Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains (311 views visite)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2016; 208: 9-16.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.402, 5-year impact factor Impact factor a 5 anni: 2.121
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948578282&doi=10.1016%2fj.bpc.2015.07.010&partnerID=40&md5=7b6fca7a42f2c0fef181878c3b2423e9
Keywords Parole chiave: Aβ-Membrane Interaction, Double Layer Perturbation, Isothermal Titration Calorimetry, Small Angle X-Ray Scattering, Amyloid Beta Protein, Cholesterol, Ganglioside Gm1, Liposome, Article, Light Scattering, Lipid Bilayer, Membrane Model, Membrane Structure, Nerve Cell Membrane, Priority Journal, Protein Lipid Interaction, Thermodynamics, X Ray Crystallography, Chemistry, Differential Scanning Calorimetry, Amyloid Beta-Peptides, G(m1) Ganglioside,
Affiliations Affiliazioni:
*** IBB - CNR ***
National Research Council, Institute of Biophysics, Via Ugo La Malfa 153, Palermo, 90146, Italy
Department of Life and Environmental Sciences, Università Politecnica Delle Marche, Ancona, Italy
Department of Physics and Chemistry, Università di Palermo, Italy
References Riferimenti:
Hering, H., Lin, C.C., Sheng, M., Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability (2003) J. Neurosci., 23 (8), pp. 3262-327
Yanagisawa, K., Ihara, Y., Ganglioside-bound amyloid β-protein in Alzheimer's Disease brain (1998) Neurobiol. Aging, 19 (1), pp. S65-S67
Yanagisawa, K., Odaka, A., Suzuki, N., Ihara, Y., GM1 ganglioside-bound amyloid β-protein (Aβ): A possible form of preamyloid in Alzheimer's disease (1995) Nat. Med., 1, pp. 1062-1066
Matsuzaki, K., How do membranes initiate Alzheimer's Disease? Formation of toxic amyloid fibrils by the amyloid β-protein on ganglioside clusters (2014) Acc. Chem. Res., 47 (8), pp. 2397-2404
Kakio, A., Nishimoto, S.I., Yanagisawa, K., Kozutsumi, Y., Matsuzaki, K., Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid (2001) J. Biol. Chem., 276 (27), pp. 24985-24990
McLaurin, J., Franklin, T., Fraser, P.E., Chakrabartty, A., Structural transitions associated with the interaction of Alzheimer beta-amyloid peptides with gangliosides (1998) J. Biol. Chem., 273 (8), pp. 4506-4515
Fantini, J., Nouara, Y., Garmy, N., Cholesterol accelerates the binding of Alzheimer's β-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation (2013) Front. Physiol., 4, p. 120
Choo-Smith, L.P., Surewicz, W.K., (1997) FEBS Lett., 402 (2-3), pp. 95-98
Kurganov, B., Doh, M., Arispe, N., Aggregation of liposomes induced by the toxic peptides Alzheimer's Abetas, human amylin and prion (106-126): Facilitation by membrane-bound GM1 ganglioside (2004) Peptides, 25 (2), pp. 217-232
Mandal, P.K., Pettegrew, J.W., Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment (2004) Neurochem. Res., 29 (2), pp. 447-453
Tashima, Y., Oe, R., Lee, S., Sugihara, G., Chambers, E.J., Takahashi, M., Yamada, T., The effect of cholesterol and monosialoganglioside (GM1) on the release and aggregation of amyloid beta-peptide from liposomes prepared from brain membrane-like lipids (2004) J. Biol. Chem., 279 (17), pp. 17587-17595
Williams, T.L., Serpell, L.C., Membrane and surface interactions of Alzheimer's Aβ peptide -insights into the mechanism of cytotoxicity (2011) FEBS J., 278 (20), pp. 3905-3917
Valdes-Gonzalez, T., Inagawa, J., Ido, T., Characterization of the interactions of ß-amyloid peptides with glycolipid receptors by surface plasmon resonance (2003) Spectroscopy, 17 (2-3), pp. 241-254
Lin, M.S., Chiu, H.M., Fan, F.J., Tsai, H.T., Wang, S.S., Chang, Y., Chen, W.Y., Kinetics and enthalpy measurements of interaction between beta-amyloid and liposomes by surface plasmon resonance and isothermal titration microcalorimetry (2007) Colloids Surf. B: Biointerfaces, 58 (2), pp. 231-236
Hirai, M., Kimura, R., Takeuchi, K., Sugiyama, M., Kasahara, K., Ohta, N., Farago, B., Zaccai, G., Change of dynamics of raft-model membrane induced by amyloid-β protein binding (2013) Eur. Phys. J. E., 36 (7), p. 74
Fezoui, Y., Hartley, D.M., Harper, J.D., Khurana, R., Walsh, D.M., Condron, M.M., Selkoe, D.J., Teplow, D.B., An improving method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments (2000) Amyloid, 7 (3), pp. 166-178
