The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves (247 visite)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(3): 570-579.
Tipo di articolo: Journal Article,
Impact factor: 3.825, Impact factor a 5 anni: 3.986
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77249119672&partnerID=40&md5=8fcd68b535285d6303ddc8022ccfb8ac
Parole chiave: Adenine, Isoprotein, Polysaccharide, Recombinant Protein, Ribosome Inactivating Protein 1, Synthetic Dna, Vegetable Protein, Animal, Article, Cell Strain 3t3, Chemical Structure, Chemistry, Circular Dichroism, Genetics, Glycosylation, Ion Exchange Chromatography, Mass Spectrometry, Metabolism, Mouse, Plant Leaf, Pokeweed, Spectrofluorometry, Structure Activity Relation, Temperature, Models, Molecular, Nih 3t3 Cells, Phytolacca, Plant Leaves, Plant Proteins, Protein Isoforms, Type 1, Fluorescence, Structure-Activity Relationship, Phytolacca Dioica, Phytolaccaceae,
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze della Vita, Seconda Università di Napoli, Via Vivaldi 43, I-81100 Caserta, Italy
Dipartimento Delle Scienze Biologiche, Sez. Biostrutture, Università Degli Studi di Napoli Federico II, Via Mezzocannone 16, I-80134 Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, I-80134 Napoli, Italy
Dipartimento di Biologia di Base Ed Applicata, Università Degli Studi di l'Aquila, Via Vetoio, I-67010 Coppito, Italy
Riferimenti:
Barbieri, L., Battelli, M.G., Stirpe, F., (1993) Biochim. Biophys. Acta, 1154, pp. 237-28
Stirpe, F., Gasperi-Campani, A., Barbieri, L., Falasca, A., Abbondanza, A., Stevens, W.A., (1983) Biochem. J., 216, pp. 617-625
Stirpe, F., Bailey, S., Miller, S.P., Bodley, J.W., (1988) Nucleic Acids Res., 16, pp. 1349-1357
Endo, Y., Tsurugi, K., Lambert, J.M., (1988) Biochem. Biophys. Res. Commun., 150, pp. 1032-1036
Walsh, T.A., Morgan, A.E., Hey, T.D., (1991) J. Biol. Chem., 266, pp. 23422-23427
Reinbothe, S., Reinbothe, C., Lehmann, J., Becker, W., Apel, K., Parthier, B., (1994) Proc. Natl. Acad. Sci. U. S. A., 91, pp. 7012-7016
Peumans, W.J., Hao, Q., Van Damme, E.J., (2001) FASEB J., 15, pp. 1493-1506
Bolognesi, A., Polito, L., Lubelli, C., Barbieri, L., Parente, A., Stirpe, F., (2002) J. Biol. Chem., 277, pp. 13709-13716
Barbieri, L., Valbonesi, P., Bonora, E., Gorini, P., Bolognesi, A., Stirpe, F., (1997) Nucleic Acids Res., 25, pp. 518-522
Di Maro, A., Valbonesi, P., Bolognesi, A., Stirpe, F., De Luca, P., Siniscalco Gigliano, G., Gaudio, L., Parente, A., (1999) Planta, 208, pp. 125-131
Di Maro, A., Chambery, A., Carafa, V., Costantini, S., Colonna, G., Parente, A., (2009) Biochimie, 91, pp. 352-363
Chambery, A., Di Maro, A., Parente, A., (2008) Phytochemistry, 69, pp. 1973-1982
Chambery, A., Pisante, M., Di Maro, A., Di Zazzo, E., Ruvo, M., Costantini, S., Colonna, G., Parente, A., (2007) Proteins: Struct., Funct., Bioinf., 67, pp. 209-218
Ruggiero, A., Di Maro, A., Severino, V., Chambery, A., Berisio, R., (2009) Biopolymers, 91, pp. 1135-1142
Minor, W., Tomchick, D., Otwinowski, Z., (2000) Structure, 8, pp. 105-110
Potterton, E., Briggs, P., Turkenburg, M., Dodson, E., (2003) Acta Crystallogr., Sect. D: Biol. Crystallogr., 59, pp. 1131-1137
Murshudov, G.N., Vagin, A.A., Dodson, E.J., (1997) Acta Crystallogr., Sect. D: Biol. Crystallogr., 53, pp. 240-255
