Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage (323 views visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1135-1142.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.605, 5-year impact factor Impact factor a 5 anni: 2.474
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-71749090850&partnerID=40&md5=6abbd805dd16f63a0563471ce03a0feb
Keywords Parole chiave: Crystal, Dna, Ribosome Inactivating Protein, Dna Cleavage, Double Strands, E. Coli, Functional Behaviors, Functional Changes, Glycosylated, Molecular Replacements, Phase Determination, Plasmid Pbr322, Ribosome-Inactivating Protein, Seeding Techniques, Structural Determinants, Two-Component, Escherichia Coli, Esterification, Fluorine Containing Polymers, Genes, Glycosylation, Nucleic Acids, Single Crystals, X Ray Crystallography, Crystal Structure, Protein Pd L1, Unclassified Drug, Vegetable Protein, Double Stranded Dna, Amino Acid Sequence, Article, Controlled Study, Nonhuman, Plant Leaf, Pokeweed, Protein Dna Interaction, Protein Expression, Protein Family, Protein Function, Protein Glycosylation, Protein Structure, Sequence Analysis, Binding Sites, X-Ray, Bacterial, Models, Molecular Sequence Data, Phytolacca, Plant Leaves, Plant Proteins, Protein Isoforms, Secondary, Tertiary, Recombinant Proteins, Type 1, Sequence Homology, Phytolacca Dioica,
Affiliations Affiliazioni:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, C.N.R., Napoli I-80134, Italy
Dipartimento di Scienze Della Vita, Seconda Università di Napoli, Via Vivaldi 43, Caserta I-81100, Italy
References Riferimenti:
Harms, J., Schluenzen, F., Zarivach, R., Bashan, A., Gat, S., Agmon, I., Bartels, H., Yonath, A., (2001) Cell, 107, pp. 679-68
Endo, Y., Tsurugi, K., (1987) J Biol Chem, 262, pp. 8128-8130
Endo, Y., Mitsui, K., Motizuki, M., Tsurugi, K., (1987) J Biol Chem, 262, pp. 5908-5912
Endo, Y., Chan, Y.L., Lin, A., Tsurugi, K., Wool, I.G., (1988) J Biol Chem, 263, pp. 7917-7920
Stirpe, F., Battelli, M.G., (2006) Cell Mol Life Sci, 63, pp. 1850-1866
Barbieri, L., Valbonesi, P., Bonora, E., Gorini, P., Bolognesi, A., Stirpe, F., (1997) Nucleic Acids Res, 25, pp. 518-522
Aceto, S., Di Maro, A., Conforto, B., Siniscalco, G.G., Parente, A., Delli Bovi, P., Gaudio, L., (2005) Biol Chem, 386, pp. 307-317
Bolognesi, A., Polito, L., Lubelli, C., Barbieri, L., Parente, A., Stirpe, F., (2002) J Biol Chem, 277, pp. 13709-13716
Mccluskey, A.J., Poon, G.M., Bolewska-Pedyczak, E., Srikumar, T., Jeram, S.M., Raught, B., Gariepy, J., (2008) J Mol Biol, 378, pp. 375-386
Chan, D.S., Chu, L.O., Lee, K.M., Too, P.H., Ma, K.W., Sze, K.H., Zhu, G., Wong, K.B., (2007) Nucleic Acids Res
Voss, C., Eyol, E., Frank, M., Von Der Lieth, C.W., Berger, M.R., (2006) FASEB J, 20, pp. 1194-1196
Schoffski, P., Riggert, S., Fumoleau, P., Campone, M., Bolte, O., Marreaud, S., Lacombe, D., Twelves, C., (2004) Ann Oncol, 15, pp. 1816-1824
Chu, K.T., Ng, T.B., (2006) Biochem Biophys Res Commun, 340, pp. 118-124
Wang, J.H., Nie, H.L., Tam, S.C., Huang, H., Zheng, Y.T., (2002) FEBS Lett, 531, pp. 295-298
Wang, Y.Y., Ouyang, D.Y., Huang, H., Chan, H., Tam, S.C., Zheng, Y.T., (2005) Biochem Biophys Res Commun, 331, pp. 1075-1080
Poyet, J.L., Hoeveler, A., Jongeneel, C.V., (1998) Biochem Biophys Res Commun, 253, pp. 582-587
Walker, D., Lancaster, L., James, R., Kleanthous, C., (2004) Protein Sci, 13, pp. 1603-1611
Mccullough, A.K., Sanchez, A., Dodson, M.L., Marapaka, P., Taylor, J.S., Lloyd, R.S., (2001) Biochemistry, 40, pp. 561-568
Robertus, J.D., Monzingo, A.F., (2004) Mini Rev Med Chem, 4, pp. 477-486
Day, P.J., Lord, J.M., Roberts, L.M., (1998) Eur J Biochem, 258, pp. 540-545
Ghosh, P., Batra, J.K., (2006) Biochem J, 400, pp. 99-104
Bagga, S., Seth, D., Batra, J.K., (2003) J Biol Chem, 278, pp. 4813-4820
Choudhary, N.L., Yadav, O.P., Lodha, M.L., (2008) Biochemistry, 73, pp. 273-277. , Mosc
Begam, M., Narwal, S., Roy, S., Kumar, S., Lodha, M.L., Kapoor, H.C., (2006) Biochemistry, 71 (SUPPL. 1), pp. S44-S48. , Mosc
Gasperi-Campani, A., Brognara, I., Baiocchi, D., Roncuzzi, L., (2005) Toxicon, 45, pp. 475-480
He, W.J., Liu, W.Y., (2004) Biochem J, 377, pp. 17-23
Brigotti, M., Carnicelli, D., Ravanelli, E., Vara, A.G., Martinelli, C., Alfieri, R.R., Petronini, P.G., Sestili, P., (2007) Infect Immun, 75, pp. 2201-2207
Wang, P., Tumer, N.E., (1999) Nucleic Acids Res, 27, pp. 1900-1905
Parente, A., Conforto, B., Di Maro, A., Chambery, A., De Luca, P., Bolognesi, A., Iriti, M., Faoro, F., (2008) Planta, 228, pp. 963-975
Di Maro, A., Valbonesi, P., Bolognesi, A., Stirpe, F., De Luca, P., Siniscalco Gigliano, G., Gaudio, L., Parente, A., (1999) Planta, 208, pp. 125-131
Chambery, A., Di Maro, A., Parente, A., (2008) Phytochemistry, 69, pp. 1973-1982
Esnouf, R.M., (1999) Acta Crystallogr D Biol Crystallogr, 55, pp. 938-940
Merritt, E.A., Bacon, D.J., (1997) Methods Enzymol, 277, pp. 505-524
Ruggiero, A., Chambery, A., Di Maro, A., Parente, A., Berisio, R., (2008) Proteins, 71, pp. 8-15
Kurinov, I.V., Myers, D.E., Irvin, J.D., Uckun, F.M., (1999) Protein Sci, 8, pp. 1765-1772
Ak, P., Benham, C.J., (2005) PLoS Comput Biol, 1, pp. e7
Benham, C.J., Bi, C., (2004) J Comput Biol, 11, pp. 519-543
Guo, Q., Zhou, W., Too, H.M., Li, J., Liu, Y., Bartlam, M., Dong, Y., Rao, Z., (2003) Protein Eng, 16, pp. 391-396
Nicolas, E., Beggs, J.M., Taraschi, T.F., (2000) J Biol Chem, 275, pp. 31399-31406
Yang, C.G., Yi, C., Duguid, E.M., Sullivan, C.T., Jian, X., Rice, P.A., He, C., (2008) Nature, 452, pp. 961-965
Wang, H., Kaloper, M., Benham, C.J., (2006) Nucl Acids Res, 34, pp. D373-D378
Vesnaver, G., Chang, C.N., Eisenberg, M., Grollman, A.P., Breslauer, K.J., (1989) Proc Natl Acad Sci USA, 86, pp. 3614-3618
Minor, W., Tomchick, D., Otwinowski, Z., (2000) Structure, 8, pp. R105-R110
Caliandro, R., Carrozzini, B., Cascarano, G.L., De Caro, L., Giacovazzo, C., Mazzone, A.M., Siliqi, D., (2006) J Appl Cryst, 39, pp. 185-193
Potterton, E., Briggs, P., Turkenburg, M., Dodson, E., (2003) Acta Crystallogr D Biol Crystallogr, 59, pp. 1131-1137
Murshudov, G.N., Vagin, A.A., Dodson, E.J., (1997) Acta Crystallogr D Biol Crystallogr, 53, pp. 240-255
Morris, R.J., Perrakis, A., Lamzin, V.S., (2003) Meth Enzymol, 374, pp. 229-244
Endo, Y., Chan, Y. L., Lin, A., Tsurugi, K., Wool, I. G., (1988) J Biol Chem, 263, pp. 7917-7920
Mccluskey, A. J., Poon, G. M., Bolewska-Pedyczak, E., Srikumar, T., Jeram, S. M., Raught, B., Gariepy, J., (2008) J Mol Biol, 378, pp. 375-386
Chan, D. S., Chu, L. O., Lee, K. M., Too, P. H., Ma, K. W., Sze, K. H., Zhu, G., Wong, K. B., (2007) Nucleic Acids Res
Chu, K. T., Ng, T. B., (2006) Biochem Biophys Res Commun, 340, pp. 118-124
Wang, J. H., Nie, H. L., Tam, S. C., Huang, H., Zheng, Y. T., (2002) FEBS Lett, 531, pp. 295-298
Wang, Y. Y., Ouyang, D. Y., Huang, H., Chan, H., Tam, S. C., Zheng, Y. T., (2005) Biochem Biophys Res Commun, 331, pp. 1075-1080
Poyet, J. L., Hoeveler, A., Jongeneel, C. V., (1998) Biochem Biophys Res Commun, 253, pp. 582-587
Mccullough, A. K., Sanchez, A., Dodson, M. L., Marapaka, P., Taylor, J. S., Lloyd, R. S., (2001) Biochemistry, 40, pp. 561-568
Robertus, J. D., Monzingo, A. F., (2004) Mini Rev Med Chem, 4, pp. 477-486
Day, P. J., Lord, J. M., Roberts, L. M., (1998) Eur J Biochem, 258, pp. 540-545
Choudhary, N. L., Yadav, O. P., Lodha, M. L., (2008) Biochemistry, 73, pp. 273-277. , Mosc
He, W. J., Liu, W. Y., (2004) Biochem J, 377, pp. 17-23
Wang, P., Tumer, N. E., (1999) Nucleic Acids Res, 27, pp. 1900-1905
Esnouf, R. M., (1999) Acta Crystallogr D Biol Crystallogr, 55, pp. 938-940
Merritt, E. A., Bacon, D. J., (1997) Methods Enzymol, 277, pp. 505-524
Kurinov, I. V., Myers, D. E., Irvin, J. D., Uckun, F. M., (1999) Protein Sci, 8, pp. 1765-1772
Ak, P., Benham, C. J., (2005) PLoS Comput Biol, 1, pp. e7
Benham, C. J., Bi, C., (2004) J Comput Biol, 11, pp. 519-543
Yang, C. G., Yi, C., Duguid, E. M., Sullivan, C. T., Jian, X., Rice, P. A., He, C., (2008) Nature, 452, pp. 961-965
Murshudov, G. N., Vagin, A. A., Dodson, E. J., (1997) Acta Crystallogr D Biol Crystallogr, 53, pp. 240-255
Morris, R. J., Perrakis, A., Lamzin, V. S., (2003) Meth Enzymol, 374, pp. 229-244
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1135-1142.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.605, 5-year impact factor Impact factor a 5 anni: 2.474
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-71749090850&partnerID=40&md5=6abbd805dd16f63a0563471ce03a0feb
Keywords Parole chiave: Crystal, Dna, Ribosome Inactivating Protein, Dna Cleavage, Double Strands, E. Coli, Functional Behaviors, Functional Changes, Glycosylated, Molecular Replacements, Phase Determination, Plasmid Pbr322, Ribosome-Inactivating Protein, Seeding Techniques, Structural Determinants, Two-Component, Escherichia Coli, Esterification, Fluorine Containing Polymers, Genes, Glycosylation, Nucleic Acids, Single Crystals, X Ray Crystallography, Crystal Structure, Protein Pd L1, Unclassified Drug, Vegetable Protein, Double Stranded Dna, Amino Acid Sequence, Article, Controlled Study, Nonhuman, Plant Leaf, Pokeweed, Protein Dna Interaction, Protein Expression, Protein Family, Protein Function, Protein Glycosylation, Protein Structure, Sequence Analysis, Binding Sites, X-Ray, Bacterial, Models, Molecular Sequence Data, Phytolacca, Plant Leaves, Plant Proteins, Protein Isoforms, Secondary, Tertiary, Recombinant Proteins, Type 1, Sequence Homology, Phytolacca Dioica,
Affiliations Affiliazioni:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, C.N.R., Napoli I-80134, Italy
Dipartimento di Scienze Della Vita, Seconda Università di Napoli, Via Vivaldi 43, Caserta I-81100, Italy
References Riferimenti:
Harms, J., Schluenzen, F., Zarivach, R., Bashan, A., Gat, S., Agmon, I., Bartels, H., Yonath, A., (2001) Cell, 107, pp. 679-68
Endo, Y., Tsurugi, K., (1987) J Biol Chem, 262, pp. 8128-8130
Endo, Y., Mitsui, K., Motizuki, M., Tsurugi, K., (1987) J Biol Chem, 262, pp. 5908-5912
Endo, Y., Chan, Y.L., Lin, A., Tsurugi, K., Wool, I.G., (1988) J Biol Chem, 263, pp. 7917-7920
