Radicals Generated in Tetramolecular Guanine Quadruplexes by Photoionization: Spectral and Dynamical Features (55 views visite)
J Phys Chem B (ISSN: 1520-5207linking), 2019 Jun 13; 123(23): 4950-4957.
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Paper type Tipo di articolo: Journal Article
Impact factor: 3.603, 5-year impact factor Impact factor a 5 anni: 4.425
Url: Not available. Non disponibile.
Keywords Parole chiave: Not available. Non disponibili.
Affiliations Affiliazioni:
*** IBB - CNR ***
LIDYL, CEA, CNRS, Universite Paris-Saclay , F-91191 Gif-sur-Yvette , France., Univ Lyon, ENS de Lyon, CNRS UMR 5182 , Universite Claude Bernard Lyon 1, Laboratoire de Chimie , F-69342 Lyon , France., Departamento de Quimica , Universidad Autonoma de Madrid , c/ Francisco Tomas y Valiente 7, Cantoblanco , 28049 Madrid , Spain., Univ. Grenoble-Alpes, CEA, CNRS, SyMMES UMR , 5819 Grenoble , France., Istituto Biostrutture e Bioimmagini-Consiglio Nazionale delle Ricerche , Via Mezzocannone 16 , I-80134 Napoli , Italy.,
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Not available. Non disponibili.
J Phys Chem B (ISSN: 1520-5207linking), 2019 Jun 13; 123(23): 4950-4957.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article
Impact factor: 3.603, 5-year impact factor Impact factor a 5 anni: 4.425
Url: Not available. Non disponibile.
Keywords Parole chiave: Not available. Non disponibili.
Affiliations Affiliazioni:
*** IBB - CNR ***
LIDYL, CEA, CNRS, Universite Paris-Saclay , F-91191 Gif-sur-Yvette , France., Univ Lyon, ENS de Lyon, CNRS UMR 5182 , Universite Claude Bernard Lyon 1, Laboratoire de Chimie , F-69342 Lyon , France., Departamento de Quimica , Universidad Autonoma de Madrid , c/ Francisco Tomas y Valiente 7, Cantoblanco , 28049 Madrid , Spain., Univ. Grenoble-Alpes, CEA, CNRS, SyMMES UMR , 5819 Grenoble , France., Istituto Biostrutture e Bioimmagini-Consiglio Nazionale delle Ricerche , Via Mezzocannone 16 , I-80134 Napoli , Italy.,
References Riferimenti:
Not available. Non disponibili.
Radicals Generated in Tetramolecular Guanine Quadruplexes by Photoionization: Spectral and Dynamical Features
G-quadruplexes are four-stranded DNA structures playing a key role in many biological functions and are promising for applications in the field of nanoelectronics. Characterizing the generation and fate of radical cations (electron holes) within these systems is important in relation to the DNA oxidative damage and/or conductivity issues. This study focuses on guanine radicals in G-quadruplexes formed by association of four TGGGGT strands in the presence of Na(+) cations, (TG4T)4/Na(+). Using nanosecond transient spectroscopy with 266 nm excitation, we quantitatively characterize hydrated ejected electrons and three types of guanine radicals. We show that, at an energy lower by 2.7 eV than the guanine ionization potential, one-photon ionization occurs with quantum yield of (3.5 +/- 0.5) x 10(-3). Deprotonation of the radical cations is completed within 20 mus, leading to the formation of (G-H2)(*) radicals, following a strongly nonexponential decay pattern. Within 10 ms, the latter undergoes tautomerization to deprotonated (G-H1)(*) radicals. The dynamics of the various radicals determined for (TG4T)4/Na(+), in connection to those reported previously for telomeric G-quadruplexes TEL21/Na(+), is correlated with energetic factors computed by quantum chemical methods. The faster deprotonation of radical cations in (TG4T)4/Na(+) compared to TEL21/Na(+) explains that irradiation of the former does not generate 8-oxodGuo, which is readily detected by high-performance liquid chromatography/mass spectrometry in the case of TEL21/Na(+).
