Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease
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Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (361 visite)

Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS

Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.



Tipo di articolo: Journal Article, Review, Research Support, Non-U. S. Gov'T, Comparative Study,

Impact factor: 0.913, Impact factor a 5 anni: 0.843

Url: Non disponibile.

Parole chiave: Metabolic Syndromes, Non Alcoholic Fatty Liver Disease, Nutrition, Adipokines, Adipose Tissue, Physiopathology, Adiposity, Animals, Fibrosis, Hepatocytes, Cytology, Humans, Inflammation, Lipids, Chemistry, Non-Alcoholic Fatty Liver Disease, Complications, Obesity, Vitamin D, Administration, Dosage, Vitamin D Deficiency, Adipose Tissue Dysfunction, Non-Alcoholic Steatohepatitis, Steatosis, Adult, Alanine Transaminase, Blood, Aspartate Aminotransferases, Blood Glucose, Caloric Restriction, Cholesterol, Dietary Supplements, Exercise, Female, Epidemiology, Middle Aged, Therapy, Abdominal, Prevalence, Randomized Controlled Trials As Topic, Risk Factors, Ultraviolet Rays, Diagnosis, Drug Therapy, Weight Loss, Weight Reduction Programs, Sunlight Exposure, Albuminuria, Analysis, C-Peptide, Creatinine, Fasting, Insulin, Outpatients, Regression Analysis, Seasons, Adiponectin, Biomarkers, Blood Pressure, Case-Control Studies, Cross-Sectional Studies, Hypertension, Analogs, Derivatives, Aniline Hydroxylase, Ascorbic Acid Deficiency, Cytochrome P-450 Enzyme System, Disease Progression, Lipid Peroxides, Etiology, Vitamin E Deficiency, Antigens, Bile Ducts, Immunology, Biopsy, Immunoenzyme Techniques, Keratins, Retrospective Studies, Vitamin A Deficiency,

Affiliazioni:

Alcohological Regional Center, Ligurian Region, ASL3 c/o San Martino Hospital, Genoa, Italy - gianni.testino@hsanmartino.it., Alcohological Regional Center, Ligurian Region, ASL3 c/o San Martino Hospital, Genoa, Italy., Institute for Biostructures and Bioimages (CNR), c/o Molecular Biotechnology Center, Turin, Italy., EURECAT, Reus, Spain., q-genomics, barcelona, Spain., University Rovira i Virgili, Tarragona, Spain., Universitat Autonoma de Barcelona, Barcelona, Spain., EURECAT, Reus, Spain antoni.caimari@ctns.cat., Flavia A Cimini, Ilaria Barchetta, Maria-Gisella Cavallo, Laura Bertoccini, Marco G Baroni, Department of Experimental Medicine, Sapienza University of Rome, 00128 Rome, Italy., Benaroya Research Institute at Virginia Mason Medical Center, Seattle, Washington, USA., Seattle Children's Research Institute, Seattle, Washington, USA., Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, Maryland, USA., Department of Physiological Nursing, University of California at San Francisco, San Francisco, California, USA., Institute for Human Genetics, University of California at San Francisco, San Francisco, California, USA., Liver Care Network, Swedish Medical Center, Seattle, Washington, USA., Departments of Laboratory Medicine and Medicine, University of Washington, Seattle, Washington, USA., Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA., Department of Food and Nutrition, Sungshin Women's University, Seoul, Republic of Korea., Department of Internal Medicine, Hanyang University School of Medicine, Seoul, Republic of Korea. Electronic address: noshin@hanyang.ac.kr., Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: choyk2004.cho@samsung.com., Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey., Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, Ankara


