Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis?
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Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis? (123 visite)

Peca C, Pacelli R, Elefante A, Del Basso De Caro ML, Vergara P, Mariniello G, Giamundo A, Maiuri F

Clin Neurol Neurosurg (ISSN: 0303-8467), 2009 May; 111(4): 331-334.



Tipo di articolo: Journal Article,

Impact factor: 1.303, Impact factor a 5 anni: 1.581

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449141069&partnerID=40&md5=942c7beafb47e145f5d3965ef414bc0a

Parole chiave: Glioblastoma, Radionecrosis, Recurrence, Temozolomide, Adult, Aged, Article, Ataxia, Brain Radiation, Brain Tumor, Cancer Growth, Cancer Patient, Cancer Radiotherapy, Cancer Survival, Clinical Feature, Clinical Protocol, Confusion, Controlled Study, Differential Diagnosis, External Beam Radiotherapy, Female, Follow Up, Histopathology, Human, Medical Record Review, Mental Deterioration, Multimodality Cancer Therapy, Multiple Cycle Treatment, Neuroradiology, Nuclear Magnetic Resonance Spectroscopy, Outcome Assessment, Prevalence, Radiation Necrosis, Radiosensitization, Reoperation, Tumor Recurrence, Antineoplastic Agents, Alkylating, Brain Neoplasms, Chemotherapy, Adjuvant, Dacarbazine, Follow-Up Studies, Middle Aged, Neoplasm Recurrence, Local, Radiation Injuries, Radiation Tolerance, Treatment Outcome,

Affiliazioni:

*** IBB - CNR ***
Department of Neurological Sciences, Neurosurgical Clinic, University Federico II, Naples, Italy
Service of Neuroradiology, University Federico II, Naples, Italy
Department of Diagnostic Imaging, Service of Radiotherapy, University Federico II, Naples, Italy
Department of Biomorphological and Functional Sciences, Service of Pathology, University Federico II, Naples, Italy


Riferimenti:

Watne, K., Hager, B., Heier, M., Hirschberg, H., Reversible oedema and necrosis after irradiation of the brain. Diagnostic procedures and clinical manifestations (1990) Acta Oncol, 29, pp. 891-89

Crossen, J.R., Garwood, D., Glatstein, E., Neuwelt, E.A., Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy (1994) J Clin Oncol, 12, pp. 627-642

Sheline, G.E., Wara, W.M., Smith, V., Therapeutic irradiation and brain injury (1980) Int J Radiat Oncol Biol Phys, 6, pp. 1215-1228

Al-Mefty, O., Kersh, J.E., Routh, A., Smith, R.R., The long-term side effects of radiation therapy for benign brain tumors in adults (1990) J Neurosurg, 73, pp. 502-512

Rottenberg, D., Acute and chronic effects of radiation therapy on the nervous system (1991) Neurological Complications of Cancer Treatment, , Rottenberg D. (Ed), Butterworth-Heineman, Boston pp. 3-18

Stupp, R., Dietrich, P.Y., Ostermann Kraljevic, S., Pica, A., Maillard, I., Maeder, P., Promising survival for patients with newly diagnosed glioblastoma multiform treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide (2002) J Clin Oncol, 20, pp. 1375-1382

Stupp, R., Mason, W.P., van den Bent, M.J., Weller, M., Fisher, B., Taphoorn, M.J., Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma (2005) N Engl J Med, 352, pp. 987-996

DeAngelis, L.M., Brain tumors (2001) N Engl J Med, 344, pp. 114-123

de Wit, M.C., de Bruin, H.G., Eijkenboom, W., Sillevis Smitt, P.A., van den Bent, M.J., Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression (2004) Neurology, 63, pp. 535-537

Chamberlain, M.C., Treatment options for glioblastoma (2006) Neurosurg Focus, 20, pp. E2

Esteve, F., Rubin, C., Grand, S., Kolodie, H., Le Bas, J.F., Transient metabolic changes observed with proton MR spectroscopy in normal human brain after radiation therapy (1998) Int J Radiat Oncol Biol Phys, 40, pp. 279-286

Nelson, S.J., Graves, E., Pirzkall, A., Li, X., Antiniw Chan, A., Vigneron, D.B., In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI (2002) J Magn Reson Imaging, 16, pp. 464-476

Kashimura, H., Inoue, T., Beppu, T., Ogasawara, K., Ogawa, A., Diffusion tensor imaging for differentiation of recurrent brain tumor and radiation necrosis after radiotherapy-three case reports (2007) Clin Neurol Neurosurg, 109, pp. 106-110

Cross, N.E., Glantz, M.J., Neurologic complications of radiation therapy (2003) Neurol Clin, 21, pp. 249-277

Wedge, S.R., Porteous, J.K., Glaser, M.G., Marcus, K., Newlands, E.S., In vitro evaluation of temozolomide combined with X-irradiation (1997) Anticancer Drugs, 8, pp. 92-97

van Rijn, J., Heimans, J.J., van den Berg, J., van der Valk, P., Slotman, B.J., Survival of human glioma cells treated with various combination of temozolomide and X-rays (2000) Int J Radiat Oncol Biol Phys, 47, pp. 779-784

