Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: a pilot study (190 views visite)
Clin Nutr (ISSN: 0261-5614linking), 2019 Dec; 38(6): 2727-2734.
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Paper type Tipo di articolo: Journal Article, Randomized Controlled Trial , Research Support, Non-U. S. Gov'T,
Impact factor: 0.5, 5-year impact factor Impact factor a 5 anni: 4.581
Url: Not available. Non disponibile.
Keywords Parole chiave: Adult , Blood Glucose Analysis Drug Effects Metabolism , Cross-Over Studies , Fruit And Vegetable Juices , Gallic Acid Blood , Humans , Insulin Blood Metabolism , Insulin Resistance Physiology , Male , Pilot Projects , Polyphenols Administration, Dosage Pharmacology , Triglycerides Blood Metabolism , Vitis Chemistry , Young Adult , Glucose Metabolism , Grape Polyphenols , Insulin Secretion , Insulin Sensitivity,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Clinical Medicine and Surgery, Federico II University of Naples, Via S. Pansini 5, 80131, Naples, Italy.
CNR-Institute of Biostructures and Bioimaging, Via Tommaso De Amicis, 95, 80131, Naples, Italy.
Department of Chemical Sciences, Federico II University of Naples, Via Cintia 21, 80126, Naples, Italy.
Metabolic Unit, CNR Institute of Neuroscience, Corso Stati Uniti 4, 35127, Padova, Italy.
Department of Food & Drugs, University of Parma, Via Volturno 39, 43125 Parma, Italy.
Department of Veterinary Science, University of Parma, Via Volturno 39, 43125 Parma, Italy
Microbiome Research Hub, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Institute of Food Science, National Research Council, Via Roma 64, 83100 Avellino, Italy.
References Riferimenti:
Not available. Non disponibili.
Clin Nutr (ISSN: 0261-5614linking), 2019 Dec; 38(6): 2727-2734.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Randomized Controlled Trial , Research Support, Non-U. S. Gov'T,
Impact factor: 0.5, 5-year impact factor Impact factor a 5 anni: 4.581
Url: Not available. Non disponibile.
Keywords Parole chiave: Adult , Blood Glucose Analysis Drug Effects Metabolism , Cross-Over Studies , Fruit And Vegetable Juices , Gallic Acid Blood , Humans , Insulin Blood Metabolism , Insulin Resistance Physiology , Male , Pilot Projects , Polyphenols Administration, Dosage Pharmacology , Triglycerides Blood Metabolism , Vitis Chemistry , Young Adult , Glucose Metabolism , Grape Polyphenols , Insulin Secretion , Insulin Sensitivity,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Clinical Medicine and Surgery, Federico II University of Naples, Via S. Pansini 5, 80131, Naples, Italy.
CNR-Institute of Biostructures and Bioimaging, Via Tommaso De Amicis, 95, 80131, Naples, Italy.
Department of Chemical Sciences, Federico II University of Naples, Via Cintia 21, 80126, Naples, Italy.
Metabolic Unit, CNR Institute of Neuroscience, Corso Stati Uniti 4, 35127, Padova, Italy.
Department of Food & Drugs, University of Parma, Via Volturno 39, 43125 Parma, Italy.
Department of Veterinary Science, University of Parma, Via Volturno 39, 43125 Parma, Italy
Microbiome Research Hub, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Institute of Food Science, National Research Council, Via Roma 64, 83100 Avellino, Italy.
References Riferimenti:
Not available. Non disponibili.
Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: a pilot study
BACKGROUND & AIMS: Dietary polyphenols have beneficial effects on glucose/lipid metabolism in subjects at high risk to develop type 2 diabetes; however, the underlying mechanisms are not clear. We aimed to evaluate: 1) the acute effects of the consumption of a drink rich in polyphenols from red grape pomace (RGPD) on glucose/insulin and triglyceride responses to a standard meal in healthy individuals, and, 2) the relationship between plasma levels of phenolic metabolites and metabolic parameters. METHODS: Twelve healthy men, aged 20-40 years participated in a randomized, controlled study according to a cross-over design. After a 3-day low-polyphenol diet, all participants consumed, on two different days and separated by a one week interval, after an overnight fast, a drink rich in polyphenols (1.562 g gallic acid equivalents (GAE)) or a control drink (CD, no polyphenols), followed after 3 h by a standard meal (960 kcal, 18% protein, 30% fat, 52% CHO). Blood samples were taken at fasting, 3 h after the drink, over 5 h after the standard meal and at fasting on the next day to measure plasma concentrations of glucose, insulin, triglyceride and phenolic metabolites. RESULTS: Glycemic and triglyceride post-meal responses were similar after both the RGPD and the control drink. In contrast, postprandial insulin incremental area (iAUC(0-5h)) was 31% lower (p < 0.05), insulin secretion index was 18% lower (p < 0.016) and insulin sensitivity (S(I)) index was 36% higher (p = 0.037) after the RGPD compared to CD. Among phenolic metabolites, gallic acid correlated inversely with the insulin response (r = -0.604; p = 0.032) and positively with the S(I) index (r = 0.588, p = 0.037). CONCLUSIONS: RGPD consumption acutely reduced postprandial insulin levels and improved insulin sensitivity. This effect could be likely related to the increase in gallic acid levels. This drink, added to usual diet, could contribute to increase the daily intake of polyphenols, with potential health benefits. CLINICALTRIALS. GOV IDENTIFIER: NCT02865278.
BACKGROUND & AIMS: Dietary polyphenols have beneficial effects on glucose/lipid metabolism in subjects at high risk to develop type 2 diabetes; however, the underlying mechanisms are not clear. We aimed to evaluate: 1) the acute effects of the consumption of a drink rich in polyphenols from red grape pomace (RGPD) on glucose/insulin and triglyceride responses to a standard meal in healthy individuals, and, 2) the relationship between plasma levels of phenolic metabolites and metabolic parameters. METHODS: Twelve healthy men, aged 20-40 years participated in a randomized, controlled study according to a cross-over design. After a 3-day low-polyphenol diet, all participants consumed, on two different days and separated by a one week interval, after an overnight fast, a drink rich in polyphenols (1.562 g gallic acid equivalents (GAE)) or a control drink (CD, no polyphenols), followed after 3 h by a standard meal (960 kcal, 18% protein, 30% fat, 52% CHO). Blood samples were taken at fasting, 3 h after the drink, over 5 h after the standard meal and at fasting on the next day to measure plasma concentrations of glucose, insulin, triglyceride and phenolic metabolites. RESULTS: Glycemic and triglyceride post-meal responses were similar after both the RGPD and the control drink. In contrast, postprandial insulin incremental area (iAUC(0-5h)) was 31% lower (p < 0.05), insulin secretion index was 18% lower (p < 0.016) and insulin sensitivity (S(I)) index was 36% higher (p = 0.037) after the RGPD compared to CD. Among phenolic metabolites, gallic acid correlated inversely with the insulin response (r = -0.604; p = 0.032) and positively with the S(I) index (r = 0.588, p = 0.037). CONCLUSIONS: RGPD consumption acutely reduced postprandial insulin levels and improved insulin sensitivity. This effect could be likely related to the increase in gallic acid levels. This drink, added to usual diet, could contribute to increase the daily intake of polyphenols, with potential health benefits. CLINICALTRIALS. GOV IDENTIFIER: NCT02865278.
Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: a pilot study
No results. Nessun risultato. |
Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: a pilot study
De Natale C, Minerva V, Patti L, Mazzarella R, Ciano O, Maione S, Luongo D, Naviglio D, Marotta G, Turco S, Ciati R, Melegari C, Rivellese AA, Riccardi G
* Effects Of Baked Products Enriched With N-3 Fatty Acids, Folates, β -Glucans, And Tocopherol In Patients With Mild Mixed Hyperlipidemia (275 visite)
J Am Coll Nutr (ISSN: 1541-1087, 0731-5724), 2012 Oct; 31(5): 311-319.
Impact Factor: 1.738
Dettagli Esporta in BibTeX Esporta in EndNote
Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
* Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people (559 visite)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2010 Mar; 20(3): 186-194.
