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Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves (184 visite)

Monfregola L, De Luca S

Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2011 Oct; 41(4): 981-990.



Tipo di articolo: Journal Article,

Impact factor: 3.248, Impact factor a 5 anni: 3.138

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-83255189527&partnerID=40&md5=bdef1a057f6cb9eeca5ece371ebd2f21

Parole chiave: Molecular Sieves, N-Alkylated Amino Acids, N-Alkylation, Peptidomimetics, Alkylate Amino Acid, Halogenoalkane, N Alpha (9 Fluorenylmethoxycarbonyl) N Beta 1 Heptenyl N, Beta 2 Nitrobenzensulfonyl Levo 2, 3 Diaminopropionic Acid, N Alpha (9 Fluorenylmethoxycarbonyl) N Beta 2 Phenylethyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Beta 3 Phenylpropyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Beta Benzyl N, Beta Methylthrityl Levo 2, Beta Tert Butoxycarbonyl Levo 2, N Alpha (9 Fluorenylmethoxycarbonyl) N Beta Diphenylmethyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Beta Ethyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Beta Methyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Beta Naphthylmethyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Beta Propyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Beta Tert Butylacetyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Delta Benzyl N, Delta 2 Nitrobenzensulfonyl Levo Ornithine, N Alpha (9 Fluorenylmethoxycarbonyl) N Epsilon 2 Phenylethyl N, Epsilon 2 Nitrobenzensulfonyl Levo Lysine, N Alpha (9 Fluorenylmethoxycarbonyl) N Epsilon 3 Phenylethyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Epsilon Benzyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Epsilon Diphenylmethyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Epsilon Ethyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Epsilon Methyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Epsilon Naphthylmethyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Epsilon Propyl N, N Alpha (9 Fluorenylmethoxycarbonyl) N Epsilon Tert Butylacetyl N, N Alpha [9 Fluorenylmethoxycarbonyl] N Beta Benzyl N, 4 Diemthyl 2, 6 Dioxocycloex 1 Ylidene) 3 Methylbutyl Levo 2, Unclassified Drug, Amino Acid Sequence, Article, Chemical Structure, Mass Spectrometry, Nuclear Magnetic Resonance Spectroscopy, Particle Size, Priority Journal, Protein Synthesis,

Affiliazioni:

*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Research Council, 80138 Naples, Italy



Riferimenti:

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A new synthetic strategy to alkylate amino groups under mild conditions has been developed. It utilizes only 4 angstrom molecular sieves as base in order to promote the N-alkylation reaction, in presence of the appropriate alkyl halide. The methodology was validated by the simple and efficient side-chain N-alkylation of o-Ns-protected Fmoc-amino acid. One of them was introduced as building block into a peptide sequence, thus allowing the preparation of site-specific alkylated peptide molecules.
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Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
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13 Records (13 escludendo Abstract e Conferenze).
Impact factor totale: 62.937 (62.937 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 65.107 (65.107 escludendo Abstract e Conferenze).







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