Hirose, Y., Berger, M.S., Pieper, R.O., p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells (2001) Cancer Res, 61, pp. 1957-1963

Hegi, M.E., Diserens, A.C., Godard, S., Dietrich, P.Y., Regli, L., Ostermann, S., Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide (2004) Clin Cancer Res, 10, pp. 1871-1874

Antonadou, D., Paraskevaidis, M., Sarris, G., Coliarakis, N., Economou, I., Karageorgis, P., Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases (2002) J Clin Oncol, 20, pp. 3644-3650

Antonadou D, Temozolomide enhances radiation treatment efficacy in brain metastases: a randomized phase II study (2001) 92th Annual Meeting of the American Association for Cancer Research, , New Orleans

Verger, E., Gil, M., Yaya, R., Vinolas, N., Villa, S., Pujol, T., Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial (2005) Int J Radiat Oncol Biol Phys, 61, pp. 185-191

Crossen, J. R., Garwood, D., Glatstein, E., Neuwelt, E. A., Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy (1994) J Clin Oncol, 12, pp. 627-642

Sheline, G. E., Wara, W. M., Smith, V., Therapeutic irradiation and brain injury (1980) Int J Radiat Oncol Biol Phys, 6, pp. 1215-1228

DeAngelis, L. M., Brain tumors (2001) N Engl J Med, 344, pp. 114-123

de Wit, M. C., de Bruin, H. G., Eijkenboom, W., Sillevis Smitt, P. A., van den Bent, M. J., Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression (2004) Neurology, 63, pp. 535-537

Chamberlain, M. C., Treatment options for glioblastoma (2006) Neurosurg Focus, 20, pp. E2

Nelson, S. J., Graves, E., Pirzkall, A., Li, X., Antiniw Chan, A., Vigneron, D. B., In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI (2002) J Magn Reson Imaging, 16, pp. 464-476

Cross, N. E., Glantz, M. J., Neurologic complications of radiation therapy (2003) Neurol Clin, 21, pp. 249-277

Wedge, S. R., Porteous, J. K., Glaser, M. G., Marcus, K., Newlands, E. S., In vitro evaluation of temozolomide combined with X-irradiation (1997) Anticancer Drugs, 8, pp. 92-97

Hegi, M. E., Diserens, A. C., Godard, S., Dietrich, P. Y., Regli, L., Ostermann, S., Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide (2004) Clin Cancer Res, 10, pp. 1871-1874



Objectives: This study investigates the diagnosis and management of patients with resected brain glioblastomas who presented early clinical and neuroradiological worsening after the completion of the Stupp protocol. Its aim is to discuss the occurrence of early radionecrosis. Methods: Fifty patients with brain glioblastoma treated by surgical resection and Stupp protocol were reviewed; 15 among them (30%) had early clinical and neuroradiological worsening at the 6-month follow-up. The MR spectroscopy and surgical findings of these patients are reviewed. Results: MR spectroscopy was in favour of tumour recurrence in 14 among 15 patients and showed radionecrosis in one. Among 10 patients who were reoperated on, 7 had histologically verified tumour recurrence or regrowth, whereas in 3 histopathology showed necrosis without evidence of tumour. The 7 patients with tumour progression had prevalence of focal neuroradiological signs (6/7) and a survival of 7.5-12 months (median survival 10 months). The 4 patients with early radionecrosis (including one patient who was not reoperated on) had clinical worsening with mental deterioration, confusion and ataxia, and MR spectroscopy positive for tumour recurrence in 3. Three were alive 24-30 months after the end of the radiotherapy, whereas one died at 40 months. Conclusion: Early radionecrosis after the Stupp protocol is not a rare event due to the radiosensitization effect of temozolomide. This phenomenon may predict a durable response to radiotherapy. MR spectroscopy may simulate tumour recurrence. A correct diagnosis is necessary to avoid useless reoperations and incorrect withdrawal of temozolomide. © 2008.
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Dettagli    Esporta in BibTeX    Esporta in EndNote

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Dettagli    Esporta in BibTeX    Esporta in EndNote

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Dettagli    Esporta in BibTeX    Esporta in EndNote

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Impact Factor: 5.774
Dettagli    Esporta in BibTeX    Esporta in EndNote

