Home Ricerca Sedi Chi siamo Organigramma Personale Contatti Didattica Login Documenti EN
Progetti in evidenza
INCIPIT
(Link esterno)

ISTAPCA
(1071 visite)

LightDyNAmics
(933 visite)

Fondo Europeo Pesca
(476 visite)

 INMiND
(1087 visite)

Fondazione Veronesi
(Link esterno)

Instruct-IT
(Link esterno)

Euro-BioImaging
(Link esterno)

 PRIN
(1230 visite)

 eHealthNet
(1008 visite)

  Ponrec
(947 visite)

MFAG Grant
(1037 visite)

MERIT
(Link esterno)


Collegamenti



Statin: New life for an old drug (104 visite)

Gustavsson T, Banyasz A, Sarkar N, Markovitsi D, Improta R

Pharmacol Res Academic Press, 2008 Jun 23; 350(1-3): 1-2.

Tipo di articolo: Journal Article,

Impact factor: 3.976

Impact factor a 5 anni: 4.483


Parole chiave: Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor, Antioxidant Activity, Blood Clotting, Bone Metabolism, Cardiovascular Effect, Drug Mechanism, Drug Metabolism, Drug Safety, Editorial, Human, Immunoregulation, Metabolic Regulation, Myopathy, Neuroprotection, Pharmacogenomics, Priority Journal, Sepsis, Conical Intersection, Excited States, Femtosecond, Fluorescence Upconversion, Nucleobases, Pyrimidines, Solvent Effect, Thymine, Uracil,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84906790576&partnerID=40&md5=0affe368fbeda69452be1e433a8680a5

The excited state lifetimes of uracil, thymine and 5-fluorouracil have been measured using femtosecond UV fluorescence upconversion in various protic and aprotic polar solvents. The fastest decays are observed in acetonitrile and the slowest in aqueous solution while those observed in alcohols are intermediate. No direct correlation with macroscopic solvent parameters such as polarity or viscosity is found, but hydrogen bonding is one key factor affecting the fluorescence decay. It is proposed that the solvent modulates the relative energy of two close-lying electronically excited states, the bright pi pi* and the dark pi pi* states. This relative energy gap controls the non-radiative relaxation of the pi pi* state through a conical intersection close to the Franck-Condon region competing with the ultrafast internal conversion to the ground state. In addition, an inverse isotope effect is observed in D2O where the decays are faster than in H2O. (C) 2008 Elsevier B.V. All rights reserved.
*** IBB - CNR ***

Department of Medicine and Surgery, University of Salerno, 84081 Baronissi, Salerno, Italy

Biopharm Research Laboratories, Inc., Tokyo 181-0013, Japan

Laboratoire Francis Perrin, CEA/DSM/DRECAM/SPAM - CNRS URA 2453, CEA/Saclay, F-91191 Gif-sur-Yvette, France

Department of Chemistry, Indian Institute of Technology, Kharagpur, 721 302 WB, India

Dipartimento di Chimica, Universita Federico II, Complesso Universitario Monte S. Angelo, Via Cintia, I-80126 Napoli, Italy

Istituto Biostrutture e Bioimmagini, CNR, V. Mezzocannone 6, 80134 Napoli, Italy
Stossel, T.P., The discovery of statins (2008) Cell, 134 (6), pp. 903-90

Endo, A., The discovery and development of HMG-CoA reductase inhibitors (1992) J Lipid Res, 33 (11), pp. 1569-1582

Endo, A., A historical perspective on the discovery of statins (2010) Proc Jpn Acad ser B: Phys Biol Sci, 86 (5), pp. 484-493

Sirtori, C.R., The pharmacology of statins (2014) Pharmacol Res, 88, pp. 3-11

Mihos, C.G., Pineda, A.M., Santana, O., Cardiovascular effects of statins, beyond lipid-lowering properties (2014) Pharmacol Res, 88, pp. 12-19

Ferri, N., Corsini, A., Clinical evidence of statin therapy in non-dyslipidemic disorders (2014) Pharmacol Res, 88, pp. 20-30

