Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis?
CNR Ibb | back to homepage
▲NavBar
Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis? (120 visite)

Peca C, Pacelli R, Elefante A, Del Basso De Caro ML, Vergara P, Mariniello G, Giamundo A, Maiuri F

Clin Neurol Neurosurg (ISSN: 0303-8467), 2009 May; 111(4): 331-334.



Tipo di articolo: Journal Article,

Impact factor: 1.303, Impact factor a 5 anni: 1.581

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449141069&partnerID=40&md5=942c7beafb47e145f5d3965ef414bc0a

Parole chiave: Glioblastoma, Radionecrosis, Recurrence, Temozolomide, Adult, Aged, Article, Ataxia, Brain Radiation, Brain Tumor, Cancer Growth, Cancer Patient, Cancer Radiotherapy, Cancer Survival, Clinical Feature, Clinical Protocol, Confusion, Controlled Study, Differential Diagnosis, External Beam Radiotherapy, Female, Follow Up, Histopathology, Human, Medical Record Review, Mental Deterioration, Multimodality Cancer Therapy, Multiple Cycle Treatment, Neuroradiology, Nuclear Magnetic Resonance Spectroscopy, Outcome Assessment, Prevalence, Radiation Necrosis, Radiosensitization, Reoperation, Tumor Recurrence, Antineoplastic Agents, Alkylating, Brain Neoplasms, Chemotherapy, Adjuvant, Dacarbazine, Follow-Up Studies, Middle Aged, Neoplasm Recurrence, Local, Radiation Injuries, Radiation Tolerance, Treatment Outcome,

Affiliazioni:

*** IBB - CNR ***
Department of Neurological Sciences, Neurosurgical Clinic, University Federico II, Naples, Italy
Service of Neuroradiology, University Federico II, Naples, Italy
Department of Diagnostic Imaging, Service of Radiotherapy, University Federico II, Naples, Italy
Department of Biomorphological and Functional Sciences, Service of Pathology, University Federico II, Naples, Italy


Riferimenti:

Watne, K., Hager, B., Heier, M., Hirschberg, H., Reversible oedema and necrosis after irradiation of the brain. Diagnostic procedures and clinical manifestations (1990) Acta Oncol, 29, pp. 891-89

Crossen, J.R., Garwood, D., Glatstein, E., Neuwelt, E.A., Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy (1994) J Clin Oncol, 12, pp. 627-642

Sheline, G.E., Wara, W.M., Smith, V., Therapeutic irradiation and brain injury (1980) Int J Radiat Oncol Biol Phys, 6, pp. 1215-1228

Al-Mefty, O., Kersh, J.E., Routh, A., Smith, R.R., The long-term side effects of radiation therapy for benign brain tumors in adults (1990) J Neurosurg, 73, pp. 502-512

Rottenberg, D., Acute and chronic effects of radiation therapy on the nervous system (1991) Neurological Complications of Cancer Treatment, , Rottenberg D. (Ed), Butterworth-Heineman, Boston pp. 3-18

Stupp, R., Dietrich, P.Y., Ostermann Kraljevic, S., Pica, A., Maillard, I., Maeder, P., Promising survival for patients with newly diagnosed glioblastoma multiform treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide (2002) J Clin Oncol, 20, pp. 1375-1382

Stupp, R., Mason, W.P., van den Bent, M.J., Weller, M., Fisher, B., Taphoorn, M.J., Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma (2005) N Engl J Med, 352, pp. 987-996

DeAngelis, L.M., Brain tumors (2001) N Engl J Med, 344, pp. 114-123

de Wit, M.C., de Bruin, H.G., Eijkenboom, W., Sillevis Smitt, P.A., van den Bent, M.J., Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression (2004) Neurology, 63, pp. 535-537

Chamberlain, M.C., Treatment options for glioblastoma (2006) Neurosurg Focus, 20, pp. E2

Esteve, F., Rubin, C., Grand, S., Kolodie, H., Le Bas, J.F., Transient metabolic changes observed with proton MR spectroscopy in normal human brain after radiation therapy (1998) Int J Radiat Oncol Biol Phys, 40, pp. 279-286

