Antiproliferative Activity of Mycalin A and Its Analogues on Human Skin Melanoma and Human Cervical Cancer Cells (15 views visite)
Mar Drugs (ISSN: 1660-3397linking), 2020 Jul 29; 18(8): N/D-N/D.
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Paper type Tipo di articolo: Journal Article
Impact factor: 4.379, 5-year impact factor Impact factor a 5 anni: 4.031
Url: Not available. Non disponibile.
Keywords Parole chiave: A375 And Hela Cell Lines, C15 Acetogenins, Mycalin A, Antiproliferative Activity, Synthetic Analogues
Affiliations Affiliazioni:
*** IBB - CNR ***
CESTEV, University of Naples Federico II, 80145 Naples, Italy.
Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
Institute of Biostructures and Bioimaging, CNR, 80134 Naples, Italy.
Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
References Riferimenti:
Not available. Non disponibili.
Mar Drugs (ISSN: 1660-3397linking), 2020 Jul 29; 18(8): N/D-N/D.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article
Impact factor: 4.379, 5-year impact factor Impact factor a 5 anni: 4.031
Url: Not available. Non disponibile.
Keywords Parole chiave: A375 And Hela Cell Lines, C15 Acetogenins, Mycalin A, Antiproliferative Activity, Synthetic Analogues
Affiliations Affiliazioni:
*** IBB - CNR ***
CESTEV, University of Naples Federico II, 80145 Naples, Italy.
Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
Institute of Biostructures and Bioimaging, CNR, 80134 Naples, Italy.
Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
References Riferimenti:
Not available. Non disponibili.
Antiproliferative Activity of Mycalin A and Its Analogues on Human Skin Melanoma and Human Cervical Cancer Cells
Mycalin A, a polybrominated C(15) acetogenin isolated from the encrusting sponge Mycale rotalis, displays an antiproliferative activity on human melanoma (A375) and cervical adenocarcinoma (HeLa) cells and induces cell death by an apoptotic mechanism. Various analogues and degraded derivatives of the natural substance have been prepared. A modification of the left-hand part of the molecule generates the most active substances. A structurally simplified lactone derivative of mycalin A, lacking the C1-C3 side chain, is the most active among the synthesized compounds exhibiting a strong cytotoxicity on both A375 and HeLa cells but not but not on human dermal fibroblast (HDF) used as healthy cells. Further evidence on a recently discovered chlorochromateperiodate-catalyzed process, used to oxidise mycalin A, have been collected.
Mycalin A, a polybrominated C(15) acetogenin isolated from the encrusting sponge Mycale rotalis, displays an antiproliferative activity on human melanoma (A375) and cervical adenocarcinoma (HeLa) cells and induces cell death by an apoptotic mechanism. Various analogues and degraded derivatives of the natural substance have been prepared. A modification of the left-hand part of the molecule generates the most active substances. A structurally simplified lactone derivative of mycalin A, lacking the C1-C3 side chain, is the most active among the synthesized compounds exhibiting a strong cytotoxicity on both A375 and HeLa cells but not but not on human dermal fibroblast (HDF) used as healthy cells. Further evidence on a recently discovered chlorochromateperiodate-catalyzed process, used to oxidise mycalin A, have been collected.
Antiproliferative Activity of Mycalin A and Its Analogues on Human Skin Melanoma and Human Cervical Cancer Cells
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Antiproliferative Activity of Mycalin A and Its Analogues on Human Skin Melanoma and Human Cervical Cancer Cells
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Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
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Dettagli Esporta in BibTeX Esporta in EndNote
17 Records (16 escludendo Abstract e Conferenze).
Impact factor totale: 53.883 (50.649 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 44.449 (40.747 escludendo Abstract e Conferenze).
Impact factor totale: 53.883 (50.649 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 44.449 (40.747 escludendo Abstract e Conferenze).
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