Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis? (186 visite)
Clin Neurol Neurosurg (ISSN: 0303-8467), 2009 May; 111(4): 331-334.
Tipo di articolo: Journal Article,
Impact factor: 1.303, Impact factor a 5 anni: 1.581
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449141069&partnerID=40&md5=942c7beafb47e145f5d3965ef414bc0a
Parole chiave: Glioblastoma, Radionecrosis, Recurrence, Temozolomide, Adult, Aged, Article, Ataxia, Brain Radiation, Brain Tumor, Cancer Growth, Cancer Patient, Cancer Radiotherapy, Cancer Survival, Clinical Feature, Clinical Protocol, Confusion, Controlled Study, Differential Diagnosis, External Beam Radiotherapy, Female, Follow Up, Histopathology, Human, Medical Record Review, Mental Deterioration, Multimodality Cancer Therapy, Multiple Cycle Treatment, Neuroradiology, Nuclear Magnetic Resonance Spectroscopy, Outcome Assessment, Prevalence, Radiation Necrosis, Radiosensitization, Reoperation, Tumor Recurrence, Antineoplastic Agents, Alkylating, Brain Neoplasms, Chemotherapy, Adjuvant, Dacarbazine, Follow-Up Studies, Middle Aged, Neoplasm Recurrence, Local, Radiation Injuries, Radiation Tolerance, Treatment Outcome,
Affiliazioni:
*** IBB - CNR ***
Department of Neurological Sciences, Neurosurgical Clinic, University Federico II, Naples, Italy
Service of Neuroradiology, University Federico II, Naples, Italy
Department of Diagnostic Imaging, Service of Radiotherapy, University Federico II, Naples, Italy
Department of Biomorphological and Functional Sciences, Service of Pathology, University Federico II, Naples, Italy
Riferimenti:
Watne, K., Hager, B., Heier, M., Hirschberg, H., Reversible oedema and necrosis after irradiation of the brain. Diagnostic procedures and clinical manifestations (1990) Acta Oncol, 29, pp. 891-89
Crossen, J.R., Garwood, D., Glatstein, E., Neuwelt, E.A., Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy (1994) J Clin Oncol, 12, pp. 627-642
Sheline, G.E., Wara, W.M., Smith, V., Therapeutic irradiation and brain injury (1980) Int J Radiat Oncol Biol Phys, 6, pp. 1215-1228
Al-Mefty, O., Kersh, J.E., Routh, A., Smith, R.R., The long-term side effects of radiation therapy for benign brain tumors in adults (1990) J Neurosurg, 73, pp. 502-512
Rottenberg, D., Acute and chronic effects of radiation therapy on the nervous system (1991) Neurological Complications of Cancer Treatment, , Rottenberg D. (Ed), Butterworth-Heineman, Boston pp. 3-18
Stupp, R., Dietrich, P.Y., Ostermann Kraljevic, S., Pica, A., Maillard, I., Maeder, P., Promising survival for patients with newly diagnosed glioblastoma multiform treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide (2002) J Clin Oncol, 20, pp. 1375-1382
Stupp, R., Mason, W.P., van den Bent, M.J., Weller, M., Fisher, B., Taphoorn, M.J., Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma (2005) N Engl J Med, 352, pp. 987-996
DeAngelis, L.M., Brain tumors (2001) N Engl J Med, 344, pp. 114-123
de Wit, M.C., de Bruin, H.G., Eijkenboom, W., Sillevis Smitt, P.A., van den Bent, M.J., Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression (2004) Neurology, 63, pp. 535-537
Chamberlain, M.C., Treatment options for glioblastoma (2006) Neurosurg Focus, 20, pp. E2
