Structural Isomers of Cyclodextrin-Bearing IOX1 Compound as Inhibitors of Aβ Aggregation (185 visite)
Chemistryselect (ISSN: 2365-6549), 2017; 2(2): 655-659.
Tipo di articolo: Journal Article,
Impact factor: 1.505, Impact factor a 5 anni: 1.505
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041741485&doi=10.1002%2fslct.201601651&partnerID=40&md5=62c2b39627d9b7251317c21d53c6fd62
Parole chiave: Amyloid-Beta, Antiaggregant, Cyclodextrin, Glycoconjugate, Hydroxyquinoline,
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università degli Studi di Catania, viale A. Doria 6, Catania, 95125, Italy
Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, C.I.R.C.M.S.B, Unità di Ricerca di Catania, Catania, 95125, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Viale P. Gaifami 18, Catania, 95126, Italy
Riferimenti:
Alzheimer's, A., (2015) Alzheimers Dement., 11, pp. 332-38
Findeis, A., (2002) Curr. Top. Med. Chem., 2, pp. 417-423
Liu, G., Men, P., Kudo, W., Perry, G., Smith, M.A., (2009) Neurosci. Lett., 455, pp. 187-190
Re, F., Airoldi, C., Zona, C., Masserini, M., Ferla, B.L., Quattrocchi, N., Nicotra, F., (2010) Curr. Med. Chem., 17, pp. 2990-3006
Aguzzi, A., O’Connor, T., (2010) Nat. Rev. Drug Discov., 9, pp. 237-248
Citron, M., (2010) Nat. Rev. Drug Discov., 9, pp. 387-398
Reinke, A.A., Gestwicki, J.E., (2007) Chem. Biol. Drug Des., 70, pp. 206-215
Oliveri, V., Vecchio, G., (2016) Eur. J. Med. Chem., 120, pp. 252-274
Liu, R., Barkhordarian, H., Emadi, S., Park, C.B., Sierks, M.R., (2005) Neurobiol. Dis., 20, pp. 74-81
Du, J., Liang, Y., Xu, F., Sun, B., Wang, Z., (2013) J. Pharm. Pharmacol., 65, pp. 1753-1756
Iacovino, R., Rapuano, F., Caso, J.V., Russo, A., Lavorgna, M., Russo, C., Isidori, M., Isernia, C., (2013) Int. J. Mol. Sci., 14, pp. 13022-13041
Caso, J.V., Russo, L., Palmieri, M., Malgieri, G., Galdiero, S., Falanga, A., Isernia, C., Iacovino, R., (2015) Amino Acids, 47, pp. 2215-2227
Davis, M.E., Brewster, M.E., (2004) Nat. Rev. Drug Discov., 3, pp. 1023-1035
Ryan, T.M., Roberts, B.R., McColl, G., Hare, D.J., Doble, P.A., Li, Q.X., Lind, M., Masters, C.L., (2015) J. Neurosci., 35, pp. 2871-2884
Bush, A.I., Tanzi, R.E., (2008) Neurotherapeutics, 5, pp. 421-432
Hopkinson, R.J., Tumber, A., Yapp, C., Chowdhury, R., Aik, W., Che, K.H., Li, X.S., Kawamura, A., (2013) Chem. Sci., 4, pp. 3110-3117
Schiller, R., Scozzafava, G., Tumber, A., Wickens, J.R., Bush, J.T., Rai, G., Lejeune, C., Kawamura, A., (2014) ChemMed Chem., 9, pp. 566-571
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Oliveri, V., Grasso, G.I., Bellia, F., Attanasio, F., Viale, M., Vecchio, G., (2015) Inorg. Chem., 54, pp. 2591-2602
Oliveri, V., Giuffrida, M.L., Vecchio, G., Aiello, C., Viale, M., (2012) Dalton Trans., 41, pp. 4530-4535
Oliveri, V., Bellia, F., Grasso, G.I., Pietropaolo, A., Vecchio, G., (2016) RSC Adv., 6, pp. 47229-47236
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Szejtli, J., (1998) Chem. Rev., 98, pp. 1743-1754
Oliveri, V., Pietropaolo, A., Sgarlata, C., Vecchio, G., (2017) Chem.-Asian J., 12, pp. 110-115
Kodaka, M., (1991) J. Phys. Chem., 95, pp. 2110-2112
Puglisi, A., Spencer, J., Oliveri, V., Vecchio, G., Kong, X., Clarke, J., Milton, J., (2012) Dalton Trans., 41, pp. 2877-2883
Chemistryselect (ISSN: 2365-6549), 2017; 2(2): 655-659.
