Recruitment of stromal cells into tumour microenvironment promote the metastatic spread of breast cancer(145 views visite)(PDF restricted privato28 views visite) Hill BS, Sarnella A, D'Avino G, Zannetti A
Semin Cancer Biol (ISSN: 1044-579xlinking), 2020 Feb; 60: 202-213.
Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy.
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Recruitment of stromal cells into tumour microenvironment promote the metastatic spread of breast cancer
Currently, metastasis remains the primary cause of death of patients with breast cancer despite the important advances in the treatment of this disease. In the complex tumour microenvironment network, several malignant and non-malignant cell types as well as components of extracellular matrix cooperate in promoting the metastatic spread of breast carcinoma. Many components of the stromal compartment are recruited from distant sites to the tumour including mesenchymal stem cells, endothelial cells, macrophages and other immune cells whereas other cells such as fibroblasts are already present in both primary and secondary lesions. When these cells come into contact with cancer cells they are "educated" and acquire a pro-tumoural phenotype, which support all the steps of the metastatic cascade. In this Review, we highlight the role played by each stromal component in guiding cancer cells in their venture towards colonizing metastatic sites.
Recruitment of stromal cells into tumour microenvironment promote the metastatic spread of breast cancer
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349 Records (320 escludendo Abstract e Conferenze). Impact factor totale: 1534.844 (1433.048 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 1505.07 (1381.812 escludendo Abstract e Conferenze).
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