Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (89 views visite)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
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Paper type Tipo di articolo: Journal Article
Impact factor: 3.345, 5-year impact factor Impact factor a 5 anni: 4.031
Url: Not available. Non disponibile.
Keywords Parole chiave: Ms , Nmr , Skeletonema Marinoi , Bioactive Lipids , Cytotoxic Activity , Diatoms, Antineoplastic Agents Pharmacology , Apoptosis Drug Effects , Caspase 3 Metabolism , Caspase 7 Metabolism , Cell Cycle Drug Effects , Cell Survival Drug Effects , Diatoms Chemistry , Humans , Microalgae
Affiliations Affiliazioni:
*** IBB - CNR ***
CEINGE-Biotecnologie Avanzate s.c.ar.l., 80145 Naples, Italy. micelim@ceinge.unina.it.
CNR-Institute of Biomolecular Chemistry, Via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy. acutignano@icb.cnr.it.
Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy. mariarosaria.conte@unicampania.it.
Institute of Biostructures and Bioimaging (IBB-CNR), Via Mezzocannone 16, 80134 Naples, Italy. raffaella.u@libero.it.
Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. raffaella.u@libero.it.
Department of Pharmaceutical Sciences, University of Milan, via Venezian 21, 20133 Milan, Italy. alessandra.romanelli@unimi.it.
References Riferimenti:
Not available. Non disponibili.
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article
Impact factor: 3.345, 5-year impact factor Impact factor a 5 anni: 4.031
Url: Not available. Non disponibile.
Keywords Parole chiave: Ms , Nmr , Skeletonema Marinoi , Bioactive Lipids , Cytotoxic Activity , Diatoms, Antineoplastic Agents Pharmacology , Apoptosis Drug Effects , Caspase 3 Metabolism , Caspase 7 Metabolism , Cell Cycle Drug Effects , Cell Survival Drug Effects , Diatoms Chemistry , Humans , Microalgae
Affiliations Affiliazioni:
*** IBB - CNR ***
CEINGE-Biotecnologie Avanzate s.c.ar.l., 80145 Naples, Italy. micelim@ceinge.unina.it.
CNR-Institute of Biomolecular Chemistry, Via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy. acutignano@icb.cnr.it.
Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy. mariarosaria.conte@unicampania.it.
Institute of Biostructures and Bioimaging (IBB-CNR), Via Mezzocannone 16, 80134 Naples, Italy. raffaella.u@libero.it.
Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. raffaella.u@libero.it.
Department of Pharmaceutical Sciences, University of Milan, via Venezian 21, 20133 Milan, Italy. alessandra.romanelli@unimi.it.
References Riferimenti:
Not available. Non disponibili.
Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells
Microalgae are an excellent source of valuable compounds for nutraceutical and cosmeceutical applications. These photosynthesizing microorganisms are amenable for large-scale production, thus overcoming the bottleneck of biomass supply for chemical and activity characterization of bioactive compounds. This characteristic has recently also prompted the screening of microalgae for potential pharmaceutical applications. Here, we show that monoacylglycerides (MAGs) purified from the marine diatom Skeletonema marinoi have selective cytotoxic activity against the haematological cancer cell line U-937 and colon cancer cell line HCT-116 compared to normal MePR-2B cells. LC-MS analysis of the raw extract revealed that in their natural form, MAGs occur as 2-monoacyl derivatives and include mainly C16 and C20 analogues, but they are converted into the corresponding 1-isomers during purification processes. Pure compounds along with the synthetic 1-monoarachidonoylglycerol tested on HCT-116 and U-937 tumor cell lines induced cell death via apoptosis. The mechanism of action was investigated, and we show that it involves the induction of apoptosis through caspase 3/7 activation. These findings pave the way for the possible use of these molecules as potential anticancer agents or as precursors for the generation of new and more potent and selective compounds against tumor cells.
