The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis
CNR Ibb | back to homepage
▲NavBar
Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis (25 visite)

Korotkyi OH, Vovk AA, Dranitsina AS, Falalyeyeva TM, Dvorshchenko KO, Fagoonee S, Ostapchenko LI

Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2019 Apr 1; 110(5): 419-424.



Tipo di articolo: Journal Article, Comparative Study

Impact factor: 2.863, Impact factor a 5 anni: 1.515

Url: Non disponibile.

Parole chiave: Animals , Cartilage, Articular Drug Effects Metabolism , Chondroitin Sulfates Administration, Dosage Therapeutic Use , Collagen Type Ii Biosynthesis Genetics , Cyclooxygenase 2 Biosynthesis Genetics , Drug Evaluation, Preclinical , Food-Drug Interactions , Gene Expression Regulation Drug Effects , Iodoacetic Acid Toxicity , Microbiota , Osteoarthritis, Knee Chemically Induced Diet Therapy Drug Therapy Metabolism , Probiotics Therapeutic Use , Messenger Biosynthesis , Transforming Growth Factor Beta1 Biosynthesis Genetics

Affiliazioni:

*** IBB - CNR ***
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, Turin, Italy.


Riferimenti:

Non disponibile.

BACKGROUND: Osteoarthritis (OA) is a common worldwide disease induced by a wide range of biochemical processes, mainly inflammation and degradation of collagen. The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats. METHODS: OA was induced in male rats by injecting monoiodoacetate in right hind knee. Therapeutic groups received 3 mg/kg of CS for 28 days and/or 1.4 g/kg of multistrain PB for 14 days. Knee cartilage were taken 30 days after monoiodoacetate injection. RNA was extracted and the expression of Ptgs2, Tgfb1 and Col2a1 were analyzed using SYBR Green 1-step real-time quantitative polymerase chain reaction. RESULTS: Induction of OA caused an upregulation in Ptgs2, Tgfb1 expression, and downregulation of Col2a1. Separate administration of PB and CS reduced Ptgs2 and Tgfb1 expressions. Their combined administration significantly decreased the expression of these pro-inflammatory cytokines, comparable to controls. Expression of Col2a1 showed similar behaviour, with upregulation in therapeutic group with separate administration and the cumulative effects in case of co-administration. CONCLUSIONS: The multistrain PB diet may offer a perspective to improve the standard treatment of OA and, necessitates further investigation with clinical trials.<br>
Nessun risultato.

Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]
Vai a fine pagina   Versione per copia e incolla facile   Esporta tutto in BibTeX   Esporta tutto in EndNote


Wang L, Coric P, Broussy S, Di Stasi R, Zhou L, D'Andrea LD, Ji L, Vidal M, Bouaziz S, Liu WQ
* Structural studies of the binding of an antagonistic cyclic peptide to the VEGFR1 domain (18 visite)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2019 May 1; 169: 65-75.
Impact Factor: 2.882
Dettagli    Esporta in BibTeX    Esporta in EndNote

Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (130 visite)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Feb 07; 8(6): 10007-10024.
Impact Factor: 5.168
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (357 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
Dettagli    Esporta in BibTeX    Esporta in EndNote

Rosa D, Balato G, Ciaramella G, Soscia E, Improta G, Triassi M
* Long-term clinical results and MRI changes after autologous chondrocyte implantation in the knee of young and active middle aged patients (204 visite)
J Orthop Traumatol (ISSN: 1590-9999electronic, 1590-9921linking), 2015 Oct 24; 17(1): 55-62.
Impact Factor: 1.28
Dettagli    Esporta in BibTeX    Esporta in EndNote

Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (221 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
Dettagli    Esporta in BibTeX    Esporta in EndNote

Di Minno MN, Iervolino S, Soscia E, Tosetto A, Coppola A, Schiavulli M, Marrone E, Ruosi C, Salvatore M, Di Minno G
* Magnetic resonance imaging and ultrasound evaluation of "healthy" joints in young subjects with severe haemophilia (163 visite)
Haemophilia (ISSN: 1351-8216), 2013 May; 19(3): e167-e167.
Impact Factor: 2.468
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sirignano C, Soscia E, Iodice D, Palma G, Greco D, Innocenti S, Alfano B, Salvatore M
* To Evaluate The Usefulness And The Applicability To The Study Of Joint Knee Cartilage Of T2 And T2ρ Maps Obtained With A New Sequence Protocol On A Dedicated Open Mri System (111 visite) (PDF 130 visite)
Ismrm March 2011, 2011; N/D: P66-P66.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote



7 Records (5 escludendo Abstract e Conferenze).
Impact factor totale: 29.258 (26.79 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 28.486 (25.708 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote