Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells (134 views visite)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2019 Jul 31; 20(15): N/D-N/D.
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Paper type Tipo di articolo: Journal Article, Review
Impact factor: 4.183, 5-year impact factor Impact factor a 5 anni: 2.617
Url: Not available. Non disponibile.
Keywords Parole chiave: Cell Behavior, Cellular Reprogramming, Drug Resistance, Gastric Cancer, Atp-Binding Cassette Transporters Genetics Metabolism , Antineoplastic Agents Therapeutic Use , Autophagy Drug Effects Genetics , Autophagy-Related Proteins Genetics Metabolism , Cell Survival Genetics , Neoplasm Genetics , Epithelial Cells Drug Effects Metabolism Pathology , Epithelial-Mesenchymal Transition Genetics , Gene Expression Regulation, Helicobacter Infections Drug Therapy Genetics Metabolism Pathology , Helicobacter Pylori Growth, Development Pathogenicity , Humans , Hypoxia Drug Therapy Genetics Metabolism Pathology , Inactivation, Metabolic Genetics , Micrornas Genetics Metabolism , Neoplasm Proteins Genetics Metabolism , Neovascularization, Pathologic Drug Therapy Genetics Metabolism Pathology , Stomach Neoplasms Drug Therapy Genetics Metabolism Pathology , Tumor Microenvironment Drug Effects Genetics
Affiliations Affiliazioni:
*** IBB - CNR ***
Laboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture (PZ), Italy.
Institute of Experimental Endocrinology and Oncology, National Research Council, 80131 Naples, Italy.
Section of Stem Cell and Development, Istituto di Ricerche Genetiche "Gaetano Salvatore" Biogem s.c. a.r.l., 83031 Ariano Irpino, Italy.
Department of Nuclear Medicine, IRCCS-Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture (PZ), Italy.
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80145 Napoli, Italy.
Laboratory of Clinical Research and Advanced Diagnostics, IRCCS-Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture (PZ), Italy.
Scientific Direction, IRCCS-Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture (PZ), Italy.
Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
References Riferimenti:
Not available. Non disponibili.
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2019 Jul 31; 20(15): N/D-N/D.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Review
Impact factor: 4.183, 5-year impact factor Impact factor a 5 anni: 2.617
Url: Not available. Non disponibile.
Keywords Parole chiave: Cell Behavior, Cellular Reprogramming, Drug Resistance, Gastric Cancer, Atp-Binding Cassette Transporters Genetics Metabolism , Antineoplastic Agents Therapeutic Use , Autophagy Drug Effects Genetics , Autophagy-Related Proteins Genetics Metabolism , Cell Survival Genetics , Neoplasm Genetics , Epithelial Cells Drug Effects Metabolism Pathology , Epithelial-Mesenchymal Transition Genetics , Gene Expression Regulation, Helicobacter Infections Drug Therapy Genetics Metabolism Pathology , Helicobacter Pylori Growth, Development Pathogenicity , Humans , Hypoxia Drug Therapy Genetics Metabolism Pathology , Inactivation, Metabolic Genetics , Micrornas Genetics Metabolism , Neoplasm Proteins Genetics Metabolism , Neovascularization, Pathologic Drug Therapy Genetics Metabolism Pathology , Stomach Neoplasms Drug Therapy Genetics Metabolism Pathology , Tumor Microenvironment Drug Effects Genetics
Affiliations Affiliazioni:
*** IBB - CNR ***
Laboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture (PZ), Italy.
Institute of Experimental Endocrinology and Oncology, National Research Council, 80131 Naples, Italy.
Section of Stem Cell and Development, Istituto di Ricerche Genetiche "Gaetano Salvatore" Biogem s.c. a.r.l., 83031 Ariano Irpino, Italy.
Department of Nuclear Medicine, IRCCS-Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture (PZ), Italy.
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80145 Napoli, Italy.
Laboratory of Clinical Research and Advanced Diagnostics, IRCCS-Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture (PZ), Italy.
Scientific Direction, IRCCS-Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture (PZ), Italy.
Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
References Riferimenti:
Not available. Non disponibili.
Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells
Despite the significant recent advances in clinical practice, gastric cancer (GC) represents a leading cause of cancer-related deaths in the world. In fact, occurrence of chemo-resistance still remains a daunting hindrance to effectiveness of the current approach to GC therapy. There is accumulating evidence that a plethora of cellular and molecular factors is implicated in drug-induced phenotypical switching of GC cells. Among them, epithelial-mesenchymal transition (EMT), autophagy, drug detoxification, DNA damage response and drug target alterations, have been reported as major determinants. Intriguingly, resistant GC phenotype may be the result of GC cell-induced tumor microenvironment (TME) remodeling, which is currently emerging as a key player in promoting drug resistance and overcoming cytotoxic effects of drugs. In this review, we discuss the possible mechanisms of drug resistance and their involvement in determining current GC therapies failure.<br>
Despite the significant recent advances in clinical practice, gastric cancer (GC) represents a leading cause of cancer-related deaths in the world. In fact, occurrence of chemo-resistance still remains a daunting hindrance to effectiveness of the current approach to GC therapy. There is accumulating evidence that a plethora of cellular and molecular factors is implicated in drug-induced phenotypical switching of GC cells. Among them, epithelial-mesenchymal transition (EMT), autophagy, drug detoxification, DNA damage response and drug target alterations, have been reported as major determinants. Intriguingly, resistant GC phenotype may be the result of GC cell-induced tumor microenvironment (TME) remodeling, which is currently emerging as a key player in promoting drug resistance and overcoming cytotoxic effects of drugs. In this review, we discuss the possible mechanisms of drug resistance and their involvement in determining current GC therapies failure.<br>
Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells
| ▼ Gadd45 beta and its implication in chronic inflammation |
Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells
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Ribaldone DG, Fagoonee S, Astegiano M, Durazzo M, Morgando A, Sprujevnik T, Giordanino C, Baronio M, De Angelis C, Saracco GM, Pellicano R
* Rifabutin-Based Rescue Therapy for Helicobacter pylori Eradication: A Long-Term Prospective Study in a Large Cohort of Difficult-to-Treat Patients (174 visite)
J Clin Med (ISSN: 2077-0383linking), 2019 Feb 6; 8(2): N/D-N/D.
Impact Factor: 5.583
Dettagli Esporta in BibTeX Esporta in EndNote
Pellicano R, Fagoonee S
* Helicobacter pylori and Prevention of Gastric Cancer (177 visite)
N Engl J Med (ISSN: 0028-4793linking, 1533-4406electronic), 2018 Jun 7; 378(23): 2244-2244.
Impact Factor: 72.406
Dettagli Esporta in BibTeX Esporta in EndNote
Fagoonee S, Durazzo M
* HOTAIR and gastric cancer: a lesson from two meta-analyses (123 visite)
Panminerva Med (ISSN: 0031-0808, 1827-1898electronic), 2017 Sep; 59(3): 201-202.
Impact Factor: 2.102
Dettagli Esporta in BibTeX Esporta in EndNote
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (179 visite)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
Dettagli Esporta in BibTeX Esporta in EndNote
GrassoG, Satriano C, Milardi D
* A neglected modulator of insulin-degrading enzyme activity and conformation: The pH (320 visite)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2015; 203-204: 33-40.
Impact Factor: 2.363
Dettagli Esporta in BibTeX Esporta in EndNote
Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (404 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Marchant J, Squeglia F, Makarov V, De Simone A, Berisio R
* Molecular determinants of inactivation of the resuscitation promoting factor B from Mycobacterium tuberculosis (281 visite)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2013 Feb 1; 31(2): 195-205.
Impact Factor: 2.983
Dettagli Esporta in BibTeX Esporta in EndNote
Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (349 visite)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
Dettagli Esporta in BibTeX Esporta in EndNote
Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (270 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
Dettagli Esporta in BibTeX Esporta in EndNote
Palmieri G, Catara G, Saviano M, Langella E, Gogliettino M, Rossi M
* First archaeal PEPB-serine protease inhibitor from sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop (244 visite)
J Proteome Res (ISSN: 1535-3893), 2009 Jan; 8(1): 327-334.
Impact Factor: 5.132
Dettagli Esporta in BibTeX Esporta in EndNote
Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (328 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
Dettagli Esporta in BibTeX Esporta in EndNote
Esposito G, Tempesta A, Galati MG, De Bellis M, Rossi GB, Potena MI, Marone P, Daniele B, Del Vecchio S
Mucosal expression of carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with gastritis and gastric cancer (248 visite)
Cancer Detect Prev (ISSN: 0361-090x, 0361-090xlinking), 1999; 23(2): 116-122.
Impact Factor: 0.927
Dettagli Esporta in BibTeX Esporta in EndNote
12 Records (11 escludendo Abstract e Conferenze).
Impact factor totale: 174.417 (170.687 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 149.147 (144.903 escludendo Abstract e Conferenze).
Impact factor totale: 174.417 (170.687 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 149.147 (144.903 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Gennaro Angrisano on in data Sunday 12 July 2020, 13:14:40
134 views visite. Last view on Ultima visita in data Monday 23 November 2020, 6:54:18
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