G-quadruplexes are four-stranded DNA structures playing a key role in many biological functions and are promising for applications in the field of nanoelectronics. Characterizing the generation and fate of radical cations (electron holes) within these systems is important in relation to the DNA oxidative damage and/or conductivity issues. This study focuses on guanine radicals in G-quadruplexes formed by association of four TGGGGT strands in the presence of Na(+) cations, (TG4T)4/Na(+). Using nanosecond transient spectroscopy with 266 nm excitation, we quantitatively characterize hydrated ejected electrons and three types of guanine radicals. We show that, at an energy lower by 2.7 eV than the guanine ionization potential, one-photon ionization occurs with quantum yield of (3.5 +/- 0.5) x 10(-3). Deprotonation of the radical cations is completed within 20 mus, leading to the formation of (G-H2)(*) radicals, following a strongly nonexponential decay pattern. Within 10 ms, the latter undergoes tautomerization to deprotonated (G-H1)(*) radicals. The dynamics of the various radicals determined for (TG4T)4/Na(+), in connection to those reported previously for telomeric G-quadruplexes TEL21/Na(+), is correlated with energetic factors computed by quantum chemical methods. The faster deprotonation of radical cations in (TG4T)4/Na(+) compared to TEL21/Na(+) explains that irradiation of the former does not generate 8-oxodGuo, which is readily detected by high-performance liquid chromatography/mass spectrometry in the case of TEL21/Na(+).
Radicals Generated in Tetramolecular Guanine Quadruplexes by Photoionization: Spectral and Dynamical Features
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Radicals Generated in Tetramolecular Guanine Quadruplexes by Photoionization: Spectral and Dynamical Features
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Balanikas E, Martinez-fernandez L, Improta R, Podbevšek P, Baldacchino G, Markovitsi D
* The Structural Duality of Nucleobases in Guanine Quadruplexes Controls Their Low-Energy Photoionization (2 visite)
J Phys Chem Lett (ISSN: 1948-7185linking), 2021 Sep 2; 12(34): 8309-8313.
Impact Factor: 6.475
Dettagli Esporta in BibTeX Esporta in EndNote
Mulliri S, Laaksonen A, Spanu P, Farris R, Farci M, Mingoia F, Roviello GN, Mocci F
Spectroscopic and In Silico Studies on the Interaction of Substituted Pyrazolo[1, 2-a]benzo[1, 2, 3, 4]tetrazine-3-one Derivatives with c-Myc G4-DNA (16 visite)
Int J Mol Sci (ISSN: 1422-0067linking), 2021 Jun 2; 22(11): 6028-6028.
Impact Factor: 5.923
Dettagli Esporta in BibTeX Esporta in EndNote
Platella C, Napolitano E, Riccardi C, Musumeci D, Montesarchio D
* Disentangling the Structure-Activity Relationships of Naphthalene Diimides as Anticancer G-Quadruplex-Targeting Drugs (2 visite)
J Med Chem (ISSN: 0022-2623linking), 2021 Apr 8; 64(7): 3578-3603.
Impact Factor: 7.446
Dettagli Esporta in BibTeX Esporta in EndNote
Green JA, Asha H, Santoro F, Improta R
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Impact Factor: 5.39
Dettagli Esporta in BibTeX Esporta in EndNote
Martínez-fernández L, Esposito L, Improta R
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Impact Factor: 2.831
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Impact Factor: 3.232
Dettagli Esporta in BibTeX Esporta in EndNote
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Impact Factor: 6.205
Dettagli Esporta in BibTeX Esporta in EndNote
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J Inorg Biochem (ISSN: 0162-0134linking), 2020 Feb; 203: 110868-110868.