Stirpe, F., Battelli, M.G., (2006) Cell Mol Life Sci, 63, pp. 1850-1866
Barbieri, L., Valbonesi, P., Bonora, E., Gorini, P., Bolognesi, A., Stirpe, F., (1997) Nucleic Acids Res, 25, pp. 518-522
Aceto, S., Di Maro, A., Conforto, B., Siniscalco, G.G., Parente, A., Delli Bovi, P., Gaudio, L., (2005) Biol Chem, 386, pp. 307-317
Bolognesi, A., Polito, L., Lubelli, C., Barbieri, L., Parente, A., Stirpe, F., (2002) J Biol Chem, 277, pp. 13709-13716
Mccluskey, A.J., Poon, G.M., Bolewska-Pedyczak, E., Srikumar, T., Jeram, S.M., Raught, B., Gariepy, J., (2008) J Mol Biol, 378, pp. 375-386
Chan, D.S., Chu, L.O., Lee, K.M., Too, P.H., Ma, K.W., Sze, K.H., Zhu, G., Wong, K.B., (2007) Nucleic Acids Res
Voss, C., Eyol, E., Frank, M., Von Der Lieth, C.W., Berger, M.R., (2006) FASEB J, 20, pp. 1194-1196
Schoffski, P., Riggert, S., Fumoleau, P., Campone, M., Bolte, O., Marreaud, S., Lacombe, D., Twelves, C., (2004) Ann Oncol, 15, pp. 1816-1824
Chu, K.T., Ng, T.B., (2006) Biochem Biophys Res Commun, 340, pp. 118-124
Wang, J.H., Nie, H.L., Tam, S.C., Huang, H., Zheng, Y.T., (2002) FEBS Lett, 531, pp. 295-298
Wang, Y.Y., Ouyang, D.Y., Huang, H., Chan, H., Tam, S.C., Zheng, Y.T., (2005) Biochem Biophys Res Commun, 331, pp. 1075-1080
Poyet, J.L., Hoeveler, A., Jongeneel, C.V., (1998) Biochem Biophys Res Commun, 253, pp. 582-587
Walker, D., Lancaster, L., James, R., Kleanthous, C., (2004) Protein Sci, 13, pp. 1603-1611
Mccullough, A.K., Sanchez, A., Dodson, M.L., Marapaka, P., Taylor, J.S., Lloyd, R.S., (2001) Biochemistry, 40, pp. 561-568
Robertus, J.D., Monzingo, A.F., (2004) Mini Rev Med Chem, 4, pp. 477-486
Day, P.J., Lord, J.M., Roberts, L.M., (1998) Eur J Biochem, 258, pp. 540-545
Ghosh, P., Batra, J.K., (2006) Biochem J, 400, pp. 99-104
Bagga, S., Seth, D., Batra, J.K., (2003) J Biol Chem, 278, pp. 4813-4820
Choudhary, N.L., Yadav, O.P., Lodha, M.L., (2008) Biochemistry, 73, pp. 273-277. , Mosc
Begam, M., Narwal, S., Roy, S., Kumar, S., Lodha, M.L., Kapoor, H.C., (2006) Biochemistry, 71 (SUPPL. 1), pp. S44-S48. , Mosc
Gasperi-Campani, A., Brognara, I., Baiocchi, D., Roncuzzi, L., (2005) Toxicon, 45, pp. 475-480
He, W.J., Liu, W.Y., (2004) Biochem J, 377, pp. 17-23
Brigotti, M., Carnicelli, D., Ravanelli, E., Vara, A.G., Martinelli, C., Alfieri, R.R., Petronini, P.G., Sestili, P., (2007) Infect Immun, 75, pp. 2201-2207
Wang, P., Tumer, N.E., (1999) Nucleic Acids Res, 27, pp. 1900-1905
Parente, A., Conforto, B., Di Maro, A., Chambery, A., De Luca, P., Bolognesi, A., Iriti, M., Faoro, F., (2008) Planta, 228, pp. 963-975
Di Maro, A., Valbonesi, P., Bolognesi, A., Stirpe, F., De Luca, P., Siniscalco Gigliano, G., Gaudio, L., Parente, A., (1999) Planta, 208, pp. 125-131
Chambery, A., Di Maro, A., Parente, A., (2008) Phytochemistry, 69, pp. 1973-1982
Esnouf, R.M., (1999) Acta Crystallogr D Biol Crystallogr, 55, pp. 938-940
Merritt, E.A., Bacon, D.J., (1997) Methods Enzymol, 277, pp. 505-524
Ruggiero, A., Chambery, A., Di Maro, A., Parente, A., Berisio, R., (2008) Proteins, 71, pp. 8-15
Kurinov, I.V., Myers, D.E., Irvin, J.D., Uckun, F.M., (1999) Protein Sci, 8, pp. 1765-1772
Ak, P., Benham, C.J., (2005) PLoS Comput Biol, 1, pp. e7
Benham, C.J., Bi, C., (2004) J Comput Biol, 11, pp. 519-543
Guo, Q., Zhou, W., Too, H.M., Li, J., Liu, Y., Bartlam, M., Dong, Y., Rao, Z., (2003) Protein Eng, 16, pp. 391-396
Nicolas, E., Beggs, J.M., Taraschi, T.F., (2000) J Biol Chem, 275, pp. 31399-31406
Yang, C.G., Yi, C., Duguid, E.M., Sullivan, C.T., Jian, X., Rice, P.A., He, C., (2008) Nature, 452, pp. 961-965
Wang, H., Kaloper, M., Benham, C.J., (2006) Nucl Acids Res, 34, pp. D373-D378
Vesnaver, G., Chang, C.N., Eisenberg, M., Grollman, A.P., Breslauer, K.J., (1989) Proc Natl Acad Sci USA, 86, pp. 3614-3618
Minor, W., Tomchick, D., Otwinowski, Z., (2000) Structure, 8, pp. R105-R110
Caliandro, R., Carrozzini, B., Cascarano, G.L., De Caro, L., Giacovazzo, C., Mazzone, A.M., Siliqi, D., (2006) J Appl Cryst, 39, pp. 185-193
Potterton, E., Briggs, P., Turkenburg, M., Dodson, E., (2003) Acta Crystallogr D Biol Crystallogr, 59, pp. 1131-1137
Murshudov, G.N., Vagin, A.A., Dodson, E.J., (1997) Acta Crystallogr D Biol Crystallogr, 53, pp. 240-255
Morris, R.J., Perrakis, A., Lamzin, V.S., (2003) Meth Enzymol, 374, pp. 229-244
Endo, Y., Chan, Y. L., Lin, A., Tsurugi, K., Wool, I. G., (1988) J Biol Chem, 263, pp. 7917-7920
Mccluskey, A. J., Poon, G. M., Bolewska-Pedyczak, E., Srikumar, T., Jeram, S. M., Raught, B., Gariepy, J., (2008) J Mol Biol, 378, pp. 375-386
Chan, D. S., Chu, L. O., Lee, K. M., Too, P. H., Ma, K. W., Sze, K. H., Zhu, G., Wong, K. B., (2007) Nucleic Acids Res
Chu, K. T., Ng, T. B., (2006) Biochem Biophys Res Commun, 340, pp. 118-124
Wang, J. H., Nie, H. L., Tam, S. C., Huang, H., Zheng, Y. T., (2002) FEBS Lett, 531, pp. 295-298
Wang, Y. Y., Ouyang, D. Y., Huang, H., Chan, H., Tam, S. C., Zheng, Y. T., (2005) Biochem Biophys Res Commun, 331, pp. 1075-1080
Poyet, J. L., Hoeveler, A., Jongeneel, C. V., (1998) Biochem Biophys Res Commun, 253, pp. 582-587