Esteve, F., Rubin, C., Grand, S., Kolodie, H., Le Bas, J.F., Transient metabolic changes observed with proton MR spectroscopy in normal human brain after radiation therapy (1998) Int J Radiat Oncol Biol Phys, 40, pp. 279-286
Nelson, S.J., Graves, E., Pirzkall, A., Li, X., Antiniw Chan, A., Vigneron, D.B., In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI (2002) J Magn Reson Imaging, 16, pp. 464-476
Kashimura, H., Inoue, T., Beppu, T., Ogasawara, K., Ogawa, A., Diffusion tensor imaging for differentiation of recurrent brain tumor and radiation necrosis after radiotherapy-three case reports (2007) Clin Neurol Neurosurg, 109, pp. 106-110
Cross, N.E., Glantz, M.J., Neurologic complications of radiation therapy (2003) Neurol Clin, 21, pp. 249-277
Wedge, S.R., Porteous, J.K., Glaser, M.G., Marcus, K., Newlands, E.S., In vitro evaluation of temozolomide combined with X-irradiation (1997) Anticancer Drugs, 8, pp. 92-97
van Rijn, J., Heimans, J.J., van den Berg, J., van der Valk, P., Slotman, B.J., Survival of human glioma cells treated with various combination of temozolomide and X-rays (2000) Int J Radiat Oncol Biol Phys, 47, pp. 779-784
Hirose, Y., Berger, M.S., Pieper, R.O., p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells (2001) Cancer Res, 61, pp. 1957-1963
Hegi, M.E., Diserens, A.C., Godard, S., Dietrich, P.Y., Regli, L., Ostermann, S., Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide (2004) Clin Cancer Res, 10, pp. 1871-1874
Antonadou, D., Paraskevaidis, M., Sarris, G., Coliarakis, N., Economou, I., Karageorgis, P., Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases (2002) J Clin Oncol, 20, pp. 3644-3650
Antonadou D, Temozolomide enhances radiation treatment efficacy in brain metastases: a randomized phase II study (2001) 92th Annual Meeting of the American Association for Cancer Research, , New Orleans
Verger, E., Gil, M., Yaya, R., Vinolas, N., Villa, S., Pujol, T., Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial (2005) Int J Radiat Oncol Biol Phys, 61, pp. 185-191
Crossen, J. R., Garwood, D., Glatstein, E., Neuwelt, E. A., Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy (1994) J Clin Oncol, 12, pp. 627-642
Sheline, G. E., Wara, W. M., Smith, V., Therapeutic irradiation and brain injury (1980) Int J Radiat Oncol Biol Phys, 6, pp. 1215-1228
DeAngelis, L. M., Brain tumors (2001) N Engl J Med, 344, pp. 114-123
de Wit, M. C., de Bruin, H. G., Eijkenboom, W., Sillevis Smitt, P. A., van den Bent, M. J., Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression (2004) Neurology, 63, pp. 535-537
Chamberlain, M. C., Treatment options for glioblastoma (2006) Neurosurg Focus, 20, pp. E2
Nelson, S. J., Graves, E., Pirzkall, A., Li, X., Antiniw Chan, A., Vigneron, D. B., In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI (2002) J Magn Reson Imaging, 16, pp. 464-476
Cross, N. E., Glantz, M. J., Neurologic complications of radiation therapy (2003) Neurol Clin, 21, pp. 249-277
Wedge, S. R., Porteous, J. K., Glaser, M. G., Marcus, K., Newlands, E. S., In vitro evaluation of temozolomide combined with X-irradiation (1997) Anticancer Drugs, 8, pp. 92-97
Hegi, M. E., Diserens, A. C., Godard, S., Dietrich, P. Y., Regli, L., Ostermann, S., Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide (2004) Clin Cancer Res, 10, pp. 1871-1874
Clin Neurol Neurosurg (ISSN: 0303-8467), 2009 May; 111(4): 331-334.