Microalgae are an excellent source of valuable compounds for nutraceutical and cosmeceutical applications. These photosynthesizing microorganisms are amenable for large-scale production, thus overcoming the bottleneck of biomass supply for chemical and activity characterization of bioactive compounds. This characteristic has recently also prompted the screening of microalgae for potential pharmaceutical applications. Here, we show that monoacylglycerides (MAGs) purified from the marine diatom Skeletonema marinoi have selective cytotoxic activity against the haematological cancer cell line U-937 and colon cancer cell line HCT-116 compared to normal MePR-2B cells. LC-MS analysis of the raw extract revealed that in their natural form, MAGs occur as 2-monoacyl derivatives and include mainly C16 and C20 analogues, but they are converted into the corresponding 1-isomers during purification processes. Pure compounds along with the synthetic 1-monoarachidonoylglycerol tested on HCT-116 and U-937 tumor cell lines induced cell death via apoptosis. The mechanism of action was investigated, and we show that it involves the induction of apoptosis through caspase 3/7 activation. These findings pave the way for the possible use of these molecules as potential anticancer agents or as precursors for the generation of new and more potent and selective compounds against tumor cells.
Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells
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Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells
Marzano M, Falanga AP, Marasco D, Borbone N, D'Errico S, Piccialli G, Roviello GN, Oliviero G
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Impact Factor: 4.566
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Marzano M, Falanga AP, Marasco D, Borbone N, D'Errico S, Piccialli G, Roviello GN, Oliviero G
* Evaluation of an Analogue of the Marine epsilon-PLL Peptide as a Ligand of G-quadruplex DNA Structures (101 visite) (PDF 47 visite)
Mar Drugs (ISSN: 1660-3397linking), 2020 Jan 11; 18(1): 49-60.
Impact Factor: 4.073
Dettagli Esporta in BibTeX Esporta in EndNote
Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
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Impact Factor: 5.08
Dettagli Esporta in BibTeX Esporta in EndNote
Angeli A, Buonanno M, Donald WA, Monti SM, Supuran CT
* The zinc - but not cadmium - containing zeta-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids (119 visite)
Bioorg Chem (ISSN: 1090-2120electronic, 0045-2068linking), 2018 Oct; 80: 261-265.
Impact Factor: 3.929
Dettagli Esporta in BibTeX Esporta in EndNote
Soprano M, Sorriento D, Rusciano MR, Maione AS, Limite G, Forestieri P, D'Angelo D, D'Alessio M, Campiglia P, Formisano P, Iaccarino G, Bianco R, Illario M
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Impact Factor: 2.806
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Impact Factor: 8.738
Dettagli Esporta in BibTeX Esporta in EndNote
Alterio V, Langella E, De Simone G, Monti SM
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Impact Factor: 3.345
Dettagli Esporta in BibTeX Esporta in EndNote
Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
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Impact Factor: 8.722
Dettagli Esporta in BibTeX Esporta in EndNote
Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
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Impact Factor: 3.972
Dettagli Esporta in BibTeX Esporta in EndNote
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
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Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
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Dettagli Esporta in BibTeX Esporta in EndNote
Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
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Impact Factor: 5.177
Dettagli Esporta in BibTeX Esporta in EndNote
Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (414 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
Dettagli Esporta in BibTeX Esporta in EndNote
Alterio V, Langella E, Viparelli F, Vullo D, Ascione G, Dathan NA, Morel FM, Supuran CT, De Simone G, Monti SM
* Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii (323 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1232-1241.
Impact Factor: 3.142
Dettagli Esporta in BibTeX Esporta in EndNote
Sandomenico A, Russo A, Palmieri G, Bergamo P, Gogliettino M, Falcigno L, Ruvo M
* Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation (407 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012 Mar 8; 55(5): 2102-2111.
Impact Factor: 5.614
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (499 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (385 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (402 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
Dettagli Esporta in BibTeX Esporta in EndNote
Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (435 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
Dettagli Esporta in BibTeX Esporta in EndNote
18 Records (17 escludendo Abstract e Conferenze).
Impact factor totale: 93.249 (88.072 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 92.181 (86.821 escludendo Abstract e Conferenze).
Impact factor totale: 93.249 (88.072 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 92.181 (86.821 escludendo Abstract e Conferenze).
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