Dobesh, P.P., Olsen, K.M., Statins role in the prevention and treatment of sepsis (2014) Pharmacol Res, 88, pp. 31-40

Ulivieri, C., Baldari, C.T., Statins: From cholesterol-lowering drugs to novel immunomodulators for the treatment of th17-mediated autoimmune diseases (2014) Pharmacol Res, 88, pp. 41-52

Zhang, Y., Bradley, A.D., Wang, D., Reinhardt, R.A., Statins, bone metabolism and treatment of bone catabolic diseases (2014) Pharmacol Res, 88, pp. 53-61

Kassimatis, T., Goldsmith, D.J.A., Statins in chronic kidney disease and kidney transplantation (2014) Pharmacol Res, 88, pp. 62-73

Malfitano, A.M., Marasco, G., Proto, M.C., Laezza, C., Gazzerro, P., Bifulco, M., Statins in neurological disorders: An overview and update (2014) Pharmacol Res, 88, pp. 74-83

Pisanti, S., Picardi, P., Ciaglia, E., D'Alessandro, A., Bifulco, M., Novel prospects of statins as therapeutic agents in cancer (2014) Pharmacol Res, 88, pp. 84-98

Gelissen, I.C., McLachlan, A.J., The pharmacogenomics of statins (2014) Pharmacol Res, 88, pp. 99-106

Norata, G.D., Tibolla, G., Catapano, A.L., Statins and skeletal muscles toxicity: From clinical trials to everyday practice (2014) Pharmacol Res, 88, pp. 107-113

Kohler, B., (2007) Photochem. Photobiol., 83, p. 59

Crespo-Hern ndez, C. E., Cohen, B., Hare, P. M., Kohler, B., (2004) Chem. Rev., 104, p. 1977

Matsika, S., (2004) J. Phys. Chem. A, 108, p. 7584

Matsika, S., (2005) J. Phys. Chem. A, 109, p. 7538

Improta, R., Barone, V., (2004) J. Am. Chem. Soc., 126, p. 14320

Zgierski, M. Z., Patchkovskii, S., Fujiwara, T., Lim, E. C., (2005) J. Phys. Chem. A, 109, p. 9384

Merch n, M., Gonzalez-Luque, R., Climent, T., Serrano-Andres, L., Rodriguez, E., Reguero, M., Pelaez, D., (2006) J. Phys. Chem. B, 110, p. 26471

Hudock, H. R., Levine, B. G., Thompson, A. L., Satzger, H., Townsend, D., Gador, N., Ullrich, S., Martinez, T. J., (2007) J. Phys. Chem. A, 111, p. 8500

Ismail, N., Blancafort, L., Olivucci, M., Kohler, B., Robb, M. A., (2002) J. Am. Chem. Soc., 124, p. 6818

Blancafort, L., Robb, M. A., (2004) J. Phys. Chem. A, 108, p. 10609

Blancafort, L., Cohen, B., Hare, P. M., Kohler, B., Robb, M. A., (2005) J. Phys. Chem. A, 109, p. 4431

Zgierski, M. Z., Alavi, S., (2006) Chem. Phys. Lett., 426, p. 398

Blancafort, L., (2007) Photochem. Photobiol., 83, p. 603

Kistler, K. A., Matsika, S., (2007) J. Phys. Chem. A, 111, p. 2650

Zgierski, M. Z., Fujiwara, T., Kofron, W. G., Lim, E. C., (2007) Phys. Chem. Chem. Phys., 9, p. 3206

Marian, C. M., (2005) J. Chem. Phys., 122, p. 104314

Marian, C., Nolting, D., Weinkauf, R., (2005) Phys. Chem. Chem. Phys., 7, p. 3306

Nielsen, S. B., S lling, T. I., (2005) ChemPhysChem., 6, p. 1276

Perun, S., Sobolewski, A. L., Domcke, W., (2005) Chem. Phys., 313, p. 107

Barbatti, M., Lischka, H., (2007) J. Phys. Chem. A, 111, p. 2852

Chung, W. C., Lan, Z., Ohtsuki, Y., Shimakura, N., Domcke, W., Fujimura, Y., (2007) Phys. Chem. Chem. Phys., 9, p. 2075