Morris, R.J., Perrakis, A., Lamzin, V.S., (2003) Methods Enzymol., 374, pp. 229-244
Ferrige, A.G., Seddon, M.J., Green, B.N., Jarvis, S.A., Skilling, J., (1992) Rapid Commun. Mass Spectrom., 6, pp. 707-711
Shental-Bechor, D., Levy, Y., (2008) Proc. Natl. Acad. Sci. U. S. A., 105, pp. 8256-8261
Ruggiero, A., Chambery, A., Di Maro, A., Parente, A., Berisio, R., (2008) Proteins: Struct., Funct., Bioinf., 71, pp. 8-15
Roberts, L.M., Lord, J.M., (2004) Mini Rev Med Chem, 4, pp. 505-512
Rayon, C., Lerouge, P., Faye, L., (1998) J. Exp. Bot., 49, pp. 1463-1472
Ceriotti, A., Duranti, M., Bollini, R., (1998) J. Exp. Bot., 49, pp. 1091-1103
Helenius, A., Aebi, M., (2001) Science, 291, pp. 2364-2369
O'Hare, M., Roberts, L.M., Thorpe, P.E., Watson, G.J., Prior, B., Lord, J.M., (1987) FEBS Lett., 216, pp. 73-78
Hou, X., Chen, M., Chen, L., Meehan, E.J., Xie, J., Huang, M., (2007) BMC Struct. Biol., 7, p. 29
Hou, X., Meehan, E.J., Xie, J., Huang, M., Chen, M., Chen, L., (2008) J. Struct. Biol., 164, pp. 81-87
Daubenfeld, T., Hossann, M., Trommer, W.E., Niedner-Schatteburg, G., (2005) Biochem. Biophys. Res. Commun., 333, pp. 984-989
Zhai, X., Malakhova, M.L., Pike, H.M., Benson, L.M., Bergen III, H.R., Sugar, I.P., Malinina, L., Brown, R.E., (2009) J. Biol. Chem., 284, pp. 13620-13628
Hebert, E., Monsigny, M., (1994) Biol. Cell, 81, pp. 73-76
Kawakami, S., Sato, A., Nishikawa, M., Yamashita, F., Hashida, M., (2000) Gene Ther., 7, pp. 292-299
Colaco, M., Misquith, S., Bapat, M.M., Wattiaux-De Coninck, S., Wattiaux, R., (2004) Biochem. Biophys. Res. Commun., 319, pp. 1299-1306
Stirpe, F., Barbieri, L., Battelli, M.G., Soria, M., Lappi, D.A., (1992) Bio/Technology, 10, pp. 405-412
Selbo, P.K., Sandvig, K., Kirveliene, V., Berg, K., (2000) Biochim. Biophys. Acta, Gen. Subj., 1475, pp. 307-313
Colaco, M., Bapat, M.M., Misquith, S., Jadot, M., Wattiaux-De Coninck, S., Wattiaux, R., (2002) Biochem. Biophys. Res. Commun., 296, pp. 1180-1185
Cavallaro, U., Nykjaer, A., Nielsen, M., Soria, M.R., (1995) Eur. J. Biochem., 232, pp. 165-171
Ippoliti, R., Lendaro, E., Benedetti, P.A., Torrisi, M.R., Belleudi, F., Carpani, D., Soria, M.R., Fabbrini, M.S., (2000) FASEB J., 14, pp. 1335-1344
Vago, R., Marsden, C.J., Lord, J.M., Ippoliti, R., Flavell, D.J., Flavell, S.U., Ceriotti, A., Fabbrini, M.S., (2005) FEBS J., 272, pp. 4983-4995
Moisenovich, M., Tonevitsky, A., Agapov, I., Niwa, H., Schewe, H., Bereiter-Hahn, J., (2002) Eur. J. Cell Biol., 81, pp. 529-538
Walsh, T. A., Morgan, A. E., Hey, T. D., (1991) J. Biol. Chem., 266, pp. 23422-23427
Peumans, W. J., Hao, Q., Van Damme, E. J., (2001) FASEB J., 15, pp. 1493-1506
Murshudov, G. N., Vagin, A. A., Dodson, E. J., (1997) Acta Crystallogr., Sect. D: Biol. Crystallogr., 53, pp. 240-255
Morris, R. J., Perrakis, A., Lamzin, V. S., (2003) Methods Enzymol., 374, pp. 229-244
Ferrige, A. G., Seddon, M. J., Green, B. N., Jarvis, S. A., Skilling, J., (1992) Rapid Commun. Mass Spectrom., 6, pp. 707-711
Roberts, L. M., Lord, J. M., (2004) Mini Rev Med Chem, 4, pp. 505-512
Hou, X., Meehan, E. J., Xie, J., Huang, M., Chen, M., Chen, L., (2008) J. Struct. Biol., 164, pp. 81-87
Selbo, P. K., Sandvig, K., Kirveliene, V., Berg, K., (2000) Biochim. Biophys. Acta, Gen. Subj., 1475, pp. 307-313
Mol Biosyst (ISSN: 1742-206x), 2010; 6(3): 570-579.