Tipo di articolo: Journal Article,
Impact factor: 1.303, Impact factor a 5 anni: 1.581
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449141069&partnerID=40&md5=942c7beafb47e145f5d3965ef414bc0a
Parole chiave: Glioblastoma, Radionecrosis, Recurrence, Temozolomide, Adult, Aged, Article, Ataxia, Brain Radiation, Brain Tumor, Cancer Growth, Cancer Patient, Cancer Radiotherapy, Cancer Survival, Clinical Feature, Clinical Protocol, Confusion, Controlled Study, Differential Diagnosis, External Beam Radiotherapy, Female, Follow Up, Histopathology, Human, Medical Record Review, Mental Deterioration, Multimodality Cancer Therapy, Multiple Cycle Treatment, Neuroradiology, Nuclear Magnetic Resonance Spectroscopy, Outcome Assessment, Prevalence, Radiation Necrosis, Radiosensitization, Reoperation, Tumor Recurrence, Antineoplastic Agents, Alkylating, Brain Neoplasms, Chemotherapy, Adjuvant, Dacarbazine, Follow-Up Studies, Middle Aged, Neoplasm Recurrence, Local, Radiation Injuries, Radiation Tolerance, Treatment Outcome,
Affiliazioni:
*** IBB - CNR ***
Department of Neurological Sciences, Neurosurgical Clinic, University Federico II, Naples, Italy
Service of Neuroradiology, University Federico II, Naples, Italy
Department of Diagnostic Imaging, Service of Radiotherapy, University Federico II, Naples, Italy
Department of Biomorphological and Functional Sciences, Service of Pathology, University Federico II, Naples, Italy
Riferimenti:
Watne, K., Hager, B., Heier, M., Hirschberg, H., Reversible oedema and necrosis after irradiation of the brain. Diagnostic procedures and clinical manifestations (1990) Acta Oncol, 29, pp. 891-89
Crossen, J.R., Garwood, D., Glatstein, E., Neuwelt, E.A., Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy (1994) J Clin Oncol, 12, pp. 627-642
Sheline, G.E., Wara, W.M., Smith, V., Therapeutic irradiation and brain injury (1980) Int J Radiat Oncol Biol Phys, 6, pp. 1215-1228
Al-Mefty, O., Kersh, J.E., Routh, A., Smith, R.R., The long-term side effects of radiation therapy for benign brain tumors in adults (1990) J Neurosurg, 73, pp. 502-512
Rottenberg, D., Acute and chronic effects of radiation therapy on the nervous system (1991) Neurological Complications of Cancer Treatment, , Rottenberg D. (Ed), Butterworth-Heineman, Boston pp. 3-18
Stupp, R., Dietrich, P.Y., Ostermann Kraljevic, S., Pica, A., Maillard, I., Maeder, P., Promising survival for patients with newly diagnosed glioblastoma multiform treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide (2002) J Clin Oncol, 20, pp. 1375-1382
Stupp, R., Mason, W.P., van den Bent, M.J., Weller, M., Fisher, B., Taphoorn, M.J., Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma (2005) N Engl J Med, 352, pp. 987-996
DeAngelis, L.M., Brain tumors (2001) N Engl J Med, 344, pp. 114-123
de Wit, M.C., de Bruin, H.G., Eijkenboom, W., Sillevis Smitt, P.A., van den Bent, M.J., Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression (2004) Neurology, 63, pp. 535-537
Chamberlain, M.C., Treatment options for glioblastoma (2006) Neurosurg Focus, 20, pp. E2
Esteve, F., Rubin, C., Grand, S., Kolodie, H., Le Bas, J.F., Transient metabolic changes observed with proton MR spectroscopy in normal human brain after radiation therapy (1998) Int J Radiat Oncol Biol Phys, 40, pp. 279-286
Nelson, S.J., Graves, E., Pirzkall, A., Li, X., Antiniw Chan, A., Vigneron, D.B., In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI (2002) J Magn Reson Imaging, 16, pp. 464-476
Kashimura, H., Inoue, T., Beppu, T., Ogasawara, K., Ogawa, A., Diffusion tensor imaging for differentiation of recurrent brain tumor and radiation necrosis after radiotherapy-three case reports (2007) Clin Neurol Neurosurg, 109, pp. 106-110
Cross, N.E., Glantz, M.J., Neurologic complications of radiation therapy (2003) Neurol Clin, 21, pp. 249-277
Wedge, S.R., Porteous, J.K., Glaser, M.G., Marcus, K., Newlands, E.S., In vitro evaluation of temozolomide combined with X-irradiation (1997) Anticancer Drugs, 8, pp. 92-97