Nelson, S.J., Graves, E., Pirzkall, A., Li, X., Antiniw Chan, A., Vigneron, D.B., In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI (2002) J Magn Reson Imaging, 16, pp. 464-476

Kashimura, H., Inoue, T., Beppu, T., Ogasawara, K., Ogawa, A., Diffusion tensor imaging for differentiation of recurrent brain tumor and radiation necrosis after radiotherapy-three case reports (2007) Clin Neurol Neurosurg, 109, pp. 106-110

Cross, N.E., Glantz, M.J., Neurologic complications of radiation therapy (2003) Neurol Clin, 21, pp. 249-277

Wedge, S.R., Porteous, J.K., Glaser, M.G., Marcus, K., Newlands, E.S., In vitro evaluation of temozolomide combined with X-irradiation (1997) Anticancer Drugs, 8, pp. 92-97

van Rijn, J., Heimans, J.J., van den Berg, J., van der Valk, P., Slotman, B.J., Survival of human glioma cells treated with various combination of temozolomide and X-rays (2000) Int J Radiat Oncol Biol Phys, 47, pp. 779-784

Hirose, Y., Berger, M.S., Pieper, R.O., p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells (2001) Cancer Res, 61, pp. 1957-1963

Hegi, M.E., Diserens, A.C., Godard, S., Dietrich, P.Y., Regli, L., Ostermann, S., Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide (2004) Clin Cancer Res, 10, pp. 1871-1874

Antonadou, D., Paraskevaidis, M., Sarris, G., Coliarakis, N., Economou, I., Karageorgis, P., Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases (2002) J Clin Oncol, 20, pp. 3644-3650

Antonadou D, Temozolomide enhances radiation treatment efficacy in brain metastases: a randomized phase II study (2001) 92th Annual Meeting of the American Association for Cancer Research, , New Orleans

Verger, E., Gil, M., Yaya, R., Vinolas, N., Villa, S., Pujol, T., Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial (2005) Int J Radiat Oncol Biol Phys, 61, pp. 185-191

Crossen, J. R., Garwood, D., Glatstein, E., Neuwelt, E. A., Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy (1994) J Clin Oncol, 12, pp. 627-642

Sheline, G. E., Wara, W. M., Smith, V., Therapeutic irradiation and brain injury (1980) Int J Radiat Oncol Biol Phys, 6, pp. 1215-1228

DeAngelis, L. M., Brain tumors (2001) N Engl J Med, 344, pp. 114-123

de Wit, M. C., de Bruin, H. G., Eijkenboom, W., Sillevis Smitt, P. A., van den Bent, M. J., Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression (2004) Neurology, 63, pp. 535-537

Chamberlain, M. C., Treatment options for glioblastoma (2006) Neurosurg Focus, 20, pp. E2

Nelson, S. J., Graves, E., Pirzkall, A., Li, X., Antiniw Chan, A., Vigneron, D. B., In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI (2002) J Magn Reson Imaging, 16, pp. 464-476

Cross, N. E., Glantz, M. J., Neurologic complications of radiation therapy (2003) Neurol Clin, 21, pp. 249-277

Wedge, S. R., Porteous, J. K., Glaser, M. G., Marcus, K., Newlands, E. S., In vitro evaluation of temozolomide combined with X-irradiation (1997) Anticancer Drugs, 8, pp. 92-97

Hegi, M. E., Diserens, A. C., Godard, S., Dietrich, P. Y., Regli, L., Ostermann, S., Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide (2004) Clin Cancer Res, 10, pp. 1871-1874