Mccullough, A. K., Sanchez, A., Dodson, M. L., Marapaka, P., Taylor, J. S., Lloyd, R. S., (2001) Biochemistry, 40, pp. 561-568
Robertus, J. D., Monzingo, A. F., (2004) Mini Rev Med Chem, 4, pp. 477-486
Day, P. J., Lord, J. M., Roberts, L. M., (1998) Eur J Biochem, 258, pp. 540-545
Choudhary, N. L., Yadav, O. P., Lodha, M. L., (2008) Biochemistry, 73, pp. 273-277. , Mosc
He, W. J., Liu, W. Y., (2004) Biochem J, 377, pp. 17-23
Wang, P., Tumer, N. E., (1999) Nucleic Acids Res, 27, pp. 1900-1905
Esnouf, R. M., (1999) Acta Crystallogr D Biol Crystallogr, 55, pp. 938-940
Merritt, E. A., Bacon, D. J., (1997) Methods Enzymol, 277, pp. 505-524
Kurinov, I. V., Myers, D. E., Irvin, J. D., Uckun, F. M., (1999) Protein Sci, 8, pp. 1765-1772
Ak, P., Benham, C. J., (2005) PLoS Comput Biol, 1, pp. e7
Benham, C. J., Bi, C., (2004) J Comput Biol, 11, pp. 519-543
Yang, C. G., Yi, C., Duguid, E. M., Sullivan, C. T., Jian, X., Rice, P. A., He, C., (2008) Nature, 452, pp. 961-965
Murshudov, G. N., Vagin, A. A., Dodson, E. J., (1997) Acta Crystallogr D Biol Crystallogr, 53, pp. 240-255
Morris, R. J., Perrakis, A., Lamzin, V. S., (2003) Meth Enzymol, 374, pp. 229-244
Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage
The structure of the highly glycosylated type 1 ribosome inactivating protein PD-L1 was determined by X-ray crystallography. This protein belongs to a group of four PD-Ls (PD-L1-4) expressed in Phytolacca dioica leaves. Of these, PD-L1 and PD-L2 are endowed with the ability to cleave double strand DNA, a property which is not shared by the other two components of the family. Single crystals of native PD-L1, the most glycosylated, were obtained using seeding techniques and phase determination was achieved using molecular replacement. To investigate the role of glycosylation in the different functionality of these proteins, we performed DNA cleavage assays on the E. coli plasmid pBR322. These experiments revealed that DNA cleaving ability does not depend on the level of glycosylation of PD-L1, since there is no difference in the activities displayed by native PD-L1 and a recombinant non-glycosylated form. Besides, confirming that DNA cleavage by PD-L1 cannot be attributed to contaminations, these data unambiguously show that functional changes between PD-L1 and PD-L4 are solely to be attributed to their sequence differences. On the basis of the comparison of PD-L1 and PD-L4 crystal structures, we propose possible structural determinants responsible for their different functional behavior. © 2009 Wiley Periodicals, Inc.
The structure of the highly glycosylated type 1 ribosome inactivating protein PD-L1 was determined by X-ray crystallography. This protein belongs to a group of four PD-Ls (PD-L1-4) expressed in Phytolacca dioica leaves. Of these, PD-L1 and PD-L2 are endowed with the ability to cleave double strand DNA, a property which is not shared by the other two components of the family. Single crystals of native PD-L1, the most glycosylated, were obtained using seeding techniques and phase determination was achieved using molecular replacement. To investigate the role of glycosylation in the different functionality of these proteins, we performed DNA cleavage assays on the E. coli plasmid pBR322. These experiments revealed that DNA cleaving ability does not depend on the level of glycosylation of PD-L1, since there is no difference in the activities displayed by native PD-L1 and a recombinant non-glycosylated form. Besides, confirming that DNA cleavage by PD-L1 cannot be attributed to contaminations, these data unambiguously show that functional changes between PD-L1 and PD-L4 are solely to be attributed to their sequence differences. On the basis of the comparison of PD-L1 and PD-L4 crystal structures, we propose possible structural determinants responsible for their different functional behavior. © 2009 Wiley Periodicals, Inc.
Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage
| ▼ Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Nucleic acid and protein binding studies |
Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage
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Sonia D, Emiliano B, Alfredo L, Emilia P, Luciano P, Michele S, Serena T, Domenica C, Alfonso I
* Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved (45 visite)
Carbohydr Res, 2019 Aug 1; 482: 107740-107740.
Impact Factor: 1.91
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Comegna D, Del Gatto A, Saviano M, Zaccaro L
* On-Bead Peptoid Dimerization Induced by Incorporation of Glycosylated Bridging Units in Submonomer Solid-Phase Approach to Glycopeptoids (120 visite)
Org Lett (ISSN: 1523-7052linking, 1523-7052electronic, 1523-7060), 2019 Jun 21; 21(12): 4454-4458.
Impact Factor: 5.128
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Calce E, Digilio G, Menchise V, Saviano M, De Luca S
* Chemoselective Glycosylation of Peptides through S-Alkylation Reaction (602 visite) (PDF 139 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Apr 20; 24(23): 6231-6238.
