Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna(45 views visite) Falanga A, Mercurio FA, Siciliano A, Lombardi L, Galdiero S, Guida M, Libralato G, Leone M, Galdiero E
Keywords Parole chiave: Animals
, Anti-Bacterial Agents Pharmacology
, Antimicrobial Cationic Peptides Toxicity
, Antioxidants Metabolism
, Arginine Metabolism
, Catalase Metabolism
, Daphnia Drug Effects
, Female
, Lysine Metabolism
, Magnetic Resonance Spectroscopy
, Metabolome Drug Effects
, Metabolomics
, Oxidation-Reduction Drug Effects
, Oxidative Stress Drug Effects
, Quantum Dots Toxicity
, Reactive Oxygen Species Metabolism
, Reproduction Drug Effects
, Water Pollutants, Chemical Toxicity
, Enzyme Activity
, Multigenerational
, Qds-Indolicidin
Affiliations Affiliazioni: *** IBB - CNR ***
Department of Pharmacy, University of Naples Federico II, Via Mezzocannone 16, 80134, Naples, Italy.
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples 'Federico II', Via Mezzocannone 16, 80134, Naples, Italy
Institute of Biostructures and Bioimaging (IBB), CNR, via Mezzocannone 16, 80134, Naples, Italy.
Department of Biology, University of Naples Federico II, via Cinthia, 80126, Naples, Italy.
References Riferimenti: Not available. Non disponibili.
Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna
This study evaluated the effect of QDs functionalized with the antimicrobial peptide indolicidin on oxidative stress and metabolomics profiles of Daphnia magna across three generations (F0, F1, and F2). Exposing D. magna to sub-lethal concentrations of the complex QDs-indolicidin, a normal survival of daphnids was observed from F0 to F2, but a delay of first brood, fewer broods per female, a decrease of length of about 50% compared to control. In addition, QDs-indolicidin induced a significantly higher production of reactive oxygen species (ROS) gradually in each generation and an impairment of enzymes response to oxidative stress such as superoxide dismutase (SOD), catalase (CAT) and glutathione transferase (GST). Effects were confirmed by metabolomics profiles that pointed out a gradual decrease of metabolomics content over the three generations and a toxic effect of QDs-indolicidin likely related to the higher accumulation of ROS and decreased antioxidant capacity in F1 and F2 generations. Results highlighted the capability of metabolomics to reveal an early metabolic response to stress induced by environmental QDs-indolicidin complex.
Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna
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