A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies (127 views visite)
Alzheimers Dement (ISSN: 1552-5260linking), 2019 Jun 20; N/D: N/D-N/D.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 14.43, 5-year impact factor Impact factor a 5 anni: 0
Url: Not available. Non disponibile.
Keywords Parole chiave: Amyloid, Neuroinflammation, Pet Molecular Imaging, Protheinopathies, Radiotracers,
Affiliations Affiliazioni:
*** IBB - CNR ***
Vita-Salute San Raffaele University, Nuclear Medicine Unit San Raffaele Hospital, Division of Neuroscience San Raffaele Scientific Institute, Milan, Italy., Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands., Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK; Neurology Imaging Unit, Imperial College London, London, UK., Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, Amsterdam, The Netherlands., Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden; Memory Clinic, Skane University Hospital, Malmo, Sweden., Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Center for Alzheimer Research, Stockholm, Sweden., European Institute for Molecular Imaging, University of Munster, Munster, Germany; Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany. Electronic address: ahjacobs@uni-muenster.de.,
References Riferimenti:
Not available. Non disponibili.
Alzheimers Dement (ISSN: 1552-5260linking), 2019 Jun 20; N/D: N/D-N/D.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 14.43, 5-year impact factor Impact factor a 5 anni: 0
Url: Not available. Non disponibile.
Keywords Parole chiave: Amyloid, Neuroinflammation, Pet Molecular Imaging, Protheinopathies, Radiotracers,
Affiliations Affiliazioni:
*** IBB - CNR ***
Vita-Salute San Raffaele University, Nuclear Medicine Unit San Raffaele Hospital, Division of Neuroscience San Raffaele Scientific Institute, Milan, Italy., Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands., Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK; Neurology Imaging Unit, Imperial College London, London, UK., Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, Amsterdam, The Netherlands., Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden; Memory Clinic, Skane University Hospital, Malmo, Sweden., Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Center for Alzheimer Research, Stockholm, Sweden., European Institute for Molecular Imaging, University of Munster, Munster, Germany; Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany. Electronic address: ahjacobs@uni-muenster.de.,
References Riferimenti:
Not available. Non disponibili.
A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies
Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications.
Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications.
A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies
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A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies
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Rendina A, Drongitis D, Donizetti A, Fucci L, Milan G, Tripodi F, Giustezza F, Postiglione A, Pappata S, Ferrari R, Bossù P, Angiolillo A, Di Costanzo A, Caiazzo M, Vitale E
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Impact Factor: 14.423
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Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappata S
* Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography (221 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 60-75.
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* In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (458 visite) (PDF 231 visite)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 2015 Mar; 42(3): 309-316.
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Dettagli Esporta in BibTeX Esporta in EndNote
Quarantelli M
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Dettagli Esporta in BibTeX Esporta in EndNote
Jacobs AH, Tavitian B, TheInmindG, Pappata S, Quarantelli M
* Noninvasive molecular imaging of neuroinflammation (252 visite) (PDF 172 visite)
J Cereb Blood Flow Metab (ISSN: 0271-678x, 1559-7016electronic), 2012 Jul; 32(7): 1393-1415.
Impact Factor: 5.398
Dettagli Esporta in BibTeX Esporta in EndNote
Cuocolo A, Cittanti C, Acampa W, Larobina M, Petretta M
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Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
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Dettagli Esporta in BibTeX Esporta in EndNote
Acampa W, Di Benedetto C, Cuocolo A
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13 Records (13 escludendo Abstract e Conferenze).
Impact factor totale: 49.993 (49.993 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 30.488 (30.488 escludendo Abstract e Conferenze).
Impact factor totale: 49.993 (49.993 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 30.488 (30.488 escludendo Abstract e Conferenze).
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