Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease(23 visite) Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Alcohological Regional Center, Ligurian Region, ASL3 c/o San Martino Hospital, Genoa, Italy - gianni.testino@hsanmartino.it., Alcohological Regional Center, Ligurian Region, ASL3 c/o San Martino Hospital, Genoa, Italy., Institute for Biostructures and Bioimages (CNR), c/o Molecular Biotechnology Center, Turin, Italy., EURECAT, Reus, Spain., q-genomics, barcelona, Spain., University Rovira i Virgili, Tarragona, Spain., Universitat Autonoma de Barcelona, Barcelona, Spain., EURECAT, Reus, Spain antoni.caimari@ctns.cat., Flavia A Cimini, Ilaria Barchetta, Maria-Gisella Cavallo, Laura Bertoccini, Marco G Baroni, Department of Experimental Medicine, Sapienza University of Rome, 00128 Rome, Italy., Benaroya Research Institute at Virginia Mason Medical Center, Seattle, Washington, USA., Seattle Children's Research Institute, Seattle, Washington, USA., Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, Maryland, USA., Department of Physiological Nursing, University of California at San Francisco, San Francisco, California, USA., Institute for Human Genetics, University of California at San Francisco, San Francisco, California, USA., Liver Care Network, Swedish Medical Center, Seattle, Washington, USA., Departments of Laboratory Medicine and Medicine, University of Washington, Seattle, Washington, USA., Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA., Department of Food and Nutrition, Sungshin Women's University, Seoul, Republic of Korea., Department of Internal Medicine, Hanyang University School of Medicine, Seoul, Republic of Korea. Electronic address: noshin@hanyang.ac.kr., Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: choyk2004.cho@samsung.com., Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey., Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, Ankara
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The clinical and histologic significance of cytokeratin antigen expression in various intrahepatic locations was assessed in 57 patients with alcoholic liver disease as part of a large Veterans Administration Cooperative Study of Alcoholic Hepatitis. Cytokeratin antigen was demonstrated in fixed, paraffin-embedded liver tissue by an avidin-biotin peroxidase method using a mixture of two different monoclonal antibodies, AE1 (acidic; 48, 50 and 56.5 kD) and AE3 (basic; 52, 56, 58 and 65 to 67 kD). In contrast to the normal liver, in which only bile duct epithelium was positive, this antibody mixture stained both bile ducts and hepatocytes in pathologic livers. Serum levels of vitamin A showed a significant inverse correlation with the amount of cytokeratin antigen (scale: 0 to 3) in hepatocytes without Mallory bodies (p = 0.001), in Mallory body-containing hepatocytes (p less than 0.0001) and in bile ducts (p = 0.0074). Increased amount of cytokeratin antigen in each of these locations, in turn, correlated directly with the histologic severity of the liver disease. Histologic severity (fibrosis, parenchymal degeneration/necrosis, hepatocyte regeneration and inflammation) was significantly higher in patients when either Mallory bodies (p less than 0.0001) or cytokeratin antigen (p = 0.0021) was present in hepatocytes. Demonstration of cytokeratin antigen in hepatocytes which contained Mallory bodies correlated positively (p = 0.03) with clinical severity of the liver disease as determined by high serum bilirubin and prolonged prothrombin time (Maddrey's discriminant function).(ABSTRACT TRUNCATED AT 250 WORDS)
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(38 visite) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 DettagliEsporta in BibTeXEsporta in EndNote
73 Records (69 escludendo Abstract e Conferenze). Impact factor totale: 303.631 (288.369 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 313.953 (298.374 escludendo Abstract e Conferenze).
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