Impact Factor: 3.224
Dettagli Esporta in BibTeX Esporta in EndNote
Martinez-fernandez L, Changenet P, Banyasz A, Gustavsson T, Markovitsi D, Improta R
* Comprehensive Study of Guanine Excited State Relaxation and Photoreactivity in G-quadruplexes (48 visite)
J Phys Chem Lett (ISSN: 1948-7185linking), 2019 Nov 7; 10(21): 6873-6877.
Impact Factor: 6.687
Dettagli Esporta in BibTeX Esporta in EndNote
Marzano M, Falanga AP, D'Errico S, Pinto B, Roviello GN, Piccialli G, Oliviero G, Borbone N
* New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes (221 visite)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2019 Feb 12; 24(3): 654-654.
Impact Factor: 3.06
Dettagli Esporta in BibTeX Esporta in EndNote
Martinez-fernandez L, Banyasz A, Markovitsi D, Improta R
* Topology Controls the Electronic Absorption and Delocalization of Electron Holes in Guanine Quadruplexes (246 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Oct 12; 24(57): 15185-15189.
Impact Factor: 5.476
Dettagli Esporta in BibTeX Esporta in EndNote
Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K
* Specific Recognition of G-Quadruplexes Over Duplex-DNA by a Macromolecular NIR Two-Photon Fluorescent Probe (220 visite)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2017 Dec 7; 8(23): 5915-5920.
Impact Factor: 8.709
Dettagli Esporta in BibTeX Esporta in EndNote
Banyasz A, Martinez-fernandez L, Balty C, Perron M, Douki T, Improta R, Markovitsi D
* Absorption of Low-Energy UV Radiation by Human Telomere G-Quadruplexes Generates Long-Lived Guanine Radical Cations (171 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2017 Aug 2; 139(30): 10561-10568.
Impact Factor: 14.357
Dettagli Esporta in BibTeX Esporta in EndNote
Platella C, Guida S, Bonmassar L, Aquino A, Bonmassar E, Ravagnan G, Montesarchio D, Roviello GN, Musumeci D, Fuggetta MP
* Antitumour activity of resveratrol on human melanoma cells: a possible mechanism related to its interaction with malignant cell telomerase (259 visite)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Aug 02; 1861(11PtA): 2843-2851.
Impact Factor: 4.28
Dettagli Esporta in BibTeX Esporta in EndNote
Platella C, Riccardi C, Montesarchio D, Roviello GN, Musumeci D
* G-quadruplex-based aptamers against protein targets in therapy and diagnostics (268 visite)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 1872-8006electronic), 2017 May; 1861(5PtB): 1429-1447.
Impact Factor: 3.679
Dettagli Esporta in BibTeX Esporta in EndNote
Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D
* G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (377 visite)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2014 Jun; 1840(6): 2050-2059.
Impact Factor: 5.353
Dettagli Esporta in BibTeX Esporta in EndNote
Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (334 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
Dettagli Esporta in BibTeX Esporta in EndNote
Hua Y, Changenet-Barret P, Improta R, Vaya I, Gustavsson T, Kotlyar AB, Zikich D, Sket P, Plavec J, Markovitsi D
* Cation effect on the electronic excited states of guanine nanostructures studied by time-resolved fluorescence spectroscopy (363 visite)
J Phys Chem C (ISSN: 1932-7447), 2012 Jul 12; 116(27): 14682-14689.
Impact Factor: 4.814
Dettagli Esporta in BibTeX Esporta in EndNote
Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (558 visite)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
Dettagli Esporta in BibTeX Esporta in EndNote
Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F
* Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer (335 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309, 1532-2335electronic), 2010 Aug 1; 66(Pt8): 961-963.
Impact Factor: 0.563
Dettagli Esporta in BibTeX Esporta in EndNote
20 Records (18 escludendo Abstract e Conferenze).
Impact factor totale: 105.077 (100.835 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 100.557 (95.268 escludendo Abstract e Conferenze).
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