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The clinical and histologic significance of cytokeratin antigen expression in various intrahepatic locations was assessed in 57 patients with alcoholic liver disease as part of a large Veterans Administration Cooperative Study of Alcoholic Hepatitis. Cytokeratin antigen was demonstrated in fixed, paraffin-embedded liver tissue by an avidin-biotin peroxidase method using a mixture of two different monoclonal antibodies, AE1 (acidic; 48, 50 and 56.5 kD) and AE3 (basic; 52, 56, 58 and 65 to 67 kD). In contrast to the normal liver, in which only bile duct epithelium was positive, this antibody mixture stained both bile ducts and hepatocytes in pathologic livers. Serum levels of vitamin A showed a significant inverse correlation with the amount of cytokeratin antigen (scale: 0 to 3) in hepatocytes without Mallory bodies (p = 0.001), in Mallory body-containing hepatocytes (p less than 0.0001) and in bile ducts (p = 0.0074). Increased amount of cytokeratin antigen in each of these locations, in turn, correlated directly with the histologic severity of the liver disease. Histologic severity (fibrosis, parenchymal degeneration/necrosis, hepatocyte regeneration and inflammation) was significantly higher in patients when either Mallory bodies (p less than 0.0001) or cytokeratin antigen (p = 0.0021) was present in hepatocytes. Demonstration of cytokeratin antigen in hepatocytes which contained Mallory bodies correlated positively (p = 0.03) with clinical severity of the liver disease as determined by high serum bilirubin and prolonged prothrombin time (Maddrey's discriminant function).(ABSTRACT TRUNCATED AT 250 WORDS)
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Mancini M, Di Donato O, Saldalamacchia G, Liuzzi R, Rivellese A, Salvatore M
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Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 2013 Mar; 118(2): 206-214.
Impact Factor: 1.368
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Pasanisi F, Pace L, Fonti R, Marra M, Sgambati D, De Caprio C, De Filippo E, Vaccaro A, Salvatore M, Contaldo F
* Evidence of brown fat activity in constitutional leanness (329 visite)
J Clin Endocrinol Metab (ISSN: 1945-7197, 0021-972x, 0021-972xlinking), 2013 Mar; 98(3): 1214-1218.
Impact Factor: 6.31
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Fonti R, Sgambati D, Vaccaro A, Pasanisi F, De Caprio C, Pace L, Contaldo F, Salvatore M
* Evidence of Brown Adipose Tissue Activity Assessed by 18F-FDG-PET/CT in Females with Constitutional Leanness (164 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
Impact Factor: 5.114
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (418 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Fonti R, Sgambati D, Vaccaro A, Pasanisi F, De Caprio C, Salvatore M, Pace L, Contaldo F
* Evidence Of Brown Adipose Tissue Astivity Assessed By 18f-Fdg-Pet/Ct In Females With Constitutional Leanness (175 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012; 39: S401-S401.
Impact Factor: 5.114
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Esposito G, De Falco F, Tinto N, Testa F, Vitagliano L, Tandurella IC, Iannone L, Rossi S, Rinaldi E, Simonelli F, Zagari A, Salvatore F
* Comprehensive mutation analysis (20 families) of the choroideremia gene reveals a missense variant that prevents the binding of REP1 with Rab geranylgeranyl transferase (289 visite)
Hum Mutat (ISSN: 1059-7794, 1098-1004, 1098-1004electronic), 2011 Dec; 32(12): 1460-1469.
Impact Factor: 5.686
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Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Gasperi M, Prinster A, Vacca G, Pivonello C, Orefice G, Colao A, Morra VB
* Insulin-like growth factor (IGF)-I and IGF-binding protein-3 serum levels in relapsing-remitting and secondary progressive multiple sclerosis patients (201 visite)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic), 2011 Dec; 18(12): 1402-1406.
Impact Factor: 3.692
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Pace L, Nicolai E, D'Amico D, Ibello F, Della Morte AM, Salvatore B, Pizzuti LM, Salvatore M, Soricelli A
* Determinants of physiologic 18F-FDG uptake in brown adipose tissue in sequential PET/CT examinations (328 visite)
Molecular Imaging And Biology (ISSN: 1860-2002, 1536-1632), 2011 Oct; 13(5): 1029-1035.
Impact Factor: 3.844
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Durazzo M, Campion D, Fagoonee S, Pellicano R, Sonne JU, Erckenbrecht JF, Grassi M, Petraccia L, Mennuni G, Fontana M, Scarno A, Sabetta S, Fraioli A
