*** IBB - CNR *** National Research Council, Institute of Biostructures and Bioimaging, Napoli, Italy. Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy.
Mathematical models of normal tissue complication probability (NTCP) able to robustly predict radiation-induced morbidities (RIM) play an essential role in the identification of a personalized optimal plan, and represent the key to maximizing the benefits of technological advances in radiation therapy (RT). Most modern RT techniques pose, however, new challenges in estimating the risk of RIM. The aim of this report is to schematically review NTCP models in the framework of advanced radiation therapy techniques. Issues relevant to hypofractionated stereotactic body RT and ion beam therapy are critically reviewed. Reirradiation scenarios for new or recurrent malignances and NTCP are also illustrated. A new phenomenological approach to predict RIM is suggested.<br>
32 Records (30 escludendo Abstract e Conferenze). Impact factor totale: 112.681 (108.742 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 116.631 (112.315 escludendo Abstract e Conferenze).