell. Neurosci., 11, p. 301
Kummer, M.P., Heneka, M.T., (2014) Alzheimers Res. Ther., 6
Travaglia, A., Arena, G., Fattorusso, R., Isernia, C., La Mendola, D., Malgieri, G., Nicoletti, V.G., Rizzarelli, E., (2011) Chem. Eur. J., 17, pp. 3726-3738
Iversen, L.L., Mortishire-Smith, R.J., Pollack, S.J., Shearman, M.S., (1995) Biochem. J., 311, pp. 1-16
Kaminsky, Y.G., Marlatt, M.W., Smith, M.A., Kosenko, E.A., (2010) Exp. Neurol., 221, pp. 26-37
Kubo, T., Nishimura, S., Kumagae, Y., Kaneko, I., (2002) J. Neurosci. Res., 70, pp. 474-483
Millucci, L., Raggiaschi, R., Franceschini, D., Terstappen, G., Santucci, A., (2009) J. Biosci., 34, pp. 293-303
Clementi, M.E., Marini, S., Coletta, M., Orsini, F., Giardina, B., Misiti, F., (2005) FEBS Lett., 579, pp. 2913-2918
Rao, K.V.R., Kielian, T., (2016) Neuroscience, 323, pp. 195-206
Masters, C.L., Multhaup, G., Simms, G., Pottgiesser, J., Martins, R.N., Beyreuther, K., (1985) EMBO J., 4, pp. 2757-2763
Lewis, D., Beher, N., Cookson, A., Oakley, M., Piggott, C.M., Morris, E., Jaros, R., Kalaria, R.N., (2006) Neuropathol. Appl. Neurobiol., 32, pp. 103-118
Portelius, E., Dean, R.A., Gustavsson, M.K., Andreasson, U., Zetterberg, H., Siemers, E., Blennow, K., (2010) Alzheimers Res. Ther., 2, p. 7
Tomidokoro, Y., Lashley, T., Rostagno, A., Neubert, T.A., Bojsen-Moller, M., Braendgaard, H., Plant, G., Ghiso, J., (2005) J. Biol. Chem., 280, pp. 36883-36894
Fukuchi, K., Accavitti-Loper, M.A., Kim, H.D., Tahara, K., Cao, Y., Lewis, T.L., Caughey, R.C., Lalonde, R., (2006) Biochem. Biophys. Res. Commun., 344, pp. 79-86
Miravalle, L., Calero, M., Takao, M., Roher, A.E., Ghetti, B., Vidal, R., (2005) Biochemistry (Mosc), 44, pp. 10810-10821
Howell, S., Nalbantoglu, J., Crine, P., (1995) Peptides, 16, pp. 647-652
Joshi, S., Chen, L., Winter, M.B., Lin, Y.L., Yang, Y., Shapovalova, M., Smith, P.M., LeBeau, A.M., (2017) Sci. Rep., 7, p. 1424
Iwata, H., Tomita, T., Maruyama, K., Iwatsubo, T., (2001) J. Biol. Chem., 276, pp. 21678-21685
Carson, J.A., Turner, A.J., (2002) J. Neurochem., 81, pp. 1-8
Barritt, J.D., Viles, J.H., (2015) J. Biol. Chem., 290, pp. 27791-27802
Pike, C.J., Walencewicz-Wasserman, A.J., Kosmoski, J., Cribbs, D.H., Glabe, C.G., Cotman, C.W., (1995) J. Neurochem., 64, pp. 253-265
Wildburger, N.C., Esparza, T.J., LeDuc, R.D., Fellers, R.T., Thomas, P.M., Cairns, N.J., Kelleher, N.L., Brody, D.L., (2017) Sci. Rep., 7
Arai, T., Akiyama, H., Ikeda, K., Kondo, H., Mori, H., (1999) Brain Res., 823, pp. 202-206
Wiltfang, J., Esselmann, H., Cupers, P., Neumann, M., Kretzschmar, H., Beyermann, M., Schleuder, D., Saftig, P., (2001) J. Biol. Chem., 276, pp. 42645-42657
Bibl, M., Gallus, M., Welge, V., Lehmann, S., Sparbier, K., Esselmann, H., Wiltfang, J., (2012) Proteomics Clin. Appl., 6, pp. 163-169
Drew, S.C., Masters, C.L., Barnham, K.J., (2009) J. Am. Chem. Soc., 131, pp. 8760-8761
Schieb, H., Kratzin, H., Jahn, O., Mobius, W., Rabe, S., Staufenbiel, M., Wiltfang, J., Klafki, H.W., (2011) J. Biol. Chem., 286, pp. 33747-33758
Casas, C., Sergeant, N., Itier, J.M., Blanchard, V., Wirths, O., van der Kolk, N., Vingtdeux, V., Pradier, L., (2004) Am. J. Pathol., 165, pp. 1289-1300
Murayama, K.S., Kametani, F., Tabira, T., Araki, W., (2007) J. Neurosci. Methods, 161, pp. 244-249
House, E., Collingwood, J., Khan, A., Korchazkina, O., Berthon, G., Exley, C., (2004) J. Alzheimers Dis., 6, pp. 291-301
Milardi, D., Pappalardo, G., Rizzarelli, E., Sovago, I., (2011) Neurodegeneration: Metallostasis and Proteostasis, pp. 112-140. , The Royal Society of Chemistry London
Bourassa, M.W., Leskovjan, A.C., Tappero, R.V., Farquhar, E.R., Colton, C.A., Van Nostrand, W.E., Miller, L.M., (2013) Biomed. Spectrosc. Imaging, 2, pp. 129-139
Chen, X., Guo, C., Kong, J., (2012) Neural Regen. Res., 7, pp. 376-385
Arena, G., Pappalardo, G., Sovago, I., Rizzarelli, E., (2012) Coord. Chem. Rev., 256, pp. 3-12
Damante, C.A., Ösz, K., Nagy, Z., Pappalardo, G., Grasso, G., Impellizzeri, G., Rizzarelli, E., Sóvágó, I., (2008) Inorg. Chem., 47, pp. 9669-9683
Yoshiike, Y., Tanemura, K., Murayama, O., Akagi, T., Murayama, M., Sato, S., Sun, X., Takashima, A., (2001) J. Biol. Chem., 276, pp. 32293-32299
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., (2009) J. Neurosci., 29, pp. 10582-10587
Giuffrida, M.L., Tomasello, M.F., Pandini, G., Caraci, F., Battaglia, G., Busceti, C., Di Pietro, P., Copani, A., (2015) Front. Cell. Neurosci., 9, p. 297
Zimbone, S., Monaco, I., Gianì, F., Pandini, G., Copani, A., Giuffrida, M., Rizzarelli, E., (2017) Aging Cell
Bush, A.I., (2003) Alzheimer Dis. Assoc. Disord., 17, pp. 147-150
Tahmasebinia, F., Emadi, S., (2017) BioMetals, 30, pp. 285-293
Zhang, Q., Hu, X., Wang, W., Yuan, Z., (2016) Biomacromolecules, 17, pp. 661-668
Di Natale, G., Bellia, F., Sciacca, M.F.M., Campagna, T., Pappalardo, G., (2017) Inorg. Chim. Acta
Lin, C.J., Huang, H.C., Jiang, Z.F., (2010) Brain Res. Bull., 82, pp. 235-242
Cassagnes, L.E., Herve, V., Nepveu, F., Hureau, C., Faller, P., Collin, F., (2013) Angew. Chem. Int. Ed., 52, pp. 11110-11113
Poduslo, J.F., Gilles, E.J., Ramakrishnan, M., Howell, K.G., Wengenack, T.M., Curran, G.L., Kandimalla, K.K., (2010) PLoS One, 5, p. e8813
Faller, P., Hureau, C., La Penna, G., (2014) Acc. Chem. Res., 47, pp. 2252-2259
Gamez, P., Caballero, A.B., (2015) Aip Adv., 5, p. 92503
Kowalik-Jankowska, T., Ruta, M., Wisniewska, K., Lankiewicz, L., (2003) J. Inorg. Biochem., 95, pp. 270-282
Kepp, K.P., (2016) Prog. Neurobiol., 143, pp. 36-60
Lewis, H., Beher, D., Cookson, N., Oakley, A., Piggott, M., Morris, C.M., Jaros, E., Kalaria, R.N., (2006) Neuropathol. Appl. Neurobiol., 32, pp. 103-118
Portelius, E., Bogdanovic, N., Gustavsson, M.K., Volkmann, I., Brinkmalm, G., Zetterberg, H., Winblad, B., Blennow, K., (2010) Acta Neuropathol., 120, pp. 185-193
Drew, S.C., Noble, C.J., Masters, C.L., Hanson, G.R., Barnham, K.J., (2009) J. Am. Chem. Soc., 131, pp. 1195-1207
Harford, C., Sarkar, B., (1997) Acc. Chem. Res., 30, pp. 123-130
Drew, S.C., Barnham, K.J., (2011) Acc. Chem. Res., 44, pp. 1146-1155
Wiloch, M.Z., Wawrzyniak, U.E., Ufnalska, I., Bonna, A., Bal, W., Drew, S.C., Wróblewski, W., (2016) J. Electrochem. Soc., 163, pp. G196-G199
Mital, M., Wezynfeld, N.E., Fraczyk, T., Wiloch, M.Z., Wawrzyniak, U.E., Bonna, A., Tumpach, C., Drew, S.C., (2015) Angew. Chem. Int. Ed. Engl., 54, pp. 10460-10464
Wezynfeld, N.E., Stefaniak, E., Stachucy, K., Drozd, A., Plonka, D., Drew, S.C., Krezel, A., Bal, W., (2016) Angew. Chem., 55, pp. 8235-8238
Santoro, A., Ewa Wezynfeld, N., Vasak, M., Bal, W., Faller, P., (2017) Chem. Commun.
