Studying the excited electronic states of guanine rich DNA quadruplexes by quantum mechanical methods: main achievements and perspectives(25 views visite) Martínez-fernández L, Esposito L, Improta R
Keywords Parole chiave: Dna Chemistry, Electrons, G-Quadruplexes, Guanine Chemistry, Light, Quantum Theory
Affiliations Affiliazioni: *** IBB - CNR ***
Departamento de Química, Facultad de Ciencias, Modulo 13 Universidad Autónoma de Madrid, Campus de Excelencia UAM-CSIC Cantoblanco, 28049 Madrid, Spain and IADCHEM, Institute for Advanced Research in Chemistry, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, I-80134 Napoli, Italy. robimp@unina.it.
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Studying the excited electronic states of guanine rich DNA quadruplexes by quantum mechanical methods: main achievements and perspectives
The main insights into the photoactivated dynamics of guanine quadruplexes (G4s) recently provided by quantum mechanical computations are concisely reviewed here. The experimental steady state absorption and circular dichroism spectra of different topologies can be reproduced and assigned. After light absorption from excited states delocalized over multiple bases, the most important decay pathways involve localization of the excitation over a single base or on two stacked guanines, excimers with different degrees of charge transfer character. Two main photochemical reactions are discussed. One involves the photodimerization of two stacked guanine bases on the 'neutral' excimer path. The other, ionization of guanine, which triggers deprotonation of the resulting cation to form (G-H2)˙ and (G-H1)˙ radicals. Both the static and dynamical properties of G4 excited states are ruled by their topology and modulated by the inner coordinated metal ions.
Studying the excited electronic states of guanine rich DNA quadruplexes by quantum mechanical methods: main achievements and perspectives
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Studying the excited electronic states of guanine rich DNA quadruplexes by quantum mechanical methods: main achievements and perspectives
72 Records (67 escludendo Abstract e Conferenze). Impact factor totale: 427.613 (413.583 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 477.861 (462.195 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Gennaro Angrisano on in data Thursday 14 January 2021, 17:52:41 25 views visite. Last view on Ultima visita in data Friday 26 February 2021, 7:55:33