Impact Factor: 3.438
Dettagli Esporta in BibTeX Esporta in EndNote
Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (381 visite)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
Dettagli Esporta in BibTeX Esporta in EndNote
Cuocolo A, Storto G, Izzo R, Iovino GL, Damiano M, Bertocchi F, Mann J, Trimarco B
Effects of valsartan on left ventricular diastolic function in patients with mild or moderate essential hypertension: Comparison with enalapril (268 visite)
Journal Of Hypertension (ISSN: 0263-6352), 1999 Dec; 17(12): 1759-1766.
Impact Factor: 3.039
Dettagli Esporta in BibTeX Esporta in EndNote
Morisco C, Cuocolo A, Romano M, Nappi A, Iaccarino G, Volpe M, Salvatore M, Trimarco B
Influence of digitalis on left ventricular functional response to exercise in congestive heart failure (383 visite)
Am J Cardiol (ISSN: 0002-9149), 1996 Mar 1; 77(7): 480-485.
Impact Factor: 2.402
Dettagli Esporta in BibTeX Esporta in EndNote
Morisco C, Nappi A, Argenziano L, Sarno D, Fonatana D, Imbriaco M, Nicolai E, Romano M, Rosiello G, Cuocolo A
Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: Effects of short-term Coenzyme Q10 treatment (320 visite)
Molecular Aspects Of Medicine (ISSN: 0098-2997, 1872-9452), 1994; 15(SUPPL.1): s155-s155.
Impact Factor: 2
Dettagli Esporta in BibTeX Esporta in EndNote
6 Records (5 escludendo Abstract e Conferenze).
Impact factor totale: 14.636 (12.636 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 29.597 (19.051 escludendo Abstract e Conferenze).
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De Natale C, Minerva V, Patti L, Mazzarella R, Ciano O, Maione S, Luongo D, Naviglio D, Marotta G, Turco S, Ciati R, Melegari C, Rivellese AA, Riccardi G
* Effects Of Baked Products Enriched With N-3 Fatty Acids, Folates, β -Glucans, And Tocopherol In Patients With Mild Mixed Hyperlipidemia (275 visite)
J Am Coll Nutr (ISSN: 1541-1087, 0731-5724), 2012 Oct; 31(5): 311-319.
Impact Factor: 1.738
Dettagli Esporta in BibTeX Esporta in EndNote
Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
* Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people (559 visite)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2010 Mar; 20(3): 186-194.
Impact Factor: 3.438
Dettagli Esporta in BibTeX Esporta in EndNote
Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (381 visite)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
Dettagli Esporta in BibTeX Esporta in EndNote
Cuocolo A, Storto G, Izzo R, Iovino GL, Damiano M, Bertocchi F, Mann J, Trimarco B
Effects of valsartan on left ventricular diastolic function in patients with mild or moderate essential hypertension: Comparison with enalapril (268 visite)
Journal Of Hypertension (ISSN: 0263-6352), 1999 Dec; 17(12): 1759-1766.
Impact Factor: 3.039
Dettagli Esporta in BibTeX Esporta in EndNote
Morisco C, Cuocolo A, Romano M, Nappi A, Iaccarino G, Volpe M, Salvatore M, Trimarco B
Influence of digitalis on left ventricular functional response to exercise in congestive heart failure (383 visite)
Am J Cardiol (ISSN: 0002-9149), 1996 Mar 1; 77(7): 480-485.
Impact Factor: 2.402
Dettagli Esporta in BibTeX Esporta in EndNote
Morisco C, Nappi A, Argenziano L, Sarno D, Fonatana D, Imbriaco M, Nicolai E, Romano M, Rosiello G, Cuocolo A
Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: Effects of short-term Coenzyme Q10 treatment (320 visite)
Molecular Aspects Of Medicine (ISSN: 0098-2997, 1872-9452), 1994; 15(SUPPL.1): s155-s155.
Impact Factor: 2
Dettagli Esporta in BibTeX Esporta in EndNote
6 Records (5 escludendo Abstract e Conferenze).
Impact factor totale: 14.636 (12.636 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 29.597 (19.051 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Wednesday 02 December 2020, 18:09:01
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