Vitamin D3 deficiency is associated with more severe insulin resistance and metformin use in patients with type 2 diabetes(12 views visite) Aludwan M, Kobyliak N, Abenavoli L, Kyriienko D, Fagoonee S, Pellicano R, Komisarenko I
Keywords Parole chiave: Not available. Non disponibili.
Affiliations Affiliazioni: *** IBB - CNR ***
Department of Endocrinology, Bogomolets National Medical University, Kyiv, Ukraine.
Department of Health Sciences, Magna Graecia University of Catanzaro, Italy.
Department of General Endocrine Pathology, Kyiv City Clinical Endocrinology Center, Kyiv, Ukraine.
Institute of Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center, Turin, Italy.
Unit of Gastroenterology, Molinette Hospital, Città della Salute e della Scienza, Turin, Italy.
References Riferimenti: Not available. Non disponibili.
Vitamin D3 deficiency is associated with more severe insulin resistance and metformin use in patients with type 2 diabetes
BACKGROUND: Vitamin D3 (vit. D3) deficiency is considered as one of the main factors involved in the development of type 2 diabetes (T2D). We assessed insulin resistance (IR), β-cell functional activity and metabolic profile according to 25(OH) vit. D3 status in patients with T2D. METHODS: The study included 109 patients with T2D, divided in 3 groups: group 1 (N.=11) with normal levels of vit. D3 (>
30 ng/mL); group 2 (N.=38) with vit. D3 insufficiency (21-29 ng/mL); and group 3 (N.=60) with vit. D3 deficiency (<20 ng/mL). IR and β-cell functional activity were assessed as change in C-peptide concentration and homeostasis model assessment-estimated (HOMA) β-cell function which was calculated using HOMA2 calculator. RESULTS: Patients with vit. D3 deficiency presented significantly higher C-peptide concentration compared to other groups. HOMA2 (3.29±1.89 vs. 2.12±0.71; P=0.049) and hemoglobin (H8b)A1c (9.11±1.63 vs. 7.75±1.06; P=0.016) levels changed significantly only in patients with vit. D3 deficiency compared to diabetics with normal vit. D3 levels. Furthermore, in univariate Pearson's correlation analysis, we observed significant association between vit. D3 levels and C-peptide, insulin sensitivity, HOMA2, triglyceride-glucose index, HbA1c and Body Mass Index, only in the vit. D3 deficiency group. In multivariate logistic regression analysis, poor glycemic control, as defined by HbA1c levels, was independent from metformin use while high density lipoprotein-cholesterol levels were associated with vit. D3 deficiency. CONCLUSIONS: Our study demonstrated that vit. D3 deficiency in patients with T2D was associated with more severe IR, poor glycemic control and obesity compared to normal status or vit. D3 insufficiency.
Vitamin D3 deficiency is associated with more severe insulin resistance and metformin use in patients with type 2 diabetes
Schutz K, Alecsandru D, Grimbacher B, Haddock J, Bruining A, Driessen G, De Vries E, Van Hagen PM, Hartmann I, Fraioli F, Milito C, Mitrevski M, Quinti I, Serra G, Kelleher P, Loebinger M, Litzman J, Postranecka V, Thon V, Babar J, Condliffe AM, Exley A, Kumararatne D, Screaton N, Jones A, Bondioni MP, Lougaris V, Plebani A, Soresina A, Sirignano C, Spadaro G, Galal N, Gonzalez-granado LI, Dettmer S, Stirling R, Chapel H, Lucas M, Patel S, Farber CM, Meyts I, Banerjee AK, Hackett S, Hurst JR, Warnatz K, Gathmann B, Weidemann J, Berthold D, Baumann U * Correction to: Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group(110 visite) J Clin Immunol (ISSN: 0271-9142linking, 1573-2592), 2019 Feb; 39(2): 225-227. Impact Factor:2.654 DettagliEsporta in BibTeXEsporta in EndNote
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760 Records (589 escludendo Abstract e Conferenze). Impact factor totale: 2763.921 (2154.605 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 2851.209 (2179.016 escludendo Abstract e Conferenze).
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