Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex
CNR Ibb | back to homepage
CNR Ibb | back to homepage
▲NavBar
Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (304 visite)

Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G

J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.



Tipo di articolo: Journal Article,

Impact factor: 3.415, Impact factor a 5 anni: 3.533

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-67349182328&partnerID=40&md5=4f8b53d13714fb99ae7fe465b22bc510

Parole chiave: Amphiphilic Gadolinium Complexes, Cck8 Peptide, Micelles, Peptide Gemini Surfactant, Small-Angle Neutron Scattering, Chelating Agent, Cholecystokinin, Contrast Medium, Cysteine, Unclassified Drug, Article, Beta Sheet, Chemical Structure, Circular Dichroism, Concentration (parameters), Conformational Transition, Controlled Study, Disulfide Bond, Fluorescence Spectroscopy, Lipophilicity, Molecular Size, Nuclear Magnetic Resonance Imaging, Priority Journal, Temperature, Molecular Structure, Biomolecular, Peptide Fragments, Protein Conformation, Surface-Active Agents,

Affiliazioni:

*** IBB - CNR ***
Department of Biological Sciences and IBB CNR, CIRPeB, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry CSGI, Consorzio Interuniversitario per Lo Sviluppo dei Sistemi A Grande Interfase, University of Naples Federico II, Via Cynthia, 80126 Naples, Italy
ISIS-CLRC, Rutherford Appleton Laboratory, Chilton, Oxfordshire OX11 0QX, United Kingdom


Riferimenti:

Caravan, P., Ellison, J., Lauffer, R., (1999) Chem Rev, 99, pp. 2293-235

Meade, T.J., Taylor, A.K., Bull, S.R., (2003) Curr Opin Neurobiol, 13, pp. 597-602

Toth, E., Helm, L., Merbach, A.E., (2001) The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, 1st Edn., pp. 45-120. , Wiley, London

Aime, S., Botta, M., Fasano, M., Terreno, E., (1998) Chem Soc Rev, 27, pp. 19-29

Weinmann, H.J., (2000) Methods in Biomedical Magnetic Resonance. Imaging and Spectroscopy, , Wiley, Chichester

Banci, L., Bertini, I., Luchinat, C., (1991) Nuclear and Electronic Relaxation, , VCH, Weinheim

Laus, S., Sour, A., Ruloff, R., Toth, E., Merbach, A.E., (2005) Chem Eur J, 11, pp. 3064-3076

Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J.S., Chin, S.-F., Gao, J., (2006) Nano Lett, 6, pp. 2427-2430

Dirksen, A., Langereis, S., De Waal, B.F.M., Van Genderen, M.H.P., Hackeng, T.M., Meijer, E.W., (2005) Chem Commun, pp. 2811-2813

Toth, E., Bolskar, R.D., Borel, A., Gonzalez, G., Helm, L., Merbach, A.E., Sitharaman, B., Wilson, L.J., (2005) J Am Chem Soc, 127, pp. 799-805

Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., (2004) J Am Chem Soc, 126, pp. 3097-3107

Gløgård, C., Stensrud, G., Hovland, R., Fossheim, S.L., Klaveness, J., (2002) Int J Pharm, 233, pp. 131-140

Nasongkla, N., Shuai, X., Ai, H., Weinberg, B.D., Pink, J., Boothman, D.A., Gao, J., (2004) Angew Chem Int Ed, 43, pp. 6323-6327

Li, K., Bednarski, M.D., (2002) J Magn Reson Imaging, 16, pp. 388-393

Reubi, J.C., (2003) Endocr Rev, 24, pp. 389-427

Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Teixeira, J., Schillen, K., Aime, S., Morelli, G., (2007) Chembiochem, 8, pp. 950-955

Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., (2007) Chemphyschem, 8, pp. 2526-2538

Wank, S.A., (1995) Am J Physiol Gastrointest Liver Physiol, 269, pp. 628-G646

Menger, F.M., Littau, C.A., (1991) J Am Chem Soc, 113, pp. 1451-1452

Zana, R., (2002) Adv Colloid Interface Sci, 97, pp. 205-253

Jennings, K., Marshall, I., Birrell, H., Edwards, A., Haskins, N., Sodermann, O., Kirby, A.J., Camilleri, P., (1998) Chem Commun, 18, pp. 1951-1952

Camilleri, P., Kremer, A., Edwards, A.J., Jennings, K.H., Jenkins, O., Marshall, I., McGregor, C., Kirby, A.J., (2000) Chem Commun, 14, pp. 1253-1254

Ronsin, G., Kirby, A.J., Rittenhouse, S., Woodnutt, G., Camilleri, P.J., (2002) Chem Soc Perkin Trans, 2, pp. 1302-1306