Singh, I., Sagare, A.P., Coma, M., Perlmutter, D., Gelein, R., Bell, R.D., Deane, R.J., Deane, R., (2013) Proc. Natl. Acad. Sci. U.S.A., 110, pp. 14771-14776
Sarell, C.J., Syme, C.D., Rigby, S.E., Viles, J.H., (2009) Biochemistry (Mosc), 48, pp. 4388-4402
Bush, A.I., Pettingell, W.H., Multhaup, G., Paradis, M.D., Vonsattel, J.P., Gusella, J.F., Beyreuther, K., Tanzi, R.E., (1994) Science, 265, pp. 1464-1467
Sopher, B.L., Fukuchi, K., Kavanagh, T.J., Furlong, C.E., Martin, G.M., (1996) Mol. Chem. Neuropathol., 29, pp. 153-168
Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R.L., Atwood, C.S., Johnson, A.B., Smith, M.A., (2001) J. Neurosci., 21, pp. 3017-3023
Alies, B., Renaglia, E., Rozga, M., Bal, W., Faller, P., Hureau, C., (2013) Anal. Chem., 85, pp. 1501-1508
Choi, S.H., Kim, Y.H., Hebisch, M., Sliwinski, C., Lee, S., D'Avanzo, C., Chen, H., Kim, D.Y., (2014) Nature, 515, pp. 274-278
White, A.R., Aschner, M., Costa, L.G., Bush, A.I., Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics (2017), Academic Press London
Giuffrida, M.L., Grasso, G., Ruvo, M., Pedone, C., Saporito, A., Marasco, D., Pignataro, B., Rizzarelli, E., (2007) J. Neurosci. Res., 85, pp. 623-633
Kozin, S.A., Zirah, S., Rebuffat, S., Hoa, G.H., Debey, P., (2001) Biochem. Biophys. Res. Commun., 285, pp. 959-964
Yang, D.S., McLaurin, J., Qin, K., Westaway, D., Fraser, P.E., (2000) Eur. J. Biochem., 267, pp. 6692-6698
Miura, T., Suzuki, K., Kohata, N., Takeuchi, H., (2000) Biochemistry, 39, pp. 7024-7031
Zirah, S., Kozin, S.A., Mazur, A.K., Blond, A., Cheminant, M., Segalas-Milazzo, I., Debey, P., Rebuffat, S., (2006) J. Biol. Chem., 281, pp. 2151-2161
Alies, B., Conte-Daban, A., Sayen, S., Collin, F., Kieffer, I., Guillon, E., Faller, P., Hureau, C., (2016) Inorg Chem., 55, pp. 10499-10509
Damante, C.A., Osz, K., Nagy, Z., Pappalardo, G., Grasso, G., Impellizzeri, G., Rizzarelli, E., Sovago, I., (2009) Inorg. Chem., 48, pp. 10405-10415
Mekmouche, Y., Coppel, Y., Hochgrafe, K., Guilloreau, L., Tallmard, C., Mazarguil, H., Faller, P., (2005) ChemBioChem, 6, pp. 1663-1671
Syme, C.D., Viles, J.H., (2006) BBA-Proteins Proteom., 1764, pp. 246-256
Danielsson, J., Pierattelli, R., Banci, L., Graslund, A., (2007) FEBS J., 274, pp. 46-59
Gaggelli, E., Janicka-Klos, A., Jankowska, E., Kozlowski, H., Migliorini, C., Molteni, E., Valensin, D., Wieczerzak, E., (2008) J. Phys. Chem. B, 112, pp. 100-109
Istrate, A.N., Kozin, S.A., Zhokhov, S.S., Mantsyzov, A.B., Kechko, O.I., Pastore, A., Makarov, A.A., Polshakov, V.I., (2016) Sci. Rep., 6, p. 21734
Haacke, E.M., Chengb, N.Y.C., House, M.J., Liu, Q., Neelavalli, J., Ogg, R.J., Khan, A., Obenaus, A., (2005) Magn. Reson. Imaging, 23, pp. 1-25
LeVine, S.M., (1997) Brain Res., 760, pp. 298-303
Tan, H., Liu, T., Wu, Y., Thacker, J., Shenkar, R., Mikati, A.G., Shi, C.B., Awad, I.A., (2014) Invest. Radiol., 49, pp. 498-504
Moon, Y., Han, S.H., Moon, W.J., (2016) J. Alzheimers Dis., 51, pp. 737-745
Lu, T., Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y.W., Yang, T.H., Yankner, B.A., (2014) Nature, 507, pp. 448-454
Valensin, D., Migliorini, C., Valensin, G., Gaggelli, E., La Penna, G., Kozlowski, H., Gabbiani, C., Messori, L., (2011) Inorg. Chem., 50, pp. 6865-6867
Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., Collin, F., (2018) Redox Biol., 14, pp. 450-464
Bousejra-ElGarah, F., Bijani, C., Coppel, Y., Faller, P., Hureau, C., (2011) Inorg. Chem., 50, pp. 9024-9030
Tong, Y.W., Yang, H., Tian, X.S., Wang, H.C., Zhou, T., Zhang, S.Z., Yu, J., Chui, D.H., (2014) J. Alzheimers Dis., 42, pp. 865-878
Srivastava, R.A.K., Jain, J.C., (2002) J. Neurol. Sci., 196, pp. 45-52
Wallin, C., Kulkarni, Y.S., Abelein, A., Jarvet, J., Liao, Q.H., Strodel, B., Olsson, L., Warmlander, S.K.T.S., (2016) J. Trace Elem. Med Biol., 38, pp. 183-193
Abdrakhmanov, R., Blokhin, D., Usachev, K., Karataeva, F., Klochkov, V., (2017) Bionanoscience, 7, pp. 204-206
Lu, Y., Prudent, M., Qiao, L.A., Mendez, M.A., Girault, H.H., (2010) Metallomics, 2, pp. 474-479
Jozsa, E., Osz, K., Kallay, C., de Bona, P., Damante, C.A., Pappalardo, G., Rizzarelli, E., Sovago, I., (2010) Dalton Trans., 39, pp. 7046-7053
Saido, T., Leissring, M.A., (2012) Cold Spring Harb. Perspect. Med., 2, p. a006379
Bateman, R.J., Munsell, L.Y., Morris, J.C., Swarm, R., Yarasheski, K.E., Holtzman, D.M., (2006) Nat Med, 12, pp. 856-861
Zheng, L., Cedazo-Minguez, A., Hallbeck, M., Jerhammar, F., Marcusson, J., Terman, A., (2012) Transl. Neurodegener., 1. , 19
Lecker, S.H., Goldberg, A.L., Mitch, W.E., (2006) J. Am. Soc. Nephrol., 17, pp. 1807-1819
Singh, R.K., Kazansky, Y., Wathieu, D., Fushman, D., (2017) Anal. Chem., 89, pp. 7852-7860
Grasso, G., Santoro, A.M., Lanza, V., Sbardella, D., Tundo, G.R., Ciaccio, C., Marini, S., Milardi, D., (2017) Coord. Chem. Rev., 347, pp. 1-22
Morozov, A.V., Yurinskaya, M.M., Mitkevich, V.A., Garbuz, D.G., Preobrazhenskaia, O.V., Vinokurov, M.G., Evgen'ev, M.B., Makarov, A.A., (2017) Mol. Biol. (Mosk), 51, pp. 166-171
Zhang, Y., Chen, X., Zhao, Y., Ponnusamy, M., Liu, Y., (2017) Rev. Neurosci.
Kaneko, M., Koike, H., Saito, R., Kitamura, Y., Okuma, Y., Nomura, Y., (2010) J. Neurosci., 30, pp. 3924-3932
Del Prete, D., Rice, R.C., Rajadhyaksha, A.M., D'Adamio, L., (2016) J. Biol. Chem., 291, pp. 17209-17227
Tai, H.C., Serrano-Pozo, A., Hashimoto, T., Frosch, M.P., Spires-Jones, T.L., Hyman, B.T., (2012) Am. J. Pathol., 181, pp. 1426-1435
Wang, P., Joberty, G., Buist, A., Vanoosthuyse, A., Stancu, I.C., Vasconcelos, B., Pierrot, N., Dewachter, I., (2017) Acta Neuropathol., 133, pp. 731-749
Iqbal, K., Liu, F., Gong, C.X., Grundke-Iqbal, I., (2010) Curr. Alzheimer Res., 7, pp. 656-664
Gumeni, S., Tsakiri, E.N., Cheimonidi, C.M., Evangelakou, Z., Gianniou, D., Tallas, K., Papanagnou, E.D., Trougakos, I.P., (2017), in: J.A. Ghiso, A.A. Rostagno (Eds.), Protein Folding Disorders of the Central Nervous System, World Scientific
Varshavsky, A., (2017) Annu. Rev. Biochem, 86, pp. 123-128
Chiu, B., Jantuan, E., Shen, F., Chiu, B., Sergi, C., (2017) Ann. Clin. Lab. Sci., 47, pp. 243-252
Martini-Stoica, H., Xu, Y., Ballabio, A., Zheng, H., (2016) Trends Neurosci., 39, pp. 221-234
Nixon, R.A., (2017) FASEB J., 31, pp. 2729-2743
Bustos, V., Pulina, M.V., Kelahmetoglu, Y., Sinha, S.C., Gorelick, F.S., Flajolet, M., Greengard, P., (2017) Proc. Natl. Acad. Sci. U.S.A., 114, pp. 7142-7147
Ntsapi, C., Lumkwana, D., Swart, C., du Toit, A., Loos, B., International Review of Cell and Molecular Biology (2017), Academic Press
Xiao, Q., Yan, P., Ma, X., Liu, H., Perez, R., Zhu, A., Gonzales, E., Lee, J.M., (2014) J. Neurosci., 34, pp. 9607-9620
Poprac, P., Jomova, K., Simunkova, M., Kollar, V., Rhodes, C.J., Valko, M., (2017) Trends Pharmacol. Sci., 38, pp. 592-607
Dam, J., Ismail, Z., Kurebwa, T., Gangat, N., Harmse, L., Marques, H.M., Lemmerer, A., de Koning, C.B., (2017) Eur. J. Med. Chem., 126, pp. 353-368
Santoro, A.M., Monaco, I., Attanasio, F., Lanza, V., Pappalardo, G., Tomasello, M.F., Cunsolo, A., Milardi, D., (2016) Sci. Rep., 6, p. 33444
Arena, G., Bellia, F., Frasca, G., Grasso, G., Lanza, V., Rizzarelli, E., Tabbi, G., Milardi, D., (2013) Inorg. Chem., 52, pp. 9567-9573
Gutierrez, E., Richardson, D.R., Jansson, P.J., (2014) J. Biol. Chem., 289, pp. 33568-33589
Zhong, W., Zhu, H.C., Sheng, F.G., Tian, Y.L., Zhou, J., Chen, Y.Y., Li, S., Lin, J., (2014) Autophagy, 10, pp. 1285-1300
Bisceglie, F., Alinovi, R., Pinelli, S., Galetti, M., Pioli, M., Tarasconi, P., Mutti, A., Pelosi, G., (2016) Metallomics, 8, pp. 1255-1265
Ding, B.B., Zhong, Q., (2017) J. Biol. Chem., 292, pp. 8531-8532
Rajapakse, D., Curtis, T.M., Chen, M., Xu, H., (2017) Oxid. Med. Cell. Longev.
Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E.A., Frosch, M.P., Eckman, C.B., Guenette, S., (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 4162-4167
Shen, Y., Joachimiak, A., Rosner, M.R., Tang, W.J., (2006) Nature, 443, pp. 870-874
Bellia, F., Pietropaolo, A., Grasso, G., (2013) J. Mass Spectrom., 48, pp. 135-140
McCord, L.A., Liang, W.G., Dowdell, E., Kalas, V., Hoey, R.J., Koide, A., Koide, S., Tang, W.J., (2013) Proc. Natl. Acad. Sci. U.S.A., 110, pp. 13827-13832
Malito, E., Ralat, L.A., Manolopoulou, M., Tsay, J.L., Wadlington, N.L., Tang, W.J., (2008) Biochemistry, 47, pp. 12822-12834
Pivovarova, O., Hohn, A., Grune, T., Pfeiffer, A.F., Rudovich, N., (2016) Ann. Med., 48, pp. 614-624
Titorenko, V.I., Terlecky, S.R., (2011) Traffic, 12, pp. 252-259
Pandini, G., Pace, V., Copani, A., Squatrito, S., Milardi, D., Vigneri, R., (2013) Endocrinology, 154, pp. 375-387
Tundo, G.R., Sbardella, D., Ciaccio, C., Bianculli, A., Orlandi, A., Desimio, M.G., Arcuri, G., Marini, S., (2013) J. Biol. Chem., 288, pp. 2281-2289
McDermott, J.R., Gibson, A.M., (1997) Neurochem. Res., 22, pp. 49-56
Zhao, Z., Xiang, Z., Haroutunian, V., Buxbaum, J.D., Stetka, B., Pasinetti, G.M., (2007) Neurobiol. Aging, 8, pp. 824-830
Grasso, G., Pietropaolo, A., Spoto, G., Pappalardo, G., Tundo, G.R., Ciaccio, C., Coletta, M., Rizzarelli, E., (2011) Chem. Eur. J., 17, pp. 2752-2762
Opazo, C.M., Greenough, M.A., Bush, A.I., (2014) Front. Aging Neurosci., 6, p. 143
Assaf, S.Y., Chung, S.H., (1984) Nature, 308, pp. 734-736
Grasso, G., Salomone, F., Tundo, G.R., Pappalardo, G., Ciaccio, C., Spoto, G., Pietropaolo, A., Rizzarelli, E., (2012) J. Inorg. Biochem., 117, pp. 351-358
Bellia, F., Grasso, G., (2014) J. Mass Spectrom., 49, pp. 274-279
Iwata, N., Tsubuki, S., Takaki, Y., Watanabe, K., Sekiguchi, M., Hosoki, E., Kawashima-Morishima, M., Saido, T.C., (2000) Nat. Med., 6, pp. 143-150
Hersh, L.B., Rodgers, D.W., (2008) Curr. Alzheimer Res., 5, pp. 225-231
Schiering, N., D'Arcy, A., Villard, F., Ramage, P., Logel, C., Cumin, F., Ksander, G.M., Mogi, M., (2016) Sci. Rep., 6, p. 27909
Wade, R.C., Gabdoulline, R.R., Ludemann, S.K., Lounnas, V., (1998) Proc. Natl. Acad. Sci. U.S.A., 95, pp. 5942-5949
Li, M., Sun, M., Liu, Y., Yu, J., Yang, H., Fan, D., Chui, D., (2010) J. Alzheimer's Dis., 19, pp. 161-169
Kim, D.K., Song, J.W., Park, J.D., Choi, B.S., (2013) Mol. Cell. Toxicol., 9, pp. 57-66
Strozyk, D., Launer, L.J., Adlard, P.A., Cherny, R.A., Tsatsanis, A., Volitakis, I., Blennow, K., Bush, A.I., (2009) Neurobiol. Aging, 30, pp. 1069-1077
Lorenzl, S., Albers, D.S., LeWitt, P.A., Chirichigno, J.W., Hilgenberg, S.L., Cudkowicz, M.E., Beal, M.F., (2003) J. Neurol. Sci., 207, pp. 71-76
Horstmann, S., Budig, L., Gardner, H., Koziol, J., Deuschle, M., Schilling, C., Wagner, S., (2010) Int. Psychogeriatr., 22, pp. 966-972
Hanzel, C.E., Iulita, M.F., Eyjolfsdottir, H., Hjorth, E., Schultzberg, M., Eriksdotter, M., Cuello, A.C., (2014) J. Alzheimer's Dis., 40, pp. 667-678
Liao, M.C., Van Nostrand, W.E., (2010) Biochemistry (Mosc), 49, pp. 1127-1136
Yan, P., Hu, X.Y., Song, H.W., Yin, K.J., Bateman, R.J., Cirrito, J.R., Xiao, Q.L., Lee, J.M., (2006) J. Biol. Chem., 281, pp. 24566-24574
Hernandez-Guillamon, M., Mawhirt, S., Blais, S., Montaner, J., Neubert, T.A., Rostagno, A., Ghiso, J., (2015) J. Biol. Chem., 290, pp. 15078-15091
Donnelly, P.S., Caragounis, A., Du, T., Laughton, K.M., Volitakis, I., Cherny, R.A., Sharples, R.A., White, A.R., (2008) J. Biol. Chem., 283, pp. 4568-4577
Zheng, C., Geetha, T., Gearing, M., Babu, J.R., (2015) J. Neurochem., 133, pp. 919-925
Taniguchi, M., Matsuura, K., Nakamura, R., Kojima, A., Konishi, M., Akizawa, T., (2017) BioMetals
Eckman, E.A., Adams, S.K., Troendle, F.J., Stodola, B.A., Kahn, M.A., Fauq, A.H., Xiao, H.D., Eckman, C.B., (2006) J. Biol. Chem., 281, pp. 30471-30478
Eckman, E.A., Reed, D.K., Eckman, C.B., (2001) J. Biol. Chem., 276, pp. 24540-24548
Eckman, E.A., Watson, M., Marlow, L., Sambamurti, K., Eckman, C.B., (2003) J. Biol. Chem., 278, pp. 2081-2084
Pacheco-Quinto, J., Herdt, A., Eckman, C.B., Eckman, E.A., (2013) J. Alzheimers Dis., 33, pp. S101-110
Hemming, M.L., Selkoe, D.J., Farris, W., (2007) Neurobiol. Dis., 26, pp. 273-281
Miners, J.S., Ashby, E., Van Helmond, Z., Chalmers, K.A., Palmer, L.E., Love, S., Kehoe, P.G., (2008) Neuropathol. Appl. Neurobiol., 34, pp. 181-193
Barker, R., Love, S., Kehoe, P.G., (2010) Brain Res., 1355, pp. 7-15
Tucker, H.M., Kihiko, M., Caldwell, J.N., Wright, S., Kawarabayashi, T., Price, D., Walker, D., Estus, S., (2000) J. Neurosci., 20, pp. 3937-3946
Ehehalt, R., Keller, P., Haass, C., Thiele, C., Simons, K., (2003) J. Cell Biol., 160, pp. 113-123
Crouch, P.J., Barnham, K.J., (2012) Acc. Chem. Res., 45, pp. 1604-1611
La Mendola, D., Giacomelli, C., Rizzarelli, E., (2016) Curr. Top. Med. Chem., 16, pp. 3103-3130
Coord Chem Rev (ISSN: 0010-8545), 2018; 369: 1-14.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 11.225, 5-year impact factor Impact factor a 5 anni: 12.752
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046631140&doi=10.1016%2fj.ccr.2018.04.004&partnerID=40&md5=76e9f85a682b66f7399d2c6b17e4afa1
Keywords Parole chiave: Alzheimer, S Disease, Aβ-Degrading Enzyme, Metal Ions, Metallostasis, Neurodegenerative Diseases,
Affiliations Affiliazioni:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, CNR Catania, Italy
Inter-university Consortium for The Research on Chemistry of Metals in Biological Systems, Bari, Italy
Department of Chemical Sciences, University of Catania, Catania, Italy
References Riferimenti:
(2016), https://www.alz.co.uk/research/WorldAlzheimerReport2016.pdf, World Alzheimer Report
Selkoe, D.J., Hardy, J., (2016) EMBO Mol. Med., 8, pp. 595-60
Benilova, I., Karran, E., De Strooper, B., (2012) Nat. Neurosci., 15, pp. 349-357
Baranello, R.J., Bharani, K.L., Padmaraju, V., Chopra, N., Lahiri, D.K., Greig, N.H., Pappolla, M.A., Sambamurti, K., (2015) Curr. Alzheimer Res., 12, pp. 32-46
Mullard, A., (2017) Nat. Rev. Drug Discov., 16, pp. 3-5
Sambamurti, K., Vasudevaraju, P., Mintzer, J., Bachman, D., Granholm, C., (2012) J. Alzheimers Dis. Parkinsonism, 2, pp. e115-116
Rosenblum, W.I., (2014) Neurobiol. Aging, 35, pp. 969-974
Acevedo, K.M., Hung, Y.H., Dalziel, A.H., Li, Q.X., Laughton, K., Wikhe, K., Rembach, A., Camakaris, J., (2011) J Biol Chem, 286, pp. 8252-8262
Mayer, M.C., Kaden, D., Schauenburg, L., Hancock, M.A., Voigt, P., Roeser, D., Barucker, C., Multhaup, G., (2014) J. Biol. Chem., 289, pp. 19019-19030
Brewer, G.J., (2015) J. Alzheimers Dis., 46, pp. 593-604
Xu, J., Church, S.J., Patassini, S., Begley, P., Waldvogel, H.J., Curtis, M.A., Faull, R.L.M., Cooper, G.J.S., (2017) Metallomics, 9, pp. 1106-1119
Deibel, M.A., Ehmann, W.D., Markesbery, W.R., (1996) J. Neurol. Sci., 143, pp. 137-142
Crouch, P.J., Hung, L.W., Adlard, P.A., Cortes, M., Lal, V., Filiz, G., Perez, K.A., Barnham, K.J., (2009) Proc. Natl. Acad. Sci. U.S.A., 106, pp. 381-386
Atrian-Blasco, E., Conte-Daban, A., Hureau, C., (2017) Dalton Trans., 46, pp. 12750-12759
Milardi, D., Rizzarelli, E., Neurodegeneration: Metallostasis and Proteostasis (2011), Royal Society of Chemistry Cambridge
White, A.R., Du, T., Laughton, K.M., Volitakis, I., Sharples, R.A., Xilinas, M.E., Hoke, D.E., Masters, C.L., (2006) J. Biol. Chem., 281, pp. 17670-17680
Valentine, J.S., Gralla, E.B., (1997) Science, 278, pp. 817-818
Chang, C.J., (2017) Acc. Chem. Res., 50, pp. 535-538
Bush, A.I., Tanzi, R.E., (2008) Neurotherapeutics, 5, pp. 421-432
Gandhi, S., Refolo, L.M., Sambamurti, K., (2004) J. Mol. Neurosci., 24, pp. 137-143
Willem, M., Tahirovic, S., Busche, M.A., Ovsepian, S.V., Chafai, M., Kootar, S., Hornburg, D., Haass, C., (2015) Nature, 526, pp. 443-447
Wild, K., August, A., Pietrzik, C.U., Kins, S., (2017) Front. Mol. Neurosci., 10
Greenough, M.A., Volitakis, I., Li, Q.X., Laughton, K., Evin, G., Ho, M., Dalziel, A.H., Bush, A.I., (2011) J. Biol. Chem., 286, pp. 9776-9786
Gerber, H., Wu, F., Dimitrov, M., Garcia Osuna, G.M., Fraering, P.C., (2017) J. Biol. Chem., 292, pp. 3751-3767
Thal, D.R., Rub, U., Orantes, M., Braak, H., (2002) Neurology, 58, pp. 1791-1800
Braak, H., Braak, E., (1991) Acta Neuropathol. (Berl), 82, pp. 239-259
Masters, C.L., Simms, G., Weinman, N.A., Multhaup, G., McDonald, B.L., Beyreuther, K., (1985) Proc. Natl. Acad. Sci. U.S.A., 82, pp. 4245-4249
Ricciarelli, R., Fedele, E., (2017) Curr. Neuropharmacol., 15, pp. 926-935
Andreasson, U., Portelius, E., Andersson, M.E., Blennow, K., Zetterberg, H., (2007) Biomark. Med., 1, pp. 59-78