* Changes, functional disorders, and diseases in the gastrointestinal tract of elderly (72 visite)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking, 1432-1289electronic), 2011 Jul; 2655108(6): 659-668.
Impact Factor: 0.913
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Striano P, Caranci F, Pappata S, Zara F, Striano S
* Hemidystonia in uncontrolled type 2 diabetes mellitus (181 visite)
Arch Neurol (ISSN: 1538-3687electronic, 0003-9942linking), 2011 May; 68(5): 674-675.
Impact Factor: 7.584
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Pedone C, Napoli N, Pozzilli P, Rossi FF, Lauretani F, Bandinelli S, Ferrucci L, Antonelli-Incalzi R
* Dietary pattern and bone density changes in elderly women: a longitudinal study (182 visite)
J Am Coll Nutr (ISSN: 1541-1087, 0731-5724), 2011 Apr; 30(2): 149-154.
Impact Factor: 2.29
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Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
* Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (241 visite)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362), 2011 Jan; 41(1): 39-44.
Impact Factor: 3.018
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Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (245 visite)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
Impact Factor: 3.451
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
* In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (313 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448.
Impact Factor: 5.036
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Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M
* SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment (330 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
Impact Factor: 5.036
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Mancini M, Prinster A, Annuzzi G, Liuzzi R, Giacco R, Medagli C, Cremone M, Clemente G, Maurea S, Riccardi G, Rivellese AA, Salvatore M
* Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with (1)H magnetic resonance spectroscopy (238 visite)
Metab Clin Exp (ISSN: 1532-8600, 0026-0495), 2009 Dec; 58(12): 1724-1730.
Impact Factor: 2.588
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Lanzillo R, Di Somma C, Quarantelli M, Gasperi M, Ventrella G, Prinster A, Vacca G, Orefice G, Colao A, Morra VB
* Serum levels of insulin like growth factor-1 and insulin like growth factor binding protein-3 in relapsing and secondary progressive multiple sclerosis (236 visite)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2009 Sep; 15(9): 1402-1406.
Impact Factor: 3.279
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (516 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (423 visite)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
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Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (373 visite)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
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Salvatore E, Varrone A, Criscuolo C, Mancini P, Sansone V, Strisciuglio C, Cicala D, Scarano V, Salvatore M, Pappata S, De Michele G, Filla A
* Nigrostriatal involvement in ataxia with oculomotor apraxia type (225 visite)
J Neurol (ISSN: 0340-5354print, 0340-5354linking, 1432-1459electronic), 2008 Jan; 255(1): 45-48.
Impact Factor: 2.536
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Barbarulo AM, Pappata S, Puoti G, Prinster A, Grossi D, Cotrufo R, Salvatore M, Trojano L
* Rehabilitation of gesture imitation: a case study with fMRI (274 visite)
Neurocase (ISSN: 1465-3656, 1355-4794), 2008; 14(4): 293-306.
Impact Factor: 0.918
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Del Giudice E, Bianchi MC, Tosetti M, Varrone A, Romano A, Crisanti AF, Titomanlio L, Imperati F
* Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment? (220 visite)
Epileptic Disord (ISSN: 1294-9361), 2006 Dec; 8(4): 289-293.
Impact Factor: 1.202
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tedeschi G, Lavorgna L, Russo P, Prinster A, Dinacci D, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone IL, Salvatore M, Bonavita V, Alfano B
* Brain atrophy and lesion load in a large population of patients with multiple sclerosis (303 visite) (PDF 211 visite)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2005 Jul 26; 65(2): 280-285.
Impact Factor: 5.065
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Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (267 visite)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