Lowik, D.W., Garcia-Hartjes, J., Meijer, J.T., Van Hest, J.C.M., (2005) Langmuir, 21, pp. 524-526

Hamley, I.W., Ansari, I.A., Castelletto, V., Nuhn, H., Rosler, A., Klok, H.A., (2005) Biomacromolecules, 6, pp. 1310-1315

Gorski, N., Kalus, J., (2001) Langmuir, 17, pp. 4211-4215

Bott, R., Wolff, T., Zierold, K., (2002) Langmuir, 18, pp. 2004-2012

Chang, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press, New York

Ellmann, G.L., (1959) Arch Biochem Biophys, 82, pp. 70-77

Barge, A., Cravotto, G., Gianolio, E., Fedeli, F., (2006) Contrast Med Mol Imaging, 1, pp. 184-188

Diwu, Z., Lu, Y., Zhang, C., Klaubert, D.H., Haugland, R.P., (1997) Photochem Photobiol, 66, pp. 424-431

Menger, F.M., (1979) Acc Chem Res, 12, pp. 111-117

Zana, R., (2002) Langmuir, 18 (20), pp. 7759-7760

Menger, F.M., Jerkumica, J.M., Jhonston, J.C., (1978) J Am Chem Soc, 100, pp. 4676-4678

Mangiapia, G., Accardo, A., Lo Celso, F., Tesauro, D., Morelli, G., Radulescu, A., Paduano, L., (2004) J Phys Chem B, 108, pp. 17611-17617

Underfriend, S., Meienhofer, J., (1985) The Peptides, 7. , IHruby VJ (ed) Academic Press, New York

Pellegrini, M., Mierke, D.F., (1999) Biochemistry, 38, pp. 14775-14783

Moroder, L., D'Ursi, A., Picone, D., Amodeo, P., Temussi, P.A., (1993) Biochem Biophys Res Commun, 190 (3), pp. 741-746

Radulescu, A., Mathers, R.T., Coates, G.W., Richter, D., Fetters, L., (2004) Macromolecules, 37, pp. 6962-6971

Kotlarchyk, M., Chen, S.H., (1983) J Chem Phys, 79, pp. 2461-2469

Nicolle, G.M., Toth, E., Eisenwiener, K.P., MacKe, H.R., Merbach, A.E., (2002) J Biol Inorg Chem, 7, pp. 757-769

Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., (2008) Coord Chem Rev, 252, pp. 2424-2443

Powell, D.H., Ni Dhubhghaill, O.M., Pubanz, D., Helm, L., Lebedev, Y.S., Schlaepfer, V., Merbach, A.E., (1996) J Am Chem Soc, 118, pp. 9333-9346

Lipari, G., Szabo, A., (1982) J Am Chem Soc, 104, pp. 4546-4559

Nicolle, G.M., Helm, L., Merbach, A.E., (2003) Magn Reson Chem, 41, pp. 794-799

Torchilin, V.P., (2005) Nat Rev Drug Discov, 4, pp. 145-154

Rjmge, B., Mulder, W.J.M., Nicolay, K., Mayo, K.H., Vljl, T., Griffioen, A.W., (2007) Bioconjug Chem, 18, pp. 785-792

Reubi, J.C., Schaer, J.C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386

Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., (1999) Bioconjug Chem, 10, pp. 137-140

Edelhoch, H., (1967) Biochemistry, 6, pp. 1948-1954

Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci, 4, pp. 2411-2423

Birdi, K.S., Singh, H.N., Dalsager, S.U., (1979) J Phys Chem, 83, pp. 2733-2737

De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., (1981) Anal Biochem, 115, pp. 278-286

Heenan, R.K., Penfold, J., King, S.M., (1997) J Appl Crystallogr, 30, pp. 1140-1147

Meade, T. J., Taylor, A. K., Bull, S. R., (2003) Curr Opin Neurobiol, 13, pp. 597-602

Weinmann, H. J., (2000) Methods in Biomedical Magnetic Resonance. Imaging and Spectroscopy, , Wiley, Chichester

Gl g rd, C., Stensrud, G., Hovland, R., Fossheim, S. L., Klaveness, J., (2002) Int J Pharm, 233, pp. 131-140

Reubi, J. C., (2003) Endocr Rev, 24, pp. 389-427

Wank, S. A., (1995) Am J Physiol Gastrointest Liver Physiol, 269, pp. 628-G646

Menger, F. M., Littau, C. A., (1991) J Am Chem Soc, 113, pp. 1451-1452

Lowik, D. W., Garcia-Hartjes, J., Meijer, J. T., Van Hest, J. C. M., (2005) Langmuir, 21, pp. 524-526

Hamley, I. W., Ansari, I. A., Castelletto, V., Nuhn, H., Rosler, A., Klok, H. A., (2005) Biomacromolecules, 6, pp. 1310-1315

Chang, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press, New York

Ellmann, G. L., (1959) Arch Biochem Biophys, 82, pp. 70-77

Menger, F. M., (1979) Acc Chem Res, 12, pp. 111-117

Menger, F. M., Jerkumica, J. M., Jhonston, J. C., (1978) J Am Chem Soc, 100, pp. 4676-4678

Nicolle, G. M., Toth, E., Eisenwiener, K. P., MacKe, H. R., Merbach, A. E., (2002) J Biol Inorg Chem, 7, pp. 757-769

Powell, D. H., Ni Dhubhghaill, O. M., Pubanz, D., Helm, L., Lebedev, Y. S., Schlaepfer, V., Merbach, A. E., (1996) J Am Chem Soc, 118, pp. 9333-9346

Nicolle, G. M., Helm, L., Merbach, A. E., (2003) Magn Reson Chem, 41, pp. 794-799

Torchilin, V. P., (2005) Nat Rev Drug Discov, 4, pp. 145-154

Reubi, J. C., Schaer, J. C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386

Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., (1999) Bioconjug Chem, 10, pp. 137-140

Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci, 4, pp. 2411-2423

Birdi, K. S., Singh, H. N., Dalsager, S. U., (1979) J Phys Chem, 83, pp. 2733-2737

Heenan, R. K., Penfold, J., King, S. M., (1997) J Appl Crystallogr, 30, pp. 1140-1147



Two gemini surfactants, [C18CysL5CCK8]2 and [C18CysDTPAGlu] 2, containing, respectively, the CCK8 peptide and the DTPAGlu chelating agent or its gadolinium complex have been prepared by linking lipophilic chains through a disulfide bond between two cysteine residues. The two surfactants aggregate in water solution forming pure or mixed micelles, with a critical micellar concentration in the 5 × 10-6-5 × 10-5 mol kg-1 range, as measured by fluorescence spectroscopy. As indicated by small-angle neutron scattering, the shape and size of the micelles are influenced by the temperature: increasing temperature leads to progressive reduction of the size of the supramolecular aggregates. Cylindrical structures found at lower temperatures (10-40 °C) evolve into ellipsoidal micelles at 50-80 °C. Furthermore, the surface-exposed CCK8 peptide changes its conformation above a transition temperature of approximately 45 °C, going from a β-sheet to a random-coil structure, as indicated by circular dichroism measurements. The mixed aggregate obtained by coaggregation of the two gemini-based amphiphilic compounds, [C18CysDTPAGlu(Gd)]2 and [C18CysL5CCK8]2 in 70:30 molar ratio, represents the first example of a peptide-containing gemini surfactant as a potential target-selective contrast agent in MRI. In fact, it presents a high relaxivity value of the gadolinium complex, 21.5 mM-1 s -1, and the CCK8 bioactive peptide exposed on the external surface is therefore capable of selective targeting of the cholecystokinin receptors. © 2009 SBIC.
Nessun risultato.
Nessun risultato.

Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]
Vai a fine pagina   Versione per copia e incolla facile   Esporta tutto in BibTeX   Esporta tutto in EndNote


Bacchella C, Nicolis S, Dell'Acqua S, Rizzarelli E, Monzani E, Casella L
* Membrane Binding Strongly Affecting the Dopamine Reactivity Induced by Copper Prion and Copper/Amyloid-beta (Abeta) Peptides. A Ternary Copper/Abeta/Prion Peptide Complex Stabilized and Solubilized in Sodium Dodecyl Sulfate Micelles (102 visite)
Inorg Chem (ISSN: 0020-1669linking, 1520-510x), 2020 Jan 6; 59(1): 900-912.
Impact Factor: 2.712
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (270 visite)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
Dettagli    Esporta in BibTeX    Esporta in EndNote

Garello F, Pagoto A, Arena F, Buffo A, Blasi F, Alberti D, Terreno E
* MRI visualization of neuroinflammation using VCAM-1 targeted paramagnetic micelles (149 visite)
Nanomedicine (ISSN: 1549-9634, 1549-9642), 2017 Nov 8; N/D: N/D-N/D.
Impact Factor: 6.5
Dettagli    Esporta in BibTeX    Esporta in EndNote

Monaco I, Arena F, Biffi S, Locatelli E, Bortot B, La Cava F, Marini GM, Severini GM, Terreno E, Comes Franchini M
* Synthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging (251 visite)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2017 May 17; 28(5): 1382-1390.
Impact Factor: 4.485
Dettagli    Esporta in BibTeX    Esporta in EndNote

Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
* ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (571 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 156: 145-152.
Impact Factor: 3.348
Dettagli    Esporta in BibTeX    Esporta in EndNote

Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (267 visite)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (267 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Vitiello M, Tesauro D, Galdiero M, Finamore E, Martora F, Mansi R, Ringhieri P, Morelli G
* Self-assembled or mixed peptide amphiphile micelles from herpes simplex virus glycoproteins as potential immunomodulatory treatment (354 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 May 7; 9(1): 2137-2148.
Impact Factor: 4.383
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (300 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (370 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
Dettagli    Esporta in BibTeX    Esporta in EndNote

Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (279 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
Dettagli    Esporta in BibTeX    Esporta in EndNote

Calce E, Monfregola L, De Luca S
* Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (315 visite)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Impact Factor: 0.825
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Morelli G
* Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors (294 visite)
Polym J (ISSN: 0032-3896), 2013 May; 45(5): 481-493.
Impact Factor: 1.554
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (296 visite)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
Dettagli    Esporta in BibTeX    Esporta in EndNote

Di Fiore A, Maresca A, Supuran CT, De Simone G
* Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (228 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840.
Impact Factor: 6.378
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (407 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tornesello AL, Aurilio M, Accardo A, Tarallo L, Barbieri A, Arra C, Tesauro D, Morelli G, Aloj L
* Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (260 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
Impact Factor: 1.799
Dettagli    Esporta in BibTeX    Esporta in EndNote

Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (340 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (351 visite)
Mol Biosyst (ISSN: 1742-206x), 2011 Mar; 7(3): 862-870.
Impact Factor: 3.534
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (350 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (307 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (270 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
Dettagli    Esporta in BibTeX    Esporta in EndNote

Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (268 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
Dettagli    Esporta in BibTeX    Esporta in EndNote

Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (304 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (248 visite)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Impact Factor: 3.825
Dettagli    Esporta in BibTeX    Esporta in EndNote

Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (395 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (430 visite)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
Dettagli    Esporta in BibTeX    Esporta in EndNote

Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (220 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
Dettagli    Esporta in BibTeX    Esporta in EndNote

Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (393 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (328 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (184 visite)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (244 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (281 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (273 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
Dettagli    Esporta in BibTeX    Esporta in EndNote

Saviano M, De Luca S, Morelli G, Tesauro D, Pedone C
* Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours (274 visite)
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2008 Feb 12; N/D: N/D-N/D.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (279 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (265 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (280 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (304 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (262 visite)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
Dettagli    Esporta in BibTeX    Esporta in EndNote

Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (256 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (284 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (291 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
Dettagli    Esporta in BibTeX    Esporta in EndNote

Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (327 visite)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (292 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Impact Factor: 3.046
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (281 visite)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A
* Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes" (258 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Apr 20; 49(8): 2456-2462.
Impact Factor: 5.115
Dettagli    Esporta in BibTeX    Esporta in EndNote

Roscigno P, D'Auria G, Falcigno L, D'Errico G, Paduano L
* Effect of the addition of a nonionic surfactant on the complex poly(asparagine)-cationic surfactant (266 visite)
Langmuir (ISSN: 0743-7463), 2005 Sep 30; 21(18): 8123-8130.
Impact Factor: 3.705
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (266 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
Dettagli    Esporta in BibTeX    Esporta in EndNote

Di Natale G, Impellizzeri G, Pappalardo G
* Conformational properties of peptide fragments homologous to the 106-114 and 106-126 residues of the human prion protein: a CD and NMR spectroscopic study (282 visite)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2005 Feb 7; 3(3): 490-497.
Impact Factor: 2.547
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (251 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (307 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
Dettagli    Esporta in BibTeX    Esporta in EndNote

Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (414 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
Dettagli    Esporta in BibTeX    Esporta in EndNote

Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (336 visite)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
Impact Factor: 1.091
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (391 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (337 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (309 visite)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, Ragone R, Bracco C, Digilio G, Tesauro D, Saviano M, Pedone C, Morelli G
* The role of segment 32-47 of cholecystokinin receptor type A in CCK8 binding: Synthesis, nuclear magnetic resonance, circular dichroism and fluorescence studies (219 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Mar; 9(3): 156-169.
Impact Factor: 1.377
Dettagli    Esporta in BibTeX    Esporta in EndNote

Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (223 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
Dettagli    Esporta in BibTeX    Esporta in EndNote

Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (379 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
Dettagli    Esporta in BibTeX    Esporta in EndNote

Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D,  De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (270 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (322 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
Impact Factor: 1.451
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (301 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 47-53.
Impact Factor: 2.405
Dettagli    Esporta in BibTeX    Esporta in EndNote



63 Records (59 escludendo Abstract e Conferenze).
Impact factor totale: 208.194 (192.073 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 223.573 (205.667 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote



















Ultima modifica di Marco Comerci in data Sunday 12 July 2020, 13:15:01
304 visite. Ultima visita in data Sunday 26 July 2020, 8:42:10