Portelius, E., Tran, A.J., Andreasson, U., Persson, R., Brinkmalm, G., Zetterberg, H., Blennow, K., Westman-Brinkmalm, A., (2007) J. Proteome Res., 6, pp. 4433-4439
Gowing, E., Roher, A.E., Woods, A.S., Cotter, R.J., Chaney, M., Little, S.P., Ball, M.J., (1994) J. Biol. Chem., 269, pp. 10987-10990
Wisniewski, T., Lalowski, M., Bobik, M., Russell, M., Strosznajder, J., Frangione, B., (1996) Biochem. J., 313, pp. 575-580
Cummings, B.J., Su, J.H., Cotman, C.W., White, R., Russell, M.J., (1993) Neurobiol. Aging, 14, pp. 547-560
Wisniewski, H.M., Wegiel, J., Morys, J., Baucher, C., Soltysiak, Z., Kim, K.S., (1990) Alzheimer's Disease. Epidemiology, Neuropathology, Neurochemistry and Clinics, pp. 151-168. , Springer-Verlag Berlin
Lalowski, M., Golabek, A., Lemere, C.A., Selkoe, D.J., Wisniewski, H.M., Beavis, R.C., Frangione, B., Wisniewski, T., (1996) J. Biol. Chem., 271, pp. 33623-33631
Jang, H., Arce, F.T., Ramachandran, S., Capone, R., Azimova, R., Kagan, B.L., Nussinov, R., Lal, R., (2010) Proc. Natl. Acad. Sci. U.S.A., 107, pp. 6538-6543
Selkoe, D.J., Abraham, C.R., Podlisny, M.B., Duffy, L.K., (1986) J. Neurochem., 46, pp. 1820-1834
Mori, H., Takio, K., Ogawara, M., Selkoe, D.J., (1992) J. Biol. Chem., 267, pp. 17082-17086
Miller, D.L., Papayannopoulos, I.A., Styles, J., Bobin, S.A., Lin, Y.Y., Biemann, K., Iqbal, K., (1993) Arch. Biochem. Biophys., 301, pp. 41-52
Roher, A.E., Lowenson, J.D., Clarke, S., Wolkow, C., Wang, R., Cotter, R.J., Reardon, I.M., Ball, M.J., (1993) J. Biol. Chem., 268, pp. 3072-3083
Abeti, R., Abramov, A.Y., Duchen, M.R., (2011) Brain, 134, pp. 1658-1672
Millucci, L., Ghezzi, L., Bernardini, G., Santucci, A., (2010) Curr. Protein Peptide Sci., 11, pp. 54-67
Dal Pra, I., Whitfileld, J.F., Pacchiana, R., Bonafini, C., Talacchi, A., Chakravarthy, B., Armato, U., Chiarini, A., (2011) J. Alzheimer's Dis., 24, pp. 335-347
Blennow, K., Mattsson, N., Scholl, M., Hansson, O., Zetterberg, H., (2015) Trends Pharmacol. Sci., 36, pp. 297-309
Takadera, T., Sakura, N., Mohri, T., Hashimoto, T., (1993) Neurosci. Lett., 161, pp. 41-44
Ohki, E.C., Langan, T.J., Rodgers, K.R., Chou, R.C., (2017) Front. Cell. Neurosci., 11, p. 301
Kummer, M.P., Heneka, M.T., (2014) Alzheimers Res. Ther., 6
Travaglia, A., Arena, G., Fattorusso, R., Isernia, C., La Mendola, D., Malgieri, G., Nicoletti, V.G., Rizzarelli, E., (2011) Chem. Eur. J., 17, pp. 3726-3738
Iversen, L.L., Mortishire-Smith, R.J., Pollack, S.J., Shearman, M.S., (1995) Biochem. J., 311, pp. 1-16
Kaminsky, Y.G., Marlatt, M.W., Smith, M.A., Kosenko, E.A., (2010) Exp. Neurol., 221, pp. 26-37
Kubo, T., Nishimura, S., Kumagae, Y., Kaneko, I., (2002) J. Neurosci. Res., 70, pp. 474-483
Millucci, L., Raggiaschi, R., Franceschini, D., Terstappen, G., Santucci, A., (2009) J. Biosci., 34, pp. 293-303
Clementi, M.E., Marini, S., Coletta, M., Orsini, F., Giardina, B., Misiti, F., (2005) FEBS Lett., 579, pp. 2913-2918
Rao, K.V.R., Kielian, T., (2016) Neuroscience, 323, pp. 195-206
Masters, C.L., Multhaup, G., Simms, G., Pottgiesser, J., Martins, R.N., Beyreuther, K., (1985) EMBO J., 4, pp. 2757-2763
Lewis, D., Beher, N., Cookson, A., Oakley, M., Piggott, C.M., Morris, E., Jaros, R., Kalaria, R.N., (2006) Neuropathol. Appl. Neurobiol., 32, pp. 103-118
Portelius, E., Dean, R.A., Gustavsson, M.K., Andreasson, U., Zetterberg, H., Siemers, E., Blennow, K., (2010) Alzheimers Res. Ther., 2, p. 7
Tomidokoro, Y., Lashley, T., Rostagno, A., Neubert, T.A., Bojsen-Moller, M., Braendgaard, H., Plant, G., Ghiso, J., (2005) J. Biol. Chem., 280, pp. 36883-36894
Fukuchi, K., Accavitti-Loper, M.A., Kim, H.D., Tahara, K., Cao, Y., Lewis, T.L., Caughey, R.C., Lalonde, R., (2006) Biochem. Biophys. Res. Commun., 344, pp. 79-86
Miravalle, L., Calero, M., Takao, M., Roher, A.E., Ghetti, B., Vidal, R., (2005) Biochemistry (Mosc), 44, pp. 10810-10821
Howell, S., Nalbantoglu, J., Crine, P., (1995) Peptides, 16, pp. 647-652
Joshi, S., Chen, L., Winter, M.B., Lin, Y.L., Yang, Y., Shapovalova, M., Smith, P.M., LeBeau, A.M., (2017) Sci. Rep., 7, p. 1424
Iwata, H., Tomita, T., Maruyama, K., Iwatsubo, T., (2001) J. Biol. Chem., 276, pp. 21678-21685
Carson, J.A., Turner, A.J., (2002) J. Neurochem., 81, pp. 1-8
Barritt, J.D., Viles, J.H., (2015) J. Biol. Chem., 290, pp. 27791-27802
Pike, C.J., Walencewicz-Wasserman, A.J., Kosmoski, J., Cribbs, D.H., Glabe, C.G., Cotman, C.W., (1995) J. Neurochem., 64, pp. 253-265
Wildburger, N.C., Esparza, T.J., LeDuc, R.D., Fellers, R.T., Thomas, P.M., Cairns, N.J., Kelleher, N.L., Brody, D.L., (2017) Sci. Rep., 7
Arai, T., Akiyama, H., Ikeda, K., Kondo, H., Mori, H., (1999) Brain Res., 823, pp. 202-206
Wiltfang, J., Esselmann, H., Cupers, P., Neumann, M., Kretzschmar, H., Beyermann, M., Schleuder, D., Saftig, P., (2001) J. Biol. Chem., 276, pp. 42645-42657
Bibl, M., Gallus, M., Welge, V., Lehmann, S., Sparbier, K., Esselmann, H., Wiltfang, J., (2012) Proteomics Clin. Appl., 6, pp. 163-169
Drew, S.C., Masters, C.L., Barnham, K.J., (2009) J. Am. Chem. Soc., 131, pp. 8760-8761
Schieb, H., Kratzin, H., Jahn, O., Mobius, W., Rabe, S., Staufenbiel, M., Wiltfang, J., Klafki, H.W., (2011) J. Biol. Chem., 286, pp. 33747-33758
Casas, C., Sergeant, N., Itier, J.M., Blanchard, V., Wirths, O., van der Kolk, N., Vingtdeux, V., Pradier, L., (2004) Am. J. Pathol., 165, pp. 1289-1300
Murayama, K.S., Kametani, F., Tabira, T., Araki, W., (2007) J. Neurosci. Methods, 161, pp. 244-249
House, E., Collingwood, J., Khan, A., Korchazkina, O., Berthon, G., Exley, C., (2004) J. Alzheimers Dis., 6, pp. 291-301
Milardi, D., Pappalardo, G., Rizzarelli, E., Sovago, I., (2011) Neurodegeneration: Metallostasis and Proteostasis, pp. 112-140. , The Royal Society of Chemistry London
Bourassa, M.W., Leskovjan, A.C., Tappero, R.V., Farquhar, E.R., Colton, C.A., Van Nostrand, W.E., Miller, L.M., (2013) Biomed. Spectrosc. Imaging, 2, pp. 129-139
Chen, X., Guo, C., Kong, J., (2012) Neural Regen. Res., 7, pp. 376-385
Arena, G., Pappalardo, G., Sovago, I., Rizzarelli, E., (2012) Coord. Chem. Rev., 256, pp. 3-12
Damante, C.A., Ösz, K., Nagy, Z., Pappalardo, G., Grasso, G., Impellizzeri, G., Rizzarelli, E., Sóvágó, I., (2008) Inorg. Chem., 47, pp. 9669-9683
Yoshiike, Y., Tanemura, K., Murayama, O., Akagi, T., Murayama, M., Sato, S., Sun, X., Takashima, A., (2001) J. Biol. Chem., 276, pp. 32293-32299
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., (2009) J. Neurosci., 29, pp. 10582-10587
Giuffrida, M.L., Tomasello, M.F., Pandini, G., Caraci, F., Battaglia, G., Busceti, C., Di Pietro, P., Copani, A., (2015) Front. Cell. Neurosci., 9, p. 297
Zimbone, S., Monaco, I., Gianì, F., Pandini, G., Copani, A., Giuffrida, M., Rizzarelli, E., (2017) Aging Cell
Bush, A.I., (2003) Alzheimer Dis. Assoc. Disord., 17, pp. 147-150
Tahmasebinia, F., Emadi, S., (2017) BioMetals, 30, pp. 285-293
Zhang, Q., Hu, X., Wang, W., Yuan, Z., (2016) Biomacromolecules, 17, pp. 661-668
Di Natale, G., Bellia, F., Sciacca, M.F.M., Campagna, T., Pappalardo, G., (2017) Inorg. Chim. Acta
Lin, C.J., Huang, H.C., Jiang, Z.F., (2010) Brain Res. Bull., 82, pp. 235-242
Cassagnes, L.E., Herve, V., Nepveu, F., Hureau, C., Faller, P., Collin, F., (2013) Angew. Chem. Int. Ed., 52, pp. 11110-11113
Poduslo, J.F., Gilles, E.J., Ramakrishnan, M., Howell, K.G., Wengenack, T.M., Curran, G.L., Kandimalla, K.K., (2010) PLoS One, 5, p. e8813
Faller, P., Hureau, C., La Penna, G., (2014) Acc. Chem. Res., 47, pp. 2252-2259
Gamez, P., Caballero, A.B., (2015) Aip Adv., 5, p. 92503
Kowalik-Jankowska, T., Ruta, M., Wisniewska, K., Lankiewicz, L., (2003) J. Inorg. Biochem., 95, pp. 270-282
Kepp, K.P., (2016) Prog. Neurobiol., 143, pp. 36-60
Lewis, H., Beher, D., Cookson, N., Oakley, A., Piggott, M., Morris, C.M., Jaros, E., Kalaria, R.N., (2006) Neuropathol. Appl. Neurobiol., 32, pp. 103-118
Portelius, E., Bogdanovic, N., Gustavsson, M.K., Volkmann, I., Brinkmalm, G., Zetterberg, H., Winblad, B., Blennow, K., (2010) Acta Neuropathol., 120, pp. 185-193
Drew, S.C., Noble, C.J., Masters, C.L., Hanson, G.R., Barnham, K.J., (2009) J. Am. Chem. Soc., 131, pp. 1195-1207
Harford, C., Sarkar, B., (1997) Acc. Chem. Res., 30, pp. 123-130
Drew, S.C., Barnham, K.J., (2011) Acc. Chem. Res., 44, pp. 1146-1155
Wiloch, M.Z., Wawrzyniak, U.E., Ufnalska, I., Bonna, A., Bal, W., Drew, S.C., Wróblewski, W., (2016) J. Electrochem. Soc., 163, pp. G196-G199
Mital, M., Wezynfeld, N.E., Fraczyk, T., Wiloch, M.Z., Wawrzyniak, U.E., Bonna, A., Tumpach, C., Drew, S.C., (2015) Angew. Chem. Int. Ed. Engl., 54, pp. 10460-10464
Wezynfeld, N.E., Stefaniak, E., Stachucy, K., Drozd, A., Plonka, D., Drew, S.C., Krezel, A., Bal, W., (2016) Angew. Chem., 55, pp. 8235-8238
Santoro, A., Ewa Wezynfeld, N., Vasak, M., Bal, W., Faller, P., (2017) Chem. Commun.
