N-(1-carbamoyl-2-phenylethyl) butyramide reduces antibiotic-induced intestinal injury, innate immune activation and modulates microbiota composition (193 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2019 Mar 18; 9(1): 4832-4832.
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Paper type: Journal Article,
Impact factor: 5.078, 5-year impact factor: 5.078
Url: Not available.
Keywords: Acetylation Drug Effects , Animals , Anti-Bacterial Agents Adverse Effects , Bacterial Translocation Drug Effects , Butyrates Administration, Dosage Metabolism , Ceftriaxone Adverse Effects , Colitis Chemically Induced Drug Therapy Immunology Microbiology , Colon Drug Effects Immunology Microbiology Pathology , Disease Models, Dysbiosis Chemically Induced Drug Therapy Immunology Microbiology , Gastrointestinal Microbiome Drug Effects , Histones Metabolism , Humans , Immunity, Innate Drug Effects , Intestinal Mucosa Drug Effects Immunology Microbiology Pathology , Lactic Acid Metabolism , Monocarboxylic Acid Transporters Metabolism , Receptors, G-Protein-Coupled Metabolism , Symporters Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131, Naples, Italy.
Task Force on Microbiome Studies, University of Naples "Federico II", Via D. Montesano 49, 80131, Naples, Italy.
Institute for Experimental Endocrinology and Oncology, IEOS, Via S. Pansini 5, 80131, Naples, Italy.
Department of Biology, University of Naples "Federico II", Cupa Nuova Cinthia 21, 80126, Naples, Italy.
Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
Department of Advanced Biomedical Sciences, University of Naples "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
Institute of Biostructure and Bioimaging, Consiglio Nazionale delle Ricerche CNR, Via S. Pansini 5, 80131, Naples, Italy.
References:
Not available.
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2019 Mar 18; 9(1): 4832-4832.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.078, 5-year impact factor: 5.078
Url: Not available.
Keywords: Acetylation Drug Effects , Animals , Anti-Bacterial Agents Adverse Effects , Bacterial Translocation Drug Effects , Butyrates Administration, Dosage Metabolism , Ceftriaxone Adverse Effects , Colitis Chemically Induced Drug Therapy Immunology Microbiology , Colon Drug Effects Immunology Microbiology Pathology , Disease Models, Dysbiosis Chemically Induced Drug Therapy Immunology Microbiology , Gastrointestinal Microbiome Drug Effects , Histones Metabolism , Humans , Immunity, Innate Drug Effects , Intestinal Mucosa Drug Effects Immunology Microbiology Pathology , Lactic Acid Metabolism , Monocarboxylic Acid Transporters Metabolism , Receptors, G-Protein-Coupled Metabolism , Symporters Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131, Naples, Italy.
Task Force on Microbiome Studies, University of Naples "Federico II", Via D. Montesano 49, 80131, Naples, Italy.
Institute for Experimental Endocrinology and Oncology, IEOS, Via S. Pansini 5, 80131, Naples, Italy.
Department of Biology, University of Naples "Federico II", Cupa Nuova Cinthia 21, 80126, Naples, Italy.
Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
Department of Advanced Biomedical Sciences, University of Naples "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
Institute of Biostructure and Bioimaging, Consiglio Nazionale delle Ricerche CNR, Via S. Pansini 5, 80131, Naples, Italy.
References:
Not available.
N-(1-carbamoyl-2-phenylethyl) butyramide reduces antibiotic-induced intestinal injury, innate immune activation and modulates microbiota composition
The use/misuse of antibiotics leads to pathological features referring to antibiotic-induced intestinal injury (AIJ), a clinical issue that plays a prominent role in the development of severe digestive disturbances. AIJ is characterized by loss of intestinal architecture and function, dysbiosis and bacterial translocation into the liver, triggering hepatic inflammation. This study aimed at determining the beneficial effect of N-(1-carbamoyl-2-phenylethyl) butyramide (FBA), a butyrate releasing compound, in ceftriaxone-induced intestinal injury. To this purpose, mice receiving ceftriaxone (8 g∙kg(-1)/die, per os) for five days, were treated with FBA (212,5 mg∙kg(-1)/die, per os) for five or fifteen days. FBA modulated key players of innate immunity in antibiotic-injured gut tissues, reducing inflammatory process and improving the anti-inflammatory and resolving pattern. FBA also improved colonic architecture and intestinal integrity. Interestingly, we also observed a remodeling of gut microbiota composition related to an increase of metabolic pathways related to lactate and butyrate production. At mechanistic level, FBA induced histone acetylation and increased the expression of GPR43 and monocarboxylate transporter 1 in colon. Our data clearly demonstrated that FBA has multiple converging mechanisms in limiting intestinal and hepatic alterations to counteract AIJ.
The use/misuse of antibiotics leads to pathological features referring to antibiotic-induced intestinal injury (AIJ), a clinical issue that plays a prominent role in the development of severe digestive disturbances. AIJ is characterized by loss of intestinal architecture and function, dysbiosis and bacterial translocation into the liver, triggering hepatic inflammation. This study aimed at determining the beneficial effect of N-(1-carbamoyl-2-phenylethyl) butyramide (FBA), a butyrate releasing compound, in ceftriaxone-induced intestinal injury. To this purpose, mice receiving ceftriaxone (8 g∙kg(-1)/die, per os) for five days, were treated with FBA (212,5 mg∙kg(-1)/die, per os) for five or fifteen days. FBA modulated key players of innate immunity in antibiotic-injured gut tissues, reducing inflammatory process and improving the anti-inflammatory and resolving pattern. FBA also improved colonic architecture and intestinal integrity. Interestingly, we also observed a remodeling of gut microbiota composition related to an increase of metabolic pathways related to lactate and butyrate production. At mechanistic level, FBA induced histone acetylation and increased the expression of GPR43 and monocarboxylate transporter 1 in colon. Our data clearly demonstrated that FBA has multiple converging mechanisms in limiting intestinal and hepatic alterations to counteract AIJ.
N-(1-carbamoyl-2-phenylethyl) butyramide reduces antibiotic-induced intestinal injury, innate immune activation and modulates microbiota composition
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N-(1-carbamoyl-2-phenylethyl) butyramide reduces antibiotic-induced intestinal injury, innate immune activation and modulates microbiota composition
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (276 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
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* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (276 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
View Export to BibTeX Export to EndNote
1 Records (1 excluding Abstracts).
Total impact factor: 5.012 (5.012 excluding Abstracts).
Total 5 year impact factor: 4.681 (4.681 excluding Abstracts).
Total impact factor: 5.012 (5.012 excluding Abstracts).
Total 5 year impact factor: 4.681 (4.681 excluding Abstracts).
193 views. Last view on Friday 09 September 2022, 21:40:59
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