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Role of side chains in collagen triple helix stabilization and partner recognition (71 views)

Berisio R, De Simone A, Ruggiero A, Improta R, Vitagliano L

J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 131-140.

Abstract
Collagen is a widespread protein family involved in a variety of biological processes. The complexity of collagen and its fibrous nature prevent detailed investigations on the full-length protein. Reductionist approaches conducted by dissecting the protein complexity through the use of model peptides have proved to be quite effective. There are, however, several issues regarding structure-stability relationships, aggregation in higher-order assemblies, and partner recognition that are still extensively investigated. In this review, we discuss the role that side chains play in triple helix stabilization and in partner recognition. On the basis of recent literature data, we show that collagen triple helix stability is the result of the interplay of different factors. As a general trend, interactions established by amino/ imino acid side chains within the triple helix scaffold effectively modulate the intrinsic residue propensity for this common structural motif. The use of peptidemodels has also highlighted the role that side chains play in collagen self-association and in its interactions with receptors. Valuable examples in these fields are illustrated. Finally, future actions required to obtain more detailed information on the structure and the function of this complex protein are also delineated. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.

Affiliations ▼
*** IBB - CNR Affiliation

Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, I-80134 Napoli, Italy

Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom

Details ▼
Impact factor: 1.862, 5-year impact factor: 1.715

Paper type: Journal Article,

Keywords: Collagen, Iminoacids, Molecular Recognition, Protein Stability, Triple Helix, Amino Acid, Imino Acid, Peptide, Receptor, Conference Paper, Molecular Interaction, Molecular Stability, Priority Journal, Protein Family, Protein Function, Protein Motif, Protein Structure, Chemical Structure, Chemistry, Metabolism, Protein Secondary Structure, Protein Tertiary Structure, Review, Models,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449103818&partnerID=40&md5=2937f6856803c162f38cbdece9d543b7

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Persikov, A. V., Ramshaw, J. A. M., Kirkpatrick, A., Brodsky, B., Amino acid propensities for the collagen triple-helix (2000) Biochemistry, 39, pp. 14960-14967

Jenkins, C. L., Raines, R. T., Insights on the conformational stability of collagen (2002) Nat. Prod. Rep, 19, pp. 49-59

Engel, J., B chinger, H., Structure, stability and folding of the collagen triple helix (2005) Top. Curr. Chem, 247, pp. 7-33

B achinger, H., Engel, J., The thermodynamics and kinetics of collagen folding (2005) Protein Folding Handbook, 2, pp. 1059-1111. , Buchner J, Kiefhaber T eds, Wiley-VCH: Weinheim

Kramer, R. Z., Vitagliano, L., Bella, J., Berisio, R., Mazzarella, L., Brodsky, B., Zagari, A., Berman, H. M., X-Ray crystallographic determination of a collagen-like peptide with the repeating sequence (Pro-Pro-Gly) (1998) J. Mol. Biol, 280, pp. 623-638

Kramer, R. Z., Bella, J., Mayville, P., Brodsky, B., Berman, H. M., Sequence dependent conformational variations of collagen triple-helical structure (1999) Nat. Struct. Biol, 6, pp. 454-457

Kramer, R. Z., Venugopal, M. G., Bella, J., Mayville, P., Brodsky, B., Berman, H. M., Staggered molecular packing in crystals of a collagen-like peptide with a single charged pair (2000) J. Mol. Biol, 301, pp. 1191-1205

Schumacher, M. A., Mizuno, K., B chinger, H. P., The crystal structure of a collagen-like polypeptide with 3 (S) -Hydroxyproline residues in the Xaa position forms a standard 7/2 collagen triple helix (2006) J. Biol. Chem, 281, pp. 27566-27574

Mooney, S. D., Klein, T. E., Structural models of Osteogenesis imperfecta-associated variants in the col1a1 gene (2002) Mol. Cell Proteomics, 1, pp. 868-875

Park, S., Klein, T. E., Pande, V. S., Folding and misfolding of the collagen triple helix: Markov analysis of molecular dynamics simulations (2007) Biophys. J, 93, pp. 4108-4115

Radmer, R. J., Klein, T. E., Triple helical structure and stabilization of collagen-like molecules with 4 (R) -hydroxyproline in the Xaa position (2006) Biophys. J, 90, pp. 578-588

Mogilner, I. G., Ruderman, G., Grigera, J. R., Collagen stability, hydration and native state (2002) J. Mol. Graph. Model, 21, pp. 209-213