Impact Factor: 5.476
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Chattopadhyay A, Cogdell R, Crespo-hernandez CE, Datta A, De A, Haacke S, Hariharan M, Helliwell J, Hughes A, Improta R, Jones M, Joseph J, Karsili T, Kohler B, Krishnan R, Kuriakose A, L , M , Markovitsi D, Medhi H, Periyasamy G, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Schapiro I, Schertler GFX, Schlichting I, Segarra-marti J, Swaminathan R, V , V , Van Grondelle R, Venkatraman RK, Venkatramani R, Watts A
* Light induced charge and energy transport in nucleic acids and proteins: general discussion (100 visite)
Faraday Discuss (ISSN: 1359-6640print, 1359-6640linking), 2018 Apr 1; 207: 153-180.
Impact Factor: 4.194
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Chandra A, Cogdell R, Crespo-hernandez CE, Datta A, Giussani A, Haacke S, Helliwell J, Improta R, Jayasree RS, Jones M, Karsili T, Kohler B, L , M , Mandal I, Markovitsi D, Medhi H, Mishra PP, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Schapiro I, Schlichting I, Segarra-marti J, Sharma A, V , V , Van Grondelle R, Watts A
* Light induced damage and repair in nucleic acids and proteins: general discussion (84 visite)
Faraday Discuss (ISSN: 1359-6640print, 1359-6640linking), 2018 Apr 1; 207: 389-408.
Impact Factor: 4.194
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (287 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Impact Factor: 5.476
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Bhat V, Cogdell R, Crespo-hernández CE, Datta A, De A, Haacke S, Helliwell J, Improta R, Joseph J, Karsili T, Kohler B, Krishnan R, Mahil LM, Lewis F, Mandal I, Markovitsi D, Mishra PP, Paul S, Periyasamy G, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Sasikumar D, Schapiro I, Schertler GFX, Schlichting I, Segarra-martí J, Swaminathan R, Vishnu V, Van Grondelle R, Varghese R, Venkatramani R
* Photocrosslinking between nucleic acids and proteins: general discussion (90 visite)
Faraday Discussions, 2018; N/D: N/D-N/D.
Impact Factor: 3.427
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Piras L, Avitabile C, D'Andrea LD, Saviano M, Romanelli A
* Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2 (202 visite)
Biochem Bioph Res Co (ISSN: 0006-291x), 2017 Sep 15; N/D: N/D-N/D.
Impact Factor: 2.559
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (287 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2017 Mar 16; 18(6): 527-538.
Impact Factor: 2.774
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Troise AD, Buonanno M, Fiore A, Monti SM, Fogliano V
* Evolution of protein bound Maillard reaction end-products and free Amadori compounds in low lactose milk in presence of fructosamine oxidase (217 visite)
Food Chem (ISSN: 0308-8146, 0308-8146print), 2016 Dec 1; 212: 722-729.
Impact Factor: 4.529
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Sholokh M, Improta R, Mori M, Sharma R, Kenfack C, Shin D, Voltz K, Stote RH, Zaporozhets OA, Botta M, Tor Y, Mely Y
* Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels (199 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2016 Jun 8; N/D: N/D-N/D.
Impact Factor: 11.994
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Improta R, Santoro F, Blancafort L
* Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases (273 visite)
Chem Rev (ISSN: 0009-2665), 2016; 116(6): 3540-3593.
Impact Factor: 47.928
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Roviello GN, Roviello V, Autiero I, Saviano M
* Solid phase synthesis of TyrT, a thymine-tyrosine conjugate with poly(A) RNA-binding ability (423 visite)
Rsc Adv (ISSN: 2046-2069), 2016; 6(33): 27607-27613.
Impact Factor: 3.108
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Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (550 visite) (PDF 237 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Sep 7; 16(9): 21342-21362.
Impact Factor: 3.257
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (335 visite)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
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Roviello GN, Musumeci D, Roviello V, Pirtskhalava M, Egoyan A, Mirtskhulava M
* Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure (306 visite)
Beilstein J Nanotech (ISSN: 2190-4286), 2015; 6(1): 1338-1347.
Impact Factor: 2.778
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Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L
* Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics (364 visite)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015; 17(3): 640-643.
Impact Factor: 6.732
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Fahleson T, Kauczor J, Norman P, Santoro F, Improta R, Coriani S
* TD-DFT investigation of the magnetic circular dichroism spectra of some purine and pyrimidine bases of nucleic acids (250 visite)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2015; 119(21): 5476-5489.
Impact Factor: 2.883
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Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Binding ability of a thymine-functionalized oligolysine towards nucleic acids (251 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2014 Feb 1; 22(3): 997-1002.
Impact Factor: 2.793
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Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F
* A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex (280 visite)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Feb; 70(2): 362-370.
Impact Factor: 7.232
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Andreotti G, Pedone E, Giordano A, Cubellis MV
* Biochemical phenotype of a common disease-causing mutation and a possible therapeutic approach for the phosphomannomutase 2-associated disorder of glycosylation (186 visite)
Molecular Genetics & Genomic Medicine (ISSN: 2324-9269), 2013 May; 1(1): 32-44.
Impact Factor: 2.082
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Zanoli LM, Spoto G
* Isothermal amplification methods for the detection of nucleic acids in microfluidic devices (272 visite)
Biosensors (ISSN: 2079-6374), 2013 Mar; 3(1): 18-43.
Impact Factor: 0
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Zanoli LM, Licciardello M, D'Agata R, Lantano C, Calabretta A, Corradini R, Marchelli R, Spoto G
* Peptide nucleic acid molecular beacons for the detection of PCR amplicons in droplet-based microfluidic devices (209 visite)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 615-624.
Impact Factor: 3.578
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (279 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (333 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (317 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Marciano C, Galderisi M, Gargiulo P, Acampa W, D'Amore C, Esposito R, Capasso E, Savarese G, Casaretti L, Lo Iudice F, Esposito G, Rengo G, Leosco D, Cuocolo A, Perrone-Filardi P
* Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (368 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Jul; 39(7): 1199-1206.
Impact Factor: 5.114
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Avitabile C, Saviano M, D'Andrea LD, Bianchi N, Fabbri E, Brognara E, Gambari R, Romanelli A
* Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation (366 visite)
Artif Dna Pna Xnaartificial Dna Pna & Xna (ISSN: 1949-9096, 1949-0968, 1949-095x), 2012 Apr; 3(2): 88-96.