Singh, I., Sagare, A.P., Coma, M., Perlmutter, D., Gelein, R., Bell, R.D., Deane, R.J., Deane, R., (2013) Proc. Natl. Acad. Sci. U.S.A., 110, pp. 14771-14776
Sarell, C.J., Syme, C.D., Rigby, S.E., Viles, J.H., (2009) Biochemistry (Mosc), 48, pp. 4388-4402
Bush, A.I., Pettingell, W.H., Multhaup, G., Paradis, M.D., Vonsattel, J.P., Gusella, J.F., Beyreuther, K., Tanzi, R.E., (1994) Science, 265, pp. 1464-1467
Sopher, B.L., Fukuchi, K., Kavanagh, T.J., Furlong, C.E., Martin, G.M., (1996) Mol. Chem. Neuropathol., 29, pp. 153-168
Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R.L., Atwood, C.S., Johnson, A.B., Smith, M.A., (2001) J. Neurosci., 21, pp. 3017-3023
Alies, B., Renaglia, E., Rozga, M., Bal, W., Faller, P., Hureau, C., (2013) Anal. Chem., 85, pp. 1501-1508
Choi, S.H., Kim, Y.H., Hebisch, M., Sliwinski, C., Lee, S., D'Avanzo, C., Chen, H., Kim, D.Y., (2014) Nature, 515, pp. 274-278
White, A.R., Aschner, M., Costa, L.G., Bush, A.I., Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics (2017), Academic Press London
Giuffrida, M.L., Grasso, G., Ruvo, M., Pedone, C., Saporito, A., Marasco, D., Pignataro, B., Rizzarelli, E., (2007) J. Neurosci. Res., 85, pp. 623-633
Kozin, S.A., Zirah, S., Rebuffat, S., Hoa, G.H., Debey, P., (2001) Biochem. Biophys. Res. Commun., 285, pp. 959-964
Yang, D.S., McLaurin, J., Qin, K., Westaway, D., Fraser, P.E., (2000) Eur. J. Biochem., 267, pp. 6692-6698
Miura, T., Suzuki, K., Kohata, N., Takeuchi, H., (2000) Biochemistry, 39, pp. 7024-7031
Zirah, S., Kozin, S.A., Mazur, A.K., Blond, A., Cheminant, M., Segalas-Milazzo, I., Debey, P., Rebuffat, S., (2006) J. Biol. Chem., 281, pp. 2151-2161
Alies, B., Conte-Daban, A., Sayen, S., Collin, F., Kieffer, I., Guillon, E., Faller, P., Hureau, C., (2016) Inorg Chem., 55, pp. 10499-10509
Damante, C.A., Osz, K., Nagy, Z., Pappalardo, G., Grasso, G., Impellizzeri, G., Rizzarelli, E., Sovago, I., (2009) Inorg. Chem., 48, pp. 10405-10415
Mekmouche, Y., Coppel, Y., Hochgrafe, K., Guilloreau, L., Tallmard, C., Mazarguil, H., Faller, P., (2005) ChemBioChem, 6, pp. 1663-1671
Syme, C.D., Viles, J.H., (2006) BBA-Proteins Proteom., 1764, pp. 246-256
Danielsson, J., Pierattelli, R., Banci, L., Graslund, A., (2007) FEBS J., 274, pp. 46-59
Gaggelli, E., Janicka-Klos, A., Jankowska, E., Kozlowski, H., Migliorini, C., Molteni, E., Valensin, D., Wieczerzak, E., (2008) J. Phys. Chem. B, 112, pp. 100-109
Istrate, A.N., Kozin, S.A., Zhokhov, S.S., Mantsyzov, A.B., Kechko, O.I., Pastore, A., Makarov, A.A., Polshakov, V.I., (2016) Sci. Rep., 6, p. 21734
Haacke, E.M., Chengb, N.Y.C., House, M.J., Liu, Q., Neelavalli, J., Ogg, R.J., Khan, A., Obenaus, A., (2005) Magn. Reson. Imaging, 23, pp. 1-25
LeVine, S.M., (1997) Brain Res., 760, pp. 298-303
Tan, H., Liu, T., Wu, Y., Thacker, J., Shenkar, R., Mikati, A.G., Shi, C.B., Awad, I.A., (2014) Invest. Radiol., 49, pp. 498-504
Moon, Y., Han, S.H., Moon, W.J., (2016) J. Alzheimers Dis., 51, pp. 737-745
Lu, T., Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y.W., Yang, T.H., Yankner, B.A., (2014) Nature, 507, pp. 448-454
Valensin, D., Migliorini, C., Valensin, G., Gaggelli, E., La Penna, G., Kozlowski, H., Gabbiani, C., Messori, L., (2011) Inorg. Chem., 50, pp. 6865-6867
Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., Collin, F., (2018) Redox Biol., 14, pp. 450-464
Bousejra-ElGarah, F., Bijani, C., Coppel, Y., Faller, P., Hureau, C., (2011) Inorg. Chem., 50, pp. 9024-9030
Tong, Y.W., Yang, H., Tian, X.S., Wang, H.C., Zhou, T., Zhang, S.Z., Yu, J., Chui, D.H., (2014) J. Alzheimers Dis., 42, pp. 865-878
Srivastava, R.A.K., Jain, J.C., (2002) J. Neurol. Sci., 196, pp. 45-52
Wallin, C., Kulkarni, Y.S., Abelein, A., Jarvet, J., Liao, Q.H., Strodel, B., Olsson, L., Warmlander, S.K.T.S., (2016) J. Trace Elem. Med Biol., 38, pp. 183-193
Abdrakhmanov, R., Blokhin, D., Usachev, K., Karataeva, F., Klochkov, V., (2017) Bionanoscience, 7, pp. 204-206
Lu, Y., Prudent, M., Qiao, L.A., Mendez, M.A., Girault, H.H., (2010) Metallomics, 2, pp. 474-479
Jozsa, E., Osz, K., Kallay, C., de Bona, P., Damante, C.A., Pappalardo, G., Rizzarelli, E., Sovago, I., (2010) Dalton Trans., 39, pp. 7046-7053
Saido, T., Leissring, M.A., (2012) Cold Spring Harb. Perspect. Med., 2, p. a006379
Bateman, R.J., Munsell, L.Y., Morris, J.C., Swarm, R., Yarasheski, K.E., Holtzman, D.M., (2006) Nat Med, 12, pp. 856-861
Zheng, L., Cedazo-Minguez, A., Hallbeck, M., Jerhammar, F., Marcusson, J., Terman, A., (2012) Transl. Neurodegener., 1. , 19
Lecker, S.H., Goldberg, A.L., Mitch, W.E., (2006) J. Am. Soc. Nephrol., 17, pp. 1807-1819
Singh, R.K., Kazansky, Y., Wathieu, D., Fushman, D., (2017) Anal. Chem., 89, pp. 7852-7860
Grasso, G., Santoro, A.M., Lanza, V., Sbardella, D., Tundo, G.R., Ciaccio, C., Marini, S., Milardi, D., (2017) Coord. Chem. Rev., 347, pp. 1-22
Morozov, A.V., Yurinskaya, M.M., Mitkevich, V.A., Garbuz, D.G., Preobrazhenskaia, O.V., Vinokurov, M.G., Evgen'ev, M.B., Makarov, A.A., (2017) Mol. Biol. (Mosk), 51, pp. 166-171
Zhang, Y., Chen, X., Zhao, Y., Ponnusamy, M., Liu, Y., (2017) Rev. Neurosci.
Kaneko, M., Koike, H., Saito, R., Kitamura, Y., Okuma, Y., Nomura, Y., (2010) J. Neurosci., 30, pp. 3924-3932
Del Prete, D., Rice, R.C., Rajadhyaksha, A.M., D'Adamio, L., (2016) J. Biol. Chem., 291, pp. 17209-17227
Tai, H.C., Serrano-Pozo, A., Hashimoto, T., Frosch, M.P., Spires-Jones, T.L., Hyman, B.T., (2012) Am. J. Pathol., 181, pp. 1426-1435
Wang, P., Joberty, G., Buist, A., Vanoosthuyse, A., Stancu, I.C., Vasconcelos, B., Pierrot, N., Dewachter, I., (2017) Acta Neuropathol., 133, pp. 731-749
Iqbal, K., Liu, F., Gong, C.X., Grundke-Iqbal, I., (2010) Curr. Alzheimer Res., 7, pp. 656-664
Gumeni, S., Tsakiri, E.N., Cheimonidi, C.M., Evangelakou, Z., Gianniou, D., Tallas, K., Papanagnou, E.D., Trougakos, I.P., (2017), in: J.A. Ghiso, A.A. Rostagno (Eds.), Protein Folding Disorders of the Central Nervous System, World Scientific
Varshavsky, A., (2017) Annu. Rev. Biochem, 86, pp. 123-128
Chiu, B., Jantuan, E., Shen, F., Chiu, B., Sergi, C., (2017) Ann. Clin. Lab. Sci., 47, pp. 243-252
Martini-Stoica, H., Xu, Y., Ballabio, A., Zheng, H., (2016) Trends Neurosci., 39, pp. 221-234
Nixon, R.A., (2017) FASEB J., 31, pp. 2729-2743
Bustos, V., Pulina, M.V., Kelahmetoglu, Y., Sinha, S.C., Gorelick, F.S., Flajolet, M., Greengard, P., (2017) Proc. Natl. Acad. Sci. U.S.A., 114, pp. 7142-7147
Ntsapi, C., Lumkwana, D., Swart, C., du Toit, A., Loos, B., International Review of Cell and Molecular Biology (2017), Academic Press
Xiao, Q., Yan, P., Ma, X., Liu, H., Perez, R., Zhu, A., Gonzales, E., Lee, J.M., (2014) J. Neurosci., 34, pp. 9607-9620
Poprac, P., Jomova, K., Simunkova, M., Kollar, V., Rhodes, C.J., Valko, M., (2017) Trends Pharmacol. Sci., 38, pp. 592-607
Dam, J., Ismail, Z., Kurebwa, T., Gangat, N., Harmse, L., Marques, H.M., Lemmerer, A., de Koning, C.B., (2017) Eur. J. Med. Chem., 126, pp. 353-368
Santoro, A.M., Monaco, I., Attanasio, F., Lanza, V., Pappalardo, G., Tomasello, M.F., Cunsolo, A., Milardi, D., (2016) Sci. Rep., 6, p. 33444
Arena, G., Bellia, F., Frasca, G., Grasso, G., Lanza, V., Rizzarelli, E., Tabbi, G., Milardi, D., (2013) Inorg. Chem., 52, pp. 9567-9573
Gutierrez, E., Richardson, D.R., Jansson, P.J., (2014) J. Biol. Chem., 289, pp. 33568-33589
Zhong, W., Zhu, H.C., Sheng, F.G., Tian, Y.L., Zhou, J., Chen, Y.Y., Li, S., Lin, J., (2014) Autophagy, 10, pp. 1285-1300
Bisceglie, F., Alinovi, R., Pinelli, S., Galetti, M., Pioli, M., Tarasconi, P., Mutti, A., Pelosi, G., (2016) Metallomics, 8, pp. 1255-1265
Ding, B.B., Zhong, Q., (2017) J. Biol. Chem., 292, pp. 8531-8532
Rajapakse, D., Curtis, T.M., Chen, M., Xu, H., (2017) Oxid. Med. Cell. Longev.
Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E.A., Frosch, M.P., Eckman, C.B., Guenette, S., (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 4162-4167
Shen, Y., Joachimiak, A., Rosner, M.R., Tang, W.J., (2006) Nature, 443, pp. 870-874
Bellia, F., Pietropaolo, A., Grasso, G., (2013) J. Mass Spectrom., 48, pp. 135-140
McCord, L.A., Liang, W.G., Dowdell, E., Kalas, V., Hoey, R.J., Koide, A., Koide, S., Tang, W.J., (2013) Proc. Natl. Acad. Sci. U.S.A., 110, pp. 13827-13832
Malito, E., Ralat, L.A., Manolopoulou, M., Tsay, J.L., Wadlington, N.L., Tang, W.J., (2008) Biochemistry, 47, pp. 12822-12834
Pivovarova, O., Hohn, A., Grune, T., Pfeiffer, A.F., Rudovich, N., (2016) Ann. Med., 48, pp. 614-624
Titorenko, V.I., Terlecky, S.R., (2011) Traffic, 12, pp. 252-259
Pandini, G., Pace, V., Copani, A., Squatrito, S., Milardi, D., Vigneri, R., (2013) Endocrinology, 154, pp. 375-387
Tundo, G.R., Sbardella, D., Ciaccio, C., Bianculli, A., Orlandi, A., Desimio, M.G., Arcuri, G., Marini, S., (2013) J. Biol. Chem., 288, pp. 2281-2289
McDermott, J.R., Gibson, A.M., (1997) Neurochem. Res., 22, pp. 49-56
Zhao, Z., Xiang, Z., Haroutunian, V., Buxbaum, J.D., Stetka, B., Pasinetti, G.M., (2007) Neurobiol. Aging, 8, pp. 824-830
Grasso, G., Pietropaolo, A., Spoto, G., Pappalardo, G., Tundo, G.R., Ciaccio, C., Coletta, M., Rizzarelli, E., (2011) Chem. Eur. J., 17, pp. 2752-2762
Opazo, C.M., Greenough, M.A., Bush, A.I., (2014) Front. Aging Neurosci., 6, p. 143
Assaf, S.Y., Chung, S.H., (1984) Nature, 308, pp. 734-736
Grasso, G., Salomone, F., Tundo, G.R., Pappalardo, G., Ciaccio, C., Spoto, G., Pietropaolo, A., Rizzarelli, E., (2012) J. Inorg. Biochem., 117, pp. 351-358
Bellia, F., Grasso, G., (2014) J. Mass Spectrom., 49, pp. 274-279
Iwata, N., Tsubuki, S., Takaki, Y., Watanabe, K., Sekiguchi, M., Hosoki, E., Kawashima-Morishima, M., Saido, T.C., (2000) Nat. Med., 6, pp. 143-150
Hersh, L.B., Rodgers, D.W., (2008) Curr. Alzheimer Res., 5, pp. 225-231
Schiering, N., D'Arcy, A., Villard, F., Ramage, P., Logel, C., Cumin, F., Ksander, G.M., Mogi, M., (2016) Sci. Rep., 6, p. 27909
Wade, R.C., Gabdoulline, R.R., Ludemann, S.K., Lounnas, V., (1998) Proc. Natl. Acad. Sci. U.S.A., 95, pp. 5942-5949
Li, M., Sun, M., Liu, Y., Yu, J., Yang, H., Fan, D., Chui, D., (2010) J. Alzheimer's Dis., 19, pp. 161-169
Kim, D.K., Song, J.W., Park, J.D., Choi, B.S., (2013) Mol. Cell. Toxicol., 9, pp. 57-66
Strozyk, D., Launer, L.J., Adlard, P.A., Cherny, R.A., Tsatsanis, A., Volitakis, I., Blennow, K., Bush, A.I., (2009) Neurobiol. Aging, 30, pp. 1069-1077
Lorenzl, S., Albers, D.S., LeWitt, P.A., Chirichigno, J.W., Hilgenberg, S.L., Cudkowicz, M.E., Beal, M.F., (2003) J. Neurol. Sci., 207, pp. 71-76
Horstmann, S., Budig, L., Gardner, H., Koziol, J., Deuschle, M., Schilling, C., Wagner, S., (2010) Int. Psychogeriatr., 22, pp. 966-972
Hanzel, C.E., Iulita, M.F., Eyjolfsdottir, H., Hjorth, E., Schultzberg, M., Eriksdotter, M., Cuello, A.C., (2014) J. Alzheimer's Dis., 40, pp. 667-678
Liao, M.C., Van Nostrand, W.E., (2010) Biochemistry (Mosc), 49, pp. 1127-1136
Yan, P., Hu, X.Y., Song, H.W., Yin, K.J., Bateman, R.J., Cirrito, J.R., Xiao, Q.L., Lee, J.M., (2006) J. Biol. Chem., 281, pp. 24566-24574
Hernandez-Guillamon, M., Mawhirt, S., Blais, S., Montaner, J., Neubert, T.A., Rostagno, A., Ghiso, J., (2015) J. Biol. Chem., 290, pp. 15078-15091
Donnelly, P.S., Caragounis, A., Du, T., Laughton, K.M., Volitakis, I., Cherny, R.A., Sharples, R.A., White, A.R., (2008) J. Biol. Chem., 283, pp. 4568-4577
Zheng, C., Geetha, T., Gearing, M., Babu, J.R., (2015) J. Neurochem., 133, pp. 919-925
Taniguchi, M., Matsuura, K., Nakamura, R., Kojima, A., Konishi, M., Akizawa, T., (2017) BioMetals
Eckman, E.A., Adams, S.K., Troendle, F.J., Stodola, B.A., Kahn, M.A., Fauq, A.H., Xiao, H.D., Eckman, C.B., (2006) J. Biol. Chem., 281, pp. 30471-30478
Eckman, E.A., Reed, D.K., Eckman, C.B., (2001) J. Biol. Chem., 276, pp. 24540-24548
Eckman, E.A., Watson, M., Marlow, L., Sambamurti, K., Eckman, C.B., (2003) J. Biol. Chem., 278, pp. 2081-2084
Pacheco-Quinto, J., Herdt, A., Eckman, C.B., Eckman, E.A., (2013) J. Alzheimers Dis., 33, pp. S101-110
Hemming, M.L., Selkoe, D.J., Farris, W., (2007) Neurobiol. Dis., 26, pp. 273-281
Miners, J.S., Ashby, E., Van Helmond, Z., Chalmers, K.A., Palmer, L.E., Love, S., Kehoe, P.G., (2008) Neuropathol. Appl. Neurobiol., 34, pp. 181-193
Barker, R., Love, S., Kehoe, P.G., (2010) Brain Res., 1355, pp. 7-15
Tucker, H.M., Kihiko, M., Caldwell, J.N., Wright, S., Kawarabayashi, T., Price, D., Walker, D., Estus, S., (2000) J. Neurosci., 20, pp. 3937-3946
Ehehalt, R., Keller, P., Haass, C., Thiele, C., Simons, K., (2003) J. Cell Biol., 160, pp. 113-123
Crouch, P.J., Barnham, K.J., (2012) Acc. Chem. Res., 45, pp. 1604-1611
La Mendola, D., Giacomelli, C., Rizzarelli, E., (2016) Curr. Top. Med. Chem., 16, pp. 3103-3130
An inorganic overview of natural Aβ fragments: Copper(II) and zinc(II)-mediated pathways
Unravelling the molecular basis for Alzheimer's disease (AD) represents one of the main scientific challenges we face when it comes to treating and – most importantly – preventing the onset of this devastating condition. The amyloid-beta peptide (Aβ) is a key element around which the metabolic pathways linked to sporadic AD forms have been investigated. The right balance between production and degradation of Aβ is fundamental to the physiological activity of the peptide and to preventing the formation of toxic aggregated species. Whilst the metabolic pathways for the formation of Aβ from the amyloid precursor protein (APP) have been unveiled, the mechanism involved in the control of Aβ levels through enzymatic systems (UPS, lysosomes and Aβ-degrading enzymes), both in vitro and in vivo, is underexplored. Overwhelming evidence clearly indicates that the abnormal aggregation of Aβ is not the main – or even the only – biochemical event that characterizes the onset and progression of AD, which can be also driven by the alteration of metallostasis (metal homeostasis) of d-block metal ions, such as copper(II) and zinc(II). The “Metal Hypothesis” in AD also concerns the effects of these metal ions on the formation and activity of Aβ fragments. Once Aβ is processed by the Aβ-degrading systems, the amyloid fragments can lose, maintain or modify the metal binding properties, unlike the full-length peptide. In addition, the physiological and/or pathological functions of the peptide fragments and their metal complexes can be different from those exerted by Aβ and its metal complex systems. We will outline the Aβ fragments detected in human fluids and tissues from both healthy and AD patients, as well as the structural and biochemical features of copper(II) and zinc(II) complexes with the naturally-occurring Aβ fragments. Then we will delve into the essential features and functionalities of the enzymatic systems involved in the clearance and degradation of Aβ and the effects of Cu2+ and Zn2+ in their activity. Finally, we will explain how we to match the cleavage sites of the Aβ-degrading enzymes to the natural-occurring cleavage sites of Aβ. © 2018 Elsevier B.V.
Unravelling the molecular basis for Alzheimer's disease (AD) represents one of the main scientific challenges we face when it comes to treating and – most importantly – preventing the onset of this devastating condition. The amyloid-beta peptide (Aβ) is a key element around which the metabolic pathways linked to sporadic AD forms have been investigated. The right balance between production and degradation of Aβ is fundamental to the physiological activity of the peptide and to preventing the formation of toxic aggregated species. Whilst the metabolic pathways for the formation of Aβ from the amyloid precursor protein (APP) have been unveiled, the mechanism involved in the control of Aβ levels through enzymatic systems (UPS, lysosomes and Aβ-degrading enzymes), both in vitro and in vivo, is underexplored. Overwhelming evidence clearly indicates that the abnormal aggregation of Aβ is not the main – or even the only – biochemical event that characterizes the onset and progression of AD, which can be also driven by the alteration of metallostasis (metal homeostasis) of d-block metal ions, such as copper(II) and zinc(II). The “Metal Hypothesis” in AD also concerns the effects of these metal ions on the formation and activity of Aβ fragments. Once Aβ is processed by the Aβ-degrading systems, the amyloid fragments can lose, maintain or modify the metal binding properties, unlike the full-length peptide. In addition, the physiological and/or pathological functions of the peptide fragments and their metal complexes can be different from those exerted by Aβ and its metal complex systems. We will outline the Aβ fragments detected in human fluids and tissues from both healthy and AD patients, as well as the structural and biochemical features of copper(II) and zinc(II) complexes with the naturally-occurring Aβ fragments. Then we will delve into the essential features and functionalities of the enzymatic systems involved in the clearance and degradation of Aβ and the effects of Cu2+ and Zn2+ in their activity. Finally, we will explain how we to match the cleavage sites of the Aβ-degrading enzymes to the natural-occurring cleavage sites of Aβ. © 2018 Elsevier B.V.