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6 (7), pp. 1948-1954
Dickey, A., Faller, R., Examining the contributions of lipid shape and headgroup charge on bilayer behavior (2008) Biophys. J., 95 (6), pp. 2636-2646
Kucerka, N., Nieh, M.-P., Katsaras, J., Fluid phase lipid areas and bilayer thicknesses of commonly used phosphatidylcholines as a function of temperature (2011) BBA, 1808 (11), pp. 2761-2771
Stepanek, P., (1993) Dynamic Light Scattering: The Method and Some Applications, p. 177. , W. Brown, Clarendon Press Oxford, UK
Freire, E., Mayorga, O.L., Straume, M., (1990) Anal. Chem., 62, pp. 950A-958A
Hammersley, A.P., Svensson, S.O., Hanfland, M., Fitch, A.N., Häusermann, D., Two-dimensional detector software: From real detector to idealised image or two-Theta scan (1996) High Pressure Res., 14, pp. 235-248
Guinier, A., (1963) X-ray Diffraction in Crystals, Imperfect Crystals, and Amorphous Bodies, , Courier Dover Publications San Francisco and London
Brzustowicz, M.R., Brunger, A.T., X-ray scattering from unilamellar lipid vesicles (2005) J. Appl. Crystallogr., 38, pp. 126-131
Castorph, S., Arleth, L., Sztucki, M., Vainio, U., Ghosh, S.K., Holt, M., Jahn, R., Salditt, T., Synaptic vesicles studied by SAXS: Derivation and validation of a model form factor (2010) J. Phys. Conf. Ser., 247 (1), p. 012015
Castorph, S., Riedel, D., Arleth, L., Sztucki, M., Jahn, R., Holt, M., Salditt, T., Structure parameters of synaptic vesicles quantified by small-angle X-ray scattering (2010) Biophys. J., 98 (7), pp. 1200-1208
Baroni, D., Zegarra-Moran, O., Moran, O., Functional and pharmacological induced structural changes of the cystic fibrosis transmembrane conductance regulator in the membrane solved using SAXS (2015) Cell. Mol. Life Sci., 72 (7), pp. 1363-1375
Pabst, G., Rappolt, M., Amenitsch, H., Laggner, P., Structural information from multilamellar liposomes at full hydration: Full q-range fitting with high-quality X-ray data (2000) Phys. Rev. E, 62 (3), pp. 4000-4009
Finean, J.B., Interaction between cholesterol and phospholipid in hydrated bilayers (1990) Chem. Phys. Lipids, 54 (3-4), pp. 147-156
Bhattacharya, S., Haldar, S., Interactions between cholesterol and lipids in bilayer membranes. Role of lipid head group and hydrocarbon chain-backbone linkage (2000) Biochim. Biophys. Acta, 1467 (1), pp. 39-53
McMullen, T.P., Lewis, R.N., McElhaney, R.N., Comparative differential scanning calorimetric and FTIR and 31PP-NMR spectroscopic studies of the effects of cholesterol and androstenol on the thermotropic phase behavior and organization of phosphatidylcholine bilayers (1994) Biophys. J., 66 (3), pp. 741-752
Matos, C., Lima, J.L.C., Reis, S., Lopes, A., Bastos, M., Interaction of anti-inflammatory drugs with EPC liposomes: Calorimetric study in a broad concentration range (2004) Biophys. J., 86, pp. 946-954
Van Meer, G., Voelker, D.R., Feigenson, G.W., Membrane lipids: Where they are and how they behave (2008) Nat. Rev. Mol. Cell Biol., 9, pp. 112-124
Carrotta, R., Canale, C., Diaspro, A., Trapani, A., San Biagio, P.L., Bulone, D., Inhibiting effect of αs1-casein on Aβ1-40 fibrillogenesis (2012) Biochim. Biophys. Acta, 1820 (2), pp. 124-132
Corsale, C., Carrotta, R., Mangione, M.R., Vilasi, S., Provenzano, A., Cavallaro, G., Bulone, D., San Biagio, P.L., Entrapment of Aβ(1-40) peptide in unstructured aggregates (2012) J. Phys. Condens. Matter, 24 (24), p. 244103
Canale, C., Seghezza, S., Vilasi, S., Carrotta, R., Bulone, D., Diaspro, A., San Biagio, P.L., Dante, S., Different effects of Alzheimer's peptide Aβ(1-40) oligomers and fibrils on supported lipid membranes (2013) Biophys. Chem., 182, pp. 23-29
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2016; 208: 9-16.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.402, 5-year impact factor Impact factor a 5 anni: 2.121
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948578282&doi=10.1016%2fj.bpc.2015.07.010&partnerID=40&md5=7b6fca7a42f2c0fef181878c3b2423e9
Keywords Parole chiave: Aβ-Membrane Interaction, Double Layer Perturbation, Isothermal Titration Calorimetry, Small Angle X-Ray Scattering, Amyloid Beta Protein, Cholesterol, Ganglioside Gm1, Liposome, Article, Light Scattering, Lipid Bilayer, Membrane Model, Membrane Structure, Nerve Cell Membrane, Priority Journal, Protein Lipid Interaction, Thermodynamics, X Ray Crystallography, Chemistry, Differential Scanning Calorimetry, Amyloid Beta-Peptides, G(m1) Ganglioside,