van Rijn, J., Heimans, J.J., van den Berg, J., van der Valk, P., Slotman, B.J., Survival of human glioma cells treated with various combination of temozolomide and X-rays (2000) Int J Radiat Oncol Biol Phys, 47, pp. 779-784
Hirose, Y., Berger, M.S., Pieper, R.O., p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells (2001) Cancer Res, 61, pp. 1957-1963
Hegi, M.E., Diserens, A.C., Godard, S., Dietrich, P.Y., Regli, L., Ostermann, S., Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide (2004) Clin Cancer Res, 10, pp. 1871-1874
Antonadou, D., Paraskevaidis, M., Sarris, G., Coliarakis, N., Economou, I., Karageorgis, P., Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases (2002) J Clin Oncol, 20, pp. 3644-3650
Antonadou D, Temozolomide enhances radiation treatment efficacy in brain metastases: a randomized phase II study (2001) 92th Annual Meeting of the American Association for Cancer Research, , New Orleans
Verger, E., Gil, M., Yaya, R., Vinolas, N., Villa, S., Pujol, T., Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial (2005) Int J Radiat Oncol Biol Phys, 61, pp. 185-191
Crossen, J. R., Garwood, D., Glatstein, E., Neuwelt, E. A., Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy (1994) J Clin Oncol, 12, pp. 627-642
Sheline, G. E., Wara, W. M., Smith, V., Therapeutic irradiation and brain injury (1980) Int J Radiat Oncol Biol Phys, 6, pp. 1215-1228
DeAngelis, L. M., Brain tumors (2001) N Engl J Med, 344, pp. 114-123
de Wit, M. C., de Bruin, H. G., Eijkenboom, W., Sillevis Smitt, P. A., van den Bent, M. J., Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression (2004) Neurology, 63, pp. 535-537
Chamberlain, M. C., Treatment options for glioblastoma (2006) Neurosurg Focus, 20, pp. E2
Nelson, S. J., Graves, E., Pirzkall, A., Li, X., Antiniw Chan, A., Vigneron, D. B., In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI (2002) J Magn Reson Imaging, 16, pp. 464-476
Cross, N. E., Glantz, M. J., Neurologic complications of radiation therapy (2003) Neurol Clin, 21, pp. 249-277
Wedge, S. R., Porteous, J. K., Glaser, M. G., Marcus, K., Newlands, E. S., In vitro evaluation of temozolomide combined with X-irradiation (1997) Anticancer Drugs, 8, pp. 92-97
Hegi, M. E., Diserens, A. C., Godard, S., Dietrich, P. Y., Regli, L., Ostermann, S., Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide (2004) Clin Cancer Res, 10, pp. 1871-1874
Objectives: This study investigates the diagnosis and management of patients with resected brain glioblastomas who presented early clinical and neuroradiological worsening after the completion of the Stupp protocol. Its aim is to discuss the occurrence of early radionecrosis. Methods: Fifty patients with brain glioblastoma treated by surgical resection and Stupp protocol were reviewed; 15 among them (30%) had early clinical and neuroradiological worsening at the 6-month follow-up. The MR spectroscopy and surgical findings of these patients are reviewed. Results: MR spectroscopy was in favour of tumour recurrence in 14 among 15 patients and showed radionecrosis in one. Among 10 patients who were reoperated on, 7 had histologically verified tumour recurrence or regrowth, whereas in 3 histopathology showed necrosis without evidence of tumour. The 7 patients with tumour progression had prevalence of focal neuroradiological signs (6/7) and a survival of 7.5-12 months (median survival 10 months). The 4 patients with early radionecrosis (including one patient who was not reoperated on) had clinical worsening with mental deterioration, confusion and ataxia, and MR spectroscopy positive for tumour recurrence in 3. Three were alive 24-30 months after the end of the radiotherapy, whereas one died at 40 months. Conclusion: Early radionecrosis after the Stupp protocol is not a rare event due to the radiosensitization effect of temozolomide. This phenomenon may predict a durable response to radiotherapy. MR spectroscopy may simulate tumour recurrence. A correct diagnosis is necessary to avoid useless reoperations and incorrect withdrawal of temozolomide. © 2008.