Objectives: This study investigates the diagnosis and management of patients with resected brain glioblastomas who presented early clinical and neuroradiological worsening after the completion of the Stupp protocol. Its aim is to discuss the occurrence of early radionecrosis. Methods: Fifty patients with brain glioblastoma treated by surgical resection and Stupp protocol were reviewed; 15 among them (30%) had early clinical and neuroradiological worsening at the 6-month follow-up. The MR spectroscopy and surgical findings of these patients are reviewed. Results: MR spectroscopy was in favour of tumour recurrence in 14 among 15 patients and showed radionecrosis in one. Among 10 patients who were reoperated on, 7 had histologically verified tumour recurrence or regrowth, whereas in 3 histopathology showed necrosis without evidence of tumour. The 7 patients with tumour progression had prevalence of focal neuroradiological signs (6/7) and a survival of 7.5-12 months (median survival 10 months). The 4 patients with early radionecrosis (including one patient who was not reoperated on) had clinical worsening with mental deterioration, confusion and ataxia, and MR spectroscopy positive for tumour recurrence in 3. Three were alive 24-30 months after the end of the radiotherapy, whereas one died at 40 months. Conclusion: Early radionecrosis after the Stupp protocol is not a rare event due to the radiosensitization effect of temozolomide. This phenomenon may predict a durable response to radiotherapy. MR spectroscopy may simulate tumour recurrence. A correct diagnosis is necessary to avoid useless reoperations and incorrect withdrawal of temozolomide. © 2008.
▼    Segmentazione cerebrale per applicazioni in radiologia oncologica

Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]
Vai a fine pagina   Versione per copia e incolla facile   Esporta tutto in BibTeX   Esporta tutto in EndNote


Russo M, Malandrino P, Moleti M, Vermiglio F, D'Angelo A, La Rosa G, Sapuppo G, Calaciura F, Regalbuto C, Belfiore A, Vigneri R, Pellegriti G
* Differentiated thyroid cancer in children: Heterogeneity of predictive risk factors (43 visite)
Pediatr Blood Cancer (ISSN: 1545-5009linking), 2018 Sep; 65(9): e27226-e27226.
Impact Factor: 2.513
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ugga L, Romeo V, Tedeschi E, Brunetti A, Quarantelli M
* Superparamagnetic iron oxide nanocolloids in MRI studies of neuroinflammation (31 visite)
J Neurosci Methods (ISSN: 0165-0270linking, 1872-678xelectronic), 2018 Jun 18; 310: 12-23.
Impact Factor: 2.668
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ferrucci V, De Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor MD, Cinalli G, Zollo M
* Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition (101 visite)
Brain (ISSN: 1460-2156electronic, 0006-8950linking), 2018 May 1; 141(5): 1300-1319.
Impact Factor: 9.915
Dettagli    Esporta in BibTeX    Esporta in EndNote

Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (47 visite)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Apr; 31(6): N/D-N/D.
Impact Factor: 2.872
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lanzillo R, Carbone F, Quarantelli M, Bruzzese D, Carotenuto A, De RosaV, Colamatteo A, Micillo T, De Luca Picione C, Saccà F, De Rosa A, Moccia M, Brescia Morra V, Matarese G
* Immunometabolic profiling of patients with multiple sclerosis identifies new biomarkers to predict disease activity during treatment with interferon beta-1a (62 visite)
CLIN IMMUNOL (ISSN: 1521-6616), 2017 Oct; 183: 249-253.
Impact Factor: 3.557
Dettagli    Esporta in BibTeX    Esporta in EndNote

Scollo C, Russo M, Trovato MA, Sambataro D, Giuffrida D, Manusia M, Sapuppo G, Malandrino P, Vigneri R, Pellegriti G
* Prognostic Factors for Adrenocortical Carcinoma Outcomes (70 visite)
FRONT ENDOCRINOL (ISSN: 1664-2392), 2016 Jul 25; 7: 99-99.
Impact Factor: 3.675
Dettagli    Esporta in BibTeX    Esporta in EndNote

Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (579 visite) (PDF 172 visite)
CANCER LETT (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 5.992
Dettagli    Esporta in BibTeX    Esporta in EndNote