Affiliations Affiliazioni:
*** IBB - CNR ***
National Research Council, Institute of Biophysics, Via Ugo La Malfa 153, Palermo, 90146, Italy
Department of Life and Environmental Sciences, Università Politecnica Delle Marche, Ancona, Italy
Department of Physics and Chemistry, Università di Palermo, Italy
References Riferimenti:
Hering, H., Lin, C.C., Sheng, M., Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability (2003) J. Neurosci., 23 (8), pp. 3262-327
Yanagisawa, K., Ihara, Y., Ganglioside-bound amyloid β-protein in Alzheimer's Disease brain (1998) Neurobiol. Aging, 19 (1), pp. S65-S67
Yanagisawa, K., Odaka, A., Suzuki, N., Ihara, Y., GM1 ganglioside-bound amyloid β-protein (Aβ): A possible form of preamyloid in Alzheimer's disease (1995) Nat. Med., 1, pp. 1062-1066
Matsuzaki, K., How do membranes initiate Alzheimer's Disease? Formation of toxic amyloid fibrils by the amyloid β-protein on ganglioside clusters (2014) Acc. Chem. Res., 47 (8), pp. 2397-2404
Kakio, A., Nishimoto, S.I., Yanagisawa, K., Kozutsumi, Y., Matsuzaki, K., Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid (2001) J. Biol. Chem., 276 (27), pp. 24985-24990
McLaurin, J., Franklin, T., Fraser, P.E., Chakrabartty, A., Structural transitions associated with the interaction of Alzheimer beta-amyloid peptides with gangliosides (1998) J. Biol. Chem., 273 (8), pp. 4506-4515
Fantini, J., Nouara, Y., Garmy, N., Cholesterol accelerates the binding of Alzheimer's β-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation (2013) Front. Physiol., 4, p. 120
Choo-Smith, L.P., Surewicz, W.K., (1997) FEBS Lett., 402 (2-3), pp. 95-98
Kurganov, B., Doh, M., Arispe, N., Aggregation of liposomes induced by the toxic peptides Alzheimer's Abetas, human amylin and prion (106-126): Facilitation by membrane-bound GM1 ganglioside (2004) Peptides, 25 (2), pp. 217-232
Mandal, P.K., Pettegrew, J.W., Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment (2004) Neurochem. Res., 29 (2), pp. 447-453
Tashima, Y., Oe, R., Lee, S., Sugihara, G., Chambers, E.J., Takahashi, M., Yamada, T., The effect of cholesterol and monosialoganglioside (GM1) on the release and aggregation of amyloid beta-peptide from liposomes prepared from brain membrane-like lipids (2004) J. Biol. Chem., 279 (17), pp. 17587-17595
Williams, T.L., Serpell, L.C., Membrane and surface interactions of Alzheimer's Aβ peptide -insights into the mechanism of cytotoxicity (2011) FEBS J., 278 (20), pp. 3905-3917
Valdes-Gonzalez, T., Inagawa, J., Ido, T., Characterization of the interactions of ß-amyloid peptides with glycolipid receptors by surface plasmon resonance (2003) Spectroscopy, 17 (2-3), pp. 241-254
Lin, M.S., Chiu, H.M., Fan, F.J., Tsai, H.T., Wang, S.S., Chang, Y., Chen, W.Y., Kinetics and enthalpy measurements of interaction between beta-amyloid and liposomes by surface plasmon resonance and isothermal titration microcalorimetry (2007) Colloids Surf. B: Biointerfaces, 58 (2), pp. 231-236
Hirai, M., Kimura, R., Takeuchi, K., Sugiyama, M., Kasahara, K., Ohta, N., Farago, B., Zaccai, G., Change of dynamics of raft-model membrane induced by amyloid-β protein binding (2013) Eur. Phys. J. E., 36 (7), p. 74
Fezoui, Y., Hartley, D.M., Harper, J.D., Khurana, R., Walsh, D.M., Condron, M.M., Selkoe, D.J., Teplow, D.B., An improving method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments (2000) Amyloid, 7 (3), pp. 166-178
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6 (7), pp. 1948-1954
Dickey, A., Faller, R., Examining the contributions of lipid shape and headgroup charge on bilayer behavior (2008) Biophys. J., 95 (6), pp. 2636-2646
Kucerka, N., Nieh, M.-P., Katsaras, J., Fluid phase lipid areas and bilayer thicknesses of commonly used phosphatidylcholines as a function of temperature (2011) BBA, 1808 (11), pp. 2761-2771
Stepanek, P., (1993) Dynamic Light Scattering: The Method and Some Applications, p. 177. , W. Brown, Clarendon Press Oxford, UK
Freire, E., Mayorga, O.L., Straume, M., (1990) Anal. Chem., 62, pp. 950A-958A