An inorganic overview of natural Aβ fragments: Copper(II) and zinc(II)-mediated pathways
An inorganic overview of natural Aβ fragments: Copper(II) and zinc(II)-mediated pathways
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Impact Factor: 3.249
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Pietropaolo A, Magri A, Greco V, Losasso V, La Mendola D, Sciuto S, Carloni P, Rizzarelli E
* Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays (213 visite)
Acs Chem Neurosci (ISSN: 1948-7193electronic, 1948-7193linking), 2018 Jan 12; N/D: N/D-N/D.
Impact Factor: 4.348
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (305 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Galati C, Spinella N, Renna L, Milardi D, Attanasio F, Sciacca MFM, Bongiorno C
* Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology (392 visite)
Beilstein J Nanotech (ISSN: 2190-4286), 2017 Nov 20; 8(1): 2446-2453.
Impact Factor: 2.968
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Albanese S, Greco A, Auletta L, Mancini M
* Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component (297 visite)
Brain Imaging Behav (ISSN: 1931-7557), 2017 Oct 26; N/D: N/D-N/D.
Impact Factor: 3.719
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Magrì A, Tabbì G, Breglia R, De Gioia L, Fantucci P, Bruschi M, Bonomo RP, La Mendola D
* Copper ion interaction with the RNase catalytic site fragment of the angiogenin protein: an experimental and theoretical investigation (329 visite) (PDF 171 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2017 Jul 04; 46(26): 8524-8538.
Impact Factor: 4.099
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Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappata S
* Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography (290 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 60-75.
Impact Factor: 2.368
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (537 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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Monti S, Cocozza S, Borrelli P, Straub S, Ladd ME, Salvatore M, Tedeschi E, Palma G
* MAVEN: An Algorithm for Multi-Parametric Automated Segmentation of Brain Veins from Gradient Echo Acquisitions (190 visite) (PDF 181 visite)
Ieee T Med Imaging (ISSN: 0278-0062), 2017; 36(5): 1054-1065.
Impact Factor: 6.131
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Accardo A, Del Zoppo L, Morelli G, Condorelli D, Barresi V, Musso N, Spampinato G, Bellia F, Tabbì G, Rizzarelli E
* Liposome antibody-ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration (170 visite)
Med Chem Comm, 2016 Sep; 7: 2364-2367.
Impact Factor: 2.319
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Varrone A, Pappatà S, Quarantelli M
* Movement disorders: Focus on Parkinson’s disease and related disorders (261 visite)
Pet Ct And Pet Mri In Neurology (ISSN: 9783-3193161479783319316123), 2016; N/D: 103-125.
Impact Factor: 0
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Trusso Sfrazzetto G, Satriano C, Tomaselli GA, Rizzarelli E
* Synthetic fluorescent probes to map metallostasis and intracellular fate of zinc and copper (306 visite)
Coord Chem Rev (ISSN: 0010-8545), 2016; 311: 125-167.
Impact Factor: 13.324
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (914 visite)
Rsc Adv (ISSN: 2046-2069), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
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Alterio V, Tanc M, Ivanova J, Zalubovskis R, Vozny I, Monti SM, Di Fiore A, De Simone G, Supuran CT
* X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor (316 visite)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2015 Apr 7; 13(13): 4064-4069.
Impact Factor: 3.559
Dettagli Esporta in BibTeX Esporta in EndNote
Di Natale G, Turi I, Pappalardo G, Sóvágó I, Rizzarelli E
* Cross-Talk Between the Octarepeat Domain and the Fifth Binding Site of Prion Protein Driven by the Interaction of Copper(II) with the N-terminus (428 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Mar 2; 21(10): 4071-4084.
Impact Factor: 5.771
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Bellia F, Pietropaolo A, Vecchio G
* Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (425 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015; 21(40): 14047-14059.
Impact Factor: 5.771
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Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M
* Cd And Nmr Conformational Studies Of A Peptide Encompassing The Mid Loop Interface Of Ship2-Sam (312 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Nov; 101(11): 1088-1098.
Impact Factor: 2.385
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
* Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting (434 visite)
Neuroimage-Clin (ISSN: 2213-1582, 2213-1582electronic), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (530 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
Dettagli Esporta in BibTeX Esporta in EndNote
Tedeschi E, Lanzillo R, Mancini M, Russo C, Cianflone A, Liuzzi R, Cocozza S, Postiglione E, Palma G, Caprio MG, Incoronato MR, Criscuolo C, Brescia Morra V, Salvatore M
* Imaging Of Brain Perfusion In Multiple Sclerosis And Neurodegenerative Diseases: Association With Endothelial Factors. An Interim Analysis (297 visite) (PDF 199 visite)
2014 Joint Actrims-Ectrims Meeting, 2014 Apr 28; N/D: N/D-N/D.
Impact Factor: 0
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (433 visite)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
Dettagli Esporta in BibTeX Esporta in EndNote
Arena G, Bellia F, Frasca G, Grasso G, Lanza V, Rizzarelli E, Tabbì G, Zito V, Milardi D
* Inorganic stressors of ubiquitin (331 visite) (PDF 194 visite)
Inorg Chem (ISSN: 1520-510x, 1520-510xelectronic, 0020-1669linking), 2013 Sep 19; 52(16): 9567-9573.
Impact Factor: 4.794
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (535 visite)
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
Impact Factor: 2.983
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Palmieri M, Malgieri G, Russo L, Baglivo I, Esposito S, Netti F, Del Gatto A, De Paola I, Zaccaro L, Pedone PV, Isernia C, Milardi D, Fattorusso R
* Structural Zn(II) Implies a Switch from Fully Cooperative to Partly Downhill Folding in Highly Homologous Proteins (372 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2013 Apr 2; 135(13): 5220-5228.
Impact Factor: 11.444
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (319 visite)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Arena G, Attanasio F, Zhang D, Yang Y, Bartsch RA, Sgarlata C
* Selective sensing of Hg2+ by a proton-ionizable calix[4]arene fluoroionophore (318 visite)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 1133-1137.
Impact Factor: 3.578
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Pietropaolo A, Grasso G
* Formation of insulin fragments by insulin-degrading enzyme: The role of zinc(II) and cystine bridges (346 visite)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2013; 48(2): 135-140.
Impact Factor: 2.709
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Faiella M, Maglio O, Nastri F, Lombardi A, Lista L, Hagen WR, Pavone V
* De Novo Design, Synthesis and Characterisation of MP3, A New Catalytic Four-Helix Bundle Hemeprotein (426 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2012 Dec 7; 18(50): 15960-15971.
Impact Factor: 5.831
Dettagli Esporta in BibTeX Esporta in EndNote
Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (473 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (338 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
Impact Factor: 3.197
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Stanzione F, De Simone A, Esposito L, Vitagliano L
* Dynamical Properties of Steric Zipper Polymorphs Formed by a IAPP-Derived Peptide (421 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Sep; 19(8): 846-851.
Impact Factor: 1.994
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (842 visite)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Hua Y, Changenet-Barret P, Improta R, Vaya I, Gustavsson T, Kotlyar AB, Zikich D, Sket P, Plavec J, Markovitsi D
* Cation effect on the electronic excited states of guanine nanostructures studied by time-resolved fluorescence spectroscopy (363 visite)
J Phys Chem C (ISSN: 1932-7447), 2012 Jul 12; 116(27): 14682-14689.
Impact Factor: 4.814
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Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (425 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
Dettagli Esporta in BibTeX Esporta in EndNote
Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (457 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (374 visite)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
Dettagli Esporta in BibTeX Esporta in EndNote
Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (527 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (417 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (367 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (517 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, La Mendola D, Milardi D
Metal Ions and the Clearance of Misfolded Proteins (205 visite)
Neurodegeneration (ISSN: 2041-3203), 2011; (7): N/D-N/D.
Impact Factor: 2.082
Dettagli Esporta in BibTeX Esporta in EndNote
La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (428 visite)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
Dettagli Esporta in BibTeX Esporta in EndNote
Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (433 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
Dettagli Esporta in BibTeX Esporta in EndNote
La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1010 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Torres Martin De Rosales R, Faiella M, Farquhar E, Que L, J , Andreozzi C, Pavone V, Maglio O, Nastri F, Lombardi A
* Spectroscopic and metal-binding properties of DF3: an artificial protein able to accommodate different metal ions (287 visite)
J Biol Inorg Chem (ISSN: 1432-1327electronic, 0949-8257linking, 0949-8257print), 2010 Jun; 15(5): 717-728.
Impact Factor: 3.287
Dettagli Esporta in BibTeX Esporta in EndNote
Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (348 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
Dettagli Esporta in BibTeX Esporta in EndNote
Vitagliano L, Stanzione F, De Simone A, Esposito L
* Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (379 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1161-1171.
Impact Factor: 2.605
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, Rizzarelli E, Spoto G
* The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study (386 visite)
J Mass Spectrom (ISSN: 1096-9888, 1076-5174), 2009 May; 44(5): 735-741.
Impact Factor: 3.411
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (671 visite)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
Dettagli Esporta in BibTeX Esporta in EndNote
Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (539 visite)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
Impact Factor: 2.648
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (740 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
Dettagli Esporta in BibTeX Esporta in EndNote
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (375 visite)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (356 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (398 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
Dettagli Esporta in BibTeX Esporta in EndNote
Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (694 visite)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
Dettagli Esporta in BibTeX Esporta in EndNote
Pappalardo M, Sciacca MFM, Milardi D, Grasso DM, La Rosa C
* Thermodynamics Of Azurin Folding: The Role Of The Copper Ion (286 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2008 Sep; 93(2): 575-581.
Impact Factor: 1.63
Dettagli Esporta in BibTeX Esporta in EndNote
Varrone A, Sansone V, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT (321 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jul; 35(7): 1343-1349.
Impact Factor: 4.532
Dettagli Esporta in BibTeX Esporta in EndNote
Salvatore E, Varrone A, Criscuolo C, Mancini P, Sansone V, Strisciuglio C, Cicala D, Scarano V, Salvatore M, Pappata S, De Michele G, Filla A
* Nigrostriatal involvement in ataxia with oculomotor apraxia type (314 visite)
J Neurol (ISSN: 0340-5354print, 0340-5354linking, 1432-1459electronic), 2008 Jan; 255(1): 45-48.
Impact Factor: 2.536
Dettagli Esporta in BibTeX Esporta in EndNote
Barbarulo AM, Pappata S, Puoti G, Prinster A, Grossi D, Cotrufo R, Salvatore M, Trojano L
* Rehabilitation of gesture imitation: a case study with fMRI (369 visite)
Neurocase (ISSN: 1465-3656, 1355-4794), 2008; 14(4): 293-306.
Impact Factor: 0.918
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (545 visite)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
Dettagli Esporta in BibTeX Esporta in EndNote
Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (293 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
Dettagli Esporta in BibTeX Esporta in EndNote
Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (571 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
Dettagli Esporta in BibTeX Esporta in EndNote
Joszal V, Nagy Z, Osz K, Sanna D, Di Natale G, La Mendola D, Pappalardo G, Rizzarelli E, Sovago I
* Transition metal complexes of terminally protected peptides containing histidyl residues (436 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2006 Sep; 100(8): 1399-1409.
Impact Factor: 2.654
Dettagli Esporta in BibTeX Esporta in EndNote
D'Auria G, Flores G, Falcigno L, Oliva R, Vacatello M, Corsaro MM, Parrilli M, Paolillo L
* Hyaluronate tetrasaccharide-Cu(II) interaction: A NMR study (288 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Oct; 70(2): 260-269.
Impact Factor: 2.733
Dettagli Esporta in BibTeX Esporta in EndNote
67 Records (65 escludendo Abstract e Conferenze).
Impact factor totale: 310.03 (307.948 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 312.11 (309.864 escludendo Abstract e Conferenze).