Tipo di articolo: Journal Article,
Impact factor: 3.825, Impact factor a 5 anni: 3.986
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77249119672&partnerID=40&md5=8fcd68b535285d6303ddc8022ccfb8ac
Parole chiave: Adenine, Isoprotein, Polysaccharide, Recombinant Protein, Ribosome Inactivating Protein 1, Synthetic Dna, Vegetable Protein, Animal, Article, Cell Strain 3t3, Chemical Structure, Chemistry, Circular Dichroism, Genetics, Glycosylation, Ion Exchange Chromatography, Mass Spectrometry, Metabolism, Mouse, Plant Leaf, Pokeweed, Spectrofluorometry, Structure Activity Relation, Temperature, Models, Molecular, Nih 3t3 Cells, Phytolacca, Plant Leaves, Plant Proteins, Protein Isoforms, Type 1, Fluorescence, Structure-Activity Relationship, Phytolacca Dioica, Phytolaccaceae,
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze della Vita, Seconda Università di Napoli, Via Vivaldi 43, I-81100 Caserta, Italy
Dipartimento Delle Scienze Biologiche, Sez. Biostrutture, Università Degli Studi di Napoli Federico II, Via Mezzocannone 16, I-80134 Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, I-80134 Napoli, Italy
Dipartimento di Biologia di Base Ed Applicata, Università Degli Studi di l'Aquila, Via Vetoio, I-67010 Coppito, Italy
Riferimenti:
Barbieri, L., Battelli, M.G., Stirpe, F., (1993) Biochim. Biophys. Acta, 1154, pp. 237-28
Stirpe, F., Gasperi-Campani, A., Barbieri, L., Falasca, A., Abbondanza, A., Stevens, W.A., (1983) Biochem. J., 216, pp. 617-625
Stirpe, F., Bailey, S., Miller, S.P., Bodley, J.W., (1988) Nucleic Acids Res., 16, pp. 1349-1357
Endo, Y., Tsurugi, K., Lambert, J.M., (1988) Biochem. Biophys. Res. Commun., 150, pp. 1032-1036
Walsh, T.A., Morgan, A.E., Hey, T.D., (1991) J. Biol. Chem., 266, pp. 23422-23427
Reinbothe, S., Reinbothe, C., Lehmann, J., Becker, W., Apel, K., Parthier, B., (1994) Proc. Natl. Acad. Sci. U. S. A., 91, pp. 7012-7016
Peumans, W.J., Hao, Q., Van Damme, E.J., (2001) FASEB J., 15, pp. 1493-1506
Bolognesi, A., Polito, L., Lubelli, C., Barbieri, L., Parente, A., Stirpe, F., (2002) J. Biol. Chem., 277, pp. 13709-13716
Barbieri, L., Valbonesi, P., Bonora, E., Gorini, P., Bolognesi, A., Stirpe, F., (1997) Nucleic Acids Res., 25, pp. 518-522
Di Maro, A., Valbonesi, P., Bolognesi, A., Stirpe, F., De Luca, P., Siniscalco Gigliano, G., Gaudio, L., Parente, A., (1999) Planta, 208, pp. 125-131
Di Maro, A., Chambery, A., Carafa, V., Costantini, S., Colonna, G., Parente, A., (2009) Biochimie, 91, pp. 352-363
Chambery, A., Di Maro, A., Parente, A., (2008) Phytochemistry, 69, pp. 1973-1982
Chambery, A., Pisante, M., Di Maro, A., Di Zazzo, E., Ruvo, M., Costantini, S., Colonna, G., Parente, A., (2007) Proteins: Struct., Funct., Bioinf., 67, pp. 209-218
Ruggiero, A., Di Maro, A., Severino, V., Chambery, A., Berisio, R., (2009) Biopolymers, 91, pp. 1135-1142
Minor, W., Tomchick, D., Otwinowski, Z., (2000) Structure, 8, pp. 105-110
Potterton, E., Briggs, P., Turkenburg, M., Dodson, E., (2003) Acta Crystallogr., Sect. D: Biol. Crystallogr., 59, pp. 1131-1137
Murshudov, G.N., Vagin, A.A., Dodson, E.J., (1997) Acta Crystallogr., Sect. D: Biol. Crystallogr., 53, pp. 240-255
Morris, R.J., Perrakis, A., Lamzin, V.S., (2003) Methods Enzymol., 374, pp. 229-244
Ferrige, A.G., Seddon, M.J., Green, B.N., Jarvis, S.A., Skilling, J., (1992) Rapid Commun. Mass Spectrom., 6, pp. 707-711
Shental-Bechor, D., Levy, Y., (2008) Proc. Natl. Acad. Sci. U. S. A., 105, pp. 8256-8261
Ruggiero, A., Chambery, A., Di Maro, A., Parente, A., Berisio, R., (2008) Proteins: Struct., Funct., Bioinf., 71, pp. 8-15
Roberts, L.M., Lord, J.M., (2004) Mini Rev Med Chem, 4, pp. 505-512
Rayon, C., Lerouge, P., Faye, L., (1998) J. Exp. Bot., 49, pp. 1463-1472
Ceriotti, A., Duranti, M., Bollini, R., (1998) J. Exp. Bot., 49, pp. 1091-1103
Helenius, A., Aebi, M., (2001) Science, 291, pp. 2364-2369
O'Hare, M., Roberts, L.M., Thorpe, P.E., Watson, G.J., Prior, B., Lord, J.M., (1987) FEBS Lett., 216, pp. 73-78
Hou, X., Chen, M., Chen, L., Meehan, E.J., Xie, J., Huang, M., (2007) BMC Struct. Biol., 7, p. 29
Hou, X., Meehan, E.J., Xie, J., Huang, M., Chen, M., Chen, L., (2008) J. Struct. Biol., 164, pp. 81-87