Hammersley, A.P., Svensson, S.O., Hanfland, M., Fitch, A.N., Häusermann, D., Two-dimensional detector software: From real detector to idealised image or two-Theta scan (1996) High Pressure Res., 14, pp. 235-248
Guinier, A., (1963) X-ray Diffraction in Crystals, Imperfect Crystals, and Amorphous Bodies, , Courier Dover Publications San Francisco and London
Brzustowicz, M.R., Brunger, A.T., X-ray scattering from unilamellar lipid vesicles (2005) J. Appl. Crystallogr., 38, pp. 126-131
Castorph, S., Arleth, L., Sztucki, M., Vainio, U., Ghosh, S.K., Holt, M., Jahn, R., Salditt, T., Synaptic vesicles studied by SAXS: Derivation and validation of a model form factor (2010) J. Phys. Conf. Ser., 247 (1), p. 012015
Castorph, S., Riedel, D., Arleth, L., Sztucki, M., Jahn, R., Holt, M., Salditt, T., Structure parameters of synaptic vesicles quantified by small-angle X-ray scattering (2010) Biophys. J., 98 (7), pp. 1200-1208
Baroni, D., Zegarra-Moran, O., Moran, O., Functional and pharmacological induced structural changes of the cystic fibrosis transmembrane conductance regulator in the membrane solved using SAXS (2015) Cell. Mol. Life Sci., 72 (7), pp. 1363-1375
Pabst, G., Rappolt, M., Amenitsch, H., Laggner, P., Structural information from multilamellar liposomes at full hydration: Full q-range fitting with high-quality X-ray data (2000) Phys. Rev. E, 62 (3), pp. 4000-4009
Finean, J.B., Interaction between cholesterol and phospholipid in hydrated bilayers (1990) Chem. Phys. Lipids, 54 (3-4), pp. 147-156
Bhattacharya, S., Haldar, S., Interactions between cholesterol and lipids in bilayer membranes. Role of lipid head group and hydrocarbon chain-backbone linkage (2000) Biochim. Biophys. Acta, 1467 (1), pp. 39-53
McMullen, T.P., Lewis, R.N., McElhaney, R.N., Comparative differential scanning calorimetric and FTIR and 31PP-NMR spectroscopic studies of the effects of cholesterol and androstenol on the thermotropic phase behavior and organization of phosphatidylcholine bilayers (1994) Biophys. J., 66 (3), pp. 741-752
Matos, C., Lima, J.L.C., Reis, S., Lopes, A., Bastos, M., Interaction of anti-inflammatory drugs with EPC liposomes: Calorimetric study in a broad concentration range (2004) Biophys. J., 86, pp. 946-954
Van Meer, G., Voelker, D.R., Feigenson, G.W., Membrane lipids: Where they are and how they behave (2008) Nat. Rev. Mol. Cell Biol., 9, pp. 112-124
Carrotta, R., Canale, C., Diaspro, A., Trapani, A., San Biagio, P.L., Bulone, D., Inhibiting effect of αs1-casein on Aβ1-40 fibrillogenesis (2012) Biochim. Biophys. Acta, 1820 (2), pp. 124-132
Corsale, C., Carrotta, R., Mangione, M.R., Vilasi, S., Provenzano, A., Cavallaro, G., Bulone, D., San Biagio, P.L., Entrapment of Aβ(1-40) peptide in unstructured aggregates (2012) J. Phys. Condens. Matter, 24 (24), p. 244103
Canale, C., Seghezza, S., Vilasi, S., Carrotta, R., Bulone, D., Diaspro, A., San Biagio, P.L., Dante, S., Different effects of Alzheimer's peptide Aβ(1-40) oligomers and fibrils on supported lipid membranes (2013) Biophys. Chem., 182, pp. 23-29
Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains
Neuronal membrane damage is related to the early impairments appearing in Alzheimer's disease due to the interaction of the amyloid β-peptide (Aβ) with the phospholipid bilayer. In particular, the ganglioside GM1, present with cholesterol in lipid rafts, seems to be able to initiate Aβ aggregation on membrane. We studied the thermodynamic and structural effects of the presence of GM1 on the interaction between Aβ and liposomes, a good membrane model system. Isothermal Titration Calorimetry highlighted the importance of the presence of GM1 in recruiting monomeric Aβ toward the lipid bilayer. Light and Small Angle X-ray Scattering revealed a different pattern for GM1 containing liposomes, both before and after interaction with Aβ. The results suggest that the interaction with GM1 brings to insertion of Aβ in the bilayer, producing a structural perturbation down to the internal layers of the liposome, as demonstrated by the obtained electron density profiles. © 2015 Elsevier B.V.