Palfi, V. K., Perczel, A., How stable is a collagen triple helix? An ab initio study on various collagen and -sheet forming sequences (2008) J. Comput. Chem, 29, pp. 1374-1386

Shah, N. K., Ramshaw, J. A., Kirkpatrick, A., Shah, C., Brodsky, B., A host-guest set of triple-helical peptides: Stability of Gly-X-Y triplets containing common nonpolar residues (1996) Biochemistry, 35, pp. 10262-10268

Holmgren, S. K., Taylor, K. M., Bretscher, L. E., Raines, R. T., Code for collagen's stability deciphered (1998) Nature, 392, pp. 666-667

Raines, R. T., Emil Thomas Kaiser award (2005) Protein Sci, 2006 (15), pp. 1219-1225

Renner, C., Sacc, B., Moroder, L., Synthetic heterotrimeric collagen peptides as mimics of cell adhesion sites of the basement membrane (2004) Biopolymers, 76, pp. 34-47

Petsko, G. A., Structural basis of thermostability in hyperthermophilic proteins, or "there's more than one way to skin a cat (2001) Methods Enzymol, 334, pp. 469-478

Privalov, P. L., Stability of proteins. Proteins which do not present a single cooperative system (1982) Adv. Protein Chem, 35, pp. 1-104

Burjanadze, T. V., New analysis of thephylogenetic change of collagen thermostability (2000) Biopolymers, 53, pp. 523-528

Gustavson, K. H., The function of hydroxyproline in collagens (1955) Nature, 175, pp. 70-74

Holmgren, S. K., Bretscher, L. E., Taylor, K. M., Raines, R. T., A hyperstable collagenmimic (1999) Chem. Biol, 6, pp. 63-70

Bretscher, L. E., Jenkins, C. L., Taylor, K. M., DeRider, M. L., Raines, R. T., Conformational stability of collagen relies on a stereoelectronic effect (2001) J. Am. Chem. Soc, 123, pp. 777-778

(4 (S) -fluoroproline-Pro-Gly) 10 forms a triple helix, but (4 (R) -fluoroproline-Pro-Gly) 10 does not (2003) J. Am. Chem. Soc, 125, pp. 9922-9923

Bann, J. G., Bachinger, H. P., Glycosylation/hydroxylation-induced stabilization of the collagen triple helix. 4-trans-hydroxyproline in the Xaa position can stabilize the triple helix (2000) J. Biol. Chem, 275, pp. 24466-24469

Ramachandran, G. N., Bansal, M., Bhatnagar, R. S., A hypothesis on the role of hydroxyproline in stabilizing collagen structure (1973) Biochim. Biophys. Acta, 322, pp. 166-171

Hodges, J. A., Raines, R. T., Stereoelectronic effects on collagen stability: The dichotomy of 4-fluoroproline diastereomers (2003) J. Am. Chem. Soc, 125, pp. 9262-9263

Shoulders, M. D., Hodges, J. A., Raines, R. T., Reciprocity of steric and stereoelectronic effects in the collagen triple helix (2006) J. Am. Chem. Soc, 128, pp. 8112-8113

Cadamuro, S. A., Reichold, R., Kusebauch, U., Musiol, H. J., Renner, C., Tavan, P., Moroder, L., Conformational properties of 4- mercaptoproline and related derivatives (2008) Angew. Chem., Int. Ed. Engl, 47, pp. 2143-2146

Raman, S. S., Parthasarathi, R., Subramanian, V., Ramasami, T., Role of aspartic acid in collagen structure and stability: A molecular dynamics investigation (2006) J. Phys. Chem. B, 110, pp. 20678-20685

Xu, Y., Keene, D. R., Bujnicki, J. M., Hook, M., Lukomski, S., Streptococcal scl1 and scl2 proteins form collagen-like triple helices (2002) J. Biol. Chem, 277, pp. 27312-27318

Ravikumar, K. M., Hwang, W., Region-specific role of water in collagen unwinding and assembly (2008) Proteins, 72, pp. 1320-1332

Sacc, B., Sinner, E. K., Kaiser, J., L bken, C., Eble, J. A., Moroder, L., Binding and docking of synthetic heterotrimeric collagen type IV peptides with 1 1 integrin (2002) ChemBioChem, 3, pp. 904-907