Daubenfeld, T., Hossann, M., Trommer, W.E., Niedner-Schatteburg, G., (2005) Biochem. Biophys. Res. Commun., 333, pp. 984-989
Zhai, X., Malakhova, M.L., Pike, H.M., Benson, L.M., Bergen III, H.R., Sugar, I.P., Malinina, L., Brown, R.E., (2009) J. Biol. Chem., 284, pp. 13620-13628
Hebert, E., Monsigny, M., (1994) Biol. Cell, 81, pp. 73-76
Kawakami, S., Sato, A., Nishikawa, M., Yamashita, F., Hashida, M., (2000) Gene Ther., 7, pp. 292-299
Colaco, M., Misquith, S., Bapat, M.M., Wattiaux-De Coninck, S., Wattiaux, R., (2004) Biochem. Biophys. Res. Commun., 319, pp. 1299-1306
Stirpe, F., Barbieri, L., Battelli, M.G., Soria, M., Lappi, D.A., (1992) Bio/Technology, 10, pp. 405-412
Selbo, P.K., Sandvig, K., Kirveliene, V., Berg, K., (2000) Biochim. Biophys. Acta, Gen. Subj., 1475, pp. 307-313
Colaco, M., Bapat, M.M., Misquith, S., Jadot, M., Wattiaux-De Coninck, S., Wattiaux, R., (2002) Biochem. Biophys. Res. Commun., 296, pp. 1180-1185
Cavallaro, U., Nykjaer, A., Nielsen, M., Soria, M.R., (1995) Eur. J. Biochem., 232, pp. 165-171
Ippoliti, R., Lendaro, E., Benedetti, P.A., Torrisi, M.R., Belleudi, F., Carpani, D., Soria, M.R., Fabbrini, M.S., (2000) FASEB J., 14, pp. 1335-1344
Vago, R., Marsden, C.J., Lord, J.M., Ippoliti, R., Flavell, D.J., Flavell, S.U., Ceriotti, A., Fabbrini, M.S., (2005) FEBS J., 272, pp. 4983-4995
Moisenovich, M., Tonevitsky, A., Agapov, I., Niwa, H., Schewe, H., Bereiter-Hahn, J., (2002) Eur. J. Cell Biol., 81, pp. 529-538
Walsh, T. A., Morgan, A. E., Hey, T. D., (1991) J. Biol. Chem., 266, pp. 23422-23427
Peumans, W. J., Hao, Q., Van Damme, E. J., (2001) FASEB J., 15, pp. 1493-1506
Murshudov, G. N., Vagin, A. A., Dodson, E. J., (1997) Acta Crystallogr., Sect. D: Biol. Crystallogr., 53, pp. 240-255
Morris, R. J., Perrakis, A., Lamzin, V. S., (2003) Methods Enzymol., 374, pp. 229-244
Ferrige, A. G., Seddon, M. J., Green, B. N., Jarvis, S. A., Skilling, J., (1992) Rapid Commun. Mass Spectrom., 6, pp. 707-711
Roberts, L. M., Lord, J. M., (2004) Mini Rev Med Chem, 4, pp. 505-512
Hou, X., Meehan, E. J., Xie, J., Huang, M., Chen, M., Chen, L., (2008) J. Struct. Biol., 164, pp. 81-87
Selbo, P. K., Sandvig, K., Kirveliene, V., Berg, K., (2000) Biochim. Biophys. Acta, Gen. Subj., 1475, pp. 307-313
N-glycosylation is one of the major naturally occurring covalent co-translational modifications of proteins in plants, being involved in proteins structure, folding, stability and biological activity. In the present work the influence of carbohydrate moieties on the structure-function relationships of type 1 ribosome-inactivating proteins (RIPs) was investigated. To this aim, PD-Ls, RIPs isolated from Phytolacca dioica L. leaves, differing for their glycosylation degree, were used as an experimental system. In particular, comparative structural and biological analyses were performed using native and unglycosylated recombinant PD-L1, the most glycosylated P. dioica RIP isoform. The glycans influence on protein synthesis inhibition and adenine polynucleotide glycosidase activity was investigated. The interaction with adenine, the product of the de-adenylation reaction, was also investigated for native and recombinant PD-L1 by fluorescence spectroscopy. Furthermore, the crystal structure of PD-L1 in complex with adenine was determined. Our data confirm that the absence of glycan moieties did not affect the biological activity in terms of protein synthesis inhibition. However, the removal of carbohydrate chains significantly increased the deadenylation capability, likely as a consequence of the increased accessibility of substrates to the active site pocket. Furthermore, preliminary data on cellular uptake showed that all PD-L isoforms were internalized and, for the first time, that the vesicular distribution within cells could be influenced by the protein glycosylation degree. © 2010 The Royal Society of Chemistry.
| ▼ Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools |
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Molinaro A, Holst O, Lorenzo FD, Callaghan M, Nurisso A, D'Errico G, Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín-Santamarí S
* Chemistry of lipid a: At the heart of innate immunity (314 visite) (PDF 248 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 7; 21(2): 500-519.