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Dubbioso R, Ruggiero L, Esposito M, Tarantino P, De Angelis M, Aruta F, Pappata S, Ugga L, Piperno A, Iorio R, Santoro L, Iodice R, Manganelli F
* Different cortical excitability profiles in hereditary brain iron and copper accumulation (118 visite)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2020 Mar; 41(3): 679-685.
Impact Factor: 1.315
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Pirone L, Di Gaetano S, Rizzarelli E, Bellia F, Pedone E
* Focusing on the functional characterization of the anserinase from Oreochromis niloticus (171 visite)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Feb 22; 130: 158-165.
Impact Factor: 4.784
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Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (249 visite)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Jun; 31(6): e3920-N/D.
Impact Factor: 2.872
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Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (434 visite)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Pietropaolo A, Magri A, Greco V, Losasso V, La Mendola D, Sciuto S, Carloni P, Rizzarelli E
* Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays (213 visite)
Acs Chem Neurosci (ISSN: 1948-7193electronic, 1948-7193linking), 2018 Jan 12; N/D: N/D-N/D.
Impact Factor: 4.348
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (305 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Galati C, Spinella N, Renna L, Milardi D, Attanasio F, Sciacca MFM, Bongiorno C
* Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology (392 visite)
Beilstein J Nanotech (ISSN: 2190-4286), 2017 Nov 20; 8(1): 2446-2453.
Impact Factor: 2.968
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Albanese S, Greco A, Auletta L, Mancini M
* Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component (297 visite)
Brain Imaging Behav (ISSN: 1931-7557), 2017 Oct 26; N/D: N/D-N/D.
Impact Factor: 3.719
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Magrì A, Tabbì G, Breglia R, De Gioia L, Fantucci P, Bruschi M, Bonomo RP, La Mendola D
* Copper ion interaction with the RNase catalytic site fragment of the angiogenin protein: an experimental and theoretical investigation (329 visite) (PDF 171 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2017 Jul 04; 46(26): 8524-8538.
Impact Factor: 4.099
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Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappata S
* Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography (290 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 60-75.
Impact Factor: 2.368
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (537 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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Monti S, Cocozza S, Borrelli P, Straub S, Ladd ME, Salvatore M, Tedeschi E, Palma G
* MAVEN: An Algorithm for Multi-Parametric Automated Segmentation of Brain Veins from Gradient Echo Acquisitions (190 visite) (PDF 181 visite)
Ieee T Med Imaging (ISSN: 0278-0062), 2017; 36(5): 1054-1065.
Impact Factor: 6.131
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Accardo A, Del Zoppo L, Morelli G, Condorelli D, Barresi V, Musso N, Spampinato G, Bellia F, Tabbì G, Rizzarelli E
* Liposome antibody-ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration (170 visite)
Med Chem Comm, 2016 Sep; 7: 2364-2367.
Impact Factor: 2.319
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Varrone A, Pappatà S, Quarantelli M
* Movement disorders: Focus on Parkinson’s disease and related disorders (261 visite)
Pet Ct And Pet Mri In Neurology (ISSN: 9783-3193161479783319316123), 2016; N/D: 103-125.
Impact Factor: 0
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Trusso Sfrazzetto G, Satriano C, Tomaselli GA, Rizzarelli E
* Synthetic fluorescent probes to map metallostasis and intracellular fate of zinc and copper (306 visite)
Coord Chem Rev (ISSN: 0010-8545), 2016; 311: 125-167.
Impact Factor: 13.324
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Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (914 visite)
Rsc Adv (ISSN: 2046-2069), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
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Alterio V, Tanc M, Ivanova J, Zalubovskis R, Vozny I, Monti SM, Di Fiore A, De Simone G, Supuran CT
* X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor (316 visite)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2015 Apr 7; 13(13): 4064-4069.
Impact Factor: 3.559
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Di Natale G, Turi I, Pappalardo G, Sóvágó I, Rizzarelli E
* Cross-Talk Between the Octarepeat Domain and the Fifth Binding Site of Prion Protein Driven by the Interaction of Copper(II) with the N-terminus (428 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Mar 2; 21(10): 4071-4084.
Impact Factor: 5.771
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Oliveri V, Bellia F, Pietropaolo A, Vecchio G
* Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (425 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015; 21(40): 14047-14059.
Impact Factor: 5.771
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Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M
* Cd And Nmr Conformational Studies Of A Peptide Encompassing The Mid Loop Interface Of Ship2-Sam (312 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Nov; 101(11): 1088-1098.
Impact Factor: 2.385
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
* Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting (434 visite)
Neuroimage-Clin (ISSN: 2213-1582, 2213-1582electronic), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (530 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Tedeschi E, Lanzillo R, Mancini M, Russo C, Cianflone A, Liuzzi R, Cocozza S, Postiglione E, Palma G, Caprio MG, Incoronato MR, Criscuolo C, Brescia Morra V, Salvatore M
* Imaging Of Brain Perfusion In Multiple Sclerosis And Neurodegenerative Diseases: Association With Endothelial Factors. An Interim Analysis (297 visite) (PDF 199 visite)
2014 Joint Actrims-Ectrims Meeting, 2014 Apr 28; N/D: N/D-N/D.
Impact Factor: 0
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (433 visite)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
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Arena G, Bellia F, Frasca G, Grasso G, Lanza V, Rizzarelli E, Tabbì G, Zito V, Milardi D
* Inorganic stressors of ubiquitin (331 visite) (PDF 194 visite)
Inorg Chem (ISSN: 1520-510x, 1520-510xelectronic, 0020-1669linking), 2013 Sep 19; 52(16): 9567-9573.
Impact Factor: 4.794
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (535 visite)
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
Impact Factor: 2.983
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Palmieri M, Malgieri G, Russo L, Baglivo I, Esposito S, Netti F, Del Gatto A, De Paola I, Zaccaro L, Pedone PV, Isernia C, Milardi D, Fattorusso R
* Structural Zn(II) Implies a Switch from Fully Cooperative to Partly Downhill Folding in Highly Homologous Proteins (372 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2013 Apr 2; 135(13): 5220-5228.
Impact Factor: 11.444
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (319 visite)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Arena G, Attanasio F, Zhang D, Yang Y, Bartsch RA, Sgarlata C
* Selective sensing of Hg2+ by a proton-ionizable calix[4]arene fluoroionophore (318 visite)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 1133-1137.
Impact Factor: 3.578
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Bellia F, Pietropaolo A, Grasso G
* Formation of insulin fragments by insulin-degrading enzyme: The role of zinc(II) and cystine bridges (346 visite)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2013; 48(2): 135-140.
Impact Factor: 2.709
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Faiella M, Maglio O, Nastri F, Lombardi A, Lista L, Hagen WR, Pavone V
* De Novo Design, Synthesis and Characterisation of MP3, A New Catalytic Four-Helix Bundle Hemeprotein (426 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2012 Dec 7; 18(50): 15960-15971.
Impact Factor: 5.831
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Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (473 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (338 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
Impact Factor: 3.197
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Stanzione F, De Simone A, Esposito L, Vitagliano L
* Dynamical Properties of Steric Zipper Polymorphs Formed by a IAPP-Derived Peptide (421 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Sep; 19(8): 846-851.
Impact Factor: 1.994
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (842 visite)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Hua Y, Changenet-Barret P, Improta R, Vaya I, Gustavsson T, Kotlyar AB, Zikich D, Sket P, Plavec J, Markovitsi D
* Cation effect on the electronic excited states of guanine nanostructures studied by time-resolved fluorescence spectroscopy (363 visite)
J Phys Chem C (ISSN: 1932-7447), 2012 Jul 12; 116(27): 14682-14689.
Impact Factor: 4.814
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Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (425 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
Dettagli Esporta in BibTeX Esporta in EndNote
Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (457 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (374 visite)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (527 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Impact Factor: 5.925
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Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (417 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (367 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (517 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Grasso G, La Mendola D, Milardi D
Metal Ions and the Clearance of Misfolded Proteins (205 visite)
Neurodegeneration (ISSN: 2041-3203), 2011; (7): N/D-N/D.
Impact Factor: 2.082
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (428 visite)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (433 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1010 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Torres Martin De Rosales R, Faiella M, Farquhar E, Que L, J , Andreozzi C, Pavone V, Maglio O, Nastri F, Lombardi A
* Spectroscopic and metal-binding properties of DF3: an artificial protein able to accommodate different metal ions (287 visite)
J Biol Inorg Chem (ISSN: 1432-1327electronic, 0949-8257linking, 0949-8257print), 2010 Jun; 15(5): 717-728.
Impact Factor: 3.287
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (348 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
Dettagli Esporta in BibTeX Esporta in EndNote
Vitagliano L, Stanzione F, De Simone A, Esposito L
* Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (379 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1161-1171.
Impact Factor: 2.605
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, Rizzarelli E, Spoto G
* The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study (386 visite)
J Mass Spectrom (ISSN: 1096-9888, 1076-5174), 2009 May; 44(5): 735-741.
Impact Factor: 3.411
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Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (671 visite)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (539 visite)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
Impact Factor: 2.648
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (740 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
Dettagli Esporta in BibTeX Esporta in EndNote
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (375 visite)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (356 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (398 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
Dettagli Esporta in BibTeX Esporta in EndNote
Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (694 visite)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
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Pappalardo M, Sciacca MFM, Milardi D, Grasso DM, La Rosa C
* Thermodynamics Of Azurin Folding: The Role Of The Copper Ion (286 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2008 Sep; 93(2): 575-581.
Impact Factor: 1.63
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Varrone A, Sansone V, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT (321 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jul; 35(7): 1343-1349.
Impact Factor: 4.532
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Salvatore E, Varrone A, Criscuolo C, Mancini P, Sansone V, Strisciuglio C, Cicala D, Scarano V, Salvatore M, Pappata S, De Michele G, Filla A
* Nigrostriatal involvement in ataxia with oculomotor apraxia type (314 visite)
J Neurol (ISSN: 0340-5354print, 0340-5354linking, 1432-1459electronic), 2008 Jan; 255(1): 45-48.
Impact Factor: 2.536
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Barbarulo AM, Pappata S, Puoti G, Prinster A, Grossi D, Cotrufo R, Salvatore M, Trojano L
* Rehabilitation of gesture imitation: a case study with fMRI (369 visite)
Neurocase (ISSN: 1465-3656, 1355-4794), 2008; 14(4): 293-306.
Impact Factor: 0.918
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (545 visite)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
Dettagli Esporta in BibTeX Esporta in EndNote
Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (293 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
Dettagli Esporta in BibTeX Esporta in EndNote
Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (571 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
Dettagli Esporta in BibTeX Esporta in EndNote
Joszal V, Nagy Z, Osz K, Sanna D, Di Natale G, La Mendola D, Pappalardo G, Rizzarelli E, Sovago I
* Transition metal complexes of terminally protected peptides containing histidyl residues (436 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2006 Sep; 100(8): 1399-1409.
Impact Factor: 2.654
Dettagli Esporta in BibTeX Esporta in EndNote
D'Auria G, Flores G, Falcigno L, Oliva R, Vacatello M, Corsaro MM, Parrilli M, Paolillo L
* Hyaluronate tetrasaccharide-Cu(II) interaction: A NMR study (288 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Oct; 70(2): 260-269.
Impact Factor: 2.733
Dettagli Esporta in BibTeX Esporta in EndNote
67 Records (65 escludendo Abstract e Conferenze).
Impact factor totale: 310.03 (307.948 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 312.11 (309.864 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Sunday 12 July 2020, 13:14:42
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