Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders(25 views visite) Pepe G, Calce E, Verdoliva V, Saviano M, Maglione V, Di Pardo A, De Luca S
Int J Mol Sci (ISSN: 1422-0067linking), 2020 Nov 23; 21(22): N/D-N/D.
IRCCS Neuromed, 86077 Pozzilli, Italy.
Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy.
Institute of Crystallography, National Research Council, 70126 Bari, Italy.
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Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders
Identification of molecules able to promote neuroprotective mechanisms can represent a promising therapeutic approach to neurodegenerative disorders including Huntington's disease. Curcumin is an antioxidant and neuroprotective agent, even though its efficacy is limited by its poor absorption, rapid metabolism, systemic elimination, and limited blood-brain barrier (BBB) permeability. Herein, we report on novel biodegradable curcumin-containing nanoparticles to favor the compound delivery and potentially enhance its brain bioavailability. The prepared hyaluronan-based materials able to self-assemble in stable spherical nanoparticles, consist of natural fatty acids chemically conjugated to the natural polysaccharide. The aim of this study is to provide a possible effective delivery system for curcumin with the expectation that, after having released the drug at the specific site, the biopolymer can degrade to nontoxic fragments before renal excretion, since all the starting materials are provided by natural resource. Our findings demonstrate that curcumin-encapsulated nanoparticles enter the cells and reduce their susceptibility to apoptosis in an in vitro model of Huntington's disease.
Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders
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Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders
35 Records (34 escludendo Abstract e Conferenze). Impact factor totale: 166.543 (161.529 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 157.18 (151.889 escludendo Abstract e Conferenze).
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