On-Bead Peptoid Dimerization Induced by Incorporation of Glycosylated Bridging Units in Submonomer Solid-Phase Approach to Glycopeptoids(88 visite) Comegna D, Del Gatto A, Saviano M, Zaccaro L
Org Lett (ISSN: 1523-7052linking, 1523-7052electronic, 1523-7060), 2019 Jun 21; 21(12): 4454-4458.
Tipo di articolo: Journal Article,
Impact factor: 5.128, Impact factor a 5 anni: 4.742
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*** IBB - CNR *** Institute of Biostructures and Bioimaging-CNR , Via Mezzocannone 16 , 80134 Naples , Italy., Interdepartmental Center of Bioactive Peptide , University of Naples Federico II , Via Mezzocannone 16 , 80134 Naples , Italy., Institute of Crystallography-CNR , Via Amendola 122/O , 70126 Bari , Italy.,
A study on submonomer solid-phase synthesis of S-glycopeptoids has been carried out by screening different parameters. Dimeric species, featuring glycosylated bridging amino monomers, were found under suitable conditions. These dimers arise from an on-resin cross-linking reaction occurring with the incorporation of a glycoamino submonomer into the growing chain and subsequent nucleophilic attack of the resulting secondary amine to a still unreacted bromoacetylated unit. The arising byproduct can be regarded as a novel dimeric peptoid type.
70 Records (68 escludendo Abstract e Conferenze). Impact factor totale: 280.867 (273.54 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 266.599 (260.084 escludendo Abstract e Conferenze).