Maldi, Ap/Maldi And Esi Techniques For The Ms Detection Of Amyloid Beta-Peptides (238 visite)
Int J Mass Spectrom (ISSN: 1387-3806), 2009 Apr 15; 282(1-2): 50-55.
Tipo di articolo: Journal Article,
Impact factor: 2.117, Impact factor a 5 anni: 2.304
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-62849088434&partnerID=40&md5=09bac6b3b2d72966923887abe0884156
Parole chiave: Amyloid Peptide, Fragmentation, Maldi, Matrix,
Affiliazioni:
*** IBB - CNR ***
Chemistry Department, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, Catania, Italy
Riferimenti:
Butterfield, D.A., Reed, T., Newman, S.F., Sultana, R., (2007) Free Radic. Biol. Med., 43, p. 65
Selkoe, D.J., (1994) J. Neuropathol. Exp. Neurol., 53, p. 438
Hamley, I.W., (2007) Angew. Chem. Int. Ed., 46, p. 8128
Nilsson, K.P., Hammarstroem, P., Ahlgren, F., Herland, A., Schnell, E.A., Lindgren, M., Westermark, G.T., Inganaes, O., (2006) ChemBioChem, 7, p. 1096
Arbustivi, E., Morbini, P., Verga, L., Concardi, M., Porcu, E., Pilotto, A., Zorzoli, I., Merlini, G., (1997) Amyloid, 4, p. 157
Cleary, J., Walsh, D.M., Hofmeister, J.J., Shankar, G.M., Kuskowski, M.A., Selkoe, D.J., Ashe, K.H., (2005) Nat. Neurosci., 8, p. 79
Lambert, M.P., Barlow, A.K., Chromy, B.A., Edwards, C., Freed, R., Liosatos, M., Morgan, T.E., Klein, W.L., (1998) Proc. Natl. Acad. Sci., 95, p. 6448
Kanemitsu, H., Tomiyama, T., Mori, H., (2003) Neurosci. Lett., 350, p. 113
Turner, A.J., Fisk, L., Nalivaeva, N.N., (2004) Ann. N.Y. Acad. Sci., 1035, p. 1
Eckman, E.A., Eckman, C.B., (2005) Biochem. Soc. Trans., 33, p. 1101
Luchsinger, J.A., Tang, M.X., Shea, S., Mayeux, R., (2004) Neurology, 63, p. 1187
Qiu, W.Q., Folstein, M.F., (2006) Neurobiol. Aging, 27, p. 190
Kurochkin, I.V., Goto, S., (1994) FEBS Lett., 345, p. 33
Mukherjee, A., Song, E., Kihiko-Ehmann, M., Goodman Jr., J.P., Pyrek, J.S., Estus, S., Hersh, L.B., (2000) J. Neurosci., 20, p. 8745
Leissring, M.A., Lu, A., Condron, M.M., Teplow, D.B., Stein, R.L., Farris, W., Selkoe, D.J., (2003) J. Biol. Chem., 278, p. 37314
Morelli, L., Llovera, R., Gonzalez, S.A., Affranchino, J.L., Prelli, F., Frangine, B., Ghiso, J., Castaño, E.M., (2003) J. Biol. Chem., 278, p. 23221
Chesneau, V., Vekrellis, K., Rosner, M.R., Selkoe, D.J., (2000) Biochem. J., 351, p. 509
Grasso, G., Rizzarelli, E., Spoto, G., (2007) J. Mass Spectrom., 42, p. 1590
Calero, M., Gasset, M., (2005) Methods Mol. Biol., 299, p. 129
Hosia, W., Griffiths, W.J., Johansson, J., (2005) J. Mass Spectrom., 40, p. 142
Trimpin, S., Deinzer, M.L., (2007) J. Am. Soc. Mass Spectrom., 18, p. 1533
Shen, C.-L., Murphy, R.M., (1995) Biophys. J., 69, p. 640