Tipo di articolo: Journal Article,
Impact factor: 1.505, Impact factor a 5 anni: 1.505
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041741485&doi=10.1002%2fslct.201601651&partnerID=40&md5=62c2b39627d9b7251317c21d53c6fd62
Parole chiave: Amyloid-Beta, Antiaggregant, Cyclodextrin, Glycoconjugate, Hydroxyquinoline,
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università degli Studi di Catania, viale A. Doria 6, Catania, 95125, Italy
Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, C.I.R.C.M.S.B, Unità di Ricerca di Catania, Catania, 95125, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Viale P. Gaifami 18, Catania, 95126, Italy
Riferimenti:
Alzheimer's, A., (2015) Alzheimers Dement., 11, pp. 332-38
Findeis, A., (2002) Curr. Top. Med. Chem., 2, pp. 417-423
Liu, G., Men, P., Kudo, W., Perry, G., Smith, M.A., (2009) Neurosci. Lett., 455, pp. 187-190
Re, F., Airoldi, C., Zona, C., Masserini, M., Ferla, B.L., Quattrocchi, N., Nicotra, F., (2010) Curr. Med. Chem., 17, pp. 2990-3006
Aguzzi, A., O’Connor, T., (2010) Nat. Rev. Drug Discov., 9, pp. 237-248
Citron, M., (2010) Nat. Rev. Drug Discov., 9, pp. 387-398
Reinke, A.A., Gestwicki, J.E., (2007) Chem. Biol. Drug Des., 70, pp. 206-215
Oliveri, V., Vecchio, G., (2016) Eur. J. Med. Chem., 120, pp. 252-274
Liu, R., Barkhordarian, H., Emadi, S., Park, C.B., Sierks, M.R., (2005) Neurobiol. Dis., 20, pp. 74-81
Du, J., Liang, Y., Xu, F., Sun, B., Wang, Z., (2013) J. Pharm. Pharmacol., 65, pp. 1753-1756
Iacovino, R., Rapuano, F., Caso, J.V., Russo, A., Lavorgna, M., Russo, C., Isidori, M., Isernia, C., (2013) Int. J. Mol. Sci., 14, pp. 13022-13041
Caso, J.V., Russo, L., Palmieri, M., Malgieri, G., Galdiero, S., Falanga, A., Isernia, C., Iacovino, R., (2015) Amino Acids, 47, pp. 2215-2227
Davis, M.E., Brewster, M.E., (2004) Nat. Rev. Drug Discov., 3, pp. 1023-1035
Ryan, T.M., Roberts, B.R., McColl, G., Hare, D.J., Doble, P.A., Li, Q.X., Lind, M., Masters, C.L., (2015) J. Neurosci., 35, pp. 2871-2884
Bush, A.I., Tanzi, R.E., (2008) Neurotherapeutics, 5, pp. 421-432
Hopkinson, R.J., Tumber, A., Yapp, C., Chowdhury, R., Aik, W., Che, K.H., Li, X.S., Kawamura, A., (2013) Chem. Sci., 4, pp. 3110-3117
Schiller, R., Scozzafava, G., Tumber, A., Wickens, J.R., Bush, J.T., Rai, G., Lejeune, C., Kawamura, A., (2014) ChemMed Chem., 9, pp. 566-571
Rotili, D., Tomassi, S., Conte, M., Benedetti, R., Tortorici, M., Ciossani, G., Valente, S., Mai, A., (2013) J. Med. Chem., 57, pp. 42-55
Rotili, D., Altun, M., Kawamura, A., Wolf, A., Fischer, R., Leung, I.K., Mackeen, M.M., Schofield, C.J., (2011) Chem. Biol., 18, pp. 642-654
Oliveri, V., Grasso, G.I., Bellia, F., Attanasio, F., Viale, M., Vecchio, G., (2015) Inorg. Chem., 54, pp. 2591-2602
Oliveri, V., Giuffrida, M.L., Vecchio, G., Aiello, C., Viale, M., (2012) Dalton Trans., 41, pp. 4530-4535
