Modelling the risk of radiation induced alopecia in brain tumor patients treated with scanned proton beams (68 views visite)
Radiother Oncol (ISSN: 0167-8140linking), 2020 Mar; 144: 127-134.
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Paper type Tipo di articolo: Journal Article
Impact factor: 5.252, 5-year impact factor Impact factor a 5 anni: 4.502
Url: Not available. Non disponibile.
Keywords Parole chiave: Brain Tumors, Ntcp, Proton Therapy, Radiation-Induced Alopecia
Affiliations Affiliazioni:
*** IBB - CNR ***
National Research Council, Institute of Biostructures and Bioimaging, Napoli, Italy.
Istituto Nazionale di Fisica Nucleare, Trento Institute for Fundamental Physics and Applications, Trento, Italy.
Trento Proton Therapy Center, Azienda Provinciale per i Servizi Sanitari (APSS), Trento, Italy.
University of Trento, Physics Department, Trento, Italy.
GSI Helmholtzzentrum fur Schwerionenforschung, Biophysics Department, Darmstadt, Germany
Technische Universitat Darmstadt, Institut fur Festkorperphysik, Darmstadt, Germany.
References Riferimenti:
Not available. Non disponibili.
Radiother Oncol (ISSN: 0167-8140linking), 2020 Mar; 144: 127-134.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article
Impact factor: 5.252, 5-year impact factor Impact factor a 5 anni: 4.502
Url: Not available. Non disponibile.
Keywords Parole chiave: Brain Tumors, Ntcp, Proton Therapy, Radiation-Induced Alopecia
Affiliations Affiliazioni:
*** IBB - CNR ***
National Research Council, Institute of Biostructures and Bioimaging, Napoli, Italy.
Istituto Nazionale di Fisica Nucleare, Trento Institute for Fundamental Physics and Applications, Trento, Italy.
Trento Proton Therapy Center, Azienda Provinciale per i Servizi Sanitari (APSS), Trento, Italy.
University of Trento, Physics Department, Trento, Italy.
GSI Helmholtzzentrum fur Schwerionenforschung, Biophysics Department, Darmstadt, Germany
Technische Universitat Darmstadt, Institut fur Festkorperphysik, Darmstadt, Germany.
References Riferimenti:
Not available. Non disponibili.
Modelling the risk of radiation induced alopecia in brain tumor patients treated with scanned proton beams
PURPOSE: To develop normal tissue complication probability (NTCP) models for radiation-induced alopecia (RIA) in brain tumor patients treated with proton therapy (PT). METHODS AND MATERIALS: We analyzed 116 brain tumor adult patients undergoing scanning beam PT (median dose 54 GyRBE; range 36-72) for CTCAE v.4 grade 2 (G2) acute (90 days) and permanent (>12 months) RIA. The relative dose-surface histogram (DSH) of the scalp was extracted and used for Lyman-Kutcher-Burman (LKB) modelling. Moreover, DSH metrics (Sx: the surface receiving >/= X Gy, D2%: near maximum dose, Dmean: mean dose) and non-dosimetric variables were included in a multivariable logistic regression NTCP model. Model performances were evaluated by the cross-validated area under the receiver operator curve (ROC-AUC). RESULTS: Acute, late and permanent G2-RIA was observed in 52%, 35% and 19% of the patients, respectively. The LKB models showed a weak dose-surface effect (0.09
PURPOSE: To develop normal tissue complication probability (NTCP) models for radiation-induced alopecia (RIA) in brain tumor patients treated with proton therapy (PT). METHODS AND MATERIALS: We analyzed 116 brain tumor adult patients undergoing scanning beam PT (median dose 54 GyRBE; range 36-72) for CTCAE v.4 grade 2 (G2) acute (90 days) and permanent (>12 months) RIA. The relative dose-surface histogram (DSH) of the scalp was extracted and used for Lyman-Kutcher-Burman (LKB) modelling. Moreover, DSH metrics (Sx: the surface receiving >/= X Gy, D2%: near maximum dose, Dmean: mean dose) and non-dosimetric variables were included in a multivariable logistic regression NTCP model. Model performances were evaluated by the cross-validated area under the receiver operator curve (ROC-AUC). RESULTS: Acute, late and permanent G2-RIA was observed in 52%, 35% and 19% of the patients, respectively. The LKB models showed a weak dose-surface effect (0.09
Modelling the risk of radiation induced alopecia in brain tumor patients treated with scanned proton beams
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Modelling the risk of radiation induced alopecia in brain tumor patients treated with scanned proton beams
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Impact Factor: 4.363
Dettagli Esporta in BibTeX Esporta in EndNote
Cella L, Conson M, Pressello MC, Molinelli S, Schneider U, Donato V, Orecchia R, Salvatore M, Pacelli R
* Hodgkin's lymphoma emerging radiation treatment techniques: Trade-offs between late radio-induced toxicities and secondary malignant neoplasms (311 visite)
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Impact Factor: 2.36
Dettagli Esporta in BibTeX Esporta in EndNote
Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of IMRT and protons in the treatment of the breast and regional nodes (298 visite)
Int J Rad Oncol Biol Phys, 2003 Mar 1; 48(3Supplement): 785-792.
Impact Factor: 0.155
Dettagli Esporta in BibTeX Esporta in EndNote
Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes (300 visite)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003; 55(3): 785-792.
Impact Factor: 4.285
Dettagli Esporta in BibTeX Esporta in EndNote
Cella L, Lomax A, Miralbell R
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Dettagli Esporta in BibTeX Esporta in EndNote
Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
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Impact Factor: 3.064
Dettagli Esporta in BibTeX Esporta in EndNote
Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
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Impact Factor: 1.042
Dettagli Esporta in BibTeX Esporta in EndNote
Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
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14 Records (14 escludendo Abstract e Conferenze).
Impact factor totale: 42.912 (42.912 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 42.389 (42.389 escludendo Abstract e Conferenze).
Impact factor totale: 42.912 (42.912 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 42.389 (42.389 escludendo Abstract e Conferenze).
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