Impact Factor: 5.771
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Speciale I, Paciello I, Fazio LL, Sturiale L, Palmigiano A, Lanzetta R, Parrilli M, Garozzo D, Lemaitre B, Bernardini ML, Molinaro A, De Castro C
* Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties (208 visite)
Carbohyd Res (ISSN: 0008-6215), 2015; 412: 20-27.
Impact Factor: 1.817
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Kim JK, Son DW, Kim C-H, Cho JH, Marchetti R, Silipo A, Sturiale L, Park HY, Huh YR, Nakayama H, Fukatsu T, Molinaro A, Lee BL
* Insect gut symbiont susceptibility to host antimicrobial peptides caused by alteration of the bacterial cell envelope (384 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2015; 290(34): 21042-21053.
Impact Factor: 4.258
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Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (218 visite)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (326 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Calce E, Mignogna E, Bugatti V, Galdiero M, Vittoria V, De Luca S
* Pectin functionalized with natural fatty acids as antimicrobial agent (226 visite)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2014 Jul; 68: 28-32.
Impact Factor: 2.858
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Avitabile C, D'Andrea LD, Romanelli A
* Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells (319 visite)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2014 Mar 12; 4: 4293-4293.
Impact Factor: 5.578
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Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (266 visite)
Pharmacol Therapeut (ISSN: 0163-7258), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
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D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
* Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis (272 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Feb; 97(1): 114-120.
Impact Factor: 2.963
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Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
* Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (253 visite)
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504.
Impact Factor: 2.332
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Lin L-L, Chen Y-Y, Chi M-C, Merlino A
* Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion (193 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014; 1844(9): 1523-1529.
Impact Factor: 4.882
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Contursi P, Farina B, Pirone L, Fusco S, Russo L, Bartolucci S, Fattorusso R, Pedone E
* Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family (192 visite)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962), 2014; 42(9): 5993-6011.
Impact Factor: 9.112
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Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (224 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013 Nov 13; 8(11): e79455-e79455.
Impact Factor: 3.534
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Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E
* A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABA(B2) receptor (200 visite)
Journal Of Molecular Recognition (ISSN: 0952-3499, 0952-2349), 2013 Oct; 26(10): 488-495.
Impact Factor: 2.337
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Del Giudice I, Limauro D, Pedone E, Bartolucci S, Fiorentino G
* A novel arsenate reductase from the bacterium Thermus thermophilus HB27: Its role in arsenic detoxification (243 visite)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Oct; 1834(10): 2071-2079.
Impact Factor: 3.191
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Squeglia F, Bachert B, Romanò MF, Lukomski S, Berisio R
* Crystallization and preliminary X-ray crystallographic analysis of the variable domain of Scl2. 3, a streptococcal collagen-like protein from invasive M3-type Streptococcus pyogenes (194 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2013 Sep; 69(9): 1023-1025.
Impact Factor: 0.568
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Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (235 visite)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Sep; 69(Pt9): 1697-1706.
Impact Factor: 7.232
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Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
* Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (209 visite)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 0925-4439), 2013 Jun; 1830(6): 3767-3775.
Impact Factor: 3.829
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Monti SM, De Simone G, Dathan NA, Ludwig M, Vullo D, Scozzafava A, Capasso C, Supuran CT
* Kinetic And Anion Inhibition Studies Of A Beta-Carbonic Anhydrase (fbica 1) From The C-4 Plant Flaveria Bidentis (277 visite)
Bioorg Med Chem Lett (ISSN: 0960-894x), 2013 Mar 15; 23(6): 1626-1630.
Impact Factor: 2.331
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Correale S, Ruggiero A, Pedone E, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the l, d-transpeptidase LdtMt1 from Mycobacterium tuberculosis (232 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2013 Mar 1; 69(3): 253-256.
Impact Factor: 0.568
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (260 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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De Rosa L, Russomanno A, Romanelli A, D'Andrea LD
* Semi-Synthesis of Labeled Proteins for Spectroscopic Applications (226 visite)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2013 Jan; 18(1): 440-465.
Impact Factor: 2.095
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Pannuzzo M, Raudino A, Milardi D, La Rosa C, Karttunen M
* α-Helical structures drive early stages of self-assembly of amyloidogenic amyloid polypeptide aggregate formation in membranes (272 visite)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2013; 3: N/D-N/D.