Santoro, F., Barone, V., Improta, R., (2007) Proc. Natl. Acad. Sci. USA, 104, p. 9931

Yamazaki, S., Kato, S., (2007) J. Am. Chem. Soc., 129, p. 2901

Gustavsson, T., Banyasz, A., Lazzarotto, E., Markovitsi, D., Scalmani, G., Frisch, M. J., Barone, V., Improta, R., (2006) J. Am. Chem. Soc., 128, p. 607

Gustavsson, T., Sarkar, N., Lazzarotto, E., Markovitsi, D., Barone, V., Improta, R., (2006) J. Phys. Chem. B, 110, p. 12843

Hare, P. M., Crespo-Hern ndez, C. E., Kohler, B., (2006) J. Phys. Chem. B, 110, p. 18641

Markovitsi, D., Talbot, F., Gustavsson, T., Onidas, D., Lazzarotto, E., Marguet, S., (2006) Nature, 441, pp. E7

Onidas, D., Gustavsson, T., Lazzarotto, E., Markovitsi, D., (2007) J. Phys. Chem. B, 111, p. 9644

Buchvarov, I., Wang, Q., Raytchev, M., Trifonov, A., Fiebig, T., (2007) Proc. Natl. Acad. Sci. USA, 104, p. 4794

Gustavsson, T., Sharonov, A., Markovitsi, D., (2002) Chem. Phys. Lett., 351, p. 195

Sharonov, A., Gustavsson, T., Carr, V., Renault, E., Markovitsi, D., (2003) Chem. Phys. Lett., 380, p. 173

Shiang, J. J., Cole, A. G., Sension, R. J., Hang, K., Weng, Y., Trommel, J. S., Marzilli, L. G., Lian, T., (2006) J. Am. Chem. Soc., 128, p. 801

Marks, D., Zhang, H., Glasbeek, M., Borowicz, P., Grabowska, A., (1997) Chem. Phys. Lett., 275, p. 370

Gulbinas, V., Markovitsi, D., Gustavsson, T., Karpicz, R., Veber, M., (2000) J. Phys. Chem. A, 104, p. 5181

Gustavsson, T., Cassara, L., Marguet, S., Gurzadyan, G., Meulen, P. v. d., Pommeret, S., Mialocq, J. -C., (2003) Photochem. Photobiol. Sci., 2, p. 329

Olivucci, M., Lami, A., Santoro, F., (2005) Angew. Chem., Int. Ed., 44, p. 5118

Improta, R., Santoro, F., (2005) J. Chem. Theory Comput., 1, p. 215

F rster, T., Rokos, K., (1967) Chem. Phys. Lett., 1, p. 279

Knight, A. E. W., Selinger, B. K., (1971) Chem. Phys. Lett., 12, p. 419

Pant, D., Levinger, N. E., (1999) J. Phys. Chem. B, 103, p. 7846

Middleton, C. T., Cohen, B., Kohler, B., (2007) J. Phys. Chem. A, 111, p. 10460

Salet, C., Bensasson, R., (1975) Photochem. Photobiol., 22, p. 231

Brown, I. H., Johns, H. E., (1968) Photochem. Photobiol., 8, p. 273

Marian, C. M., Schneider, F., Kleinschmidt, M., Tatchen, J., (2002) Eur. Phys. J. D: Atom., Mol. Opt. Phys., 20, p. 357

Climent, T., Gonzalez-Luque, R., Merchan, M., Serrano-Andres, L., (2007) Chem. Phys. Lett., 441, p. 327

Crespo-Hernández, C.E., Cohen, B., Hare, P.M., Kohler, B., (2004) Chem. Rev., 104, p. 1977

Zgierski, M.Z., Patchkovskii, S., Fujiwara, T., Lim, E.C., (2005) J. Phys. Chem. A, 109, p. 9384

