Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study
CNR Ibb | back to homepage
CNR Ibb | back to homepage
▲NavBar
Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study (21 visite)

Mercurio FA, Di Natale C, Pirone L, Vincenzi M, Marasco D, De Luca S, Pedone EM, Leone M

Chembiochem (ISSN: 1439-4227linking), 2019 Sep 20; N/D: N/D-N/D.



Tipo di articolo: Journal Article

Impact factor: 2.641, Impact factor a 5 anni: 3.684

Url: Non disponibile.

Parole chiave: Epha2, Nmr, Sam Domains, Cyclic Peptides, Virtual Screening

Affiliazioni:

*** IBB - CNR ***
ITALY., Consiglio Nazionale delle Ricerche, Istitute of Biostructures and Bioimaging, Via Mezzocannone 16, 80134, Naples, ITALY.,


Riferimenti:

Non disponibile.

SAM domains are protein interaction modules with a helical fold. SAM-SAM interactions often adopt the Mid-Loop (ML)/End-Helix (EH) model in which the C-terminal helix and adjacent loops of one SAM unit (EH site) bind the central regions of another SAM domain (ML site). Herein, an original strategy to attack SAM-SAM associations is reported. It relies on the design of cyclic peptides targeting a region of the SAM domain positioned at the bottom side of the EH interface, that is thought to be important for the rise of a SAM-SAM complex. We preliminarily tested this strategy by using as model system heterotypic SAM-SAM interactions involving EphA2 receptor and implementing a multidisciplinary plan made up of computational docking studies, experimental interaction assays (by NMR and SPR techniques) and conformational analysis (by NMR and CD). This work further highlights how only a specific balance between flexibility and rigidity may be needed to generate modulators of SAM-SAM interactions.
Nessun risultato.
Nessun risultato.

Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]
Vai a fine pagina   Versione per copia e incolla facile   Esporta tutto in BibTeX   Esporta tutto in EndNote


Mercurio FA, Di Natale C, Pirone L, Marasco D, Calce E, Vincenzi M, Pedone EM, De Luca S, Leone M
* Design and analysis of EphA2-SAM peptide ligands: A multi-disciplinary screening approach (53 visite)
Bioorg Chem (ISSN: 0045-2068linking), 2019 Mar; 84: 434-443.
Impact Factor: 3.929
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vincenzi M, Mercurio FA, Leone M
* Sam domains in multiple diseases (40 visite)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2018 Oct 9; N/D: N/D-N/D.
Impact Factor: 3.469
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mercurio FA, Pirone L, Di Natale C, Marasco D, Pedone EM, Leone M
* Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2 (95 visite)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2018 Oct; 80: 602-610.
Impact Factor: 3.9
Dettagli    Esporta in BibTeX    Esporta in EndNote

Diana D, Di Salvo C, Celentano V, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* Conformational stabilization of a beta-hairpin through a triazole-tryptophan interaction (125 visite)
Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2018 Jan 31; 16(5): 787-795.
Impact Factor: 3.451
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (126 visite)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
Dettagli    Esporta in BibTeX    Esporta in EndNote

Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (192 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
Dettagli    Esporta in BibTeX    Esporta in EndNote

Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (237 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
Impact Factor: 2.282
Dettagli    Esporta in BibTeX    Esporta in EndNote

Amodeo P, Castello G, De Luca S, Scala S, Siani A, Vitale RM
* CYCLIC PEPTIDES BINDING CXCR4 RECEPTOR AND RELATIVE MEDICAL AND DIAGNOSTIC USES (199 visite)
Patent, 2010; PctWo2011092575: Pct-Pct.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (164 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
Dettagli    Esporta in BibTeX    Esporta in EndNote

Benedetti E, Pedone C
* Cyclolinopeptide A: inhibitor, immunosuppressor or other? (161 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2005 May; 11(5): 268-272.
Impact Factor: 1.803
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (182 visite)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
Dettagli    Esporta in BibTeX    Esporta in EndNote

Zanotti G, Saviano M, Saviano G, Tancredi T, Rossi F, Pedone C, Benedetti E
Structure of cyclic peptides: the crystal and solution conformation of cyclo(Phe-Phe-Aib-Leu-Pro) (223 visite)
Journal Of Peptide Research (ISSN: 1397-002x), 1998 Jun; 51(6): 460-466.
Impact Factor: 1.125
Dettagli    Esporta in BibTeX    Esporta in EndNote

D'Andrea LD, Mazzeo M, Isernia C, Rossi F, Saviano M, Gallo P, Paolillo L, Pedone C
Solution conformational preferences of a peptidic analogue of a natural macrolide (166 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(3): 349-361.
Impact Factor: 2.425
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Unusual conformational preferences of β-alanine containing cyclic peptides. VII (204 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996 Jun; 38(6): 683-691.
Impact Factor: 2.425
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lombardi A, D'Auria G, Saviano M, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
Bicyclic Peptides As Type I/Type Ii Beta-Turn Scaffolds (242 visite)
Biopolym Pept Sci Sect, 1996; 40(5): 505-518.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pavone V, Lombardi A, Saviano M, Nastri F, Fattorusso R, Maglio O, Isernia C, Paolillo L, Pedone C
β-alanine containing cyclic peptides with turned structure: The 'pseudo type II β-turn. ' VI (200 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Nov; 34(11): 1517-1526.
Impact Factor: 2.425
Dettagli    Esporta in BibTeX    Esporta in EndNote



16 Records (16 escludendo Abstract e Conferenze).
Impact factor totale: 40.24 (40.24 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 42.2 (42.2 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote

Ultima modifica di Stefania De Luca in data Wednesday 23 October 2019, 9:40:25
21 visite. Ultima visita in data Sunday 10 November 2019, 21:01:35