Impact Factor: 0
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (278 visite)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
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Castellano I, Merlino A
* γ-glutamyltranspeptidases: Sequence, structure, biochemical properties, and biotechnological applications (247 visite)
Cell Mol Life Sci (ISSN: 1420-682x), 2012; 69(20): 3381-3394.
Impact Factor: 5.615
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Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (186 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2011 Dec 9; 50(50): 12016-12019.
Impact Factor: 13.455
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (397 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
Impact Factor: 3.35
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Nucleobase-containing peptides: a spectroscopic study of their properties and nucleic acids recognition ability (317 visite)
Eur Biophys J (ISSN: 0175-7571, 1432-1017), 2011 Sep; 40: N/D-N/D.
Impact Factor: 2.139
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Moccia M, Roviello GN, Bucci EM, Pedone C, Saviano M
* Synthesis of a l-lysine-based alternate alpha, epsilon-peptide: A novel linear polycation with nucleic acids-binding ability (346 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2010 Sep 15; 397(1-2): 179-183.
Impact Factor: 3.607
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (329 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (237 visite)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
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Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
* Cell recruitment and transfection in gene activated collagen matrix (247 visite)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
Impact Factor: 7.883
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (320 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
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Severino V, Chambery A, Di Maro A, Marasco D, Ruggiero A, Berisio R, Giansanti F, Ippoliti R, Parente A
* The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves (290 visite)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(3): 570-579.
Impact Factor: 3.825
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Improta R, Santoro F, Barone V, Lami A
* Vibronic model for the quantum dynamical study of the competition between bright and charge-transfer excited states in single-strand polynucleotides: the adenine dimer case (214 visite)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic, 1089-5639linking), 2009 Dec 31; 113(52): 15346-15354.
Impact Factor: 2.899
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (308 visite)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
Dettagli Esporta in BibTeX Esporta in EndNote
Santoro F, Barone V, Improta R
* The Excited States Decay Of The A-T Dna: A Pcm/Td-Dft Study In Aqueous Solution Of The (9-Methyl-Adenine) 2 (1-Methyl-Thymine) 2 Stacked Tetramer (197 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2009; 131(42): 15232-15245.
Impact Factor: 8.58
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (330 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (287 visite)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (228 visite)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
Dettagli Esporta in BibTeX Esporta in EndNote
D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (302 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
Dettagli Esporta in BibTeX Esporta in EndNote
Improta R, Barone V
* The excited states of adenine and thymine nucleoside and nucleotide in aqueous solution: A comparative study by time-dependent DFT calculations (177 visite)
Theor Chem Acc (ISSN: 1432-881x), 2008 Jul; 120(4-6): 491-497.
Impact Factor: 2.37
Dettagli Esporta in BibTeX Esporta in EndNote
Santoro F, Barone V, Improta R
* Can TD-DFT calculations accurately describe the excited states behavior of stacked nucleobases? The cytosine dimer as a test case (225 visite)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic, 0192-8651linking), 2008 Apr 30; 29(6): 957-964.
Impact Factor: 3.39
Dettagli Esporta in BibTeX Esporta in EndNote
Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (247 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
Dettagli Esporta in BibTeX Esporta in EndNote
Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (298 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (203 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (291 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Chambery A, Di Maro A, Mastroianni A, Parente A, Berisio R
* Crystallization and preliminary X-ray diffraction analysis of PD-L1, a highly glycosylated ribosome inactivating protein with DNase activity (228 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2007; 14(4): 407-409.
Impact Factor: 1.097
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (337 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
Dettagli Esporta in BibTeX Esporta in EndNote
Moccia M, Musumeci D, Valente M, Roviello GN, Sapio R, Pedone C, Bucci EM
* Thermodynamic studies on PNA and PNA/DNA dendrimer formation (185 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1173-1176.
Impact Factor: 0.723
Dettagli Esporta in BibTeX Esporta in EndNote
Santoro F, Gustavsson T, Lami S, Barone V, Improta R
* Towards the understanding of the excited state dynamics of nucleic acids: Solvent and stacking effect on the photophysical behavior of nucleobases (182 visite)
Aip Conf Proc (ISSN: 0094-243x), 2007; 963(2): 631-634.
Impact Factor: 0
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Santoro F, Barone V, Gustavsson T, Improta R
* Solvent effect on the singlet excited-state lifetimes of nucleic acid bases: A computational study of 5-fluorouracil and uracil in acetonitrile and water (225 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Dec 20; 128(50): 16312-16322.
Impact Factor: 7.696
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (382 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
Dettagli Esporta in BibTeX Esporta in EndNote
Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (320 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (297 visite)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (377 visite)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (300 visite)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Musumeci D, Roviello GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (340 visite)
Biopolymers, 2004; 76(6): 535-542.
Impact Factor: 2.248
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (298 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (179 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
Impact Factor: 1.94
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (278 visite)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
Dettagli Esporta in BibTeX Esporta in EndNote
Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (327 visite)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
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Fogliano V, Monti SM, Visconti A, Randazzo G, Facchiano AM, Colonna G, Ritieni A
Identification of a β-lactoglobulin lactosylation site (243 visite)
Biochim Biophys Acta Protein Struct Mol Enzymol (ISSN: 0167-4838), 1998 Nov 10; 1388(2): 295-304.
Impact Factor: 1.687
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Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (204 visite)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
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Manna R, Salvatore M, Di Leo MA, Scuderi F, Greco AV, Ghirlanda G, Gambassi G
Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes (343 visite)
Diabetes Res (ISSN: 0265-5985), 1991 May; 17(1): 33-36.
Impact Factor: 0
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Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Avitabile C, Diaferia C, Roviello V, Altamura D, Giannini C, Vitagliano L, Accardo A, Romanelli A
* Fluorescence and Morphology of Self-Assembled Nucleobases and Their Diphenylalanine Hybrid Aggregates (92 visite)
Chemistry (ISSN: 0947-6539linking), 2019 Nov 22; 25(65): 14850-14857.
Impact Factor: 5.476
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Sonia D, Emiliano B, Alfredo L, Emilia P, Luciano P, Michele S, Serena T, Domenica C, Alfonso I
* Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved (41 visite)
Carbohydr Res, 2019 Aug 1; 482: 107740-107740.
Impact Factor: 1.91
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Di Gaetano S, Bedini E, Landolfi A, Pedone E, Pirone L, Saviano M, Traboni S, Capasso D, Iadonisi A
* Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved (37 visite)
Carbohydr Res, 2019 Aug 1; 482: N/D-N/D.
Impact Factor: 1.841
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Sonia D, Emiliano B, Alfredo L, Emilia P, Luciano P, Michele S, Serena T, Domenica C, Alfonso I
* Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved (45 visite)
Carbohydr Res, 2019 Aug 1; 482: 107740-107740.