Merchán, M., Gonzalez-Luque, R., Climent, T., Serrano-Andres, L., Rodriguez, E., Reguero, M., Pelaez, D., (2006) J. Phys. Chem. B, 110, p. 26471

Hudock, H.R., Levine, B.G., Thompson, A.L., Satzger, H., Townsend, D., Gador, N., Ullrich, S., Martinez, T.J., (2007) J. Phys. Chem. A, 111, p. 8500

Zgierski, M.Z., Alavi, S., (2006) Chem. Phys. Lett., 426, p. 398

Kistler, K.A., Matsika, S., (2007) J. Phys. Chem. A, 111, p. 2650

Zgierski, M.Z., Fujiwara, T., Kofron, W.G., Lim, E.C., (2007) Phys. Chem. Chem. Phys., 9, p. 3206

Marian, C.M., (2005) J. Chem. Phys., 122, p. 104314

Nielsen, S.B., Sølling, T.I., (2005) ChemPhysChem., 6, p. 1276

Chung, W.C., Lan, Z., Ohtsuki, Y., Shimakura, N., Domcke, W., Fujimura, Y., (2007) Phys. Chem. Chem. Phys., 9, p. 2075

Hare, P.M., Crespo-Hernández, C.E., Kohler, B., (2006) J. Phys. Chem. B, 110, p. 18641

Shiang, J.J., Cole, A.G., Sension, R.J., Hang, K., Weng, Y., Trommel, J.S., Marzilli, L.G., Lian, T., (2006) J. Am. Chem. Soc., 128, p. 801

Förster, T., Rokos, K., (1967) Chem. Phys. Lett., 1, p. 279

Knight, A.E.W., Selinger, B.K., (1971) Chem. Phys. Lett., 12, p. 419

Middleton, C.T., Cohen, B., Kohler, B., (2007) J. Phys. Chem. A, 111, p. 10460

Brown, I.H., Johns, H.E., (1968) Photochem. Photobiol., 8, p. 273

Marian, C.M., Schneider, F., Kleinschmidt, M., Tatchen, J., (2002) Eur. Phys. J. D: Atom., Mol. Opt. Phys., 20, p. 357

Nessun risultato.
Nessun risultato.


Contiene: [X]      Estesa  

Autori: [X]   E Tipo di lavoro: [X]

E Data iniziale: Data finale: [X]   E Sede:  E    Affiliazione IBB   [Pulisci modulo]

* Trifluoroacetylated tyrosine-rich D-tetrapeptides have potent antioxidant activity (61 visite)
Sandomenico A, Severino V, Apone F, De Lucia A, Caporale A, Doti N, Russo A, Russo R, Rega C, Del Giacco T, Falcigno L, Ruvo M, Chambery A
Peptides (ISSN: 1873-5169electronic, 0196-9781linking), 2017 Mar; 89: 50-59.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (88 visite)
Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (84 visite)
Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (95 visite)
Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (81 visite)
Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Antioxidant activity of virgin olive oil phenolic compounds in a micellar system (83 visite)
Fogliano V, Ritieni A, Monti SM, Gallo M, Della Medaglia D, Ambrosino ML, Sacchi R
Journal Of The Science Of Food And Agriculture (ISSN: 0022-5142), 1999 Oct; 79(13): 1803-1808.
Dettagli    Esporta in BibTeX    Esporta in EndNote



6 Records (6 escludendo Abstract e Conferenze).
Impact factor totale: 16.244 (16.244 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 13.62 (13.62 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor" OR [btitle] "Antioxidant Activity" OR [btitle] "Blood Clotting" OR [btitle] "Bone Metabolism" OR [btitle] "Cardiovascular Effect") AND NOT [id] = 9130)







    Esporta in BibTeX    Esporta in EndNote

Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 14:45:53
104 visite. Ultima visita in data Monday 17 September 2018, 21:17:07

Webmaster and developer: Marco Comerci
Per problemi e suggerimenti: adminibb.cnr.it
Ultimo aggiornamento: Monday 24 September 2018, 13:46:06