Oliveri, V., Bellia, F., Grasso, G.I., Pietropaolo, A., Vecchio, G., (2016) RSC Adv., 6, pp. 47229-47236
Oliveri, V., Viale, M., Aiello, C., Vecchio, G., (2015) J. Inorg. Biochem., 142, pp. 101-108
Oliveri, V., Sgarlata, C., Vecchio, G., (2016) Chem.-Asian J., 11, pp. 2436-2442
Szejtli, J., (1998) Chem. Rev., 98, pp. 1743-1754
Oliveri, V., Pietropaolo, A., Sgarlata, C., Vecchio, G., (2017) Chem.-Asian J., 12, pp. 110-115
Kodaka, M., (1991) J. Phys. Chem., 95, pp. 2110-2112
Puglisi, A., Spencer, J., Oliveri, V., Vecchio, G., Kong, X., Clarke, J., Milton, J., (2012) Dalton Trans., 41, pp. 2877-2883
Alzheimer′s disease represents a daunting challenge for healthcare because it affects millions of people worldwide. The abnormal assembly of amyloid-beta peptides into amyloid aggregates is a pathological hallmark of Alzheimer's disease. Properly functionalized cyclodextrins modulate amyloidogenesis. Here, we report the synthesis and characterization of a 6-monofunctionalized cyclodextrin-bearing a quinoline derivative (IOX1). Moreover, we tested the ability of the new compound and its 3-monofunctionalized isomer to inhibit self-induced Aβ aggregation in order to understand if the two isomers differently modulate aggregation process. The results further establish the potential of cyclodextrin conjugates as modulators of Aβ aggregation. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Impact Factor: 1.713
Dettagli Esporta in BibTeX Esporta in EndNote
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (190 visite)
J Chromatogr A (ISSN: 0021-9673), 2007; 1155(2): 172-179.
Impact Factor: 3.641
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Puglisi A, Purrello R, Rizzarelli E, Sortino S, Vecchio G
* Spectroscopic and self-association behavior of a porphyrin-β- cyclodextrin conjugate (301 visite)
New J Chem (ISSN: 1144-0546), 2007; 31(8): 1499-1506.
Impact Factor: 2.651
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Cucinotta V, Giuffrida A, Maccarrone G, Messina M, Puglisi A, Rizzarelli E, Vecchio G
* Coordination properties of 3-functionalized β-cyclodextrins. Thermodynamic stereoselectivity of copper(II) complexes of the A, B-diamino derivative and its exploitation in LECE (264 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Sep 21; (16): 2731-2736.
Impact Factor: 3.003
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Impellizzeri G, D'Alessandro F, Pappalardo G, Tringali C
* Synthesis And Structural Characterisation Of Two Novel Diastereoisomeric Naproxen-Appended Beta-Cyclodextrin Derivatives (246 visite)
J Incl Phenom (ISSN: 0923-0750), 2005; 51(3-4): 173-180.
Impact Factor: 1.02
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Puglisi A, Tabbì G, Vecchio G
* Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity (217 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jun; 98(6): 969-976.
Impact Factor: 2.225
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Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (270 visite)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (226 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
Dettagli Esporta in BibTeX Esporta in EndNote
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Vecchio G
* Ligand exchange chiral separations by cyclodextrin derivatives in capillary electrophoresis (171 visite)
Analyst (ISSN: 0003-2654), 2003; 128(2): 134-136.
Impact Factor: 2.251
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M
* The Simultaneous Separation Of Different Enantiomeric Pairs In Capillary Electrophoresis By Mixing Different Hemispherodextrins, A Very Versatile Class Of Receptors (201 visite)
J Chromatogr A (ISSN: 0021-9673), 2002 Dec 6; 979(1-2): 137-145.
Impact Factor: 3.098
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La Mendola D, Sortino S, Rizzarelli E, Vecchiog
* Synthesis Of New Carnosine Derivatives Of R-Cyclodextrin And Their Hydroxyl Radical Scavanger Ability (202 visite)
Helvetica Chimica Acta, 2002; 85: 1633-1643.
Impact Factor: 1.394
Dettagli Esporta in BibTeX Esporta in EndNote
Vecchio G, La Mendola D, Rizzarelli E, Sortino S
* SOD-like activity of copper(II) complexes of beta-cyclodextrins functionalized with carnosine (197 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Sep; 86(1): N/D-N/D.
Impact Factor: 1.729
Dettagli Esporta in BibTeX Esporta in EndNote
Impellizzeri G, Pappalardo G, D'Alessandro F, Rizzarelli E, Saviano M, Iacovino R, Benedetti E, Pedone C
Erratum: Solid state and solution conformation of 6-{4-[N-tert- butoxycarbonyl-N-(N'-ethyl)propanamide]imidazolyl}-6- deoxycyclomaltoheptaose: Evidence of self-inclusion of the boc group within the β-cyclodextrin cavity (European Journal of Organic Chemistry (2000) (1065-1076)) (323 visite)
Eur J Org Chem (ISSN: 1434-193x), 2000; (12): 2345-2345.
Impact Factor: 2.15
Dettagli Esporta in BibTeX Esporta in EndNote
Impellizzeri G, Pappalardo G, D'Alessandro F, Rizzarelli E, Saviano M, Iacovino R, Benedetti E, Pedone C
Solid state and solution conformation of 6-{4-[N-tert-butoxycarbonyl-N- (N'-ethyl)propanamide]imidazolyl}-6-deoxycyclomaltoheptaose: Evidence of self-inclusion of the Boc group within the β-cyclodextrin cavity (215 visite)
European J Org Chem (ISSN: 1434-193x), 2000; (6): 1065-1076.
Impact Factor: 2.15
Dettagli Esporta in BibTeX Esporta in EndNote
Campagna T, Grasso G, Rizzarelli E, Vecchio G
L- and D-cysteine derivatives of β-cyclodextrin: Different molecular recognition properties of their copper(II) complexes for amino acids (239 visite)
Inorg Chim Acta (ISSN: 0020-1693), 1998; 275-276: 395-400.
Impact Factor: 1.454
Dettagli Esporta in BibTeX Esporta in EndNote
Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (217 visite)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
Dettagli Esporta in BibTeX Esporta in EndNote
Bonomo RP, Pedotti S, Vecchio G, Rizzarelli E
Molecular Recognition of Amino Acids by Copper(II) Complexes of 6A, 6X-Diamino-6A, 6 X-dideoxy-β-cyclodextrin (X = B, C, D) (179 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1996 Nov 6; 35(23): 6873-6877.
Impact Factor: 2.736
Dettagli Esporta in BibTeX Esporta in EndNote
Bonomo RP, Di Blasio B, Maccarrone G, Pavone V, Pedone C, Rizzarelli E, Saviano M, Vecchio G
Crystal and Molecular Structure of the [6-Deoxy-6-[(2-(4-imidazolyl)ethyl)amino]cyclomaltoheptaose]copper(II) Ternary Complex with L-Tryptophanate. Role of Weak Forces in the Chiral Recognition Process Assisted by a Metallocyclodextrin (235 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1996 Jul 17; 35(15): 4497-4504.