Impact Factor: 1.91
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Comegna D, Del Gatto A, Saviano M, Zaccaro L
* On-Bead Peptoid Dimerization Induced by Incorporation of Glycosylated Bridging Units in Submonomer Solid-Phase Approach to Glycopeptoids (120 visite)
Org Lett (ISSN: 1523-7052linking, 1523-7052electronic, 1523-7060), 2019 Jun 21; 21(12): 4454-4458.
Impact Factor: 5.128
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Calce E, Digilio G, Menchise V, Saviano M, De Luca S
* Chemoselective Glycosylation of Peptides through S-Alkylation Reaction (602 visite) (PDF 139 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Apr 20; 24(23): 6231-6238.
Impact Factor: 5.476
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Chattopadhyay A, Cogdell R, Crespo-hernandez CE, Datta A, De A, Haacke S, Hariharan M, Helliwell J, Hughes A, Improta R, Jones M, Joseph J, Karsili T, Kohler B, Krishnan R, Kuriakose A, L , M , Markovitsi D, Medhi H, Periyasamy G, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Schapiro I, Schertler GFX, Schlichting I, Segarra-marti J, Swaminathan R, V , V , Van Grondelle R, Venkatraman RK, Venkatramani R, Watts A
* Light induced charge and energy transport in nucleic acids and proteins: general discussion (100 visite)
Faraday Discuss (ISSN: 1359-6640print, 1359-6640linking), 2018 Apr 1; 207: 153-180.
Impact Factor: 4.194
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Chandra A, Cogdell R, Crespo-hernandez CE, Datta A, Giussani A, Haacke S, Helliwell J, Improta R, Jayasree RS, Jones M, Karsili T, Kohler B, L , M , Mandal I, Markovitsi D, Medhi H, Mishra PP, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Schapiro I, Schlichting I, Segarra-marti J, Sharma A, V , V , Van Grondelle R, Watts A
* Light induced damage and repair in nucleic acids and proteins: general discussion (84 visite)
Faraday Discuss (ISSN: 1359-6640print, 1359-6640linking), 2018 Apr 1; 207: 389-408.
Impact Factor: 4.194
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (287 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Impact Factor: 5.476
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Bhat V, Cogdell R, Crespo-hernández CE, Datta A, De A, Haacke S, Helliwell J, Improta R, Joseph J, Karsili T, Kohler B, Krishnan R, Mahil LM, Lewis F, Mandal I, Markovitsi D, Mishra PP, Paul S, Periyasamy G, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Sasikumar D, Schapiro I, Schertler GFX, Schlichting I, Segarra-martí J, Swaminathan R, Vishnu V, Van Grondelle R, Varghese R, Venkatramani R
* Photocrosslinking between nucleic acids and proteins: general discussion (90 visite)
Faraday Discussions, 2018; N/D: N/D-N/D.
Impact Factor: 3.427
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Piras L, Avitabile C, D'Andrea LD, Saviano M, Romanelli A
* Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2 (202 visite)
Biochem Bioph Res Co (ISSN: 0006-291x), 2017 Sep 15; N/D: N/D-N/D.
Impact Factor: 2.559
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (287 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2017 Mar 16; 18(6): 527-538.
Impact Factor: 2.774
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Troise AD, Buonanno M, Fiore A, Monti SM, Fogliano V
* Evolution of protein bound Maillard reaction end-products and free Amadori compounds in low lactose milk in presence of fructosamine oxidase (217 visite)
Food Chem (ISSN: 0308-8146, 0308-8146print), 2016 Dec 1; 212: 722-729.
Impact Factor: 4.529
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Sholokh M, Improta R, Mori M, Sharma R, Kenfack C, Shin D, Voltz K, Stote RH, Zaporozhets OA, Botta M, Tor Y, Mely Y
* Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels (199 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2016 Jun 8; N/D: N/D-N/D.
Impact Factor: 11.994
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Improta R, Santoro F, Blancafort L
* Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases (273 visite)
Chem Rev (ISSN: 0009-2665), 2016; 116(6): 3540-3593.
Impact Factor: 47.928
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Roviello GN, Roviello V, Autiero I, Saviano M
* Solid phase synthesis of TyrT, a thymine-tyrosine conjugate with poly(A) RNA-binding ability (423 visite)
Rsc Adv (ISSN: 2046-2069), 2016; 6(33): 27607-27613.
Impact Factor: 3.108
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Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (550 visite) (PDF 237 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Sep 7; 16(9): 21342-21362.
Impact Factor: 3.257
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (335 visite)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
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Roviello GN, Musumeci D, Roviello V, Pirtskhalava M, Egoyan A, Mirtskhulava M
* Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure (306 visite)
Beilstein J Nanotech (ISSN: 2190-4286), 2015; 6(1): 1338-1347.
Impact Factor: 2.778
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Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L
* Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics (364 visite)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015; 17(3): 640-643.
Impact Factor: 6.732
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Fahleson T, Kauczor J, Norman P, Santoro F, Improta R, Coriani S
* TD-DFT investigation of the magnetic circular dichroism spectra of some purine and pyrimidine bases of nucleic acids (250 visite)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2015; 119(21): 5476-5489.
Impact Factor: 2.883
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Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Binding ability of a thymine-functionalized oligolysine towards nucleic acids (251 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2014 Feb 1; 22(3): 997-1002.
Impact Factor: 2.793
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Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F
* A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex (280 visite)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Feb; 70(2): 362-370.
Impact Factor: 7.232
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Andreotti G, Pedone E, Giordano A, Cubellis MV
* Biochemical phenotype of a common disease-causing mutation and a possible therapeutic approach for the phosphomannomutase 2-associated disorder of glycosylation (186 visite)
Molecular Genetics & Genomic Medicine (ISSN: 2324-9269), 2013 May; 1(1): 32-44.
Impact Factor: 2.082
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Zanoli LM, Spoto G
* Isothermal amplification methods for the detection of nucleic acids in microfluidic devices (272 visite)
Biosensors (ISSN: 2079-6374), 2013 Mar; 3(1): 18-43.
Impact Factor: 0
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Zanoli LM, Licciardello M, D'Agata R, Lantano C, Calabretta A, Corradini R, Marchelli R, Spoto G
* Peptide nucleic acid molecular beacons for the detection of PCR amplicons in droplet-based microfluidic devices (209 visite)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 615-624.
Impact Factor: 3.578
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (279 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (333 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (317 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Marciano C, Galderisi M, Gargiulo P, Acampa W, D'Amore C, Esposito R, Capasso E, Savarese G, Casaretti L, Lo Iudice F, Esposito G, Rengo G, Leosco D, Cuocolo A, Perrone-Filardi P
* Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (368 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Jul; 39(7): 1199-1206.
