SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and Other Drugs for the Treatment of the New Coronavirus
SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and Other Drugs for the Treatment of the New Coronavirus(55 views visite) Costanzo M, De Giglio MAR, Roviello GN
Curr Med Chem (ISSN: 0929-8673linking), 2020 Apr 16; 27: N/D-N/D.
Paper type Tipo di articolo: Doi: 10. 2174/0929867327666200416131117, Journal Article
*** IBB - CNR *** 1Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples 'Federico II', Via S. Pansini 5, I-80131 Naples, Italy; 2CEINGE - Biotecnologie Avanzate Scarl, Via G. Salvatore 486, I-80145, Naples, Italy; 3School of Medicine and Surgery, University of Naples 'Federico II', Via S. Istituto di Biostrutture e Bioimmagini IBB - CNR Via Mezzocannone 16, I80134 Naples. Italy.
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<br>Here we report on the most recent updates on experimental drugs successfully employed<br>in the treatment of the disease caused by SARS-CoV-2 coronavirus, also referred to as<br>COVID-19 (COronaVIrus Disease 19). In particular, several cases of recovered patients have<br>been reported after being treated with lopinavir/ritonavir (which is widely used to treat human<br>immunodeficiency virus (HIV) infection) in combination with the anti-flu drug oseltamivir. In<br>addition, remdesivir, which has been previously administered to Ebola virus patients, has also<br>proven effective in the U.S. against coronavirus, while antimalarial chloroquine and hydroxychloroquine,<br>favipiravir and co-administered darunavir and umifenovir (in patient therapies)<br>were also recently recorded as having anti-SARS-CoV-2 effects. Since the recoveries/deaths<br>ratio in the last weeks significantly increased, especially in China, it is clear that the experimental<br>antiviral therapy, together with the availability of intensive care unit beds in hospitals<br>and rigorous government control measures, all play an important role in dealing with this virus.<br>This also stresses the urgent need for the scientific community to devote its efforts to the<br>development of other more specific antiviral strategies.<br>