Slatter, D. A., Foley, L. A., Peachey, A. R., Nietlispach, D., Farndale, R. W., Rapid synthesis of a register-specific heterotrimeric type I collagen helix encompassing the integrin 2 1 binding site (2006) J. Mol. Biol, 359, pp. 289-298

Slatter, D. A., Miles, C. A., Bailey, A. J., Asymmetry in the triple helix of collagen-like heterotrimers confirms that external bonds stabilize collagen structure (2003) J. Mol. Biol, 329, pp. 175-183

Kotch, F. W., Raines, R. T., Self-assembly of synthetic collagen triple helices (2006) Proc. Natl. Acad. Sci. U. S. A, 103, pp. 3028-3033

Cejas, M. A., Kinney, W. A., Chen, C., Vinter, J. G., Almond Jr, H. R., Balss, K. M., Maryanoff, C. A., Maryanoff, B. E., Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions (2008) Proc. Natl. Acad. Sci. U. S. A, 105, pp. 8513-8518

Leo, J. C., Elovaara, H., Brodsky, B., Skurnik, M., Goldman, A., The yersinia adhesin yada binds to a collagenous triple-helical conformation but without sequence specificity (2008) Protein Eng. Des. Sel, 21, pp. 475-484

Sacc, B., Fiori, S., Moroder, L., Studies of the local conformational properties of the cell-adhesion domain of collagen type IV in synthetic heterotrimeric peptides (2003) Biochemistry, 42, pp. 3429-3436

Sacc, B., Renner, C., Moroder, L., The chain register in heterotrimeric collagen peptides affects triple helix stability and folding kinetics (2002) J. Mol. Biol, 324, pp. 309-318


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* Collagen-like proteins of pathogenic streptococci (26 views)
Lukomski S, Bachert B, Squeglia F, Berisio R
Mol Microbiol (ISSN: 1365-2958electronic, 0950-382xlinking), 2017; 103: 919-930.

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* Novel Approach for Evaluation of Bacteroides fragilis Protective Role against Bartonella henselae Liver Damage in Immunocompromised Murine Model (28 views) (PDF 13 views)
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* Unique Footprint in the scl1. 3 Locus Affects Adhesion and Biofilm Formation of the Invasive M3-Type Group A Streptococcus (33 views)
Bachert BA, Choi SJ, Lasala PR, Harper TI, Mcnitt DH, Boehm DT, Caswell CC, Ciborowski P, Keene DR, Flores AR, Musser JM, Squeglia F, Marasco D, Berisio R, Lukomski S
Front Cell Infect Microbiol (ISSN: 2235-2988electronic, 2235-2988linking), 2016 Aug 31; 6: 90-90.

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* A Unique Set of the Burkholderia Collagen-Like Proteins Provides Insight into Pathogenesis, Genome Evolution and Niche Adaptation, and Infection Detection (63 views)
Bachert BA, Choi SJ, Snyder AK, Rio RV, Durney BC, Holland LA, Amemiya K, Welkos SL, Bozue JA, Cote CK, Berisio R, Lukomski S
Plos One (ISSN: 1932-6203electronic, 1932-6203linking), 2015 Sep 10; 10(9): e0137578-e0137578.

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* The crystal structure of the streptococcal collagen-like protein 2 globular domain from invasive M3-type group a streptococcus shows significant similarity to immunomodulatory HIV protein gp41 (47 views)
Squeglia F, Bachert B, De Simone A, Lukomski S, Berisio R
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2014 Feb 21; 289(8): 5122-5133.

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* Renal cells from spermatogonial germline stem cells protect against kidney injury (43 views)
De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F
J Am Soc Nephrol (ISSN: 1533-3450electronic, 1046-6673linking), 2014 Feb; 25(2): 316-328.

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* Crystallization and preliminary X-ray crystallographic analysis of the variable domain of Scl2. 3, a streptococcal collagen-like protein from invasive M3-type Streptococcus pyogenes (59 views)
Squeglia F, Bachert B, Romanò MF, Lukomski S, Berisio R
Communicationsacta Crystallographica Section F Structural Biology And Crystallization (ISSN: 1744-3091, 1744-4309), 2013 Sep; 69(9): 1023-1025.

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* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (74 views)
Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.

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* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (47 views)
Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.

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* Interplay between peptide bond geometrical parameters in nonglobular structural contexts (57 views)
Esposito L, Balasco N, De Simone A, Berisio R, Vitagliano L
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: N/D-N/D.