Impact Factor: 5.114
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Avitabile C, Saviano M, D'Andrea LD, Bianchi N, Fabbri E, Brognara E, Gambari R, Romanelli A
* Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation (366 visite)
Artif Dna Pna Xnaartificial Dna Pna & Xna (ISSN: 1949-9096, 1949-0968, 1949-095x), 2012 Apr; 3(2): 88-96.
Impact Factor: 0
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (278 visite)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
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Castellano I, Merlino A
* γ-glutamyltranspeptidases: Sequence, structure, biochemical properties, and biotechnological applications (247 visite)
Cell Mol Life Sci (ISSN: 1420-682x), 2012; 69(20): 3381-3394.
Impact Factor: 5.615
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Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (186 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2011 Dec 9; 50(50): 12016-12019.
Impact Factor: 13.455
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (397 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
Impact Factor: 3.35
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Nucleobase-containing peptides: a spectroscopic study of their properties and nucleic acids recognition ability (317 visite)
Eur Biophys J (ISSN: 0175-7571, 1432-1017), 2011 Sep; 40: N/D-N/D.
Impact Factor: 2.139
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Moccia M, Roviello GN, Bucci EM, Pedone C, Saviano M
* Synthesis of a l-lysine-based alternate alpha, epsilon-peptide: A novel linear polycation with nucleic acids-binding ability (346 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2010 Sep 15; 397(1-2): 179-183.
Impact Factor: 3.607
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (329 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (237 visite)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
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Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
* Cell recruitment and transfection in gene activated collagen matrix (247 visite)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
Impact Factor: 7.883
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Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (320 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
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Severino V, Chambery A, Di Maro A, Marasco D, Ruggiero A, Berisio R, Giansanti F, Ippoliti R, Parente A
* The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves (290 visite)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(3): 570-579.
Impact Factor: 3.825
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Improta R, Santoro F, Barone V, Lami A
* Vibronic model for the quantum dynamical study of the competition between bright and charge-transfer excited states in single-strand polynucleotides: the adenine dimer case (214 visite)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic, 1089-5639linking), 2009 Dec 31; 113(52): 15346-15354.
Impact Factor: 2.899
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (308 visite)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Santoro F, Barone V, Improta R
* The Excited States Decay Of The A-T Dna: A Pcm/Td-Dft Study In Aqueous Solution Of The (9-Methyl-Adenine) 2 (1-Methyl-Thymine) 2 Stacked Tetramer (197 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2009; 131(42): 15232-15245.
Impact Factor: 8.58
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (330 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (287 visite)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (228 visite)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (302 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
Dettagli Esporta in BibTeX Esporta in EndNote
Improta R, Barone V
* The excited states of adenine and thymine nucleoside and nucleotide in aqueous solution: A comparative study by time-dependent DFT calculations (177 visite)
Theor Chem Acc (ISSN: 1432-881x), 2008 Jul; 120(4-6): 491-497.
Impact Factor: 2.37
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Santoro F, Barone V, Improta R
* Can TD-DFT calculations accurately describe the excited states behavior of stacked nucleobases? The cytosine dimer as a test case (225 visite)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic, 0192-8651linking), 2008 Apr 30; 29(6): 957-964.
Impact Factor: 3.39
Dettagli Esporta in BibTeX Esporta in EndNote
Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (247 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
Dettagli Esporta in BibTeX Esporta in EndNote
Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (298 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
Dettagli Esporta in BibTeX Esporta in EndNote
Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (203 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
Dettagli Esporta in BibTeX Esporta in EndNote
Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (291 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Chambery A, Di Maro A, Mastroianni A, Parente A, Berisio R
* Crystallization and preliminary X-ray diffraction analysis of PD-L1, a highly glycosylated ribosome inactivating protein with DNase activity (228 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2007; 14(4): 407-409.
Impact Factor: 1.097
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (337 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
Dettagli Esporta in BibTeX Esporta in EndNote
Moccia M, Musumeci D, Valente M, Roviello GN, Sapio R, Pedone C, Bucci EM
* Thermodynamic studies on PNA and PNA/DNA dendrimer formation (185 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1173-1176.
Impact Factor: 0.723
Dettagli Esporta in BibTeX Esporta in EndNote
Santoro F, Gustavsson T, Lami S, Barone V, Improta R
* Towards the understanding of the excited state dynamics of nucleic acids: Solvent and stacking effect on the photophysical behavior of nucleobases (182 visite)
Aip Conf Proc (ISSN: 0094-243x), 2007; 963(2): 631-634.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Santoro F, Barone V, Gustavsson T, Improta R
* Solvent effect on the singlet excited-state lifetimes of nucleic acid bases: A computational study of 5-fluorouracil and uracil in acetonitrile and water (225 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Dec 20; 128(50): 16312-16322.
Impact Factor: 7.696
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (382 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
Dettagli Esporta in BibTeX Esporta in EndNote
Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (320 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (297 visite)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (377 visite)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
Dettagli Esporta in BibTeX Esporta in EndNote
Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (300 visite)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
Dettagli Esporta in BibTeX Esporta in EndNote
Musumeci D, Roviello GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (340 visite)
Biopolymers, 2004; 76(6): 535-542.
Impact Factor: 2.248
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (298 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
Dettagli Esporta in BibTeX Esporta in EndNote
Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (179 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
Impact Factor: 1.94
Dettagli Esporta in BibTeX Esporta in EndNote
Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (278 visite)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
Dettagli Esporta in BibTeX Esporta in EndNote
Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (327 visite)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
Dettagli Esporta in BibTeX Esporta in EndNote
Fogliano V, Monti SM, Visconti A, Randazzo G, Facchiano AM, Colonna G, Ritieni A
Identification of a β-lactoglobulin lactosylation site (243 visite)
Biochim Biophys Acta Protein Struct Mol Enzymol (ISSN: 0167-4838), 1998 Nov 10; 1388(2): 295-304.
Impact Factor: 1.687
Dettagli Esporta in BibTeX Esporta in EndNote
Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (204 visite)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
Dettagli Esporta in BibTeX Esporta in EndNote
Manna R, Salvatore M, Di Leo MA, Scuderi F, Greco AV, Ghirlanda G, Gambassi G
Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes (343 visite)
Diabetes Res (ISSN: 0265-5985), 1991 May; 17(1): 33-36.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
73 Records (70 escludendo Abstract e Conferenze).
Impact factor totale: 306.984 (300.967 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 314.966 (305.781 escludendo Abstract e Conferenze).
Impact factor totale: 306.984 (300.967 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 314.966 (305.781 escludendo Abstract e Conferenze).
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