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Dettagli Esporta in BibTeX Esporta in EndNote
D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (186 visite)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
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Orditura M, Galizia G, Di Martino N, Ancona E, Castoro C, Pacelli R, Morgillo F, Rossetti S, Gambardella V, Farella A, Laterza MM, Ruol A, Fabozzi A, Napolitano V, Iovino F, Lieto E, Fei L, Conzo G, Ciardiello F, De Vita F
* Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study (1695 visite)
Curr Oncol (ISSN: 1198-0052), 2014 Jun; 21(3): 125-133.
Impact Factor: 1.785
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Cefalo G, Massimino M, Ruggiero A, Barone G, Ridola V, Spreafico F, Potepan P, Abate ME, Mascarin M, Garrè ML, Perilongo G, Madon E, Colosimo C, Riccardi R
* Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: An Italian multi-institutional phase II trial (177 visite)
Neuro-Oncology (ISSN: 1522-8517), 2014 May; 16(5): 748-753.
Impact Factor: 6.776
Dettagli Esporta in BibTeX Esporta in EndNote
Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (256 visite)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
Dettagli Esporta in BibTeX Esporta in EndNote
Pedicini P, Fiorentino A, Improta G, Nappi A, Salvatore M, Storto G
* Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma (163 visite)
Clin Transl Oncol (ISSN: 1699-048x), 2013 Nov; 15(11): 919-924.
Impact Factor: 1.6
Dettagli Esporta in BibTeX Esporta in EndNote
Gramanzini M, Gargiulo S, Greco A, Feliciello A, Lignitto L, Brunetti A, Salvatore M
* 18F[FLT] PET and imaging post-processing for non -invasive assessment of siRNA treatment efficacy in experimental glioblastoma (218 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
Dettagli Esporta in BibTeX Esporta in EndNote
Lignitto L, Arcella A, Sepe M, Rinaldi L, Delle Donne R, Gallo A, Stefan E, Bachmann VA, Oliva MA, Tiziana Storlazzi C, L'Abbate A, Brunetti A, Gargiulo S, Gramanzini M, Insabato L, Garbi C, Gottesman ME, Feliciello A
* Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth (210 visite)
Nat Commun (ISSN: 2041-1723, 2041-1723electronic, 2041-1723linking), 2013 May; 4: 100-105.
Impact Factor: 10.742
Dettagli Esporta in BibTeX Esporta in EndNote
Lanzillo R, Bonavita S, Quarantelli M, Vacca G, Lus G, Amato L, Carotenuto A, Tedeschi G, Orefice G, Brescia Morra V
* Natalizumab is effective in multiple sclerosis patients switching from other disease modifying therapies in clinical practice (136 visite)
Neurol Sci (ISSN: 1590-1874, 1590-0187, 1590-3478), 2013 Apr; 34(4): 521-528.
Impact Factor: 0.38
Dettagli Esporta in BibTeX Esporta in EndNote
Pacelli R, Conson M, Cella L, Liuzzi R, Troncone G, Iorio V, Solla R, Farella A, Scala S, Pagliarulo C, Salvatore M
* Radiation therapy following surgery for localized breast cancer: Outcome prediction by classical prognostic factors and approximated genetic subtypes (195 visite)
J Rad Res Journal Of Radiation Research (ISSN: 1349-9157, 0449-3060, 1349-9157electronic), 2013 Mar 1; 54(2): 292-298.
Impact Factor: 1.691
Dettagli Esporta in BibTeX Esporta in EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (224 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
Dettagli Esporta in BibTeX Esporta in EndNote
Costa B, Bendinelli S, Gabelloni P, Da Pozzo E, Daniele S, Scatena F, Vanacore R, Campiglia P, Bertamino A, Gomez-Monterrey I, Sorriento D, Del Giudice C, Iaccarino G, Novellino E, Martini C
* Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor (144 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013; 8(8): e72281-e72281.