Impact Factor: 5.078
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (229 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (316 visite)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (218 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (219 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
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Tamburino R, Severino V, Sandomenico A, Ruvo M, Parente A, Chambery A, Di Maro A
* De novo sequencing and characterization of a novel Bowman-Birk inhibitor from Lathyrus sativus L. seeds by electrospray mass spectrometry (220 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051linking, 1742-2051electronic), 2012 Oct 30; 8(12): 3232-3241.
Impact Factor: 3.35
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Berisio R
* Editorial: cell processes in bacterial diseases (226 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
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Di Maro A, Berisio R, Ruggiero A, Tamburino R, Severino V, Zacchia E, Parente A
* Structural and enzymatic properties of an in vivo proteolytic form of PD-S2, type 1 ribosome-inactivating protein from seeds of Phytolacca dioica (199 visite)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 May 11; 421(3): 514-520.
Impact Factor: 2.406
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Ascione G, de Pascale D, De Santi C, Pedone C, Dathan NA, Monti SM
* Native expression and purification of hormone-sensitive lipase from Psychrobacter sp. TA144 enhances protein stability and activity (326 visite)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2012 Apr 13; 420(3): 542-546.
Impact Factor: 2.406
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Balsamo A, Sannino F, Merlino A, Parrilli E, Tutino ML, Mazzarella L, Vergara A
* Role of the tertiary and quaternary structure in the formation of bis-histidyl adducts in cold-adapted hemoglobins (187 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 Apr; 94(4): 953-960.
Impact Factor: 3.142
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (223 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (208 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
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La Mendola D, Farkas D, Bellia F, Magri A, Travaglia A, Hansson O, Rizzarelli E
* Probing the copper(II) binding features of angiogenin. Similarities and differences between a N-terminus peptide fragment and the recombinant human protein (217 visite)
Inorg Chem (ISSN: 1520-510x, 0020-1669, 1520-510xelectronic), 2012 Jan 2; 51(1): 128-141.
Impact Factor: 4.593
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Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (262 visite)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
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Scognamiglio PL, Doti N, Grieco P, Pedone C, Ruvo M, Marasco D
* Discovery Of Small Peptide Antagonists Of Ped/Pea15-D4alpha Interaction From Simplified Combinatorial Libraries (292 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2011 May; 77(5): 319-327.
Impact Factor: 2.282
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Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (264 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
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Contursi P, D'Ambrosio K, Pirone L, Pedone E, Aucelli T, She Q, De Simone G, Bartolucci S
* C68 from the Sulfolobus islandicus plasmid-virus pSSVx is a novel member of the AbrB-like transcription factor family (286 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2011 Apr 1; 435(1): 157-166.
Impact Factor: 4.897
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Ruggiero A, Squeglia F, Marasco D, Marchetti R, Molinaro A, Berisio R
* X-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureus (193 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2011 Apr 1; 435(1): 33-41.
Impact Factor: 4.897
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Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
* Molecular organization of the cullin E3 ligase adaptor KCTD11 (254 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
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Castellano I, Di Salle A, Merlino A, Rossi M, La Cara F
* Gene cloning and protein expression of γ-glutamyltranspeptidases from Thermus thermophilus and Deinococcus radiodurans: Comparison of molecular and structural properties with mesophilic counterparts (186 visite)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2011; 15(2): 259-270.
Impact Factor: 2.941
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Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G
* Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (198 visite)
Nucleic Acids Res (ISSN: 1362-4962, 0305-1048, 1362-4962electronic), 2010 Dec; 38(22): 8239-8256.
Impact Factor: 7.836
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Esposito G, Imperato MR, Ieno L, Sorvillo R, Benigno V, Parenti G, Parini R, Vitagliano L, Zagari A, Salvatore F
* Hereditary Fructose Intolerance: Functional Study of Two Novel ALDOB Natural Variants and Characterization of a Partial Gene Deletion (235 visite)
Hum Mutat (ISSN: 1059-7794, 1098-1004, 1098-1004electronic), 2010 Dec; 31(12): 1294-1303.
Impact Factor: 5.956
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (245 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (261 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
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Alterio V, Aurilia V, Romanelli A, Parracino A, Saviano M, D'Auria S, De Simone G
* Crystal structure of an S-formylglutathione hydrolase from pseudoalteromonas haloplanktis TAC125 (191 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Sep; 93(8): 669-677.
Impact Factor: 2.572
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Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (289 visite)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Impact Factor: 4.672
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (318 visite)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
* Cell recruitment and transfection in gene activated collagen matrix (205 visite)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
Impact Factor: 7.883
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Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis (188 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2010 Jan; 17(1): 70-73.
Impact Factor: 1.849
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (192 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* VEGFR1(D2) in drug discovery: Expression and molecular characterization (203 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010; 94(6): 800-809.
Impact Factor: 2.572
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Di Maro A, Severino V, Chambery A, Berisio R
* Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage (264 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1135-1142.
Impact Factor: 2.605
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Merlino A, Russo Krauss I, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F
* Toward an Antitumor Form of Bovine Pancreatic Ribonuclease: The Crystal Structure of Three Noncovalent Dimeric Mutants (233 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1029-1037.
