Cellular distribution of aquaporins in testes of normal and cryptorchid dogs: A preliminary study on dynamic roles(131 views visite) Pelagalli A, Squillacioti C, Ali'S, Liguori G, Mirabella N
Keywords Parole chiave: Aquaporins, Dog, Fluid Transport, Reproduction, Testis,
Affiliations Affiliazioni: *** IBB - CNR ***
Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy; Institute of Biostructures and Bioimages, National Research Council, Naples, Italy., Department of Veterinary Medicine and Animal Productions, University of Naples "Federico II", Naples, Italy., Department of Veterinary Medicine and Animal Productions, University of Naples "Federico II", Naples, Italy. Electronic address: giovanna.liguori@unina.it.,
References Riferimenti: Not available. Non disponibili.
Cellular distribution of aquaporins in testes of normal and cryptorchid dogs: A preliminary study on dynamic roles
Fluid regulation within the male gonad is an important process for promoting sperm differentiation and maturation. Aquaporins (AQPs) are a family of thirteen integral membrane proteins involved in these processes. The expression of several genes of AQPs occurs in the male reproductive tract of humans and other animal species, although there are few studies on domestic animals. In this study, the localization of AQP7, AQP8, and AQP9 as well as the abundances of protein and mRNA transcripts were examined in normal and cryptorchid dog testes. There was immunohistochemical localization of AQP7, AQP8, and AQP9 in both the tubular and interstitial compartments of the normal and retained testes and crytorchid dogs, albeit there was an obvious difference in cellular localization with the testes from the cryptorchid dogs. These results were supported by western blotting and real-time RT-PCR analyses, there was a lesser AQP7 and greater AQP9 abundance of protein and mRNA transcripts in the cryptorchid testis. These findings indicate combined testicular functions of AQPs in cell volume regulation. In addition, with the cryptorchid condition characterized there was a different cellular distribution of AQPs supporting the thought that early detection is important for controlling possible side effects of cyptorchidism, such as pre-neoplastic and carcinogenic outcomes.
Cellular distribution of aquaporins in testes of normal and cryptorchid dogs: A preliminary study on dynamic roles
11 Records (11 escludendo Abstract e Conferenze). Impact factor totale: 61.55 (61.55 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 49.147 (49.147 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Sunday 12 July 2020, 13:14:40 131 views visite. Last view on Ultima visita in data Tuesday 02 February 2021, 12:53:26