Neuronal membrane damage is related to the early impairments appearing in Alzheimer's disease due to the interaction of the amyloid β-peptide (Aβ) with the phospholipid bilayer. In particular, the ganglioside GM1, present with cholesterol in lipid rafts, seems to be able to initiate Aβ aggregation on membrane. We studied the thermodynamic and structural effects of the presence of GM1 on the interaction between Aβ and liposomes, a good membrane model system. Isothermal Titration Calorimetry highlighted the importance of the presence of GM1 in recruiting monomeric Aβ toward the lipid bilayer. Light and Small Angle X-ray Scattering revealed a different pattern for GM1 containing liposomes, both before and after interaction with Aβ. The results suggest that the interaction with GM1 brings to insertion of Aβ in the bilayer, producing a structural perturbation down to the internal layers of the liposome, as demonstrated by the obtained electron density profiles. © 2015 Elsevier B.V.
Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains
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Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains
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* Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family (344 visite)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962), 2014; 42(9): 5993-6011.
Impact Factor: 9.112
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Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (425 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (492 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (553 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (315 visite)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (572 visite)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
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Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (623 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (422 visite)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (477 visite)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (545 visite)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (841 visite)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (435 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (541 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (658 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (417 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (480 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (679 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (517 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Bonaccorso C, Sgarlata C, Grasso G, Zito V, Sciotto D, Arena G
* A gemini guest triggers the self-assembly of a calixarene capsule in water at neutral pH (246 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011; 47(21): 6117-6119.
Impact Factor: 6.169
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (433 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (348 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (594 visite)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (425 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (544 visite)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (658 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (463 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (433 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (356 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (522 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (316 visite)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (393 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (428 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (540 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (443 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (391 visite)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (557 visite)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (758 visite)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (481 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (598 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (337 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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56 Records (55 escludendo Abstract e Conferenze).
Impact factor totale: 229.147 (225.055 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 237.614 (233.077 escludendo Abstract e Conferenze).