Impact Factor: 3.534
Dettagli Esporta in BibTeX Esporta in EndNote
Fonti R, Larobina M, Del Vecchio S, Fabbricini R, Catalano L, Pane F, Salvatore M, Pace L
* Metabolic tumor volume assessed by 18F-FDG PET/CT for the prediction of outcome in patients with multiple myeloma (217 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Dec; 53(12): 1829-1835.
Impact Factor: 5.774
Dettagli Esporta in BibTeX Esporta in EndNote
Lanzillo R, Quarantelli M, Bonavita S, Ventrella G, Lus G, Vacca G, Prinster A, Orefice G, Tedeschi G, Brescia Morra V
* Natalizumab vs interferon beta 1a in relapsing-remitting multiple sclerosis: A head-to-head retrospective study (173 visite)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2012 Nov; 126(5): 306-314.
Impact Factor: 2.474
Dettagli Esporta in BibTeX Esporta in EndNote
Elefante A, Peca C, Del Basso DCM, Russo C, Formicola F, Mariniello G, Brunetti A, Maiuri F
* Symptomatic spinal cord metastasis from cerebral oligodendroglioma (169 visite)
Neurol Sci (ISSN: 1590-1874, 1590-3478), 2012 Jun; 33(3): 609-613.
Impact Factor: 1.412
Dettagli Esporta in BibTeX Esporta in EndNote
Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (234 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (355 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
Dettagli Esporta in BibTeX Esporta in EndNote
Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (202 visite)
Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Impact Factor: 7.047
Dettagli Esporta in BibTeX Esporta in EndNote
Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Nagren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K
* EANM procedure guidelines for PET brain imaging using [18F]FDG, version (274 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2103-2110.
Impact Factor: 4.531
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (253 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (273 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
Dettagli Esporta in BibTeX Esporta in EndNote
Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (232 visite)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
Dettagli Esporta in BibTeX Esporta in EndNote
Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (188 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (151 visite)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
Dettagli Esporta in BibTeX Esporta in EndNote
Pace L, Nicolai E, Klain M, Salvatore M
* Diagnostic value of FDG PET/CT imaging (186 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009; 53(5): 503-512.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Acampa W, Petretta M, Evangelista L, Nappi G, Luongo L, Petretta MP, Cuocolo A
* Stress cardiac single-photon emission computed tomographic imaging late after coronary artery bypass surgery for risk stratification and estimation of time to cardiac events (123 visite)
J Thorac Cardiovasc Surg (ISSN: 0022-5223, 1097-685x), 2008 Jul; 136(1): 46-51.
Impact Factor: 3.037
Dettagli Esporta in BibTeX Esporta in EndNote
Caleo O, Maurea S, Klain M, Salvatore B, Storto G, Mancini M, Pace L, Salvatore M
* Postsurgical diagnostic evaluation of patients with differentiated thyroid carcinoma: Comparison of ultrasound, iodine-131 scintigraphy and PET with fluorine-18 fluorodeoxyglucose (157 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2008 Mar; 113(2): 278-288.
Impact Factor: 0.955
Dettagli Esporta in BibTeX Esporta in EndNote
Sabbatino F, Pacelli R, Punzo G, Fusciello C, Vernieri C, Della Vittoria Scarpati G, Pepe S
* Inhibition of poly (ADP-Ribose) polymerase synergizes with the DNA-topoisomerase-1-inhibitor, topotecan, and radiation in human glioblastoma cell lines (156 visite)
Cytom Part A (ISSN: 1552-4922), 2008 Jan; 73A(1): N/D-N/D.
Impact Factor: 3.259
Dettagli Esporta in BibTeX Esporta in EndNote
Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
* Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (201 visite)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727.
Impact Factor: 1.512
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (330 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (183 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
Dettagli Esporta in BibTeX Esporta in EndNote
Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (317 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
Dettagli Esporta in BibTeX Esporta in EndNote
Pace L, Klain M, Albanese C, Salvatore B, Storto G, Soricelli A, Salvatore M
* Short-term outcome of differentiated thyroid cancer patients receiving a second iodine-131 therapy on the basis of a detectable serum thyroglobulin level after initial treatment (205 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Feb; 33(2): 179-183.