Impact Factor: 2.736
Dettagli Esporta in BibTeX Esporta in EndNote
Di Blasio B, Galdiero S, Saviano M, Pedone C, Benedetti E, Rizzarelli E, Pedotti S, Vecchio G, Gibbons WA
Synthesis And Structural Characterization Of 6i, 6ii-Diamino-6i, 6ii-Dideoxy-Cyclomaltoheptaose, A Difunctionalized Beta-Cyclodextrin (297 visite)
Carbohydr Res, 1996 Feb 28; 282(1): 41-52.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Cucinotta V, Grasso G, Pedotti S, Rizzarelli E, Vecchio G, Di Blasio B, Isernia C, Saviano M, Pedone C
A Platinum(II) Diamino-β-cyclodextrin Complex: A Crystallographic and Solution Study. Synthesis and Structural Characterization of a Platinum(II) Complex of 6A, 6B-Diamino-6A, 6B-dideoxycyclomaltoheptaose (196 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1996; 35(26): 7535-7540.
Impact Factor: 2.736
Dettagli Esporta in BibTeX Esporta in EndNote
Di Blasio B, Galdiero S, Saviano M, De Simone G, Benedetti E, Pedone C, Gibbons WA, Deschenaux R, Rizzarelli E, Vecchio G
Functionalized cyclodextrins: Synthesis and structural characterization of 6-deoxy-6-{4-[N-tert-butoxycarbonyl-2-aminoethyl]-imidazolyl}-cyclomaltoheptaose (219 visite)
Supramol Chem (ISSN: 1061-0278), 1996; 7(1): 47-54.
Impact Factor: 3.19
Dettagli Esporta in BibTeX Esporta in EndNote
Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (367 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
Impact Factor: 1.342
Dettagli Esporta in BibTeX Esporta in EndNote
DALESSANDRO F, GULINO F, IMPELLIZZERI G, PAPPALARDO G, RIZZARELLI E, SCIOTTO D, VECCHIO G
A new water soluble host compound possessing two different hydrophobic recognition cavities: Calix[4]arene derivative conjugated with monofunctionalized β-cyclodextrin (294 visite)
Tetrahedron Lett (ISSN: 0040-4039), 1994 Jan 24; 35(4): 629-632.
Impact Factor: 2.5
Dettagli Esporta in BibTeX Esporta in EndNote
Cucinotta V, Mangano A, Nobile G, Santoro AM, Vecchio G
New platinum(II) complexes of β-cyclodextrin diamine derivatives and their antitumor activity (311 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Nov 15; 52(3): 183-190.
Impact Factor: 1.342
Dettagli Esporta in BibTeX Esporta in EndNote
Di Blasio B, Pavone V, Nastri F, Isernia C, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
Conformation for a β-cyclodextrin monosubstituted with a cyclic dipeptide (357 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 1992 Sep 1; 89(15): 7218-7221.
Impact Factor: 9.04
Dettagli Esporta in BibTeX Esporta in EndNote
Rossi F, Zaccaro L, Di Blasio B, Pavone V, Maglio O, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
beta-Cyclodextrins as potent bioactive delivery system (304 visite)
Peptides, 1992; N/D: 577-578.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Cucinotta V, D'Alessandro F, Impellizzeri G, Pappalardo G, Rizzarelli E, Vecchio G
Cyclopeptide Functionalized beta-Cyclodextrin. A New Class of Potentially Enzyme Mimicking Compound with Two Recognition Sites (204 visite)
Chem Commun, 1991; N/D: 293-294.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
64 Records (62 escludendo Abstract e Conferenze).
Impact factor totale: 243.76 (239.881 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 262.649 (256.196 escludendo Abstract e Conferenze).
Impact factor totale: 243.76 (239.881 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 262.649 (256.196 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Sunday 12 July 2020, 13:14:46
185 visite. Ultima visita in data Wednesday 16 September 2020, 23:14:00
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