Rifabutin-Based Rescue Therapy for Helicobacter pylori Eradication: A Long-Term Prospective Study in a Large Cohort of Difficult-to-Treat Patients(39 visite) Ribaldone DG, Fagoonee S, Astegiano M, Durazzo M, Morgando A, Sprujevnik T, Giordanino C, Baronio M, De Angelis C, Saracco GM, Pellicano R
J Clin Med (ISSN: 2077-0383linking), 2019 Feb 6; 8(2): N/D-N/D.
*** IBB - CNR *** Department of Surgical Sciences, University of Turin, 10123 Turin, Italy. firstname.lastname@example.org., Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, 10126 Turin, Italy. email@example.com., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. firstname.lastname@example.org., Department of Medical Sciences, University of Turin, 10123 Turin, Italy. email@example.com., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. firstname.lastname@example.org., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. email@example.com., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. firstname.lastname@example.org., Unit of Gastroenterology, Maria Vittoria Hospital, 10100 Turin, Italy. email@example.com., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. firstname.lastname@example.org., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. email@example.com., Department of Medical Sciences, University of Turin, 10123 Turin, Italy. firstname.lastname@example.org., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. email@example.com.,
The most commonly used regimens fail to eradicate Helicobacter pylori (H. pylori) infection in 5(-)10% of patients. Those not cured with treatments based on amoxicillin, clarithromycin, nitroimidazoles, fluoroquinolones, bismuth or tetracycline have no other conventional options thereafter. In this prospective long-term monocentric study, patients who failed to eradicate H. pylori following treatment with all conventional antibiotics were included. All subjects were treated with rifabutin 150 mg, amoxicillin 1 g and a standard dose of proton pump inhibitor, twice daily for 14 days. A negative (13)C-urea breath test was used four weeks after treatment completion as an index of H. pylori eradication. Three hundred and two patients were included. Fifty-four percent (164/302) had peptic ulcer disease while 45.7% (138/302) had gastritis or functional dyspepsia. Per-protocol eradication and intention-to-treat eradication were achieved in 72.7% and 71.5%, respectively. A univariate analysis showed that gender, ethnic background, smoking habits and familial history of gastric diseases were not predictive factors of response, while with multiple logistic regression analysis, the ethnic background (Italian) predicted a poor response in the second period of the study (2010(-)2017). In conclusion, this study on a large cohort of very difficult-to-treat patients showed that rifabutin-based rescue therapy is an acceptable and safe strategy after multiple eradication failures with conventional antibiotics.
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(38 visite) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 DettagliEsporta in BibTeXEsporta in EndNote
23 Records (21 escludendo Abstract e Conferenze). Impact factor totale: 163.588 (162.693 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 137.559 (136.286 escludendo Abstract e Conferenze).