Chen, M., Cook, K.D., (2007) Anal. Chem., 79, p. 2031
Klug, G.M.J.A., Losic, D., Subasinghe, S.S., Aguilar, M.-I., Martin, L.L., Small, D.H., (2003) Eur. J. Biochem., 270, p. 4282
Taylor, B.M., Sarver, R.W., Fici, G., Poorman, R.A., Lutzke, B.S., Molinari, A., Kawabe, T., Epps, D.E., (2003) J. Protein Chem., 22, p. 31
Snyder, S.W., Ladror, U.S., Wade, W.S., Wang, G.T., Barrett, L.W., Matayoshi, E.D., Huffaker, H.J., Holzman, T.F., (1994) Biophys. J., 67, p. 1216
Sabaté, R., Gallardo, M., Estelrich, J., (2005) Int. J. Biol. Macromol., 35, p. 9
Tan, P.V., Laiko, V.V., Doroshenko, V.M., (2004) Anal. Chem., 75, p. 2462
Kheterpal, I., Cook, K.D., Wetzel, R., (2006) Methods Enzymol., 413, p. 140
Kheterpal, I., Chen, M., Cook, K., Wetzel, R., (2006) J. Mol. Biol., 361, p. 785
Smith, A.M., Jahn, T.R., Ashcroft, A.E., Radford, S.E., (2006) J. Mol. Biol., 364, p. 9
Caddy, G.L., Robinson, C.V., (2006) Protein Peptide Lett., 13, p. 255
Mehl, J.T., Cummings, J.J., Rohde, E., Yates, N.N., (2003) Rapid Commun. Mass Spectrom., 17, p. 1600
Grasso, G., Fragai, M., Rizzarelli, E., Spoto, G., Kwon, J.Y., (2006) J. Mass Spectrom., 41, p. 1561
Mayrhofer, C., Krieger, S., Raptakis, E., Allmaier, G., (2006) J. Proteome Res., 5, p. 1967
Konn, D.O., Murrell, J., Despeyroux, D., Gaskell, S.J., (2005) J. Am. Soc. Mass Spectrom., 16, p. 743
Cohen, S.L., Chait, B.T., (1996) Anal. Chem., 68, p. 31
Nikogosyan, D.N., Görner, H., (1999) IEEE J. Sel. Top. Quant. Electronics, 5, p. 1107
Karas, M., Hillenkamp, F., (1988) Anal. Chem., 60, p. 2299
Brown, R.S., Feng, J., Reiber, D.C., (1997) Int. J. Ion Process. Mass Spectrom., 169-170, p. 1
Petre, B.-A., Youhnovski, N., Lukkari, J., Weber, R., Przybylski, M., (2005) Eur. J. Mass Spectrom., 11, p. 513
Sadagopan, N., Watson, J.T., (2000) J. Am. Soc. Mass Spectrom., 11, p. 107
Wang, D.-S., Dickson, D.W., Malter, J.S., (2006) J. Biomed. Biotechnol. ID, 58406, p. 1
Song, E.-S., Mukherjee, A., Juliano, M.A., St Pyrek, J., Goodman, J.P., Juliano Jr., L., Hersh, L.B., (2001) J. Biol. Chem., 276, p. 1152
Zagorski, M.G., Yang, J., Shao, H., Ma, K., Zeng, H., Hong, A., (1999) Methods Enzymol., 309, p. 189
Misiti, F., Sampaolese, B., Pezzotti, M., Marini, S., Coletta, M., Ceccarelli, L., Giardina, B., Clementi, M.E., (2005) Neurochem. Int., 46, p. 575
Grasso, G., D'Agata, R., Rizzarelli, E., Spoto, G., D'Andrea, L., Pedone, C., Picardi, A., Yeo, K.J., (2005) J. Mass Spectrom., 40, p. 1565
Butterfield, D. A., Reed, T., Newman, S. F., Sultana, R., (2007) Free Radic. Biol. Med., 43, p. 65
Selkoe, D. J., (1994) J. Neuropathol. Exp. Neurol., 53, p. 438
Hamley, I. W., (2007) Angew. Chem. Int. Ed., 46, p. 8128