Impact Factor: 2.605
Dettagli Esporta in BibTeX Esporta in EndNote
Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G
* Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (303 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Sep 22; 106(38): 16233-16238.
Impact Factor: 9.432
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Pennacchio A, Esposito L, Zagari A, Rossi M, Raia CA
* Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase (189 visite)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2009 Sep; 13(5): 751-761.
Impact Factor: 2
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De Simone G, Scozzafava A, Supuran CT
* Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates? (174 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2009 Sep; 74(3): 317-321.
Impact Factor: 2.473
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Ruggiero A, Lanzotti MA, Ruocco MR, Grimaldi P, Marasco D, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of two dimeric hyperthermostable thioredoxins isolated from Sulfolobus solfataricus (210 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2009 Jun; 65: 604-607.
Impact Factor: 0.551
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (287 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (205 visite)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (274 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
Dettagli Esporta in BibTeX Esporta in EndNote
Grimaldi P, Ruocco MR, Lanzotti MA, Ruggiero A, Ruggiero I, Arcari P, Vitagliano L, Masullo M
* Characterisation of the components of the thioredoxin system in the archaeon Sulfolobus solfataricus (235 visite)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2008 Jul; 12(4): 553-562.
Impact Factor: 1.782
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Grasso G, Rizzarelli E, Spoto G
* How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin (210 visite)
Bba-Gen Subjects (ISSN: 0006-3002, 1570-9639, 0925-4439), 2008 Jul; 1784(7-8): 1122-1126.
Impact Factor: 2.233
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Limauro D, Pedone E, Galdi I, Bartolucci S
* Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4 (212 visite)
Febs Journal (ISSN: 1742-464x), 2008 May; 275(9): 2067-2077.
Impact Factor: 3.139
Dettagli Esporta in BibTeX Esporta in EndNote
D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II (247 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Mar; 3(3): 473-477.
Impact Factor: 3.15
Dettagli Esporta in BibTeX Esporta in EndNote
Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F
* The buried diversity of bovine seminal ribonuclease: Shape and cytotoxicity of the swapped non-covalent form of the enzyme (227 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2008 Feb 15; 376(2): 427-437.
Impact Factor: 4.146
Dettagli Esporta in BibTeX Esporta in EndNote
Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R
* The role of insulin receptors and IGF-I receptors in cancer and other diseases (1249 visite)
Archives Of Physiology And Biochemistry (ISSN: 1381-3455), 2008 Feb; 114(1): 23-37.
Impact Factor: 2.028
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (224 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (398 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Chambery A, Di Maro A, Mastroianni A, Parente A, Berisio R
* Crystallization and preliminary X-ray diffraction analysis of PD-L1, a highly glycosylated ribosome inactivating protein with DNase activity (184 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2007; 14(4): 407-409.
Impact Factor: 1.097
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Chambery A, Di Maro A, Pisante M, Parente A, Berisio R
* Crystallization and preliminary x-ray diffraction analysis of PD-L4, a ribosome inactivating protein from Phytolacca dioica L. leaves (243 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2007; 14(1): 97-100.
Impact Factor: 1.097
Dettagli Esporta in BibTeX Esporta in EndNote
Saporito A, Marasco D, Chambery A, Botti P, Monti SM, Pedone C, Ruvo M
* The chemical synthesis of the GstI protein by NCL on a X-Met site (302 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Dec 5; 83(5): 508-518.
Impact Factor: 2.48
Dettagli Esporta in BibTeX Esporta in EndNote
Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (216 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
Dettagli Esporta in BibTeX Esporta in EndNote
Granata V, Palladino P, Tizzano B, Negro A, Berisio R, Zagari A
* The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH (206 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Jun 15; 82(3): 234-240.
Impact Factor: 2.48
Dettagli Esporta in BibTeX Esporta in EndNote
Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
* Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (292 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 15; 62(3): 604-616.
Impact Factor: 3.73
Dettagli Esporta in BibTeX Esporta in EndNote
Limauro D, Pedone E, Pirone L, Bartolucci S
* Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (173 visite)
Febs Journal (ISSN: 1742-464x), 2006 Feb; 273(4): 721-731.
Impact Factor: 3.033
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Masullo M, Arcari P, Raimo G, Vitagliano L, Zagari A
* Crystallization And Preliminary X-Ray Crystallographic Analysis Of The Sulfolobus Solfataricus Nucleotide-Exchange Factor 1 Beta (216 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Nov; 61(11): 1000-1002.
Impact Factor: 0.568
Dettagli Esporta in BibTeX Esporta in EndNote
D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (300 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Ruocco MR, Grimaldi P, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of Sulfolobus solfataricus thioredoxin reductase (207 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Oct; 61: 906-909.