Perri F, Pisconti S, Conson M, Pacelli R, Della Vittoria Scarpati G, Gnoni A, D'Aniello C, Cavaliere C, Licchetta A, Cella L, Giuliano M, Schiavone C, Falivene S, Di Lorenzo G, Buonerba C, Ravo V, Muto P
* Adjuvant treatment in patients at high risk of recurrence of thymoma: efficacy and safety of a three-dimensional conformal radiation therapy regimen (92 visite)
ONCOTARGETS THER (ISSN: 1178-6930), 2015 Jun 8; 8: 1345-1349.
Impact Factor: 2.272
Dettagli    Esporta in BibTeX    Esporta in EndNote

Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (20 visite)
NEW ENGL J MED (ISSN: 0028-4793), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
Dettagli    Esporta in BibTeX    Esporta in EndNote

Fonti R, Pace L, Cerchione C, Catalano L, Salvatore B,  De Luca S, Pane F, Salvatore M, Del Vecchio S
* 18F-FDG PET/CT, 99mTc-MIBI, and MRI in the prediction of outcome of patients with multiple myeloma: a comparative study (168 visite) (PDF 145 visite)
CLIN NUCL MED (ISSN: 0363-9762), 2015 Apr; 40(4): 303-308.
Impact Factor: 4.278
Dettagli    Esporta in BibTeX    Esporta in EndNote

Crisci V, Mainenti PP, Corvino F, Lauria R, Maurea S
* Bone involvement by adenocarcinoma of the uterine cervix: a rare entity (113 visite)
Pol J Radiol (ISSN: 0137-7183, 1733-134x, 1733-134xlinking), 2015 Feb 14; 80(1): 81-84.
Impact Factor: 0.567
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pace L, Klain M, Salvatore B, Nicolai E, Zampella E, Assante R, Pellegrino T, Storto G, Fonti R, Salvatore M
* Prognostic Role of 18F-FDG PET/CT in the Postoperative Evaluation of Differentiated Thyroid Cancer Patients (127 visite)
CLIN NUCL MED (ISSN: 0363-9762), 2015 Feb; 40(2): 111-115.
Impact Factor: 4.278
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pace L, Klain M, Salvatore B, Nicolai E, Zampella E, Assante R, Pellegrino T, Storto G, Fonti R, Salvatore M
* Prognostic Role Of 18f-Fluorodeoxyglucose Positron Emission Tomography/Ct In The Postoperative Evaluation Of Differentiated Thyroid Cancer Patients (97 visite)
CLIN NUCL MED (ISSN: 0363-9762), 2015 Feb; 40(2): 111-115.
Impact Factor: 4.278
Dettagli    Esporta in BibTeX    Esporta in EndNote

Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (154 visite)
HEAD NECK-J SCI SPEC (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
Dettagli    Esporta in BibTeX    Esporta in EndNote

Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (108 visite)
CELL MOL IMMUNOL (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sabbatino F, Fusciello C, Somma D, Pacelli R, Poudel R, Pepin D, Leonardi A, Carlomagno C, Della Vittoria Scarpati G, Ferrone S, Pepe S
* Effect of p53 Activity on the Sensitivity of Human Glioblastoma Cells to PARP-1 Inhibitor in Combination with Topoisomerase I Inhibitor or Radiation (97 visite)
CYTOM PART A (ISSN: 1552-4922), 2014 Nov; 85A(11): 953-961.
Impact Factor: 2.928
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pedicini P, Fiorentino A, Simeon V, Tini P, Chiumento C, Pirtoli L, Salvatore M, Storto G
* Clinical radiobiology of glioblastoma multiforme: estimation of tumor control probability from various radiotherapy fractionation schemes (158 visite)
STRAHLENTHER ONKOL (ISSN: 0179-7158), 2014 Oct; 190(10): 925-932.
Impact Factor: 2.914
Dettagli    Esporta in BibTeX    Esporta in EndNote

Conson M, Cella L, Pacelli R, Comerci M, Liuzzi R, Salvatore M, Quarantelli M
* Automated delineation of brain structures in patients undergoing radiotherapy for primary brain tumors: From atlas to dose-volume histograms (460 visite) (PDF 286 visite)
RADIOTHER ONCOL (ISSN: 0167-8140), 2014 Sep; 112(3): 326-331.
Impact Factor: 4.363
Dettagli    Esporta in BibTeX    Esporta in EndNote