Nilsson, K. P., Hammarstroem, P., Ahlgren, F., Herland, A., Schnell, E. A., Lindgren, M., Westermark, G. T., Inganaes, O., (2006) ChemBioChem, 7, p. 1096
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Klein, W. L., (1998) Proc. Natl. Acad. Sci., 95, p. 6448
Turner, A. J., Fisk, L., Nalivaeva, N. N., (2004) Ann. N. Y. Acad. Sci., 1035, p. 1
Eckman, E. A., Eckman, C. B., (2005) Biochem. Soc. Trans., 33, p. 1101
Luchsinger, J. A., Tang, M. X., Shea, S., Mayeux, R., (2004) Neurology, 63, p. 1187
Qiu, W. Q., Folstein, M. F., (2006) Neurobiol. Aging, 27, p. 190
Kurochkin, I. V., Goto, S., (1994) FEBS Lett., 345, p. 33
Leissring, M. A., Lu, A., Condron, M. M., Teplow, D. B., Stein, R. L., Farris, W., Selkoe, D. J., (2003) J. Biol. Chem., 278, p. 37314
Shen, C. -L., Murphy, R. M., (1995) Biophys. J., 69, p. 640
Chen, M., Cook, K. D., (2007) Anal. Chem., 79, p. 2031
Klug, G. M. J. A., Losic, D., Subasinghe, S. S., Aguilar, M. -I., Martin, L. L., Small, D. H., (2003) Eur. J. Biochem., 270, p. 4282
Taylor, B. M., Sarver, R. W., Fici, G., Poorman, R. A., Lutzke, B. S., Molinari, A., Kawabe, T., Epps, D. E., (2003) J. Protein Chem., 22, p. 31
Snyder, S. W., Ladror, U. S., Wade, W. S., Wang, G. T., Barrett, L. W., Matayoshi, E. D., Huffaker, H. J., Holzman, T. F., (1994) Biophys. J., 67, p. 1216
Sabat, R., Gallardo, M., Estelrich, J., (2005) Int. J. Biol. Macromol., 35, p. 9
Tan, P. V., Laiko, V. V., Doroshenko, V. M., (2004) Anal. Chem., 75, p. 2462
Smith, A. M., Jahn, T. R., Ashcroft, A. E., Radford, S. E., (2006) J. Mol. Biol., 364, p. 9
Caddy, G. L., Robinson, C. V., (2006) Protein Peptide Lett., 13, p. 255
Mehl, J. T., Cummings, J. J., Rohde, E., Yates, N. N., (2003) Rapid Commun. Mass Spectrom., 17, p. 1600
Konn, D. O., Murrell, J., Despeyroux, D., Gaskell, S. J., (2005) J. Am. Soc. Mass Spectrom., 16, p. 743
Cohen, S. L., Chait, B. T., (1996) Anal. Chem., 68, p. 31
Nikogosyan, D. N., G rner, H., (1999) IEEE J. Sel. Top. Quant. Electronics, 5, p. 1107
Brown, R. S., Feng, J., Reiber, D. C., (1997) Int. J. Ion Process. Mass Spectrom., 169-170, p. 1
Petre, B. -A., Youhnovski, N., Lukkari, J., Weber, R., Przybylski, M., (2005) Eur. J. Mass Spectrom., 11, p. 513
Wang, D. -S., Dickson, D. W., Malter, J. S., (2006) J. Biomed. Biotechnol. ID, 58406, p. 1
Song, E. -S., Mukherjee, A., Juliano, M. A., St Pyrek, J., Goodman, J. P., Juliano Jr., L., Hersh, L. B., (2001) J. Biol. Chem., 276, p. 1152
Zagorski, M. G., Yang, J., Shao, H., Ma, K., Zeng, H., Hong, A., (1999) Methods Enzymol., 309, p. 189
Int J Mass Spectrom (ISSN: 1387-3806), 2009 Apr 15; 282(1-2): 50-55.