Impact Factor: 4.041
Dettagli Esporta in BibTeX Esporta in EndNote
Pace L, Klain M, Soricelli A, Albanese C, Salvatore B, Storto G, Salvatore M
* Short Term Outcome of Differentiated Thyroid Cancer Patients with Detectable Serum Thyroglobulin after Initial Treatment Receiving a Second 131-IODINE Therapy (142 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: 179-183.
Impact Factor: 3.883
Dettagli Esporta in BibTeX Esporta in EndNote
Pace L, Del Vecchio S, Salvatore M
* Technetium 99m sestamibi in multiple myeloma (129 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 2005 Jan; 234(1): 312-313.
Impact Factor: 5.377
Dettagli Esporta in BibTeX Esporta in EndNote
Pace L, Del Vecchio S, Salvatore M, Walker RC, Angtuaco E, Sethi R, Fassas A, Barlogie B
* Technetium 99m sestamibi in multiple myeloma [3] (multiple letters) (191 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 2005; 234(1): 312-313.
Impact Factor: 5.377
Dettagli Esporta in BibTeX Esporta in EndNote
Tauchmanovà L, Colao A, Marzano LA, Sparano L, Camera L, Rossi A, Palmieri G, Marzano E, Salvatore M, Pettinato G, Lombardi G, Rossi R
* Andrenocortical carcinomas: Twelve-year prospective experience (129 visite)
World J Surg (ISSN: 0364-2313), 2004 Sep; 28(9): 896-903.
Impact Factor: 1.952
Dettagli Esporta in BibTeX Esporta in EndNote
Romano M, Amato B, Markabaoui K, Tamburrini O, Salvatore M
* Follow-up of patients with previous vascular interventions: Role of multidetector row computed tomographic angiography of the abdominal aorta and lower extremities [4] (107 visite)
J Cardiovasc Surg (ISSN: 0021-9509), 2004 Feb; 45(1): 89-91.
Impact Factor: 0.8
Dettagli Esporta in BibTeX Esporta in EndNote
Andretta C, Catalano L, Pace L, Fonti R, Annunziata G, Rotoli B
* 99mTc-sestaMIBI scintigraphy in thalidomide-treated refractory or relapsed multiple myeloma patients [2] (147 visite)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2003 Jun; 44(6): 1081-1082.
Impact Factor: 1.163
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (227 visite)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
Dettagli Esporta in BibTeX Esporta in EndNote
Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (142 visite)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
Dettagli Esporta in BibTeX Esporta in EndNote
Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging (183 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): 802-806.
Impact Factor: 3.064
Dettagli Esporta in BibTeX Esporta in EndNote
Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (223 visite) (PDF 168 visite)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
Dettagli Esporta in BibTeX Esporta in EndNote
Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (134 visite)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
Dettagli Esporta in BibTeX Esporta in EndNote
FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (134 visite)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
Dettagli Esporta in BibTeX Esporta in EndNote
Brunetti A, Tedeschi E, Belfiore G, Salvatore M
Neuroblastoma metastasis to the falx cerebri. A case report (141 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1992 Apr; 83(4): 467-470.
Impact Factor: 0.967
Dettagli Esporta in BibTeX Esporta in EndNote
Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (167 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
Dettagli Esporta in BibTeX Esporta in EndNote
Iannotti F, Fieschi C, Alfano B, Picozzi P, Mansi L, Pozzilli C, Punzo A, Del Vecchio G, Lenzi GL, Salvatore M
Simplified, noninvasive PET measurement of blood-brain barrier permeability (170 visite)
J Comput Assisted Tomogr (ISSN: 0363-8715), 1987 May; 11(3): 390-397.
Impact Factor: 1.263
Dettagli Esporta in BibTeX Esporta in EndNote
66 Records (63 escludendo Abstract e Conferenze).
Impact factor totale: 283.684 (269.434 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 292.362 (278.022 escludendo Abstract e Conferenze).
Impact factor totale: 283.684 (269.434 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 292.362 (278.022 escludendo Abstract e Conferenze).
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