Head-to-head comparison of diagnostic accuracy of stress-only myocardial perfusion imaging with conventional and cadmium-zinc telluride single-photon emission computed tomography in women with suspected coronary artery disease
Head-to-head comparison of diagnostic accuracy of stress-only myocardial perfusion imaging with conventional and cadmium-zinc telluride single-photon emission computed tomography in women with suspected coronary artery disease(8 visite) Mannarino T, Assante R, Ricciardi C, Zampella E, Nappi C, Gaudieri V, Mainolfi CG, Di Vaia E, Petretta M, Cesarelli M, Cuocolo A, Acampa W
J Nucl Cardiol (ISSN: 1071-3581linking), 2019 Jun 20; N/D: N/D-N/D.
Tipo di articolo: Journal Article
Impact factor: 2.811, Impact factor a 5 anni: 2.865
Url: Non disponibile.
Parole chiave: Cad, Diagnostic Application, Mpi, Spect
Affiliazioni:
*** IBB - CNR *** Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy., Department of Translational Medical Sciences, University Federico II, Naples, Italy., Department of Electrical Engineering and Information Technology, University Federico II, Naples, Italy., Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy. acampa@unina.it., Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy. acampa@unina.it.,
Riferimenti:
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BACKGROUND: Breast attenuation may impact the diagnostic accuracy of stress myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT). We compared the performance of conventional (C)-SPECT and cadmium-zinc-telluride (CZT)-SPECT systems in women with low-intermediate likelihood of coronary artery disease (CAD). METHODS AND RESULTS: A total of 109 consecutive women underwent stress-optional rest MPI by both C-SPECT and CZT-SPECT. In the overall study population, a weak albeit significant correlation between total perfusion defect (TPD) measured by C-SPECT and CZT-SPECT was observed (r = 0.38, P < .001) and at Bland-Altman analysis the mean difference in TPD (C-SPECT minus CZT-SPECT) was 2.40% (P < .001). Overall concordance of semi-quantitative diagnostic performance between C-SPECT and CZT-SPECT was observed in 52 (48%) women with a kappa value of 0.09. Normalcy rate was significantly higher using CZT-SPECT compared to C-SPECT (P < .001). Machine learning analysis performed through the implementation of J48 algorithm proved that CZT-SPECT has higher sensitivity, specificity, and accuracy than C-SPECT. CONCLUSIONS: In women with low-intermediate likelihood of CAD, there is a poor concordance of diagnostic performance between C-SPECT and CZT-SPECT, and CZT-SPECT allows better normalcy rate detection compared to C-SPECT.
4 Records (3 escludendo Abstract e Conferenze). Impact factor totale: 9.703 (9.703 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 8.848 (8.848 escludendo Abstract e Conferenze).
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