Impact Factor: 0.568
Dettagli Esporta in BibTeX Esporta in EndNote
Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (272 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
Dettagli Esporta in BibTeX Esporta in EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (231 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (202 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
Dettagli Esporta in BibTeX Esporta in EndNote
Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (271 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
Dettagli Esporta in BibTeX Esporta in EndNote
D'Ambrosio K, De Simone G, Pedone E, Rossi M, Bartolucci S, Pedone C
* Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase from Aeropyrum pernix K1 (212 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Mar 1; 61(3): 335-336.
Impact Factor: 0.568
Dettagli Esporta in BibTeX Esporta in EndNote
Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (274 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
Dettagli Esporta in BibTeX Esporta in EndNote
Rivieccio V, Mannini R, Concilio L, D'Auria S, Pedone C, Grimaldi G
* Expression, purification and partial characterization of the Krüppel-associated box (KRAB) from the human ZNF2 protein (169 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2005; 12(6): 527-532.
Impact Factor: 0.84
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (356 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Zannetti A, Caracó C, Del Vecchio S, Salvatore M
* Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (328 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004; 31(4): 521-527.
Impact Factor: 3.935
Dettagli Esporta in BibTeX Esporta in EndNote
Sorrentino N, De Simone G, Menchise V, Mandrich L, Rossi M, Manco G, Pedone C
* Crystallization and preliminary X-ray diffraction studies of Aes acetyl-esterase from Escherichia coli (193 visite)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2003 Oct; 59(10): 1846-1848.
Impact Factor: 2.208
Dettagli Esporta in BibTeX Esporta in EndNote
D'Auria G, Flores G, Falcigno L, Oliva R, Vacatello M, Corsaro MM, Parrilli M, Paolillo L
* Hyaluronate tetrasaccharide-Cu(II) interaction: A NMR study (199 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Oct; 70(2): 260-269.
Impact Factor: 2.733
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (253 visite)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
Dettagli Esporta in BibTeX Esporta in EndNote
Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (251 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
Dettagli Esporta in BibTeX Esporta in EndNote
Biondi B, Palmieri EA, Pagano L, Klain M, Scherillo G, Salvatore M, Fenzi G, Lombardi G, Fazio S
* Cardiovascular safety of acute recombinant human thyrotropin administration to patients monitored for differentiated thyroid cancer (247 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Jan; 88(1): 211-214.
Impact Factor: 5.873
Dettagli Esporta in BibTeX Esporta in EndNote
Esposito G, Vitagliano L, Santamaria R, Viola A, Zagari A, Salvatore F
* Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance (198 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2002 Nov 6; 531(2): 152-156.
Impact Factor: 3.912
Dettagli Esporta in BibTeX Esporta in EndNote
Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (211 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
Dettagli Esporta in BibTeX Esporta in EndNote
Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (225 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.
Impact Factor: 5.359
Dettagli Esporta in BibTeX Esporta in EndNote
Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (193 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
Dettagli Esporta in BibTeX Esporta in EndNote
Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (233 visite)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
Dettagli Esporta in BibTeX Esporta in EndNote
Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (201 visite)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
Dettagli Esporta in BibTeX Esporta in EndNote
Vitagliano L, Berisio R, Mastrangelo A, Mazzarella L, Zagari A
* Preferred proline puckerings in cis and trans peptide groups: Implications for collagen stability (226 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2001 Dec; 10(12): 2627-2632.
Impact Factor: 3.472
Dettagli Esporta in BibTeX Esporta in EndNote
De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (289 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
Dettagli Esporta in BibTeX Esporta in EndNote
Tabbì G, Fry SC, Bonomo RP
* ESR study of the non-enzymic scission of xyloglucan by an ascorbate-H2O2-copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (205 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Apr; 84(3-4): 179-187.
Impact Factor: 1.729
Dettagli Esporta in BibTeX Esporta in EndNote
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (284 visite)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
Dettagli Esporta in BibTeX Esporta in EndNote
Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (230 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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Vinci C, Caltabiano V, Santoro AM, Rabuazzo AM, Buscema M, Purrello R, Rizzarelli E, Vigneri R, Purrello F
Copper Addition Prevents The Inhibitory Effects Of Interleukin 1-Beta On Rat Pancreatic Islets (236 visite)
Diabetologia, 1995 Jan; 38(1): 39-45.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Pavone V, Rossi F, Pucci P, Andini S, Ferrara L, Di Blasio B, Pedone C
Studies on gliadin related peptides. I. Synthesis, purification and 1H n. m. r. characterization of the pentapeptide H-Tyr-(Gln)3-Pro-OH (478 visite)
Int J Pept Protein Res (ISSN: 0367-8377, 0367-8377print), 1983 Oct; 22(4): 482-488.
Impact Factor: 1.255
Dettagli Esporta in BibTeX Esporta in EndNote
123 Records (122 escludendo Abstract e Conferenze).
Impact factor totale: 460.565 (455.487 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 463.786 (458.708 escludendo Abstract e Conferenze).
Impact factor totale: 460.565 (455.487 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 463.786 (458.708 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 13:42:39
247 visite. Ultima visita in data Monday 30 March 2020, 18:30:56
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