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* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (56 views)
Berisio R
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 697-698.

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* Polyproline and triple helix motifs in Host-Pathogen recognition (228 views)
Berisio R, Vitagliano L
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 855-865.

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* Structural and Dynamic properties of incomplete immunoglobulin-like fold domains (60 views)
Berisio R, Ciccarelli L, Squeglia F, De Simone A, Vitagliano L
Protein And Peptide Letters (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1045-1053.

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* Role of hydration in collagen recognition by bacterial adhesins (41 views)
Vitagliano L, Berisio R, De Simone A
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2011 May 4; 100(9): 2253-2261.

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* Cell recruitment and transfection in gene activated collagen matrix (61 views)
Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.

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* Comment on Microfibrillar structure of type i collagen in situ by Orgel et al. (2006), Proc. Natl Acad. Sci. USA, 103, 9001-9005 (36 views)
Okuyama K, Baechinger HP, Mizuno K, Boudko S, Engel J, Berisio R, Vitagliano L
Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 2009 Sep; 65(9): 1007-1008.

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* In vivo properties of the proangiogenic peptide QK (48 views)
Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
J Transl Med Journal Of Translational Medicine (ISSN: 1479-5876, 1479-5876electronic), 2009 Jun 8; 7: 41-41.

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* Phase behavior and crystallogenesis under counter-diffusion conditions of the collagen-model peptide (Pro-Pro-Gly)10 (47 views)
Vergara A, Castagnolo D, Carotenuto L, Vitagliano L, Berisio R, Sorrentino G, Gonzalez-ramirez L, Garcia-ruiz J, Zagari A
J Cryst Growth (ISSN: 0022-0248), 2009 Jan 1; 311(2): 304-309.

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* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (47 views)
Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
J Mol Biol Journal Of Molecular Biology (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.

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* Correlation between Raman and X-ray crystallography data of (Pro-Pro-Gly)(10) (40 views)
Merlino A, Sica F, Mazzarella L, Zagari A, Vergara A
Biophysical Chemistry (ISSN: 0301-4622), 2008 Sep; 137(1): 24-27.

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* Role of hydration in collagen triple helix stabilization (54 views)
De Simone A, Vitagliano L, Berisio R
Biochem Biophys Res Commun (ISSN: 0006-291x), 2008 Jul 18; 372(1): 121-125.

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* Contribution of dipole-dipole interactions to the stability of the collagen triple helix (41 views)
Improta R, Berisio R, Vitagliano L
Protein Sci Protein Science (ISSN: 0961-8368), 2008 May; 17(5): 955-961.

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* Interleukin (il)-6 And Receptor Activator Of Nuclear Factor (nf)-Kappab Ligand (rankl) Are Increased In The Serum Of A Patient With Primary Pachydermoperiostosis (51 views)
Rendina D, De Filippo G, Viceconti R, Soscia E, Sirignano C, Salvatore M, Della Monica M, Scarano G, Mossetti G
Scand J Rheumatol (ISSN: 0300-9742), 2008 May; 37(3): 225-229.

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* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (55 views)
Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.

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* Protective effect of orally administered carnosine on bleomycin-induced lung injury (53 views)
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.

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* In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (62 views)
Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
J Mass Spectrom Journal Of Mass Spectrometry (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.

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* Polyproline helices in protein structures: A statistical survey (40 views)
Berisio R, Loguercio S, De Simone A, Zagari A, Vitagliano L
Protein And Peptide Letters (ISSN: 0929-8665, 1875-5305), 2006; 13(8): 847-854.

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* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (49 views)
Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
J Mass Spectrom Journal Of Mass Spectrometry (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.

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* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (72 views)
D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.

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* Lessons from crystals grown in the Advanced Protein Crystallisation Facility for conventional crystallisation applied to structural biology (37 views)
Vergara A, Lorber B, Sauter C, Giege R, Zagari A
Biophysical Chemistry (ISSN: 0301-4622), 2005; 118(2-3): 102-112.

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* Imino acids and collagen triple helix stability: Characterization of collagen-like polypeptides containing Hyp-Hyp-Gly sequence repeats (39 views)
Berisio R, Granata V, Vitagliano L, Zagari A
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Sep 22; 126(37): 11402-11403.

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* The polypeptide 310-helix (41 views)
Berisio R, Granata V, Vitagliano L, Zagari A
N/D, 2004 Sep 22; 16(C): 350-353.

