Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization
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Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (265 visite)

Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L

Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.



Tipo di articolo: Journal Article,

Impact factor: 4.869, Impact factor a 5 anni: 5.415

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-70349290629&partnerID=40&md5=8d7947e63d6c2f22ebe86bbfee392529

Parole chiave: Amphiphilic Molecules, Colloidal Particle, Contrast Agent, Gadolinium Complexes, Gene Delivery, Medical Diagnostics, Physico-Chemical Characterization, Supramolecular Aggregates, Surfactant Aggregation, Amines, Gene Transfer, Magnetic Resonance Imaging, Peptides, Supramolecular Chemistry, Surface Active Agents, Tumors,

Affiliazioni:

*** IBB - CNR ***
Dipartimento di Chimica, Università Degli Studi di Napoli Federico II, SGI Consorzio Interuniversitario per Lo Sviluppo Dei Sistemi A Grande Interfase, Via Cinthia, 80126 Naples, Italy
Institut für Festkörperforsching Forschungszentrum Jülich, Jülich Centre for Neutron Science, Lichtenbergstraße 1, 85748 Garching bei München, Germany
Physical Chemistry 1, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden
Dipartimento di Scienze Biologiche and CIRPeB, Via Mezzocannone 16, 80134 Naples, Italy
Institut f r Festk rperforsching Forschungszentrum J lich, J lich Centre for Neutron Science, Lichtenbergstra e 1, 85748 Garching bei M nchen, Germany


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This article highlights our recent achievements on the development and upgrade of new potential tumor-specific contrast agents for magnetic resonance imaging (MRI) based on gadolinium complexes and peptides, assemblied in amphiphilic supramolecular aggregates. The physico-chemical characterization of these aggregates provides novel and interesting opportunities to investigate surfactant aggregation properties, that may be exploited in several applications such as in medical diagnostics or in drug and gene delivery.
▼    MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (123 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (125 visite)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (109 visite)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (146 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (124 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (177 visite)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (174 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (188 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (184 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (125 visite)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (154 visite)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (140 visite)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (113 visite)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (185 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (196 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (117 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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49 Records (45 escludendo Abstract e Conferenze).
Impact factor totale: 187.095 (175.258 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 199.902 (187.525 escludendo Abstract e Conferenze).







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