D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (111 visite)
INT J CANCER (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
Dettagli    Esporta in BibTeX    Esporta in EndNote

Orditura M, Galizia G, Di Martino N, Ancona E, Castoro C, Pacelli R, Morgillo F, Rossetti S, Gambardella V, Farella A, Laterza MM, Ruol A, Fabozzi A, Napolitano V, Iovino F, Lieto E, Fei L, Conzo G, Ciardiello F, De Vita F
* Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study (1644 visite)
CURR ONCOL (ISSN: 1198-0052), 2014 Jun; 21(3): 125-133.
Impact Factor: 1.785
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cefalo G, Massimino M, Ruggiero A, Barone G, Ridola V, Spreafico F, Potepan P, Abate ME, Mascarin M, Garrè ML, Perilongo G, Madon E, Colosimo C, Riccardi R
* Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: An Italian multi-institutional phase II trial (144 visite)
NEURO-ONCOLOGY (ISSN: 1522-8517), 2014 May; 16(5): 748-753.
Impact Factor: 6.776
Dettagli    Esporta in BibTeX    Esporta in EndNote

Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (199 visite)
J IMMUNOL (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pedicini P, Fiorentino A, Improta G, Nappi A, Salvatore M, Storto G
* Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma (125 visite)
Clin Transl Oncol (ISSN: 1699-048x), 2013 Nov; 15(11): 919-924.
Impact Factor: 1.6
Dettagli    Esporta in BibTeX    Esporta in EndNote

Gramanzini M, Gargiulo S, Greco A, Feliciello A, Lignitto L, Brunetti A, Salvatore M
* 18F[FLT] PET and imaging post-processing for non -invasive assessment of siRNA treatment efficacy in experimental glioblastoma (136 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lignitto L, Arcella A, Sepe M, Rinaldi L, Delle Donne R, Gallo A, Stefan E, Bachmann VA, Oliva MA, Tiziana Storlazzi C, L'Abbate A, Brunetti A, Gargiulo S, Gramanzini M, Insabato L, Garbi C, Gottesman ME, Feliciello A
* Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth (153 visite)
Nat Commun (ISSN: 2041-1723, 2041-1723electronic, 2041-1723linking), 2013 May; 4: 100-105.
Impact Factor: 10.742
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lanzillo R, Bonavita S, Quarantelli M, Vacca G, Lus G, Amato L, Carotenuto A, Tedeschi G, Orefice G, Brescia Morra V
* Natalizumab is effective in multiple sclerosis patients switching from other disease modifying therapies in clinical practice (81 visite)
Neurol Sci (ISSN: 1590-1874, 1590-0187, 1590-3478), 2013 Apr; 34(4): 521-528.
Impact Factor: 0.38
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pacelli R, Conson M, Cella L, Liuzzi R, Troncone G, Iorio V, Solla R, Farella A, Scala S, Pagliarulo C, Salvatore M
* Radiation therapy following surgery for localized breast cancer: Outcome prediction by classical prognostic factors and approximated genetic subtypes (126 visite)
J Rad Res Journal Of Radiation Research (ISSN: 1349-9157, 0449-3060, 1349-9157electronic), 2013 Mar 1; 54(2): 292-298.
Impact Factor: 1.691
Dettagli    Esporta in BibTeX    Esporta in EndNote

Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (151 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
Dettagli    Esporta in BibTeX    Esporta in EndNote

Costa B, Bendinelli S, Gabelloni P, Da Pozzo E,  Daniele S, Scatena F, Vanacore R, Campiglia P, Bertamino A, Gomez-Monterrey I, Sorriento D, Del Giudice C, Iaccarino G, Novellino E, Martini C
* Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor (108 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013; 8(8): e72281-e72281.
Impact Factor: 3.534
Dettagli    Esporta in BibTeX    Esporta in EndNote