Tipo di articolo: Journal Article,
Impact factor: 2.117, Impact factor a 5 anni: 2.304
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-62849088434&partnerID=40&md5=09bac6b3b2d72966923887abe0884156
Parole chiave: Amyloid Peptide, Fragmentation, Maldi, Matrix,
Affiliazioni:
*** IBB - CNR ***
Chemistry Department, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, Catania, Italy
Riferimenti:
Butterfield, D.A., Reed, T., Newman, S.F., Sultana, R., (2007) Free Radic. Biol. Med., 43, p. 65
Selkoe, D.J., (1994) J. Neuropathol. Exp. Neurol., 53, p. 438
Hamley, I.W., (2007) Angew. Chem. Int. Ed., 46, p. 8128
Nilsson, K.P., Hammarstroem, P., Ahlgren, F., Herland, A., Schnell, E.A., Lindgren, M., Westermark, G.T., Inganaes, O., (2006) ChemBioChem, 7, p. 1096
Arbustivi, E., Morbini, P., Verga, L., Concardi, M., Porcu, E., Pilotto, A., Zorzoli, I., Merlini, G., (1997) Amyloid, 4, p. 157
Cleary, J., Walsh, D.M., Hofmeister, J.J., Shankar, G.M., Kuskowski, M.A., Selkoe, D.J., Ashe, K.H., (2005) Nat. Neurosci., 8, p. 79
Lambert, M.P., Barlow, A.K., Chromy, B.A., Edwards, C., Freed, R., Liosatos, M., Morgan, T.E., Klein, W.L., (1998) Proc. Natl. Acad. Sci., 95, p. 6448
Kanemitsu, H., Tomiyama, T., Mori, H., (2003) Neurosci. Lett., 350, p. 113
Turner, A.J., Fisk, L., Nalivaeva, N.N., (2004) Ann. N.Y. Acad. Sci., 1035, p. 1
Eckman, E.A., Eckman, C.B., (2005) Biochem. Soc. Trans., 33, p. 1101
Luchsinger, J.A., Tang, M.X., Shea, S., Mayeux, R., (2004) Neurology, 63, p. 1187
Qiu, W.Q., Folstein, M.F., (2006) Neurobiol. Aging, 27, p. 190
Kurochkin, I.V., Goto, S., (1994) FEBS Lett., 345, p. 33
Mukherjee, A., Song, E., Kihiko-Ehmann, M., Goodman Jr., J.P., Pyrek, J.S., Estus, S., Hersh, L.B., (2000) J. Neurosci., 20, p. 8745
Leissring, M.A., Lu, A., Condron, M.M., Teplow, D.B., Stein, R.L., Farris, W., Selkoe, D.J., (2003) J. Biol. Chem., 278, p. 37314
Morelli, L., Llovera, R., Gonzalez, S.A., Affranchino, J.L., Prelli, F., Frangine, B., Ghiso, J., Castaño, E.M., (2003) J. Biol. Chem., 278, p. 23221
Chesneau, V., Vekrellis, K., Rosner, M.R., Selkoe, D.J., (2000) Biochem. J., 351, p. 509
Grasso, G., Rizzarelli, E., Spoto, G., (2007) J. Mass Spectrom., 42, p. 1590
Calero, M., Gasset, M., (2005) Methods Mol. Biol., 299, p. 129
Hosia, W., Griffiths, W.J., Johansson, J., (2005) J. Mass Spectrom., 40, p. 142
Trimpin, S., Deinzer, M.L., (2007) J. Am. Soc. Mass Spectrom., 18, p. 1533
Shen, C.-L., Murphy, R.M., (1995) Biophys. J., 69, p. 640
Chen, M., Cook, K.D., (2007) Anal. Chem., 79, p. 2031
Klug, G.M.J.A., Losic, D., Subasinghe, S.S., Aguilar, M.-I., Martin, L.L., Small, D.H., (2003) Eur. J. Biochem., 270, p. 4282
Taylor, B.M., Sarver, R.W., Fici, G., Poorman, R.A., Lutzke, B.S., Molinari, A., Kawabe, T., Epps, D.E., (2003) J. Protein Chem., 22, p. 31
Snyder, S.W., Ladror, U.S., Wade, W.S., Wang, G.T., Barrett, L.W., Matayoshi, E.D., Huffaker, H.J., Holzman, T.F., (1994) Biophys. J., 67, p. 1216
Sabaté, R., Gallardo, M., Estelrich, J., (2005) Int. J. Biol. Macromol., 35, p. 9
Tan, P.V., Laiko, V.V., Doroshenko, V.M., (2004) Anal. Chem., 75, p. 2462
Kheterpal, I., Cook, K.D., Wetzel, R., (2006) Methods Enzymol., 413, p. 140
Kheterpal, I., Chen, M., Cook, K., Wetzel, R., (2006) J. Mol. Biol., 361, p. 785