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Monti A, Sturlese M, Caporale A, Roger JA, Mascanzoni F, Ruvo M, Doti N
* Design, synthesis, structural analysis and biochemical studies of stapled AIF(370-394) analogues as ligand of CypA (66 visite)
Biochim Biophys Acta Gen Subj (ISSN: 0304-4165linking), 2020 Dec; 1864(12): 129717-129717.
Impact Factor: 3.422
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Squeglia F, Maciejewska B, Łątka A, Ruggiero A, Briers Y, Drulis-kawa Z, Berisio R
* Structural and Functional Studies of a Klebsiella Phage Capsule Depolymerase Tailspike: Mechanistic Insights into Capsular Degradation (71 visite)
Structure (ISSN: 0969-2126linking), 2020 Jun 2; 28(6): 613-624.
Impact Factor: 4.86
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Sciacca MFM, Monaco I, La Rosa C, Milardi D
* The active role of Ca(2+) ions in Abeta-mediated membrane damage (264 visite)
Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Apr 5; 54(29): 3629-3631.
Impact Factor: 6.169
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (305 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (457 visite)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (536 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (471 visite)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (626 visite)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
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Smaldone G, Pirone L, Balasco N, Di Gaetano S, Pedone E, Vitagliano L
* Cullin 3 recognition is not a universal property among KCTD proteins (457 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2015 May 14; 10(5): e0126808-e0126808.
Impact Factor: 3.057
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (290 visite)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (442 visite)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (471 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (327 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
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Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
* Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (440 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Jul; 101(7): 712-719.
Impact Factor: 2.385
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (390 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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Palmieri M, Russo L, Malgieri G, Esposito S, Baglivo I, Rivellino A, Farina B, de Paola I, Zaccaro L, Milardi D, Isernia C, Pedone PV, Fattorusso R
* Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutant (367 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 30-36.
Impact Factor: 3.444
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Contursi P, Farina B, Pirone L, Fusco S, Russo L, Bartolucci S, Fattorusso R, Pedone E
* Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family (344 visite)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962), 2014; 42(9): 5993-6011.
Impact Factor: 9.112
Dettagli Esporta in BibTeX Esporta in EndNote
Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (425 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
Dettagli Esporta in BibTeX Esporta in EndNote
Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (492 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (553 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
Dettagli Esporta in BibTeX Esporta in EndNote
Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (315 visite)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (572 visite)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
Dettagli Esporta in BibTeX Esporta in EndNote
Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (623 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (422 visite)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (477 visite)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (545 visite)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (841 visite)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
Dettagli Esporta in BibTeX Esporta in EndNote
Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (435 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
Dettagli Esporta in BibTeX Esporta in EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (541 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (658 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
Dettagli Esporta in BibTeX Esporta in EndNote
Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (417 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
Dettagli Esporta in BibTeX Esporta in EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (480 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (679 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (517 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Bonaccorso C, Sgarlata C, Grasso G, Zito V, Sciotto D, Arena G
* A gemini guest triggers the self-assembly of a calixarene capsule in water at neutral pH (246 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011; 47(21): 6117-6119.
Impact Factor: 6.169
Dettagli Esporta in BibTeX Esporta in EndNote
Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (433 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
Dettagli Esporta in BibTeX Esporta in EndNote
Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (348 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (594 visite)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
Dettagli Esporta in BibTeX Esporta in EndNote
Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (425 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (544 visite)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
Dettagli Esporta in BibTeX Esporta in EndNote
De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (658 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (463 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
Dettagli Esporta in BibTeX Esporta in EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (433 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (356 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
Dettagli Esporta in BibTeX Esporta in EndNote
Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (522 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (316 visite)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (393 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (428 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (540 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (443 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
Dettagli Esporta in BibTeX Esporta in EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (391 visite)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
Dettagli Esporta in BibTeX Esporta in EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (557 visite)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
Dettagli Esporta in BibTeX Esporta in EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (758 visite)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
Dettagli Esporta in BibTeX Esporta in EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (481 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
Dettagli Esporta in BibTeX Esporta in EndNote
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (598 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
Dettagli Esporta in BibTeX Esporta in EndNote
Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (337 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
Dettagli Esporta in BibTeX Esporta in EndNote
56 Records (55 escludendo Abstract e Conferenze).
Impact factor totale: 229.147 (225.055 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 237.614 (233.077 escludendo Abstract e Conferenze).
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