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Imbriaco M, Ignarra R, De Rosa N, Lambiase G, Romano  M, Ragozzino A
* Parosteal lipoma of the rib: CT findings and pathologic correlation (184 visite)
Clinical Imaging (ISSN: 0899-7071, 1873-4499), 2003; 27(6): 435-437.
Impact Factor: 0.658
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Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
* Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks (293 visite) (PDF 197 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.
Impact Factor: 3.568
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Menna F, Acampa W, Florimonte L, Ferro A, Borrelli G, Mainolfi C, Cuocolo A
[Cardiac tomography with 99mTc-tetrofosmin after nitrate administration in patients with ischemic cardiopathy and left ventricular dysfunction] (178 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000 Apr; 99(4): 258-263.
Impact Factor: 1.368
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vinale F, Monti SM, Panunzi B, Fogliano V
Convenient synthesis of lactuloselysine and its use for LC-MS analysis in milk-like model systems (230 visite)
J Agric Food Chem (ISSN: 0021-8561), 1999 Nov; 47(11): 4700-4706.
Impact Factor: 1.453
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Cappabianca S, Iscaro FM, Sirignano C, Napoli E, Del Vecchio W
[Magnetic resonance in the identification and assessment of extent and severity of bone contusion damage: comparison of several types of imaging (SE/T1, GE/T2 and SE/T1) with fat suppression] (184 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998 Nov; 96(5): 439-445.
Impact Factor: 0.967
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De Michele G, Mainenti PP, Soricelli A, Di Salle F, Salvatore E, Longobardi MR, Postiglione A, Salvatore M, Filla A
Cerebral blood flow in spinocerebellar degenerations: a single photon emission tomography study in 28 patients (179 visite)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 1998 Sep; 245(9): 603-608.
Impact Factor: 2.3
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Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
[Effects left ventricle asynchrony on systolic and diastolic function in patients with non-ischemic heart failure] (164 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998 Jul; 96(1-2): 68-72.
Impact Factor: 0.967
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Cappabianca S, Iscaro FM, Sirignano C, Napoli E, Del Vecchio W
Magnetic Resonance Imaging In The Identification And Assessment Of Bone Contusion Extent And Severity: Comparison Between T1-W Se, T2?-W Ge And T1-W (168 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998; 96(5): 439-445.
Impact Factor: 0.967
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Ciarmiello A, Pace L, Betocchi S, Alfano B, Chiariello M, Salvatore M
Assessment of left ventricular regional function by radionuclide angiography: Effects of number of sectors on repeatability (215 visite) (PDF 165 visite)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1994 Sep; 21(6): 883-887.
Impact Factor: 1.042
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Betocchi S, Piscione F, Perrone-Filardi P, Pace L, Cappelli-Bigazzi M, Alfano B, Ciarmiello A, Salvatore M, Condorelli M, Chiariello M
Effects of intravenous verapamil on left ventricular relaxation and filling in stable angina pectoris (264 visite)
Am J Cardiol (ISSN: 0002-9149), 1990 Oct 1; 66(10): 818-825.
Impact Factor: 2.402
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Iannotti F, Fieschi C, Alfano B, Picozzi P, Mansi L, Pozzilli C, Punzo A, Del Vecchio G, Lenzi GL, Salvatore M
Simplified, noninvasive PET measurement of blood-brain barrier permeability (434 visite)
J Comput Assisted Tomogr (ISSN: 0363-8715), 1987 May; 11(3): 390-397.
Impact Factor: 1.263
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Betocchi S, Cuocolo A, Pace L, Chiariello M, Trimarco B, Alfano B, Ricciardelli B, Salvatore M, Condorelli M
Effects of intravenous verapamil administration on left ventricular diastolic function in systemic hypertension (453 visite)
Am J Cardiol (ISSN: 0002-9149), 1987 Mar 1; 59(6): 624-629.
Impact Factor: 2.402
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78 Records (74 escludendo Abstract e Conferenze).
Impact factor totale: 329.653 (314.391 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 331.702 (316.123 escludendo Abstract e Conferenze).







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Ultima modifica di Gennaro Angrisano in data Sunday 12 July 2020, 13:15:17
361 visite. Ultima visita in data Thursday 13 August 2020, 11:17:32