Smith, A.M., Jahn, T.R., Ashcroft, A.E., Radford, S.E., (2006) J. Mol. Biol., 364, p. 9
Caddy, G.L., Robinson, C.V., (2006) Protein Peptide Lett., 13, p. 255
Mehl, J.T., Cummings, J.J., Rohde, E., Yates, N.N., (2003) Rapid Commun. Mass Spectrom., 17, p. 1600
Grasso, G., Fragai, M., Rizzarelli, E., Spoto, G., Kwon, J.Y., (2006) J. Mass Spectrom., 41, p. 1561
Mayrhofer, C., Krieger, S., Raptakis, E., Allmaier, G., (2006) J. Proteome Res., 5, p. 1967
Konn, D.O., Murrell, J., Despeyroux, D., Gaskell, S.J., (2005) J. Am. Soc. Mass Spectrom., 16, p. 743
Cohen, S.L., Chait, B.T., (1996) Anal. Chem., 68, p. 31
Nikogosyan, D.N., Görner, H., (1999) IEEE J. Sel. Top. Quant. Electronics, 5, p. 1107
Karas, M., Hillenkamp, F., (1988) Anal. Chem., 60, p. 2299
Brown, R.S., Feng, J., Reiber, D.C., (1997) Int. J. Ion Process. Mass Spectrom., 169-170, p. 1
Petre, B.-A., Youhnovski, N., Lukkari, J., Weber, R., Przybylski, M., (2005) Eur. J. Mass Spectrom., 11, p. 513
Sadagopan, N., Watson, J.T., (2000) J. Am. Soc. Mass Spectrom., 11, p. 107
Wang, D.-S., Dickson, D.W., Malter, J.S., (2006) J. Biomed. Biotechnol. ID, 58406, p. 1
Song, E.-S., Mukherjee, A., Juliano, M.A., St Pyrek, J., Goodman, J.P., Juliano Jr., L., Hersh, L.B., (2001) J. Biol. Chem., 276, p. 1152
Zagorski, M.G., Yang, J., Shao, H., Ma, K., Zeng, H., Hong, A., (1999) Methods Enzymol., 309, p. 189
Misiti, F., Sampaolese, B., Pezzotti, M., Marini, S., Coletta, M., Ceccarelli, L., Giardina, B., Clementi, M.E., (2005) Neurochem. Int., 46, p. 575
Grasso, G., D'Agata, R., Rizzarelli, E., Spoto, G., D'Andrea, L., Pedone, C., Picardi, A., Yeo, K.J., (2005) J. Mass Spectrom., 40, p. 1565
Butterfield, D. A., Reed, T., Newman, S. F., Sultana, R., (2007) Free Radic. Biol. Med., 43, p. 65
Selkoe, D. J., (1994) J. Neuropathol. Exp. Neurol., 53, p. 438
Hamley, I. W., (2007) Angew. Chem. Int. Ed., 46, p. 8128
Nilsson, K. P., Hammarstroem, P., Ahlgren, F., Herland, A., Schnell, E. A., Lindgren, M., Westermark, G. T., Inganaes, O., (2006) ChemBioChem, 7, p. 1096
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Klein, W. L., (1998) Proc. Natl. Acad. Sci., 95, p. 6448
Turner, A. J., Fisk, L., Nalivaeva, N. N., (2004) Ann. N. Y. Acad. Sci., 1035, p. 1
Eckman, E. A., Eckman, C. B., (2005) Biochem. Soc. Trans., 33, p. 1101
Luchsinger, J. A., Tang, M. X., Shea, S., Mayeux, R., (2004) Neurology, 63, p. 1187
Qiu, W. Q., Folstein, M. F., (2006) Neurobiol. Aging, 27, p. 190
Kurochkin, I. V., Goto, S., (1994) FEBS Lett., 345, p. 33
Leissring, M. A., Lu, A., Condron, M. M., Teplow, D. B., Stein, R. L., Farris, W., Selkoe, D. J., (2003) J. Biol. Chem., 278, p. 37314
Shen, C. -L., Murphy, R. M., (1995) Biophys. J., 69, p. 640
Chen, M., Cook, K. D., (2007) Anal. Chem., 79, p. 2031
Klug, G. M. J. A., Losic, D., Subasinghe, S. S., Aguilar, M. -I., Martin, L. L., Small, D. H., (2003) Eur. J. Biochem., 270, p. 4282
Taylor, B. M., Sarver, R. W., Fici, G., Poorman, R. A., Lutzke, B. S., Molinari, A., Kawabe, T., Epps, D. E., (2003) J. Protein Chem., 22, p. 31
Snyder, S. W., Ladror, U. S., Wade, W. S., Wang, G. T., Barrett, L. W., Matayoshi, E. D., Huffaker, H. J., Holzman, T. F., (1994) Biophys. J., 67, p. 1216
Sabat, R., Gallardo, M., Estelrich, J., (2005) Int. J. Biol. Macromol., 35, p. 9
Tan, P. V., Laiko, V. V., Doroshenko, V. M., (2004) Anal. Chem., 75, p. 2462
Smith, A. M., Jahn, T. R., Ashcroft, A. E., Radford, S. E., (2006) J. Mol. Biol., 364, p. 9
Caddy, G. L., Robinson, C. V., (2006) Protein Peptide Lett., 13, p. 255
Mehl, J. T., Cummings, J. J., Rohde, E., Yates, N. N., (2003) Rapid Commun. Mass Spectrom., 17, p. 1600
Konn, D. O., Murrell, J., Despeyroux, D., Gaskell, S. J., (2005) J. Am. Soc. Mass Spectrom., 16, p. 743
Cohen, S. L., Chait, B. T., (1996) Anal. Chem., 68, p. 31
Nikogosyan, D. N., G rner, H., (1999) IEEE J. Sel. Top. Quant. Electronics, 5, p. 1107
Brown, R. S., Feng, J., Reiber, D. C., (1997) Int. J. Ion Process. Mass Spectrom., 169-170, p. 1
Petre, B. -A., Youhnovski, N., Lukkari, J., Weber, R., Przybylski, M., (2005) Eur. J. Mass Spectrom., 11, p. 513
Wang, D. -S., Dickson, D. W., Malter, J. S., (2006) J. Biomed. Biotechnol. ID, 58406, p. 1
Song, E. -S., Mukherjee, A., Juliano, M. A., St Pyrek, J., Goodman, J. P., Juliano Jr., L., Hersh, L. B., (2001) J. Biol. Chem., 276, p. 1152
Zagorski, M. G., Yang, J., Shao, H., Ma, K., Zeng, H., Hong, A., (1999) Methods Enzymol., 309, p. 189
Amyloid β-peptides (Aβs) are involved in several neuropathological conditions such as Alzheimer's disease and considerable experimental evidences have emerged indicating that different proteases play a major role in regulating the accumulation of Aβs in the brain. Particularly, insulin-degrading enzyme (IDE) has been shown to degrade Aβs at different cleavage sites, but the experimental results reported in the literature and obtained by mass spectrometry methods are somehow fragmentary. The detection of Aβs is often complicated by solubility issues, oxidation artifacts and spontaneous aggregation/cleavage and, in order to rationalize the different reported results, we analyzed Aβs solutions by three different MS approaches: matrix assisted laser desorption ionization-time of flight (MALDI-TOF), atmospheric pressure (AP) MALDI ion trap and electrospray ionization (ESI) ion trap. Differences in the obtained results are discussed and ESI is chosen as the most suitable MS method for Aβs detection. Finally, cleavage sites produced by interaction of Aβs with IDE are identified, two of which had never been reported in the literature. © 2009 Elsevier B.V. All rights reserved.
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (251 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
Dettagli Esporta in BibTeX Esporta in EndNote
Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (130 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
Dettagli Esporta in BibTeX Esporta in EndNote
8 Records (7 escludendo Abstract e Conferenze).
Impact factor totale: 28.037 (28.037 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 22.632 (22.632 escludendo Abstract e Conferenze).
Impact factor totale: 28.037 (28.037 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 22.632 (22.632 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 14:22:36
238 visite. Ultima visita in data Wednesday 18 December 2019, 3:45:47
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