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Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2012 Nov; 126(5): 306-314.
Impact Factor: 2.474
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Elefante A, Peca C, Del Basso DCM, Russo C, Formicola F, Mariniello G, Brunetti A, Maiuri F
* Symptomatic spinal cord metastasis from cerebral oligodendroglioma (122 visite)
Neurol Sci (ISSN: 1590-1874, 1590-3478), 2012 Jun; 33(3): 609-613.
Impact Factor: 1.412
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation (164 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Oct 10; 6(10): N/D-N/D.
Impact Factor: 4.092
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (243 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (140 visite)
Cellular And Molecular Life Sciences (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Impact Factor: 7.047
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Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Nagren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K
* EANM procedure guidelines for PET brain imaging using [18F]FDG, version (203 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2103-2110.
Impact Factor: 4.531
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A,  De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (131 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (163 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (124 visite)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
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Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (149 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (115 visite)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Pace L, Nicolai E, Klain M, Salvatore M
* Diagnostic value of FDG PET/CT imaging (122 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009; 53(5): 503-512.
Impact Factor: 1.724
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Acampa W, Petretta M, Evangelista L, Nappi G, Luongo L, Petretta MP, Cuocolo A
* Stress cardiac single-photon emission computed tomographic imaging late after coronary artery bypass surgery for risk stratification and estimation of time to cardiac events (102 visite)
J Thorac Cardiovasc Surg (ISSN: 0022-5223, 1097-685x), 2008 Jul; 136(1): 46-51.
Impact Factor: 3.037
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Caleo O, Maurea S, Klain M, Salvatore B, Storto G, Mancini M, Pace L, Salvatore M
* Postsurgical diagnostic evaluation of patients with differentiated thyroid carcinoma: Comparison of ultrasound, iodine-131 scintigraphy and PET with fluorine-18 fluorodeoxyglucose (119 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2008 Mar; 113(2): 278-288.
Impact Factor: 0.955
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Sabbatino F, Pacelli R, Punzo G, Fusciello C, Vernieri C, Della Vittoria Scarpati G, Pepe S
* Inhibition of poly (ADP-Ribose) polymerase synergizes with the DNA-topoisomerase-1-inhibitor, topotecan, and radiation in human glioblastoma cell lines (102 visite)
Cytom Part A (ISSN: 1552-4922), 2008 Jan; 73A(1): N/D-N/D.
Impact Factor: 3.259
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Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
* Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (138 visite)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727.
Impact Factor: 1.512
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (236 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (128 visite)
Bba-Mol Basis Dis (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (240 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
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Pace L, Klain M, Albanese C, Salvatore B, Storto G, Soricelli A, Salvatore M
* Short-term outcome of differentiated thyroid cancer patients receiving a second iodine-131 therapy on the basis of a detectable serum thyroglobulin level after initial treatment (140 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Feb; 33(2): 179-183.
Impact Factor: 4.041
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Pace L, Klain M, Soricelli A, Albanese C, Salvatore B, Storto G, Salvatore M
* Short Term Outcome of Differentiated Thyroid Cancer Patients with Detectable Serum Thyroglobulin after Initial Treatment Receiving a Second 131-IODINE Therapy (100 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: 179-183.
Impact Factor: 3.883
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Pace L, Del Vecchio S, Salvatore M
* Technetium 99m sestamibi in multiple myeloma (90 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 2005 Jan; 234(1): 312-313.
Impact Factor: 5.377
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Pace L, Del Vecchio S, Salvatore M, Walker RC, Angtuaco E, Sethi R, Fassas A, Barlogie B
* Technetium 99m sestamibi in multiple myeloma [3] (multiple letters) (102 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 2005; 234(1): 312-313.
Impact Factor: 5.377
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Tauchmanovà L, Colao A, Marzano LA, Sparano L, Camera L, Rossi A, Palmieri G, Marzano E, Salvatore M, Pettinato G, Lombardi G, Rossi R
* Andrenocortical carcinomas: Twelve-year prospective experience (99 visite)
World J Surg (ISSN: 0364-2313), 2004 Sep; 28(9): 896-903.
Impact Factor: 1.952
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Romano M, Amato B, Markabaoui K, Tamburrini O, Salvatore M
* Follow-up of patients with previous vascular interventions: Role of multidetector row computed tomographic angiography of the abdominal aorta and lower extremities [4] (84 visite)
J Cardiovasc Surg (ISSN: 0021-9509), 2004 Feb; 45(1): 89-91.
Impact Factor: 0.8
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Andretta C, Catalano L, Pace L, Fonti R, Annunziata G, Rotoli B
* 99mTc-sestaMIBI scintigraphy in thalidomide-treated refractory or relapsed multiple myeloma patients [2] (102 visite)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2003 Jun; 44(6): 1081-1082.
Impact Factor: 1.163
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (143 visite)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (98 visite)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging (118 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): 802-806.
Impact Factor: 3.064
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Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (179 visite) (PDF 143 visite)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
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Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (109 visite)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (109 visite)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Brunetti A, Tedeschi E, Belfiore G, Salvatore M
Neuroblastoma metastasis to the falx cerebri. A case report (102 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1992 Apr; 83(4): 467-470.
Impact Factor: 0.967
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (110 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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Iannotti F, Fieschi C, Alfano B, Picozzi P, Mansi L, Pozzilli C, Punzo A, Del Vecchio G, Lenzi GL, Salvatore M
Simplified, noninvasive PET measurement of blood-brain barrier permeability (115 visite)
J Comput Assisted Tomogr (ISSN: 0363-8715), 1987 May; 11(3): 390-397.
Impact Factor: 1.263
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65 Records (61 escludendo Abstract e Conferenze).
Impact factor totale: 281.514 (263.172 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 289.732 (270.855 escludendo Abstract e Conferenze).







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