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* Characterization of Collagen-Like Heterotrimers: Implications for Triple-Helix Stability (64 views)
Berisio R, Granata V, Vitagliano L, Zagari A
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 682-688.

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* Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing's disease: A prospective study (44 views)
Di Somma C, Pivonello R, Loche S, Faggiano A, Klain M, Salvatore M, Lombardi G, Colao A
Clin Endocrinol (ISSN: 0300-0664, 1365-2265), 2003 Mar; 58(3): 302-308.

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* Crystallization of the collagen-like polypeptide (PPG)10 aboard the International Space Station. 3. Analysis of residual acceleration-induced motion (61 views)
Castagnolo D, Piccolo C, Carotenuto L, Vergara A, Zagari A
Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 2003; 59(4): 773-776.

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* Crystallization of the collagen-like polypeptide (PPG)(10) aboard the International Space Station. 1. Video observation (67 views)
Vergara A, Corvino E, Sorrentino G, Piccolo C, Tortora A, Carotenuto L, Mazzarella L, Zagari A
Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 2002 Oct; 58: 1690-1694.

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* Crystallization of the collagen-like polypeptide (PPG)10 aboard the International Space Station. 2. Comparison of crystal quality by X-ray diffraction (65 views)
Berisio R, Vitagliano L, Vergara A, Sorrentino G, Mazzarella L, Zagari A
Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 2002 Oct; 58(10II): 1695-1699.

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* Understanding the role of stereoelectronic effects in determining collagen stability. 2. A quantum mechanical/molecular mechanical study of (Proline-Proline-Glycine)n polypeptides (38 views)
Improta R, Mele F, Crescenzi O, Benzi C, Barone V
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Jul 3; 124(26): 7857-7865.

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* Recent progress on collagen triple helix structure, stability and assembly (42 views)
Berisio R, Vitagliano L, Mazzarella L, Zagari A
Protein And Peptide Letters (ISSN: 0929-8665, 1875-5305), 2002 Apr; 9(2): 107-116.

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* Crystal structure of the collagen triple helix model [(Pro-Pro-Gly)10]3 (50 views)
Berisio R, Vitagliano L, Mazzarella L, Zagari A
Protein Sci Protein Science (ISSN: 0961-8368), 2002 Feb; 11(2): 262-270.

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* Preferred proline puckerings in cis and trans peptide groups: Implications for collagen stability (50 views)
Vitagliano L, Berisio R, Mastrangelo A, Mazzarella L, Zagari A
Protein Sci Protein Science (ISSN: 0961-8368), 2001 Dec; 10(12): 2627-2632.

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* Structural bases of collagen stabilization induced by proline hydroxylation (50 views)
Vitagliano L, Berisio R, Mazzarella L, Zagari A
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2001 Apr 15; 58(5): 459-464.

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Effects of microgravity on the crystal quality of a collagen-like polypeptide (42 views)
Berisio R, Vitagliano L, Sorrentino G, Carotenuto L, Piccolo C, Mazzarella L, Zagari A
Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 2000 Jan; 56(1): 55-61.

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Biomolecule crystallisation in microgravity (34 views)
Carotenuto L, Castagnolo D, Piccolo C, Berisio R, Vitagliano L, Mazzarella L, Zagari A
Eur Space Agency Spec Publ Esa Sp (ISSN: 0379-6566), 2000; (454I): 437-443.

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X-ray crystallographic determination of a collagen-like peptide with the repeating sequence (Pro-Pro-Gly) (62 views)
Kramer RZ, Vitagliano L, Bella J, Berisio R, Mazzarella L, Brodsky B, Zagari A, Berman HM
J Mol Biol Journal Of Molecular Biology (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1998 Jul 24; 280(4): 623-638.

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Isolation and characterization of human embryonic osteoblasts (26 views)
Oliva A, Marrone G, Della Ragione F, Riccio V, Palumbo R, Rossano F, Zappia V
Calcif Tissue Int (ISSN: 0171-967xprint, 0171-967xlinking), 1992 Nov; 51(5): 356-362.

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49 Records (46 excluding Abstracts and Conferences).
Total impact factor: 188.653 (182.324 excluding Abstracts and Conferences).
Total 5-year impact factor: 189.406 (182.393 excluding Abstracts and Conferences).



Your bibliography query: (([btitle, keywords, abstract] COLLAGEN)) AND NOT [id] = 9077



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