Fonti R, Larobina M, Del Vecchio S,  de Luca S, Fabbricini R, Catalano L, Pane F, Salvatore M, Pace L
* Metabolic tumor volume assessed by 18F-FDG PET/CT for the prediction of outcome in patients with multiple myeloma (155 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Dec; 53(12): 1829-1835.
Impact Factor: 5.774
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lanzillo R, Quarantelli M, Bonavita S, Ventrella G, Lus G, Vacca G, Prinster A, Orefice G, Tedeschi G, Brescia Morra V
* Natalizumab vs interferon beta 1a in relapsing-remitting multiple sclerosis: A head-to-head retrospective study (115 visite)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2012 Nov; 126(5): 306-314.
Impact Factor: 2.474
Dettagli    Esporta in BibTeX    Esporta in EndNote

Elefante A, Peca C, Del Basso DCM, Russo C, Formicola F, Mariniello G, Brunetti A, Maiuri F
* Symptomatic spinal cord metastasis from cerebral oligodendroglioma (118 visite)
Neurol Sci (ISSN: 1590-1874, 1590-3478), 2012 Jun; 33(3): 609-613.
Impact Factor: 1.412
Dettagli    Esporta in BibTeX    Esporta in EndNote

Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation (160 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Oct 10; 6(10): N/D-N/D.
Impact Factor: 4.092
Dettagli    Esporta in BibTeX    Esporta in EndNote

Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (174 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (123 visite)
Cellular And Molecular Life Sciences (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Impact Factor: 7.047
Dettagli    Esporta in BibTeX    Esporta in EndNote

Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Nagren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K
* EANM procedure guidelines for PET brain imaging using [18F]FDG, version (195 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2103-2110.
Impact Factor: 4.531
Dettagli    Esporta in BibTeX    Esporta in EndNote

Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A,  De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (116 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
Dettagli    Esporta in BibTeX    Esporta in EndNote

Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (147 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
Dettagli    Esporta in BibTeX    Esporta in EndNote

Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (120 visite)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
Dettagli    Esporta in BibTeX    Esporta in EndNote

Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (145 visite)
Q J Nucl Med Mol Imaging (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (110 visite)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pace L, Nicolai E, Klain M, Salvatore M
* Diagnostic value of FDG PET/CT imaging (117 visite)
Q J Nucl Med Mol Imaging (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009; 53(5): 503-512.
Impact Factor: 1.724
Dettagli    Esporta in BibTeX    Esporta in EndNote

Acampa W, Petretta M, Evangelista L, Nappi G, Luongo L, Petretta MP, Cuocolo A
* Stress cardiac single-photon emission computed tomographic imaging late after coronary artery bypass surgery for risk stratification and estimation of time to cardiac events (98 visite)
J Thorac Cardiovasc Surg (ISSN: 0022-5223, 1097-685x), 2008 Jul; 136(1): 46-51.
Impact Factor: 3.037
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caleo O, Maurea S, Klain M, Salvatore B, Storto G, Mancini M, Pace L, Salvatore M
* Postsurgical diagnostic evaluation of patients with differentiated thyroid carcinoma: Comparison of ultrasound, iodine-131 scintigraphy and PET with fluorine-18 fluorodeoxyglucose (116 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2008 Mar; 113(2): 278-288.
Impact Factor: 0.955
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sabbatino F, Pacelli R, Punzo G, Fusciello C, Vernieri C, Della Vittoria Scarpati G, Pepe S
* Inhibition of poly (ADP-Ribose) polymerase synergizes with the DNA-topoisomerase-1-inhibitor, topotecan, and radiation in human glioblastoma cell lines (99 visite)
Cytometry Part A (ISSN: 1552-4922), 2008 Jan; 73A(1): N/D-N/D.
Impact Factor: 3.259
Dettagli    Esporta in BibTeX    Esporta in EndNote

Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
* Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (135 visite)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727.
Impact Factor: 1.512
Dettagli    Esporta in BibTeX    Esporta in EndNote

Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (219 visite)
Q J Nucl Med Mol Imaging (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
Dettagli    Esporta in BibTeX    Esporta in EndNote

Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (125 visite)
Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (231 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pace L, Klain M, Albanese C, Salvatore B, Storto G, Soricelli A, Salvatore M
* Short-term outcome of differentiated thyroid cancer patients receiving a second iodine-131 therapy on the basis of a detectable serum thyroglobulin level after initial treatment (136 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Feb; 33(2): 179-183.
Impact Factor: 4.041
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pace L, Klain M, Soricelli A, Albanese C, Salvatore B, Storto G, Salvatore M
* Short Term Outcome of Differentiated Thyroid Cancer Patients with Detectable Serum Thyroglobulin after Initial Treatment Receiving a Second 131-IODINE Therapy (97 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: 179-183.
Impact Factor: 3.883
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pace L, Del Vecchio S, Salvatore M
* Technetium 99m sestamibi in multiple myeloma (87 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 2005 Jan; 234(1): 312-313.
Impact Factor: 5.377
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pace L, Del Vecchio S, Salvatore M, Walker RC, Angtuaco E, Sethi R, Fassas A, Barlogie B
* Technetium 99m sestamibi in multiple myeloma [3] (multiple letters) (97 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 2005; 234(1): 312-313.
Impact Factor: 5.377
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tauchmanovà L, Colao A, Marzano LA, Sparano L, Camera L, Rossi A, Palmieri G, Marzano E, Salvatore M, Pettinato G, Lombardi G, Rossi R
* Andrenocortical carcinomas: Twelve-year prospective experience (96 visite)
World J Surg (ISSN: 0364-2313), 2004 Sep; 28(9): 896-903.
Impact Factor: 1.952
Dettagli    Esporta in BibTeX    Esporta in EndNote

Romano M, Amato B, Markabaoui K, Tamburrini O, Salvatore M
* Follow-up of patients with previous vascular interventions: Role of multidetector row computed tomographic angiography of the abdominal aorta and lower extremities [4] (81 visite)
J Cardiovasc Surg (ISSN: 0021-9509), 2004 Feb; 45(1): 89-91.
Impact Factor: 0.8
Dettagli    Esporta in BibTeX    Esporta in EndNote

Andretta C, Catalano L, Pace L, Fonti R, Annunziata G, Rotoli B
* 99mTc-sestaMIBI scintigraphy in thalidomide-treated refractory or relapsed multiple myeloma patients [2] (99 visite)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2003 Jun; 44(6): 1081-1082.
Impact Factor: 1.163
Dettagli    Esporta in BibTeX    Esporta in EndNote

Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (128 visite)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
Dettagli    Esporta in BibTeX    Esporta in EndNote

Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (95 visite)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
Dettagli    Esporta in BibTeX    Esporta in EndNote

Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging (101 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): 802-806.
Impact Factor: 3.064
Dettagli    Esporta in BibTeX    Esporta in EndNote

Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (161 visite) (PDF 137 visite)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (106 visite)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
Dettagli    Esporta in BibTeX    Esporta in EndNote

FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (106 visite)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
Dettagli    Esporta in BibTeX    Esporta in EndNote

Brunetti A, Tedeschi E, Belfiore G, Salvatore M
Neuroblastoma metastasis to the falx cerebri. A case report (85 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1992 Apr; 83(4): 467-470.
Impact Factor: 0.967
Dettagli    Esporta in BibTeX    Esporta in EndNote

Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (107 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
Dettagli    Esporta in BibTeX    Esporta in EndNote

Iannotti F, Fieschi C, Alfano B, Picozzi P, Mansi L, Pozzilli C, Punzo A, Del Vecchio G, Lenzi GL, Salvatore M
Simplified, noninvasive PET measurement of blood-brain barrier permeability (112 visite)
J Comput Assisted Tomogr (ISSN: 0363-8715), 1987 May; 11(3): 390-397.
Impact Factor: 1.263
Dettagli    Esporta in BibTeX    Esporta in EndNote



65 Records (61 escludendo Abstract e Conferenze).
Impact factor totale: 281.514 (263.172 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 289.732 (270.855 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote